Dr. Juan A. Rosado
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Dr. Juan A. Rosado

Lecturer
University of Extremadura, Spain

Highest Degree
Ph.D. in Physiology from University of Extremadura, Spain

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Biography

Dr. Juan A. Rosado is currently working as Lecturer at Department of Physiology, University of Extremadura, Spain. He has received his Ph.D. in Physiology from University of Extremadura, Spain. His main area of interest focuses on Biomedical Sciences. His area of expertise includes Calcium Signaling, Platelet Biology, Calcium Channels and Physiology. He has published 154 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Calcium Signalling
62%
Blood Composition
90%
Calcium Channels
75%
Physiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Sage, S.O., G.E. Jarvis, I. Jardin, J.A. Rosado and A.G.S. Harper, 2014. The TRPV1 ion channel is expressed in human but not mouse platelets. Platelets, 25: 390-392.
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  2. Lopez, J.J., N. Dionisio, A. Berna-Erro, C. Galan, G.M. Salido and J.A. Rosado, 2013. Two-pore channel 2 (TPC2) modulates store-operated Ca2 + entry. Biochim. Biophys. Acta., 1823: 1976-1983.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Lopez, E., A. Berna-Erro, N. Bermejo, J.M. Brull and R. Martinez et al., 2013. Long-term mTOR inhibitors administration evokes altered calcium homeostasis and platelet dysfunction in kidney transplant patients. J. Cell. Mol. Med., 17: 636-647.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Lopez, E., A. Berna-Erro, J.M. Hernandez-Cruz, G.M. Salido, P.C. Redondo and J.A. Rosado, 2013. Immunophilins are involved in the altered platelet aggregation observed in patients with type 2 diabetes mellitus. Curr. Med. Chem., 20: 1912-1921.
    CrossRef  |  PubMed  |  
  5. Lopez, E., A. Berna-Erro, G.M. Salido, J.A. Rosado and P.C. Redondo, 2013. FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 1833: 652-662.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Jardin, I., N. Dionisio, I. Frischauf, A. Berna-Erro and G.E. Woodard et al., 2013. The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium. Cell Signal., 25: 1328-1337.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Jardin, I., J.J. Lopez, A. Berna-Erro, G.M. Salido and J.A. Rosado, 2013. Homer proteins in Ca2+ entry. IUBMB Life, 65: 497-504.
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  8. Regodon, S., A. Ramos, M.P. Miguez, A. Carrillo-Vico, J.A. Rosado and I. Jardin, 2012. Vaccination prepartum enhances the beneficial effects of melatonin on the immune response and reduces platelet responsiveness in sheep. BMC Vet. Res., Vol. 8., 10.1186/1746-6148-8-84.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Lopez, E., I. Jardin, A. Berna-Erro, N. Bermejo and G.M. Salido et al., 2012. STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets. Cell Signal., 24: 1315-1322.
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  10. Lopez, E., G.M. Salido, J.A. Rosado and A. Berna-Erro, 2012. Unraveling STIM2 function. J. Physiol. Biochem., 68: 619-633.
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  11. Jardin, I., L. Albarran, N. Bermejo, G.M. Salido and J.A. Rosado, 2012. Homers regulate calcium entry and aggregation in human platelets: A role for Homers in the association between STIM1 and Orai1. Biochem. J., 445: 29-38.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Dominguez-Rodriguez, A., I. Diaz, M. Rodriguez-Moyano, E. Calderon-Sanchez, J.A. Rosado, A. Ordonez and T. Smani, 2012. Urotensin-II signaling mechanism in rat coronary artery: Role of STIM1 and Orai1-dependent store operated calcium influx in vasoconstriction. Arterioscler Thromb. Vasc. Biol., 32: 1325-1332.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Dionisio, N., P.C. Redondo, I. Jardin and J.A. Rosado, 2012. Transient receptor potential channels in human platelets: Expression and functional role. Curr. Mol. Med., 12: 1319-1328.
    CrossRef  |  PubMed  |  
  14. Berna-Erro, A., P.C. Redondo and J.A. Rosado, 2012. Store-operated Ca2+ entry. Adv. Exp. Med. Biol., 740: 349-382.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Berna-Erro, A., G.E. Woodard and J.A. Rosado, 2012. Orais and STIMs: Physiological mechanisms and disease. J. Cell Mol. Med., 16: 407-424.
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  16. Berna-Erro, A., C. Galan, N. Dionisio, L.J. Gomez, G.M. Salido and J.A. Rosado, 2012. Capacitative and non-capacitative signaling complexes in human platelets. Biochim. Biophys. Acta., 1823 : 1242-1251.
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  17. Zbidi, H., I. Jardin, G.E. Woodard, J.J. Lopez, A. Berna-Erro, G.M. Salido and J.A. Rosado, 2011. STIM1 and STIM2 are located in the acidic Ca2+ stores and associates with Orai1 upon depletion of the acidic stores in human platelets. J. Biol. Chem., 286: 12257-12270.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Zbidi, H., I. Jardin, A.Bartegi, G.M. Salido and J.A. Rosado, 2011. Ca2+ leakage rate from agonist-sensitive intracellular pools is altered in platelets from patients with type 2 diabetes. Platelets, 22: 284-293.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Salido, G.M., I. Jardin and J.A. Rosado, 2011. The TRPC ion channels: Association with Orai1 and STIM1 proteins and participation in capacitative and non-capacitative calcium entry. Adv. Exp. Med. Biol., 704: 413-433.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Rosado, J.A., 2011. Acidic Ca2+ stores in platelets. Cell Calcium., 50: 168-174.
