Dr. Gerard Peter van Nieuw Amerongen
Associate ProfessorVU Medical Center, Netherlands
Highest Degree
Ph.D. in Medicine from Vrije Universiteit Amsterdam, The Netherlands
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VU Medical Center, Netherlands
Biography
Dr. Gerard Peter van Nieuw Amerongen studied Chemistry (Specialization: Biochemistry and Molecular Biology) and Pharmacochemistry (Specialization: Molecular Pharmacology) at the Vrije Universiteit, Amsterdam, The Netherlands. From 1995-1999 he was a PhD student at the Department of Internal Medicine of the Rijksuniversiteit, Leiden, posted to the Department of Vascular and Connective tissue Research. His main interest was regulation of the Endothelial Barrier, the Primary Determinant of Vascular Leak and Edema Formation, an exciting finding was the Elucidation of the Pivotal role in Prolonged Endothelial Hyperpermeability of the RhoA/Rho kinase signal transduction pathway. For these studies he received a Young Investigator Award from the German Society for Histochemistry in 1998. In 1999, he was appointed as a Post-doctoral Fellow at the Department of Physiology, Faculty of Medicine, Vrije Universiteit Amsterdam. To extend his research program on the regulation of Endothelial Functions, he spent over one year in the Center for Cardiovascular Research at the University of Rochester to study the role of tyrosine (de) phosphorylations in the signal transduction of the vascular wall. Dr. Gerard was appointed as Assistant Professor at the Institute for Cardiovascular Research of the VU university medical center (ICaR-VU), Amsterdam, where he currently serves as theme Leader of the Circulation and Metabolism program. Dr. Gerard initiated several long-term international collaborations with leading laboratories. In 2007, he started collaboration with the Fredberg lab (Harvard Public School of Health, Boston MA) on mapping of cell-exerted tractions on the sub-endothelial matrix, with work visits in December 2008 and June 2009. During the summer of 2008, he spent a Mini-Sabbatical in the Malik lab (Center for Lung and Vascular Biology, UIC, Chicago IL), imaging dynamic changes of Endothelial Cell Junctions as well as pursuing in vivo application of siRNA technology in mouse models for Pulmonary Micro vascular Leakage. To further strengthen this collaboration, Dr. Gerard holds a cross-position as Visiting Associate Professor at their UIC-Pharmacology department. Finally, Dr. Gerard has been appointed as Established Investigator of the Dutch Heart Foundation (2012-2016).
Area of Interest:
Pharmacology and Toxicology
100%
Biochemistry
62%
Molecular Biology
90%
Molecular Pharmacology
75%
Pharmaceutical Chemistry
55%
Research Publications in Numbers
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Chapters
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Articles
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Abstracts
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Selected Publications
- Daneshjou, N., N. Sieracki, G.P. van Nieuw Amerongen, M.A. Schwartz, Y.A. Komarova and A.B. Malik, 2015. Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction. J. Cell Biol., 208: 23-32.
CrossRef | PubMed | - Terpstra, M.L., J. Aman, G.P. van Nieuw Amerongen and A.J. Groeneveld, 2014. Plasma biomarkers for acute respiratory distress syndrome: A systematic review and meta-analysis. Crit. Care Med., 42: 691-700.
CrossRef | Direct Link | - Szulcek, R., H.J. Bogaard and G.P. van Nieuw Amerongen, 2014. Electric cell-substrate impedance sensing for the quantification of endothelial proliferation, barrier function and motility. J. Visualized Experiments. 10.3791/51300.
CrossRef | Direct Link | - Botros, L., G.P. Van Nieuw Amerongen, A.V. Noordegraaf and H.J. Bogaard, 2014. Recovery from mitomycin-induced pulmonary arterial hypertension. Ann. Am. Thoracic Soc., 11: 468-470.
CrossRef | PubMed | Direct Link | - Amado-Azevedo, J., E.T. Valent and G.P. Van Nieuw Amerongen, 2014. Regulation of the endothelial barrier function: A filum granum of cellular forces, Rho-GTPase signaling and microenvironment. Cell Tissue Res., 355: 557-576.
CrossRef | Direct Link | - Van Nieuw Amerongen, G.P., 2013. Barrier Maintenance in Neovessels. In: Mechanical and Chemical Signaling in Angiogenesis, Reinhart-King, C.A. (Ed.). Springer, New York, USA., ISBN: 978-3-642-30855-0, pp: 211-226.
