Dr. Emmanuel Oladipo Ajani
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Dr. Emmanuel Oladipo Ajani

Associate Professor
Kwara State University, Nigeria

Highest Degree
Ph.D. in Biochemistry from Olabisi Onabanjo University, Nigeria

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Area of Interest:

Pharmacology and Toxicology
100%
Drug Development
62%
Ethnopharmacology
90%
Phytotherapy
75%
Biochemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Saheed, S., S.O. Taofik, A.E. Oladipo and A.A.O. Tom, 2017. Spondias mombin L. (Anacardiaceae) enhances detoxification of hepatic and macromolecular oxidants in acetaminophen-intoxicated rats. Pak. J. Pharm. Sci., 30: 2109-2117.
    PubMed  |  Direct Link  |  
  2. Sabiua, S., E.O. Ajania, T.O. Sunmonud, F.O. Balogunc, A.O.T. Ashafac, R.B. Othmana and S.K. Olowaa, 2017. Mechanism of hepatoprotective potential of aqueous leaves extract of Eucalyptus oblique (Myrtaceae) in carbon tetrachloride intoxicated Wistar rats. J. Applied Pharm. Sci., 7: 183-190.
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  3. Sabiu, S., E.O. Ajani, T.O. Sunmonu and A.O.T. Ashafa, 2017. Kinetics of modulatory role of Cyperus esculentus L. on the specific activity of key carbohydrate metabolizing enzymes. Afr. J. Tradit. Complement Altern. Med., 14: 46-53.
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  4. Sabiu, S., E.O. Ajani, I.O. Nurain, A.O. Sulyman and R. Ibrahim et al., 2017. In vitro radical scavenging potential and toxicopathological implications of administration of aqueous leaf extract of Eucalyptus oblique L. Her. (Myrtaceae) in Wistar rats. Comparat. Clin. Pathol., 26: 1241-1251.
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  5. Sabiu, S., E.O. Ajani, A.A. Ajao, T.O. Sunmonu and A.S. Ibraheem et al., 2017. Biomembrane stabilization and antiulcerogenic properties of aqueous leaf extract of Gossypium barbadense L. (Malvaceae). Beni-Suef Univ. J. Basic Applied Sci. 10.1016/j.bjbas.2017.05.007.
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  6. Bamisaye, F.A., A.O. Sulyman, E.O. Ajani and V.A. Alabi, 2017. Toxicological implication of sub-chronic administration of aqueous leaves extract of Cochlospermum planchonii in albino rats. Pharmacologia, 8: 18-24.
  7. Bamisaye, F.A., A.O. Sulyman, E.O. Ajani and A.B. Muhammed, 2017. Protective effect of juice extract of mesocarp rind of Citrullus lanatus in carbon tetrachloride-induced oxidative stress in rats. J. Coastal Life Med., 5: 264-269.
  8. Akintunde, J., E. Irondi, E. Ajani and V. Olayemi, 2017. Neuromodulation of signalling systems via depletion of adenosine deaminase, monoamine oxidase-A and cholinesterase activities by dietary black seed flour in rats intoxicated with mixture of environmental metals. Neurotoxicity Res., (In Press). .
  9. Akintunde, J., E. Irondi, E. Ajani and V. Olayemi, 2017. Dietary inclusion from black seed flour inhibits ectoenzyme, adenosine deaminase and acetylcholinesterase activities in leachate-exposed reproductive toxicity in rat testes. Reprod. Toxicol., (In Press). .
  10. Ajani, E.O., S. Sabiu, M. Zakari, B.E. Olanipekun, J.K. Akintunde and F.A. Bamisaye, 2017. Antioxidant capacity of fractionated extract and structural elucidation of isolated compounds from leaf extract of Hydrocotyl bonariensis Comm. Exlam. J. Biol. Active Prod. Nat., 7: 166-177.