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  21. Rosado, J.A. and P.C. Redondo, 2011. A role for immunophilins in cellular signalling in health and disease. Curr. Med. Chem., 18: 5322-5323.
    CrossRef  |  PubMed  |  
  22. Park, H.J., J.A. Rosado, P.C. Redondo and Y.S. Cho, 2011. Immunophilin dysfunction and neuropathology. Curr. Med. Chem., 18: 5398-5407.
    CrossRef  |  PubMed  |  
  23. Lopez, E., J.A. Rosado and P.C. Redondo, 2011. Immunophilins and thrombotic disorders. Curr. Med. Chem., 18: 5414-5423.
    CrossRef  |  PubMed  |  
  24. Jardin, I., J.J. Lopez, H. Zbidi, A. Bartegi, G.M. Salido and J.A. Rosado, 2011. Attenuated store-operated divalent cation entry and association between STIM1, Orai1, hTRPC1 and hTRPC6 in platelets from type 2 diabetic patients. Blood Cells Mol. Dis., 46: 252-260.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Galan, C., N. Dionisio, T. Smani, G.M. Salido and J.A. Rosado, 2011. The cytoskeleton plays a modulatory role in the association between STIM1 and the Ca2+ channel subunits Orai1 and TRPC1. Biochem. Pharmacol., 82: 400-410.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. El Haouari, M. and J.A. Rosado, 2011. Modulation of platelet function and signaling by flavonoids. Mini Rev. Med. Chem., 11: 131-142.
    CrossRef  |  PubMed  |  
  27. Dionisio, N., L. Albarran, J.J. Lopez, A. Berna-Erro, G.M. Salido, R. Bobe and J.A. Rosado, 2011. Acidic NAADP-releasable Ca2+ compartments in the megakaryoblastic cell line MEG01. Biochim. Biophys. Acta (BBA)-Mol. Cell Res., 1813: 1483-1494.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Dionisio, N., L. Albarran, A. Berna-Erro, J.M. Hernandez-Cruz, G.M. Salido and J.A. Rosado, 2011. Functional role of the calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) site of TRPC6 in human platelet activation. Cell Signal., 23: 1850-1856.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Dionisio, N., C. Galan, I. Jardin, G.M. Salido and J.A. Rosado, 2011. Lipid rafts are essential for the regulation of SOCE by plasma membrane resident STIM1 in human platelets. Biochim. Biophys. Acta., 1813: 431-437.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Aulestia, F.J., P.C. Redondo, A. Rodriguez-Garcia, J.A. Rosado, G.M. Salido, M.T. Alonso and J. Garcia-Sancho, 2011. Two distinct calcium pools in the endoplasmic reticulum of HEK-293T cells. Biochem. J., 435: 227-235.
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  31. Zbidi, H., P.C. Redondo, J.J. Lopez, A. Bartegi, G.M. Salido and J.A. Rosado, 2010. Homocysteine induces caspase activation by endoplasmic reticulum stress in platelets from type 2 diabetics and healthy donors. J. Thromb. Haemost., 103: 1022-1032.
    CrossRef  |  PubMed  |  Direct Link  |  
  32. Woodard, G.E., J.J. Lopez, I. Jardin, G.M. Salido and J.A. Rosado, 2010. TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1. J. Biol. Chem., 285: 8045-8053.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Rosado, J.A., J.A. Pariente, G.M. Salido and P.C. Redondo, 2010. SERCA2b activity is regulated by cyclophilins in human platelets. Arterioscler. Thromb. Vasc. Biol., 30: 419-425.
    CrossRef  |  PubMed  |  Direct Link  |  
  34. Galan, C., I. Jardin, N. Dionisio, G. Salido and J.A. Rosado, 2010. Role of oxidant scavengers in the prevention of Ca2+ homeostasis disorders. Molecules, 15: 7167-7187.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Galan, C., G.E. Woodard, N. Dionisio, G.M. Salido and J.A. Rosado, 2010. Lipid rafts modulate the activation but not the maintenance of store-operated Ca2+ entry. Biochim. Biophys. Acta, 1803: 1083-1093.
    CrossRef  |  PubMed  |  Direct Link  |  
  36. Espino, J., I. Bejarano, P.C. Redondo, J.A. Rosado and C. Barriga et al., 2010. Melatonin reduces apoptosis induced by calcium signaling in human leukocytes: Evidence for the involvement of mitochondria and Bax activation. J. Membr. Biol., 233: 105-118.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Dionisio, N., I. Jardin, G.M. Salido and J.A. Rosado, 2010. Homocysteine, intracellular signaling and thrombotic disorders. Curr. Med. Chem., 17: 3109-3119.
    CrossRef  |  PubMed  |  
  38. Chapado, L., P.J. Linares-Palomino, S. Salido, J. Altarejos, J.A. Rosado and G.M. Salido, 2010. Synthesis and evaluation of the platelet antiaggregant properties of phenolic antioxidants structurally related to rosmarinic acid. Bioorganic Chem., 38: 108-114.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Zbidi, H., S. Salido, J. Altarejos, M. Perez-Bonilla, A. Bartegi, J.A. Rosado and G.M. Salido, 2009. Olive tree wood phenolic compounds with human platelet antiaggregant properties. Blood Cells Mol. Dis., 42: 279-285.