- Szulcek, R., C.M. Beckers, J. Hodzic, J. de Wit and Z. Chen et al., 2013. Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrity. Cardiovasc. Res., 99: 471-482.
CrossRef | Direct Link | - Bakhshi, F.R., M. Mao, A.N. Shajahan, T. Piegeler and Z. Chen et al., 2013. Nitrosation-dependent caveolin 1 phosphorylation, ubiquitination, and degradation and its association with idiopathic pulmonary arterial hypertension. Pulmonary Circ., 3: 816-830.
CrossRef | Direct Link | - Aman, J., M.J. Peters, C. Weenink, G.P. van Nieuw Amerongen and A. Vonk Noordegraaf, 2013. Reversal of vascular leak with imatinib. Am. J. Respir. Crit. Care Med., 188: 1171-1173.
CrossRef | Direct Link | - Aman, J., G.P. van Nieuw Amerongen and V.W.M. van Hinsbergh, 2013. Cell-Matrix Adhesions as the Safety Brakes of Failing Endothelial Adherens Junctions. In: Endothelial Cytoskeleton, Rosado, J.A. and P.C. Redondo (Eds.). CRC Press/Taylor and Francis Group, ISBN-13: 978-1466590359, pp: 167-199.
- Van Nieuw Amerongen, G.P., J. Aman and A.J. Groeneveld, 2012. The role of inflammatory mediators in the association of pulmonary edema with increased cardiac index and pulmonary vascular filling. Crit. Care Med., 40: 3107-3107.
CrossRef | Direct Link | - Chen, Z., F.R. Bakhshi, A.N. Shajahan, T. Sharma and M. Mao et al., 2012. Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition. Mol. Biol. Cell, 23: 1388-1398.
CrossRef | - Aman, J., J. van Bezu, A. Damanafshan, S. Huveneers and E.C. Eringa et al., 2012. Effective treatment of edema and endothelial barrier dysfunction with imatinib. Circulation, 126: 2728-2738.
CrossRef | PubMed | Direct Link | - Aman, J., G.P. van Nieuw Amerongen and A.J. Groeneveld, 2012. Importance of events per independent variable in logistic regression analysis. Crit. Care Med., 40: 1392-1393.
CrossRef | Direct Link | - Aman, J., E. Thunnissen, M.A. Paul, A.G. van Nieuw and A. Vonk-Noordegraaf, 2012. Successful treatment of diffuse pulmonary lymphangiomatosis with bevacizumab. Ann. Internal Med., 156: 839-840.
CrossRef | PubMed | Direct Link | - Aman, J., A.J. Groeneveld and G.P. van Nieuw Amerongen, 2012. Predictors of pulmonary edema formation during fluid loading in the critically ill with presumed hypovolemia. Crit. Care Med., 40: 793-799.
CrossRef | Direct Link | - Van der Heijden, M., G.P. van Nieuw Amerongen, J. van Bezu, M.A. Paul, A.J. Groeneveld and V.W. van Hinsbergh, 2011. Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells. PLoS ONE, Vol. 6. 10.1371/journal.pone.0023448.
CrossRef | Direct Link | - Van Nieuw Amerongen, G.P., R. Minshall and A.B. Malik, 2011. Caveolae and Signaling in Pulmonary Vascular Endothelial and Smooth Muscle Cells. In: Textbook of Pulmonary Vascular Disease, Yuan, J.X.J., J.G.N. Garcia, J.B. West, C.A. Hales, S. Rich and S.L. Archer (Eds.). Chapter 16, Springer, New York, USA., ISBN: 978-0-387-87428-9, pp: 273-285.
- Sipkens, J.A., N.E. Hahn, G.P. van Nieuw-Amerongen, C.D. Stehouwer and J.A. Rauwerda et al., 2011. Homocysteine induces phosphatidylserine exposure in cardiomyocytes through inhibition of Rho kinase and flippase activity. Cell. Physiol. Biochem., 28: 53-62.
CrossRef | Direct Link | - Aman, J., M. van der Heijden, A. van Lingen, A.R. Girbes, G.P. van Nieuw Amerongen, V.W. van Hinsbergh and A.J. Groeneveld, 2011. Plasma protein levels are markers of pulmonary vascular permeability and degree of lung injury in critically ill patients with or at risk for acute lung injury/acute respiratory distress syndrome. Crit. Care Med., 39: 89-97.