  11. Ajani, E.O., S. Sabiu, K.T. Odufuwa, T.B. Ibrahim and B.A. Salau, 2017. Evaluation of lens aldose reductase inhibitory and free radical scavenging potential of fractions of Lonchocarpus cyanescens: Potential for cataract remediation. Pharmacogn. J., 9: 62-69.
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  12. Abraham, B.F., S.A. Olarewaju, A. Ronke and A.E. Oladipo, 2017. Antidiabetic and antidyslipidemic activities of aqueous extract of Cochlospamum planchonii leaves in streptozocin induced diabetic rats. Iran. J. Med. Sci., (In Press). .
  13. Saheed, S., A.E. Oladipipo, B.O. Temitope and Y.O. Bashirat, 2016. Aqueous extract of Cyperus esculentus L. restores and boosts sexual competence in paroxetine-dysfunctioned male Wistar rats. J. Exp. Integrat. Med., 6: 12-20.
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  14. Oladipipo, A.E., S. Saheed and B.F. Abraham, 2016. Four weeks daily dose oral administration assessment of Cyperus esculentus L. aqueous extract on key metabolic markers of wistar rats. Pharmacologia, 7: 125-133.
    CrossRef  |  
  15. Ajani, E.O., S. Sabiu, F.A. Bamisaye, O.I. Nurain and O.S. Abdulsalam, 2016. Lens aldose reductase inhibitory and free radical scavenging activity of fractions of Chromolaena odorata (Siam Weed): Potential for cataract remediation. Not. Sci. Biol., 8: 263-271.
  16. Ajani, E.O., S. Sabiu, A.F. Bamisaye and A.K. Abdulmummen, 2016. Evaluation of lens aldose reductase inhibitory and free radical scavenging activity of purified fractions of Hyptis suaveolens flower: Potential for cataract remediation. Pharmacologia, 7: 318-327.
  17. Saheed, S., A.E. Oladipipo, A.A. Abdulazeez, S.A. Olarewaju and N.O. Ismaila et al., 2015. Toxicological evaluations of Stigma maydis (corn silk) aqueous extract on hematological and lipid parameters in Wistar rats. Toxicol. Rep., 2: 638-644.
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  18. Sabiu, S., T.O. Sunmonu, E.O. Ajani and T.O. Ajiboye, 2015. Combined administration of silymarin and vitamin C stalls acetaminophen-mediated hepatic oxidative insults in Wistar rats. Rev. Brasil. Farmacogn., 25: 29-34.
    CrossRef  |  
  19. Sabiu, S., T. Garuba, T. Sunmonu, E. Ajani, A. Sulyman, I. Nurain and A. Balogun, 2015. Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperate. Toxicol. Rep., 2: 261-267.
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  20. Ogunlabi, O.O., O.Z. Ogunbadejo, J. Adetutu, O. Asifat, B.O. Adegbesan and E.O. Ajani, 2015. Pre-treatment with Phyllanthus amarus stalls dyslipidemia and uterine toxicity in monosodium glutamate administered rats. J. Biol. Chem. Res., 32: 782-796.
  21. Nurain, I.O., J.K. Akintunde, K.E. Adebisi, L.A. Azeez, F.A; Bamisaye, E.O. Ajani and C.O. Bewaji, 2015. Intake of powdered tea supplemented with Moringa oleifera leaf attenuates some haematological parameters in malnourished children. J. Biol. Chem. Res., 32: 892-901.
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  22. Faponle, A.S., A. Atunnise, B.O. Adegbesan, O.O. Ogunlabi, K.T. Odufuwa and E.O. Ajani, 2015. Separate and co-administration of Amaranthus spinosus and vitamin C modulates cardiovascular disease risk in high fat diet-fed experimental rats. J. Pharmacogn. Phytother., 7: 27-34.
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  23. Faponle, A.S., A. Atunnise, B.O. Adegbesan, O.O. Ogunlabi, K.T. Odufuwa and E.O. Ajani, 2015. Combined administration of Rauwolfia vomitoria extract and vitamin C elicits hypolipidemic and anti-oxidative potentials in high-fat fed experimental rats. IOSR J. Pharm. Biol. Sci., 10: 52-60.