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  40. Zbidi, H., J.J. Lopez, N.B. Amor, A. Bartegi, G.M. Salido and J.A. Rosado, 2009. Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus. Blood Cells Mol. Dis., 43: 211-213.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Salido, G.M., S.O. Sage and J.A. Rosado, 2009. TRPC channels and store-operated Ca2+ entry. Biochimica Biophysica Acta, 1793: 223-230.
    CrossRef  |  PubMed  |  Direct Link  |  
  42. Salido, G.M., S.O. Sage and J.A. Rosado, 2009. Biochemical and functional properties of the store-operated Ca2+ channels. Cell Signal, 21: 457-461.
    CrossRef  |  PubMed  |  Direct Link  |  
  43. Regodon, S., M.D.P. Miguez, I. Jardin, J.J. Lopez, A. Ramos, S.D. Paredes and J.A. Rosado, 2009. Melatonin, as an adjuvant-like agent, enhances platelet responsiveness. J. Pineal Res., 46: 275-285.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Regodon, S., A. Ramos, S. Morgado, R. Tarazona, P. Martin-Palomino, J.A. Rosado and P. Miguez Mdel, 2009. Melatonin enhances the immune response to vaccination against A1 and C strains of Dichelobacter nodosus. Vaccine, 27: 1566-1570.
    CrossRef  |  PubMed  |  Direct Link  |  
  45. Lopez, J.J., P.C. Redondo, G.M. Salido, J.A. Pariente and J.A. Rosado, 2009. N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine induces apoptosis through the activation of caspases-3 and -8 in human platelets. A role for endoplasmic reticulum stress. J. Thromb. Haemost., 7: 992-999.
    CrossRef  |  PubMed  |  Direct Link  |  
  46. Jardin, I., L.J. Gomez, G.M. Salido and J.A. Rosado, 2009. Dynamic interaction of hTRPC6 with the Orai1-STIM1 complex or hTRPC3 mediates its role in capacitative or non-capacitative Ca2+ entry pathways. Biochem. J., 420: 267-276.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Jardin, I., J.J. Lopez, P.C. Redondo, G.M. Salido and J.A. Rosado, 2009. Store-operated Ca2+ entry is sensitive to the extracellular Ca2+ concentration through plasma membrane STIM1. Biochim. Biophys. Acta, 1793: 1614-1622.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Galan, C., H. Zbidi, A. Bartegi, G.M. Salido and J.A. Rosado, 2009. STIM1, Orai1 and hTRPC1 are important for thrombin- and ADP-induced aggregation in human platelets. Arch. Biochem. Biophys., 490: 137-144.
    CrossRef  |  PubMed  |  Direct Link  |  
  49. El Haouari, M. and J.A. Rosado, 2009. Platelet function in hypertension. Blood Cells Mol. Dis., 42: 38-43.
    CrossRef  |  PubMed  |  Direct Link  |  
  50. Dionisio, N., M.V. Garcia-Mediavilla, S. Sanchez-Campos, P.L. Majano and I. Benedicto et al., 2009. Hepatitis C virus NS5A and core proteins induce oxidative stress-mediated calcium signalling alterations in hepatocytes. J. Hepatol., 50: 872-882.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Bejarano, I., P.C. Redondo, J. Espino, J.A. Rosado and S.D. Paredes et al., 2009. Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells. J. Pineal Res., 46: 392-400.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Amor, N.B., H. Zbidi, A. Bouaziz, I. Jardin and J.M. Hernandez-Cruz et al., 2009. Acidic-store depletion is required for human platelet aggregation. Blood Coagul. Fibrinolysis., 20: 511-516.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Woodard, G.E., G.M. Salido and J.A. Rosado, 2008. Enhanced exocytotic-like insertion of Orai1 into the plasma membrane upon intracellular Ca2+ store depletion. Am. J. Physiol. Cell Physiol., 294: C1323-C1331.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Woodard, G.E. and J.A. Rosado, 2008. Natriuretic peptides in vascular physiology and pathology. Int. Rev. Cell Mol. Biol., 268: 59-93.
    CrossRef  |  PubMed  |  Direct Link  |  
  55. Redondo, P.C., J.A. Rosado, G.M. Salido and S.O. Sage, 2008. Protein complex immunological separation assay (ProCISA): A technique for investigating single protein properties. J. Physiol. Biochem., 64: 169-177.
    CrossRef  |  PubMed  |  Direct Link  |  
  56. Redondo, P.C., I. Jardin, J.J. Lopez, G.M. Salido and J.A. Rosado, 2008. Intracellular Ca2+ store depletion induces the formation of macromolecular complexes involving hTRPC1, hTRPC6, the type II IP3 receptor and SERCA3 in human platelets. Biochimica Biophysica Acta, 1783: 1163-1176.
    CrossRef  |  PubMed  |  Direct Link  |  
  57. Redondo, P.C., G.M. Salido, J.A. Pariente, S.O. Sage and J.A. Rosado, 2008. SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets. Cell Signal., 20: 337-346.
    CrossRef  |  PubMed  |  Direct Link  |  
  58. Lopez, J.J., I. Jardin, R. Bobe, J.A. Pariente, J. Enouf, G.M. Salido and J.A. Rosado, 2008. STIM1 regulates acidic Ca2+ store refilling by interaction with SERCA3 in human platelets. Biochem. Pharmacol., 75: 2157-2164.