CrossRef | Direct Link | - Weijers, E.M., P. Koolwijk, V.W.M. van Hinsbergh and G.P. van Nieuw Amerongen, 2010. Fibrin β15-42 domain is cryptic in intact fibrinogen: Comment on the study by A. Sahni et al. Int. J. Cancer, 127: 2981-2982.
CrossRef | Direct Link | - Van der Heijden, M., G.P. van Nieuw Amerongen, V.W. van Hinsbergh and A.J. Groeneveld, 2010. The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients. Shock, 33: 263-268.
CrossRef | Direct Link | - Van Nieuw Amerongen, G.P. and A.J. Groeneveld, 2010. A plethora of angiopoietin-2 effects during clinical sepsis. Crit. Care, Vol. 14. 10.1186/cc9053.
CrossRef | Direct Link | - Mouchaers, K.T.B., I. Schalij, M.A. de Boer, P.E. Postmus and V.W.M. van Hinsbergh et al., 2010. Effective reduction of MCT-PAH by Fasudil. Comparison with bosentan and sildenafil. Eur. Respir. J., 36: 800-807.
CrossRef | PubMed | Direct Link | - Minshall, R.D., E.E. Vandenbroucke, M. Holinstat, A.T. Place and C. Tiruppathi et al., 2010. Role of protein kinase Cζ in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers. Microvasc. Res., 80: 240-249.
CrossRef | Direct Link | - Krishnan, R., D.D. Klumpers, C.Y. Park, K. Rajendran and X. Trepat et al., 2010. Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces. Am. J. Physiol.-Cell Physiol., 300: C146-C154.
CrossRef | Direct Link | - Krijnen, P.A., J.A. Sipkens, J.W. Molling, J.A. Rauwerda and C.D. Stehouwer et al., 2010. Inhibition of Rho-ROCK signaling induces apoptotic and non-apoptotic PS exposure in cardiomyocytes via inhibition of flippase. J. Mol. Cell. Cardiol., 49: 781-790.
CrossRef | Direct Link | - Bradley, E.A., E.C. Eringa, C.D. Stehouwer, I. Korstjens and G.P. van Nieuw Amerongen et al., 2010. Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside in the muscle microcirculation increases nitric oxide synthesis and microvascular perfusion. Arterioscler. Thromb. Vasc. Biol., 30: 1137-1142.
CrossRef | PubMed | - Boon, R.A., T.A. Leyen, R.D. Fontijn, J.O. Fledderus and J.M. Baggen et al., 2010. KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium. Blood, 115: 2533-2542.
CrossRef | Direct Link | - Beckers, C.M., V.W. van Hinsbergh and G.P. van Nieuw Amerongen, 2010. Driving Rho GTPase activity in endothelial cells regulates barrier integrity. Thromb. Haemostasis, 19: 40-55.
CrossRef | Direct Link | - Vlasblom, R., A. Muller, C.M. Beckers, G.P. van Nieuw Amerongen and M.J. Zuidwijk et al., 2009. RhoA-ROCK signaling is involved in contraction-mediated inhibition of SERCA2a expression in cardiomyocytes. Pflugers Archiv-Eur. J. Physiol., 458: 785-793.
CrossRef | Direct Link | - Van der Heijden, M., P. Pickkers, G.P. van Nieuw Amerongen, V.W. van Hinsbergh, M.P. Bouw, J.G. van der Hoeven and A.J. Groeneveld, 2009. Circulating angiopoietin-2 levels in the course of septic shock: Relation with fluid balance, pulmonary dysfunction and mortality. Intensive Care Med., 35: 1567-1574.
CrossRef | Direct Link | - Van der Heijden, M., J. Verheij, G.P. van Nieuw Amerongen and A.B.J. Groeneveld, 2009. Crystalloid or colloid fluid loading and pulmonary permeability, edema and injury in septic and nonseptic critically ill patients with hypovolemia. Crit. Care Med., 37: 1275-1281.
CrossRef | Direct Link | - Van der Heijden, M., G.P. van Nieuw Amerongen, S. Chedamni, V.W. van Hinsbergh and A.B. Johan Groeneveld, 2009. The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury. Expert Opin. Therapeut. Targets, 13: 39-53.
CrossRef | Direct Link | - Van Nieuw Amerongen, G.P. and V.W. van Hinsbergh, 2009. Role of ROCK I/II in vascular branching. Am. J. Physiol.-Heart Circ. Physiol., 296: H903-H905.