  24. Eniola, O.W., O.A. Omobola, A.S. Joseph, S.B. Adewale and O.A. Oluwaseun et al., 2015. Phytochemical screening and toxicological implication of administration of aqueous cocoa powder extract obtained from Nigeria in albino rat. Asian J. Plant Sci. Res., 5: 4-8.
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  25. Alabi, M.A., E.O. Ajani, G. Idowu, F. Afolabi, S.A. Ayoola and F.A. Kareem, 2015. Oral administration of ascorbic acid attenuates renal and hepatic toxicity of phenobarbitone in experimental rats. J. Chem. Pharmaceut. Res., 7: 1-5.
  26. Salau, B.A., E.O. Ajani, O.L. Adebayo, A.K. Atunnise and O. Osilesi, 2014. High sucrose diet modulates calcium status in male albino rats: Possible implication on cardiovascular disease and dental caries. Ann. Biol. Sci., 2: 45-50.
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  27. Olooto, W.E., O.A. Ogundahunsi, T.A. Banjo, B.A. Salau, A.A. Amballi, E.O. Ajani and O.A. Onakomaya, 2014. Hypoglycemic and modifying effect of aqueous cocoa powder extract on diabetic-induced histologic changes in the pancreas of alloxan diabetic rats. Ann. Biol. Sci., 2: 10-18.
  28. Ogunlabi, O.O., B.O. Adegbesan, O.B. Sumaoya and E.O. Ajani, 2014. Modulating effects of Allium sativum (garlic) extract in monosodium glutamate induced injuries in rats. Med. Plants-Int. J. Phytomed. Relat. Ind., 6: 28-35.
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  29. Kareem, F.A., I.O. Osonuga, M.A. Alabi and E.O. Ajani, 2014. Haematological changes associated with administration of therapeutic dose of p-alaxin in healthy adult wistar rats. J. Nat. Sci. Res., 4: 1-5.
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  30. Emmanuel, O.A., O.A. Bukunola, O.O. Olugbenga, D.A. Ayodeji and A. Olalekan, 2014. Implication of folic acid supplementation on kidney oxidative stress and ion homeostasis in artemisinin combination therapy induced metabolic alteration. Int. J. Biol. Pharm. Res., 5: 643-650.
  31. Bamisaye, F.A., E.O. Ajani, I.O. Nurain, K.E. Adebisi, R.T. Quadri and J.B. Minari, 2014. Evaluation of growth performance of rats fed with sweet detar, Detarium microcarpum fruit as supplementary feed ingredient. IOSR J. Environ. Sci. Toxicol. Food Technol., 8: 115-121.
  32. Bamisaye, F.A., E.O. Ajani, I.O. Nurain and J.B. Minari, 2014. Nutritional evaluation of some fortified traditional weaning meals from Oriade Local Government Area of Osun State, Nigeria. Int. J. Applied Sci. Biotechnol., 2: 359-363.
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  33. Bamisaye, F.A., E.O. Ajani, I.O. Nurain and J.B. Minari, 2014. Medico-botanical investigation of siam weed (Chromolaena odorata) used among the “Ijebu” people of Ogun State, Nigeria. J. Med. Med. Sci., 5: 20-24.
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  34. Bamisaye, F.A., E.O. Ajani, A.Y. Adeyanju and J.B. Minari, 2014. Growth and toxicological effects of sweet detar, Detarium microcarpum fruit supplement on albino rat. Eur. J. Mol. Biol. Biochem., 1: 1-6.
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  35. Ajani, E.O., S. Sabiu, F.A. Bamisaye, S. Ibrahim and B.A. Salau, 2014. Evaluation of the acute and sub-acute toxicity effects of ethanolic leaves extract of Lagenaria brevifolia (Bitter gourd) on hepatic and renal function of rats. Eur. J. Med. Plants, 5: 210-219.