    CrossRef  |  PubMed  |  Direct Link  |  
  59. Lopez, J.J., I. Jardin, G.M. Salido and J.A. Rosado, 2008. Cinnamtannin B-1 as an antioxidant and platelet aggregation inhibitor. Life Sci., 82: 977-982.
    CrossRef  |  PubMed  |  Direct Link  |  
  60. Lopez, J.J., G.M. Salido, J.A. Pariente and J.A. Rosado, 2008. Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets. J. Thromb. Haemost., 6: 1780-1788.
    CrossRef  |  PubMed  |  Direct Link  |  
  61. Juska, A., I. Jardin and J.A. Rosado, 2008. Physical properties of two types of calcium stores and SERCAs in human platelets. Mol. Cell. Biochem., 311: 9-18.
    CrossRef  |  PubMed  |  Direct Link  |  
  62. Jardin, I., P.C.Redondo, G.M. Salido and J.A. Rosado, 2008. Phosphatidylinositol 4,5-bisphosphate enhances store-operated calcium entry through hTRPC6 channel in human platelets. Biochim. Biophys. Acta, 1783: 84-97.
    CrossRef  |  PubMed  |  Direct Link  |  
  63. Jardin, I., J.J. Lopez, J.A. Pariente, G.M. Salido and J.A. Rosado, 2008. Intracellular calcium release from human platelets: Different messengers for multiple stores. Trends Cardiovasc. Med., 18: 57-61.
    CrossRef  |  PubMed  |  Direct Link  |  
  64. Jardin, I., J.J. Lopez, G.M. Salido and J.A. Rosado, 2008. Orai1 mediates the interaction between STIM1 and hTRPC1 and regulates the mode of activation of hTRPC1-forming Ca2+ channels. J. Biol. Chem., 283: 25296-25304.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Jardin, I., J.J. Lopez, G.M. Salido and J.A. Rosado, 2008. Functional relevance of the de novo coupling between hTRPC1 and type II IP3 receptor in store-operated Ca2+ entry in human platelets. Cell Signal, 20: 737-747.
    CrossRef  |  PubMed  |  Direct Link  |  
  66. Jardin, I., G.M. Salido and J.A. Rosado, 2008. Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1. Channels, 2: 401-403.
    CrossRef  |  PubMed  |  Direct Link  |  
  67. El Haouari, M. and J.A. Rosado, 2008. Platelet signalling abnormalities in patients with type 2 diabetes mellitus: A review. Blood Cells Mol. Dis., 41: 119-123.
    CrossRef  |  PubMed  |  Direct Link  |  
  68. Alexandru, N., I. Jardin, D. Popov, M. Simionescu, J. Garcia-Estan, G.M. Salido and J.A. Rosado, 2008. Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus. J. Cell. Mol. Med., 12: 2015-2026.
    CrossRef  |  PubMed  |  Direct Link  |  
  69. Woodard, G.E., S.O. Sage and J.A. Rosado, 2007. Transient receptor potential channels and intracellular signaling. Int. Rev. Cytol., 256: 35-67.
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  70. Woodard, G.E. and J.A. Rosado, 2007. Recent advances in natriuretic peptide research. J. Cell Mol. Med., 11: 1263-1271.
    CrossRef  |  PubMed  |  Direct Link  |  
  71. Redondo, P.C., A.G. Harper, S.O. Sage and J.A. Rosado, 2007. Dual role of tubulin-cytoskeleton in store-operated calcium entry in human platelets. Cell Signal, 19: 2147-2154.
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  72. Redondo, P.C., A.G. Harper, M.T. Harper, S.L. Brownlow, J.A. Rosado and S.O. Sage, 2007. hTRPC1-associated α-actinin, and not hTRPC1 itself, is tyrosine phosphorylated during human platelet activation. J. Thromb. Haemost., 5: 2476-2483.
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  73. Lopez, J.J., G.M. Salido, E.Gomez-Arteta, J.A. Rosado and J.A. Pariente, 2007. Thrombin induces apoptotic events through the generation of reactive oxygen species in human platelets. J. Thromb. Haemost., 5: 1283-1291.
    CrossRef  |  PubMed  |  Direct Link  |  
  74. Jardin, I., N. Ben Amor, J.M. Hernandez-Cruz, G.M. Salido and J.A. Rosado, 2007. Involvement of SNARE proteins in thrombin-induced platelet aggregation: Evidence for the relevance of Ca2+ entry. Arch. Biochem. Biophys., 465: 16-25.
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  75. Jardin, I., N. Ben Amor, A. Bartegi, J.A. Pariente, G.M. Salido and J.A. Rosado, 2007. Differential involvement of thrombin receptors in Ca2+ release from two different intracellular stores in human platelets. Biochem. J., 401: 167-174.
    CrossRef  |  PubMed  |  Direct Link  |  
  76. El Haouari, M., J.J. Lopez, H. Mekhfi, J.A. Rosado and G.M. Salido, 2007. Antiaggregant effects of Arbutus unedo extracts in human platelets. J. Ethnopharmacol., 113: 325-331.
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  77. Bouaziz, A., S. Salido, P.J. Linares-Palomino, A. Sanchez and J. Altarejos et al., 2007. Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients. Arch. Biochem. Biophys., 457: 235-242.