CrossRef | Direct Link | - Mouchaers, K.T., I. Schalij, A.M. Versteilen, A.M. Hadi and G.P. van Nieuw Amerongen et al., 2009. Endothelin receptor blockade combined with phosphodiesterase-5 inhibition increases right ventricular mitochondrial capacity in pulmonary arterial hypertension. Am. J. Physiol.-Heart Circ. Physiol., 297: H200-H207.
CrossRef | Direct Link | - Cornet, A.D., G.P. van Nieuw Amerongen, A. Beishuizen, M.J. Schultz, A.R. Girbes and A.J. Groeneveld, 2009. Activated protein C in the treatment of acute lung injury and acute respiratory distress syndrome. Expert Opin. Drug Discovery, 4: 219-227.
CrossRef | PubMed | Direct Link | - Van der Heijden, M., G.P. van Nieuw Amerongen, P. Koolwijk, V.W. van Hinsbergh and A.J. Groeneveld, 2008. Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax, 63: 903-909.
CrossRef | Direct Link | - Van der Heijden, M., A.M. Versteilen, P. Sipkema, G.P. van Nieuw Amerongen, R.J. Musters and A.J. Groeneveld, 2008. Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis. Apoptosis, 13: 404-412.
CrossRef | Direct Link | - Van Nieuw Amerongen, G.P., R.J.P. Musters, E.C. Eringa, P. Sipkema and V.W. van Hinsbergh, 2008. Thrombin-induced endothelial barrier disruption in intact microvessels: Role of RhoA/Rho kinase-myosin phosphatase axis. Am. J. Physiol.-Cell Physiol., 294: C1234-C1241.
CrossRef | Direct Link | - Overbeek, M.J., G.P. van Nieuw Amerongen, A. Boonstra, E.F. Smit and A. Vonk-Noordegraaf, 2008. Possible role of imatinib in clinical pulmonary veno-occlusive disease. Eur. Respir. J., 32: 232-235.
CrossRef | PubMed | - Bijman, M.N., M.P. van Berkel, G.P. van Nieuw Amerongen and E. Boven, 2008. Interference with actin dynamics is superior to disturbance of microtubule function in the inhibition of human ovarian cancer cell motility. Biochem. Pharmacol., 76: 707-716.
CrossRef | Direct Link | - Beckers, C.M., J.J. Garcia-Vallejo, V.W. van Hinsbergh and G.P. van Nieuw Amerongen, 2008. Nuclear targeting of β-catenin and p120ctn during thrombin-induced endothelial barrier dysfunction. Cardiovasc. Res., 79: 679-688.
CrossRef | Direct Link | - Van der Heijden, M., A.B.J. Groeneveld and G.P. Van Nieuw Amerongen, 2007. Statins in Sepsis and Acute Lung Injury. In: Yearbook of Intensive Care and Emergency Medicine 2007, Vincent, J.L. (Ed.). Springer, New York, USA., pp: 267-275.
- Van Nieuw Amerongen, G.P., C.M.L. Beckers, I.D. Achekar, S. Zeeman, R.J.P. Musters and V.W.M. Van Hinsbergh, 2007. Involvement of Rho kinase in endothelial barrier maintenance. Arterioscler. Thromb. Vasc. Biol., 27: 2332-2339.
PubMed | - Van Nieuw Amerongen, G.P. and V.W. van Hinsbergh, 2007. Endogenous RhoA inhibitor protects endothelial barrier. Circ. Res., 101: 7-9.
PubMed | - Van de Visse, E.P., M. Van der Heijden, J. Verheij, G.P. van Nieuw Amerongen, V.W.M. van Hinsbergh, A.R.J. Girbes and A.B.J. Groeneveld, 2006. Effect of prior statin therapy on capillary permeability in the lungs after cardiac or vascular surgery. Eur. Respir. J., 27: 1026-1032.
PubMed | - Kapiteijn, K., P. Koolwijk, R.M. van der Weiden, G. van Nieuw Amerongen, M. Plaisier, V.W. van Hinsbergh and F.M. Helmerhorst, 2006. Human embryo-conditioned medium stimulates in vitro endometrial angiogenesis. Fertil. Steril., 85: 1232-1239.