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  36. Ajani, E.O., S. Sabiu, F.A. Bamisaye, M.R. Salami and I.O. Nurain, 2014. Ethanolic leaf extract of Langenaria breviflora (bitter gourd) inhibits gastric onslaught in indomethacininduced ulcerated rats. J. Applied Biosci., 85: 7871-7880.
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  37. Ajani, E.O., S. Sabiu, F.A. Bamisaye, B.V. Adenigba, D.D. Awomoyi and M.M. Adeyanju, 2014. Hepatoprotective and antioxidative effect of ethanolic leaf extract of Langenaria breviflora (bitter gourd) on indomethacin-ulcerated rats. IOSR J. Pharm. Biol. Sci., 9: 61-68.
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  38. Ajani, E.O., O.O. Ogunlabi, O. Akinwande and B.O. Adegbesan, 2014. Loranthus micranthus leaves extract attenuates risk factors of cardiovascular disease in fructose fed rats. Eur. J. Med. Plants, 4: 1489-1500.
  39. Ajani, E.O., O. O. Ogunlabi, B.O. Adegbesan, O.E. Adeosun and O. Akinwande, 2014. Nigerian mistletoe (Loranthus micranthus Linn) aqueous leaves extract modulates some cardiovascular disease risk factors in monosodium glutamate induced metabolic dysfunction. Afr. J. Biotech., 13: 3989-3998.
  40. Adegbesan, B.O., O.O. Ogunlabi and E.O. Ajani, 2014. Comparative study of protective effect of separate administration of vitamin C and folic acid in act therapy induced hepatic injury. Scient. Res. Essays, 9: 189-194.
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  41. Salau, B.A., A.O. Ketiku, O.L. Adebayo, W.E. Olooto, E.O. Ajani and O. Osilesi, 2013. Modulation of cardiovascular risk factors (haematological and haemorrheological parameters) caused by sucrose diet. Am. J. Biochem. Mol. Biol., 3: 119-126.
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  42. Salau, B.A., A. Atunnise, O.O. Sodipo, O.E. Kale and E.O. Ajani, 2013. Sub-chronic effects of methanolicbenth bark extract of BrideliaFerruginea on some selected biochemical indicesin rats. IOSR J. Pharm. Biol. Sci., 5: 81-86.
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  43. Nurain, O.I., F.A. Bamisaye and O.E. Ajani, 2013. Modulation of cellular calcium adenosine triphosphatase in tissues of rats fed with protein-deficient diet fortified with Moringa oleifera leaves. Int. J. Phytomed., 5: 519-528.
  44. Bamisaye, F.A., E.O. Ajani and J.B. Minari, 2013. Prospects of ethnobotanical uses of pawpaw (Carica papaya). J. Med. Plants Stud., 1: 171-177.
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  45. Ajani, E.O., F.A. Bamisaye, O.O. Margaret and B.A. Salau, 2013. Dietary supplementation with calcium in healthy rats administered with artemisinin based combination therapy and risk of cardiovascular disease. IOSR J. Pharm. Biol. Sci., 6: 19-23.
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  46. Ajani, E.O., B.A. Salau, W.E. Olooto and F.A. Bamisaye, 2013. Plasma electrolyte and some biochemical changes following separate and combined administration of calcium and artemisinin-lumefantrine based therapy. Asian J. Exp. Biol. Sci., 4: 97-102.
  47. Adebayo, O.L., P.D. Shallie, B.A. Salau, E.O. Ajani and G.A. Adenuga, 2013. Comparative study on the influence of fluoride on lipid peroxidation and antioxidants levels in the different brain regions of well-fed and protein undernourished rats. J. Trace Elem. Med. Biol., 27: 370-374.
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  48. Salau,, B.A. and E.O. Ajani, 2012. Methanolic extract of Musa sapientum (L var. paradisiaca) sucker improves lipid profiles in alloxan induced diabetic rats. Asian J. Biol. Sci., 5: 322-327.