    CrossRef  |  PubMed  |  Direct Link  |  
  78. Bouaziz, A., N.B. Amor, G.E. Woodard, H. Zibidi and J.J. Lopez et al., 2007. Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets. J. Thromb. Haemost., 98: 375-384.
    CrossRef  |  PubMed  |  Direct Link  |  
  79. Bouaziz, A., C. Romera-Castillo, S. Salido, P.J. Linares-Palomino and J. Altarejos et al., 2007. Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets. Apoptosis, 12: 489-498.
    CrossRef  |  PubMed  |  Direct Link  |  
  80. Ben Amor, N., A. Bouaziz, C. Romera-Castillo, S. Salido and P.J. Linares-Palomino et al., 2007. Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets. J. Med. Chem., 50: 3937-3944.
    CrossRef  |  PubMed  |  Direct Link  |  
  81. Atucha, N.M., D. Iyu, A. Alcaraz, V. Rosa and C. Martinez-Prieto et al., 2007. Altered calcium signalling in platelets from bile-duct-ligated rats. Clin. Sci. (Lond), 112: 167-174.
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  82. Woodard, G.E., J. Zhao and J.A. Rosado, 2006. Inhibitory effect of Ca2+ on ATP-mediated stimulation of NPR-A-coupled guanylyl cyclase in renal glomeruli from spontaneously hypertensive and normotensive rats. J. Physiol. Pharmacol., 57: 359-373.
    PubMed  |  Direct Link  |  
  83. Woodard, G.E., J. Zhao and J.A. Rosado, 2006. Different effect of ATP on ANP receptor guanylyl cyclase in spontaneously hypertensive and normotensive rats. Acta Physiol., 188: 195-206.
    CrossRef  |  PubMed  |  Direct Link  |  
  84. Rosado, J.A., P.C. Redondo, G.M. Salido and J.A. Pariente, 2006. Calcium signalling and reactive oxygen species in non-excitable cells. Mini Rev. Med. Chem., 6: 409-415.
    CrossRef  |  PubMed  |  
  85. Rosado, J.A., J.J. Lopez, E. Gomez-Arteta, P.C. Redondo, G.M. Salido and J.A. Pariente, 2006. Early caspase-3 activation independent of apoptosis is required for cellular function. J. Cell. Physiol., 209: 142-152.
    CrossRef  |  PubMed  |  Direct Link  |  
  86. Rosado, J.A., A.M. Nunez, J.J. Lopez, J.A. Pariente and G.M. Salido, 2006. Intracellular Ca2+ homeostasis and aggregation in platelets are impaired by ethanol through the generation of H2O2 and oxidation of sulphydryl groups. Arch. Biochem. Biophys., 452: 9-16.
    CrossRef  |  PubMed  |  Direct Link  |  
  87. Rosado, J.A., A.M. Nunez, J.A. Pariente and G.M. Salido, 2006. Alterations in intracellular calcium homeostasis and platelet aggregation induced by ethanol. Biochem. Biophys. Res. Commun., 341: 917-924.
    CrossRef  |  PubMed  |  Direct Link  |  
  88. Rosado, J.A., 2006. Discovering the mechanism of capacitative calcium entry. Am. J. Physiol. Cell. Physiol., 291: C1104-C1106.
    CrossRef  |  PubMed  |  Direct Link  |  
  89. Redondo, P.C., M.T. Harper, J.A. Rosado and S.O. Sage, 2006. A role for cofilin in the activation of store-operated calcium entry by de novo conformational coupling in human platelets. Blood, 107: 973-979.
    CrossRef  |  PubMed  |  Direct Link  |  
  90. Martinez-Burgos, M.A., M.P. Granados, A. Gonzalez, J.A. Rosado and M.D. Yago et al., 2006. Involvement of ryanodine-operated channels in tert-butylhydroperoxide-evoked Ca2+ mobilisation in pancreatic acinar cells. J. Exp. Biol., 209: 2156-2164.
    CrossRef  |  PubMed  |  Direct Link  |  
  91. Lopez, J.J., P.C. Redondo, G.M. Salido, J.A. Pariente and J.A. Rosado, 2006. Two distinct Ca2+ compartments show differential sensitivity to thrombin, ADP and vasopressin in human platelets. Cell. Signal., 18: 373-381.
    CrossRef  |  PubMed  |  Direct Link  |  
  92. Lopez, J.J., G.M. Salido, J.A. Pariente and J.A. Rosado, 2006. Interaction of STIM1 with endogenously expressed human canonical TRP1 upon depletion of intracellular Ca2+ stores. J. Biol. Chem., 281: 28254-28264.
    CrossRef  |  PubMed  |  Direct Link  |  
  93. Li, X., G.E. Woodard, J. Brown and J.A. Rosado, 2006. Renal atrial natriuretic peptide receptors binding properties and function are resistant to DOCA-salt-induced hypertension in rats. Regul. Pept., 137: 114-120.
    CrossRef  |  PubMed  |  Direct Link  |  
  94. Jardin, I., P.C. Redondo, G.M. Salido, J.A. Pariente and J.A. Rosado, 2006. Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus. Platelets, 17: 283-288.
    CrossRef  |  PubMed  |  Direct Link  |  
  95. Ben-Amor, N., P.C. Redondo, A. Bartegi, J.A. Pariente, G.M. Salido and J.A. Rosado, 2006. A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets. J. Physiol., 570: 309-323.
