Dr. Brice Korkmaz
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Dr. Brice Korkmaz

Researcher
Francois Rabelais University, France


Highest Degree
PostDoc. in Immunology from Max Planck Institute, Munich, Germany

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Area of Interest:

Chemistry
100%
Biochemistry
62%
Enzymology
90%
Neutrophil Serine Proteases
75%
Inflammatory Lung Diseases
55%

Research Publications in Numbers

Books
1
Chapters
0
Articles
74
Abstracts
0

Selected Publications

  1. Kuhl, A., B. Korkmaz, B. Utecht, A. Kniepert, U. Schonermarck, U. Specks and D.E. Jenne, 2010. Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener`s granulomatosis. J. Immunol., 185: 387-399.
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  2. Korkmaz, B., M.S. Horwitz, D.E. Jenne and F. Gauthier, 2010. Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol. Rev., 62: 726-759.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Salipante, S.J., M.E.B. Rojas, B. Korkmaz, Z. Duan and J. Wechsler et al., 2009. Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between gfi1 and neutrophil elastase. Mol. Cell. Biol., 29: 4394-4405.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Korkmaz, B., J. Jaillet, M.L. Jourdan, A. Gauthier, F. Gauthier and S. Attucci, 2009. Catalytic activity and inhibition of Wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils. J. Biol. Chem., 284: 19896-19902.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Korkmaz, B., T. Moreau and F. Gauthier, 2008. Neutrophil elastase, proteinase 3 and cathepsin G: Physicochemical properties, activity and physiopathological functions. Biochimie, 90: 227-242.
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  6. Korkmaz, B., S. Attucci, M. Juliano, T. Kalupov, M.L. Jourdan, L. Juliano and F. Gauthier, 2008. Measuring Elastase, Proteinase 3 and Cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates. Nat. Protoc., 3: 991-1000.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Korkmaz, B., A. Kuhl, B. Bayat, S. Santoso and D.E. Jenne, 2008. A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors. J. Biol. Chem., 283: 35976-35982.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Korkmaz, B., E. Hajjar, T. Kalupov, N. Reuter, T. Moreau, L. Juliano and F. Gauthier, 2007. Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase: A kinetic and molecular modeling analysis. J. Biol. Chem., 282: 1989-1997.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Hajjar, E., B. Korkmaz and N. Reuter, 2007. Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase. FEBS Lett., 581: 5685-5690.
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