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  49. Salau, B.A., W.E. Olooto, O.L. Adebayo, E.O. Ajani, K.T. Odufuwa and J.O. Olowookere, 2012. Sucrose diet elevates cardiovascular risk factors in male albino rats. Int. J. Biol. Chem., 6: 61-68.
    CrossRef  |  Direct Link  |  
  50. Oyefuga, O.H., M.A. Alabi, E.O. Ajani, P.O. Osineye, O.O. Ogunbamowo, O.T. Sotinola and O.O. Adebawo, 2012. Influence of ageing on brain's antioxidant profile of wister white albino rats. Afr. J. Med. Sci., 5: 60-70.
  51. Oyefuga, O.H., E.O. Ajani, B.A. Salau, F. Agboola and O.O. Adebawo, 2012. Honey consumption and its anti-ageing potency in white Wister albino rats. Sch. J. Biol. Sci., 1: 15-19.
  52. Ajani, E.O., B.A. Salau, O.L. Adebayo, B.O. Adegbesan and K.T. Odufuwa, 2012. Administration of Hydrocotyl bonariensis aqueous leaves extract regulates cardiovascular disease risk factors in galactose model of experimental cataractogenesis. Sci. Res. Essays, 7: 1527-1530.
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  53. Salau, B.A., E.O. Ajani, M.O. Soladoye and N.A. Bisuga, 2011. Evaluation of iodine content of some selected fruits and vegetables in Nigeria. Afr. J. Biotechnol., 10: 960-964.
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  54. Salau, B.A., E.O. Ajani, G.A. Adenuga, G.O. Idowu and E.W. Olooto, 2011. Implications of dietary sucrose on feed intake, bodyweight and blood glucose level of rats. Res. Bioscientia., 2: 7-12.
  55. Ajani, E.O., B.A. Salau, E.W. Olooto, O.L. Adebayo and G.A. Adenuga, 2011. Toxicological implications of continuous administration of aqueous leaves extract of hydrocotyl bonariensis in rats. Arch. Applied Sci. Res., 3: 471-478.
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  56. Ajani, E.O., B.A. Salau, B.O. Adegbesan, M.O. Ogunsola and G.O. Adenuga, 2011. Inhibitory effect of aqueous and organic extracts of Hydrocotyl bonariensis (largeleaf pennyworth) on rat lens aldose reductase activity. Res. Biosci., 2: 12-21.
  57. Ajani, E.O., A. Ajibola, B.A. Salau, T.K. Odufuwa and A.O. Odewabi, 2011. Preliminary report on hepatic and cardiovascular risk assessment of automobile mechanics in Nigeria. Afr. J. Biotechnol., 10: 1705-1711.
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  58. Salau, B.A., E.O. Ajani, K.T. Odufuwa, B.O. Adegbesan, and M.O. Soladoye, 2010. Effect of processing on iodine content of some selected plants food. Afr. J. Biotechnol., 9: 1200-1204.
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  59. Salau, B.A., E.O. Ajani, A.A. Akinlolu, M.N. Ekor and M.O. Soladoye, 2010. Methanolic extract of Musa sapientum sucker moderates fasting blood glucose and body weight of alloxan induced diabetic rats. Asian J. Exp. Biol. Sci., 1: 30-35.
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  60. Ajani, E.O., B.A. Salau, E.N. Ezima, O.H. Oyefuga and P.O. Osineye, 2009. A study on the combined administration of chloroquine and insulin effect on serum transferases and phosphatases activity during increased dietary fat and calcium consumption. Afr. J. Biochem. Res., 3: 13-16.
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  61. Ajani, E.O., A.A. Salako, P.D. Sharlie, W.A. Akinleye, A.O. Adeoye, B.A. Salau and O.O. Adebawo, 2009. Chemopreventive and remediation effect of Hydrocotyl bonariensis Comm. Ex Lam (Apiaceae) leave extract in galactose-induced cataract. J. Ethnopharmacol., 123: 134-142.