    CrossRef  |  PubMed  |  Direct Link  |  
  96. Ben Amor, N., J.A. Pariente, G.M. Salido, A. Bartegi and J.A. Rosado, 2006. Caspases 3 and 9 are translocated to the cytoskeleton and activated by thrombin in human platelets. Evidence for the involvement of PKC and the actin filament polymerization. Cell Signal., 18: 1252-1261.
    CrossRef  |  PubMed  |  Direct Link  |  
  97. Amor, N.B., J.A. Pariente, G.M. Salido, J.A. Rosado and A. Bartegi, 2006. Thrombin-induced caspases 3 and 9 translocation to the cytoskeleton is independent of changes in cytosolic calcium in human platelets. Blood Cells Mol. Dis., 36: 392-401.
    CrossRef  |  PubMed  |  Direct Link  |  
  98. Woodard, G.E., X. Li and J.A. Rosado, 2005. Receptor subtypes for vasonatrin peptide in renal glomeruli and arteries. Regulatory Peptides, 129: 183-189.
    CrossRef  |  PubMed  |  Direct Link  |  
  99. Woodard, G.E., X. Li and J.A. Rosado, 2005. Characteristics of the renal C-type natriuretic peptide receptor in hypertrophied and developing rat kidney. J. Mol. Endocrinol., 35: 519-530.
    CrossRef  |  PubMed  |  Direct Link  |  
  100. Rosado, J.A., P.C. Redondo, S.O. Sage, J.A. Pariente and G.M. Salido, 2005. Store-operated Ca2+ entry: Vesicle fusion or reversible trafficking and de novo conformational coupling? J. Cell. Physiol., 205: 262-269.
    CrossRef  |  PubMed  |  Direct Link  |  
  101. Rosado, J.A., P.C. Redondo, G.M. Salido, S.O. Sage and J.A. Pariente, 2005. Cleavage of SNAP-25 and VAMP-2 impairs store-operated Ca2+ entry in mouse pancreatic acinar cells. Am. J. Physiol. Cell. Physiol., 288: C214-C221.
    CrossRef  |  PubMed  |  Direct Link  |  
  102. Redondo, P.C., N. Ben-Amor, G.M. Salido, A. Bartegi, J.A. Pariente and J.A. Rosado, 2005. Ca2+-independent activation of Bruton's tyrosine kinase is required for store-mediated Ca2+ entry in human platelets. Cell Signal., 17: 1011-1021.
    CrossRef  |  PubMed  |  Direct Link  |  
  103. Redondo, P.C., J.A. Rosado, J.A. Pariente and G.M. Salido, 2005. Collaborative effect of SERCA and PMCA in cytosolic calcium homeostasis in human platelets. J. Physiol. Biochem., 61: 507-516.
    CrossRef  |  PubMed  |  Direct Link  |  
  104. Redondo, P.C., I. Jardin, J.M. Hernandez-Cruz, J.A. Pariente, G.M. Salido and J.A. Rosado, 2005. Hydrogen peroxide and peroxynitrite enhance Ca2+ mobilization and aggregation in platelets from type 2 diabetic patients. Biochem. Biophys. Res. Commun., 333: 794-802.
    CrossRef  |  PubMed  |  Direct Link  |  
  105. Morales, S., P.J. Camello, J.A. Rosado, G.M. Mawe and M.J. Pozo, 2005. Disruption of the filamentous actin cytoskeleton is necessary for the activation of capacitative calcium entry in naive smooth muscle cells. Cell Signal., 17: 635-645.
    CrossRef  |  PubMed  |  Direct Link  |  
  106. Lopez, J.J., C. Camello-Almaraz, J.A. Pariente, G.M. Salido and J.A. Rosado, 2005. Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets. Biochem. J., 390: 243-252.
    CrossRef  |  PubMed  |  Direct Link  |  
  107. Juska, A., P.C. Redondo, J.A. Rosado and G.M. Salido, 2005. Dynamics of calcium fluxes in human platelets assessed in calcium-free medium. Biochem. Biophys. Res. Commun., 334: 779-786.
    CrossRef  |  PubMed  |  Direct Link  |  
  108. Woodard, G.E., X. Li and J.A. Rosado, 2004. Water deprivation enhances the inhibitory effect of natriuretic peptides on cAMP synthesis in rat renal glomeruli. Am. J. Physiol. Renal Physiol., 287: F418-F426.
    CrossRef  |  PubMed  |  Direct Link  |  
  109. Woodard, G.E., J. Zhao, J.A. Rosado and J. Brown, 2004. Patterning of renal cGMP production by the natriuretic peptide receptor type A and blood pressure in spontaneously hypertensive rats. Regulatory Peptides, 119: 45-51.
    CrossRef  |  PubMed  |  Direct Link  |  
  110. Woodard, G.E. and J.A. Rosado, 2004. G-protein coupled receptors and calcium signaling in development. Curr. Top. Dev. Biol., 65: 189-210.
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  111. Saavedra, F.R., P.C. Redondo, J.M. Hernandez-Cruz, G.M. Salido, J.A. Pariente and J.A. Rosado, 2004. Store-operated Ca2+ entry and tyrosine kinase pp60src hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus. Arch. Biochem. Biophys., 432: 261-268.
    CrossRef  |  PubMed  |  Direct Link  |  
  112. Rosado, J.A., P.C. Redondo, G.M. Salido, E. Gomez-Arteta, S.O. Sage and J.A. Pariente, 2004. Hydrogen peroxide generation induces pp60src activation in human platelets: Evidence for the involvement of this pathway in store-mediated calcium entry. J. Biol. Chem., 279: 1665-1675.