CrossRef | Direct Link | - Gabriel, M., G.P. van Nieuw Amerongen, V.W. van Hinsbergh, A.V. van Nieuw Amerongen and A. Zentner, 2006. Direct grafting of RGD-motif-containing peptide on the surface of polycaprolactone films. J. Biomater. Sci. Polym. Edn., 17: 567-577.
CrossRef | Direct Link | - Eringa, E.C., C.D. Stehouwer, K. Walburg, A.D. Clark, G.P. van Nieuw Amerongen, N. Westerhof and P. Sipkema, 2006. Physiological concentrations of insulin induce endothelin-dependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-α dependence on c-Jun N-terminal kinase. Arterioscler. Thromb. Vasc. Biol., 26: 274-280.
PubMed | - Bijman, M.N., G.P. van Nieuw Amerongen, N. Laurens, V.W. van Hinsbergh and E. Boven, 2006. Microtubule-targeting agents inhibit angiogenesis at subtoxic concentrations, a process associated with inhibition of Rac1 and Cdc42 activity and changes in the endothelial cytoskeleton. Mol. Cancer Therapeut., 5: 2348-2357.
- Van Nieuw Amerongen, G.P., V.W.M. Van Hinsbergh and B.C. Berk, 2005. Chronic Pulmonary Vascular Hyperpermeability: Its Interaction with Vascular Remodeling. In: Perspectives on Lung Endothelial Barrier Function, Patterson, C.E. (Ed.). Elsevier, The Netherlands, ISBN-13: 9780444518347, pp: 401-422.
- Van Weel, V., M.M. Deckers, J.M. Grimbergen, K.J. van Leuven and J.H. Lardenoye et al., 2004. Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo. Circ. Res., 95: 58-66.
PubMed | - Van Nieuw Amerongen, G.P., K. Natarajan, G. Yin, R.J. Hoefen and M. Osawa et al., 2004. GIT1 mediates thrombin signaling in endothelial cells: Role in turnover of RhoA-type focal adhesions. Circ. Res., 94: 1041-1049.
PubMed | - Eringa, E.C., C.D. Stehouwer, G.P. van Nieuw Amerongen, L. Ouwehand, N. Westerhof and P. Sipkema, 2004. Vasoconstrictor effects of insulin in skeletal muscle arterioles are mediated by ERK1/2 activation in endothelium. Am. J. Physiol.-Heart Circ. Physiol., 287: H2043-H2048.
CrossRef | Direct Link | - Boer, C., G.P. van Nieuw Amerongen, A.J. Groeneveld, G.J. Scheffer and J.J. de Lange et al., 2004. Smooth muscle F-actin disassembly and RhoA/Rho-kinase signaling during endotoxin-induced alterations in pulmonary arterial compliance. Am. J. Physiol.-Lung Cell. Mol. Physiol., 287: L649-L655.
CrossRef | Direct Link | - Van Nieuw Amerongen, G.P., P. Koolwijk, A. Versteilen and V.W. van Hinsbergh, 2003. Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitro. Arterioscler. Thromb. Vasc. Biol., 23: 211-217.
PubMed | - Van Nieuw Amerongen, G.P. and V.W. van Hinsbergh, 2002. Targets for pharmacological intervention of endothelial hyperpermeability and barrier function. Vasc. Pharmacol., 39: 257-272.
CrossRef | Direct Link | - Van Hinsbergh, V.W. and G.P. van Nieuw Amerongen, 2002. Intracellular signalling involved in modulating human endothelial barrier function. J. Anatomy, 200: 549-560.
CrossRef | Direct Link | - Van Hinsbergh, V.W. and G.P. van Nieuw Amerongen, 2002. Endothelial hyperpermeability in vascular leakage. Vasc. Pharmacol., 39: 171-172.
CrossRef | PubMed | Direct Link | - Van Nieuw Amerongen, G.P., D.S.E. Loomans and V.W.M. Van Hinsbergh, 2001. Mechanisms Involved in Endothelial Hyperpermeability and Endothelial Barrier Stabilization. In: Vascular Endothelium: Mechanisms of Cell Signalling, Catravas, J.D. and M. Simionescu (Eds.). IOS Press, Amsterdam, Netherland, ISBN: 978-90-5199-443-8, pp: 135-150.
- Van Nieuw Amerongen, G.P. and V.W. van Hinsbergh, 2001. Cytoskeletal effects of Rho-like small guanine nucleotide-binding proteins in the vascular system. Arterioscler. Thromb. Vasc. Biol., 21: 300-311.