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  62. Salau, B.A., A.O. Ketiku, E.O. Ajani, E.N. Ezima, G.O. Idowu and M.O. Soladoye, 2008. Iodine contents of some selected roots/tubers, cereals and legumes consumed in Nigeria. Afr. J. Biotechnol., 7: 4328-4330.
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  63. Ajani, E.O., P.D. Shallie, B.O. Adegbesan, B.A. Salau and M. Adesanya, 2008. Protective effect of Garcinia Kola. (Kolaviron) extract on predisposition of rats to cardiovascular diseases following separate administration of amodiaquine and artesunate. Afr. J. Tradit. Complement Altern. Med., 5: 180-186.
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  64. Ajani, E.O., O.O. Adebawo, B.A. Salau, P.O. Osineye, M.M. Adeyanju and O.K. Aro, 2008. Comparative study of tissue oxidative stress in Hydrocotyl bonarienssis treated rats fed with dietary galactose. J. Biol. Environ. Sci., 2: 15-21.
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  65. Ajani, E.O., P.D. Shallie, B.O. Adegbesan, B.A. Salau and A. Akinpelu, 2007. A study of the hepatoprotective effect of Garcinia Kola water extract in amodiaquine and artesunate treated rats. Niger. J. Health Biomed. Sci., 6: 9-15.
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  66. Solahdeen, H.M., T.R. Fagbohun and E.O. Ajani, 2006. Gastropotective effects of extract of Parkia biglobossa (stem bark) on experimental ulceration in rats. Rec. Prog. Med. Plant, 11: 277-285.
  67. Adebawo, O., B. Salau, E. Ezima, O. Oyefuga and E. Ajani, 2006. Fruits and vegetables moderate lipid cardiovascular risk factor in hypertensive patients. Lipids Health Dis., 0.1186/1476-511X-5-14.
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  68. Ogunkolo, O.F., A.A. Ambali and E.O. Ajani, 2005. Prevalence of hypercalcemia in Shagamu, Ogun state, Nigeria. Niger. J. Health Biomed. Sci., 4: 149-152.
  69. Ajani, E.O., B.A. Salau, T.R. Fagbohun and A.O. Ogun, 2004. Combined effect of chloroquine and insulin administration on some biochemical parameters in rats placed on high fat and calcium diet. Afr. J. Med. Sci., 33: 365-369.
    PubMed  |  
  70. Salau, B.A., O. Osilesi, G.O. Idowu, S. Musa and E.O. Ajani, 2003. Effects of fruits and vegetables on cardiovascular disease risk factors in non-insulin dependent diabetes mellitus (N.I.D.D.M) subjects. Afr. J. Med. Pharm. Sci., 7: 21-26.
  71. Ajani, E.O., O.O. Animasahun and B.O. Ogundipe, 2003. Effects of Parkia biglobossa (African locust bean) stem bark extract on some liver and kidney enzymes in indomethacine induced gastric ulcerations. Niger. J. Biochem. Mol. Biol., 18: 34-39.
  72. Ajani, E.O., O.O. Aganbi, O.O. Okumodi and B.A. Salau, 2003. Preliminary report on the antiulcerogenic potentials of Parkia biglobossa (African locust bean) stem bark extract. Afr. J. Med. Pharm. Sci., 7: 21-29.
  73. Onyenekwe, P.C., E.O. Ajani, D.A. Ameh and K.S. Gamaniel, 1999. Antihypertensive effect of roselle (Hibiscus sabdariffa) calyx infusion in spontaneously hypertensive rats and a comparison of its toxicity with that in Wistar rats. Cell. Biochem. Funct., 17: 199-206.
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  74. Ajani, E.O., D.A. Ameh and P.C. Onyenekwe, 1999. An investigation into the biochemical effects of continuous consumption of Hibiscus sabdariffa (rossele) calyx extract (Zoborodo) in rats. Niger. J. Nutr. Sci., 20: 7-13.