    CrossRef  |  PubMed  |  Direct Link  |  
  113. Rosado, J.A., J.J. Lopez, A.G. Harper, M.T. Harper and P.C. Redondo et al., 2004. Two pathways for store-mediated calcium entry differentially dependent on the actin cytoskeleton in human platelets. J. Biol. Chem., 279: 29231-29235.
    CrossRef  |  PubMed  |  Direct Link  |  
  114. Rosado, J.A., F.R. Saavedra, P.C. Redondo, J.M. Hernandez-Cruz, G.M. Salido and J.A. Pariente, 2004. Reduced plasma membrane Ca2+-ATPase function in platelets from patients with non-insulin-dependent diabetes mellitus. Haematologica, 89: 1142-1144.
    Direct Link  |  
  115. Redondo, P.C., G.M. Salido, J.A. Rosado and J.A. Pariente, 2004. Effect of hydrogen peroxide on Ca2+ mobilisation in human platelets through sulphydryl oxidation dependent and independent mechanisms. Biochem. Pharmacol., 67: 491-502.
    CrossRef  |  PubMed  |  Direct Link  |  
  116. Redondo, P.C., G.M. Salido, J.A. Pariente and J.A. Rosado, 2004. Dual effect of hydrogen peroxide on store-mediated calcium entry in human platelets. Biochem. Pharmacol., 67: 1065-1076.
    CrossRef  |  PubMed  |  Direct Link  |  
  117. Redondo, P.C., A.G. Harper, G.M. Salido, J.A. Pariente, S.O. Sage and J.A. Rosado, 2004. A role for SNAP-25 but not VAMPs in store-mediated Ca2+ entry in human platelets. J. Physiol., 558: 99-109.
    CrossRef  |  PubMed  |  Direct Link  |  
  118. Martinez, M.A., A.I. Lajas, M.D. Yago, P.C. Redondo and M.P. Granados et al., 2004. Dietary virgin olive oil enhances secretagogue-evoked calcium signaling in rat pancreatic acinar cells. Nutrition, 20: 536-541.
    CrossRef  |  PubMed  |  Direct Link  |  
  119. Woodard, G.E., J. Zhao, J.A. Rosado and J. Brown, 2003. Differences between natriuretic peptide receptors in the olfactory bulb and hypothalamus from spontaneously hypertensive and normotensive rat brain. Neurosci. Res., 47: 421-429.
    CrossRef  |  PubMed  |  Direct Link  |  
  120. Redondo, P.C., A.I. Lajas, G.M. Salido, A. Gonzalez, J.A. Rosado and J.A. Pariente, 2003. Evidence for secretion-like coupling involving pp60src in the activation and maintenance of store-mediated Ca2+ entry in mouse pancreatic acinar cells. Biochem. J., 370: 255-263.
    CrossRef  |  PubMed  |  Direct Link  |  
  121. Woodard, G.E., J.A. Rosado and J. Brown,c 2002. Dendroaspis natriuretic peptide-like immunoreactivity and its regulation in rat aortic vascular smooth muscle. Peptides, 23: 23-29.
    CrossRef  |  PubMed  |  Direct Link  |  
  122. Woodard, G.E., J.A. Rosado and J. Brown, 2002. Expression and control of C-type natriuretic peptide in rat vascular smooth muscle cells. Am. J. Physiol. Regul. Integr. Comp. Physiol., 282: 156-165.
    PubMed  |  Direct Link  |  
  123. Woodard, G.E., J. Zhao, J.A. Rosado and J. Brown, 2002. A-type natriuretic peptide receptor in the spontaneously hypertensive rat kidney. Peptides, 23: 1637-1647.
    CrossRef  |  PubMed  |  Direct Link  |  
  124. Sage, S.O., S.L. Brownlow and J.A. Rosado, 2002. TRP channels and calcium entry in human platelets. Blood, 100: 4245-4246.
    CrossRef  |  PubMed  |  Direct Link  |  
  125. Rosado, J.A., S.L. Brownlow and S.O. Sage, 2002. Endogenously expressed Trp1 is involved in store-mediated Ca2+ entry by conformational coupling in human platelets. J. Biol. Chem., 277: 42157-42163.
    CrossRef  |  PubMed  |  Direct Link  |  
  126. Rosado, J.A., A. Gonzalez, G.M. Salido and J.A. Pariente, 2002. Effects of reactive oxygen species on actin filament polymerisation and amylase secretion in mouse pancreatic acinar cells. Cell Signal, 14: 547-556.
    CrossRef  |  PubMed  |  Direct Link  |  
  127. Rosado, J.A. and S.O. Sage, 2002. The ERK cascade, a new pathway involved in the activation of store-mediated calcium entry in human platelets. Trends Cardiovasc. Med., 12: 229-234.
    CrossRef  |  PubMed  |  Direct Link  |  
  128. Rosado, J.A., T. Porras, M. Conde and S.O. Sage, 2001. Cyclic nucleotides modulate store-mediated calcium entry through the activation of protein-tyrosine phosphatases and altered actin polymerization in human platelets. J. Biol. Chem., 276: 15666-15675.
    CrossRef  |  PubMed  |  Direct Link  |  
  129. Rosado, J.A., I. Rosenzweig, S. Harding and S.O. Sage, 2001. Tumor necrosis factor-α inhibits store-mediated Ca2+ entry in the human hepatocellular carcinoma cell line HepG2. Am. J. Physiol. Cell Physiol., 280: 1636-1644.
    PubMed  |  Direct Link  |  
  130. Rosado, J.A., E.M. Meijer, K. Hamulyak, I. Novakova and J.W. Heemskerk et al., 2001. Fibrinogen binding to the integrin αIIbβ3 modulates store-mediated calcium entry in human platelets. Blood, 97: 2648-2656.
    CrossRef  |  PubMed  |  Direct Link  |  
  131. Rosado, J.A. and S.O. Sage, 2001. Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. J. Biol. Chem., 276: 15659-15665.
    CrossRef  |  PubMed  |  Direct Link  |  
  132. Rosado, J.A. and S.O. Sage, 2001. Activation of store-mediated calcium entry by secretion-like coupling between the inositol 1,4,5-trisphosphate receptor type II and human transient receptor potential (hTrp1) channels in human platelets. Biochem. J., 15: 191-198.
    PubMed  |  Direct Link  |  
  133. Diver, J.M., S.O. Sage and J.A. Rosado, 2001. The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: Cautions for its use in studying Ca2+ influx. Cell Calcium, 30: 323-329.
    CrossRef  |  PubMed  |  Direct Link  |  
  134. Rosado. J.A. and S.O. Sage, 2000. The actin cytoskeleton in store-mediated calcium entry. J. Physiol., 2: 221-229.
    CrossRef  |  PubMed  |  Direct Link  |  
  135. Rosado, J.A., S. Jenner and S.O. Sage, 2000. A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets: Evidence for conformational coupling. J. Biol. Chem., 275: 7527-7533.
    CrossRef  |  PubMed  |  Direct Link  |  
  136. Rosado, J.A., G.M. Salido and L.J. Garcia, 2000. Activation of m3 muscarinic receptors induces rapid tyrosine phosphorylation of p125FAK, p130cas, and paxillin in rat pancreatic acini. Arch. Biochem. Biophys., 377: 85-94.
    CrossRef  |  PubMed  |  Direct Link  |  
  137. Rosado, J.A., G.M. Salido and L.J. Garcia, 2000. A role for phosphoinositides in tyrosine phosphorylation of p125 focal adhesion kinase in rat pancreatic acini. Cell. Signal, 12: 173-182.
    CrossRef  |  PubMed  |  Direct Link  |  
  138. Rosado, J.A., D. Graves and S.O. Sage, 2000. Tyrosine kinases activate store-mediated Ca2+ entry in human platelets through the reorganization of the actin cytoskeleton. Biochem J., 2: 429-437.
    PubMed  |  Direct Link  |  
  139. Rosado, J.A. and S.O. Sage, 2000. Regulation of plasma membrane Ca2+-ATPase by small gtpases and phosphoinositides in human platelets. J. Biol. Chem., 275: 19529-19535.
    CrossRef  |  PubMed  |  Direct Link  |  
  140. Rosado, J.A. and S.O. Sage, 2000. Protein kinase C activates non-capacitative calcium entry in human platelets. J. Physiol., 1: 159-169.
    CrossRef  |  PubMed  |  Direct Link  |  
  141. Rosado, J.A. and S.O. Sage, 2000. Phosphoinositides are required for store-mediated calcium entry in human platelets. J. Biol. Chem., 275: 9110-9113.
    CrossRef  |  PubMed  |  Direct Link  |  
  142. Rosado, J.A. and S.O. Sage, 2000. Farnesylcysteine analogues inhibit store-regulated Ca2+ entry in human platelets: Evidence for involvement of small GTP-binding proteins and actin cytoskeleton. Biochem. J., 1: 183-192.
    PubMed  |  Direct Link  |  
  143. Rosado, J.A. and S.O. Sage, 2000. Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted. Biochem. J., 3: 631-635.
    PubMed  |  Direct Link  |  
  144. Rosado, J.A., G.M. Salido, R.T. Jensen and L.J. Garcia, 1998. Are tyrosine phosphorylation of p125FAK and paxillin or the small GTP binding protein, rho, needed for CCK-stimulated pancreatic amylase secretion? Biochim. Biophys. Acta, 1404: 412-426.
    CrossRef  |  PubMed  |  Direct Link  |  
  145. Rosado, J.A., L.J. Garcia and G.M. Salido, 1997. Ionic requirements in histamine-evoked potassium efflux in guinea pig pancreas. Rev. Esp. Fisiol., 53: 231-237.
    PubMed  |  
  146. Rosado, J.A., J. Singh, G.M. Salido and L.J. Garcia, 1997. Acetylcholine-evoked potassium transport in the isolated guinea-pig pancreas. Exp. Physiol., 82: 149-159.
    PubMed  |  Direct Link  |  
  147. Garcia. L.J., J.A. Rosado, T. Tsuda and R.T. Jensen, 1997. CCK causes rapid tyrosine phosphorylation of p125FAK focal adhesion kinase and paxillin in rat pancreatic acini. Biochim. Biophys. Acta, 1358: 189-199.
    CrossRef  |  PubMed  |  Direct Link  |  
  148. Garcia, L.J., J.A. Rosado, A. Gonzalez and R.T. Jensen, 1997. Cholecystokinin-stimulated tyrosine phosphorylation of p125FAK and paxillin is mediated by phospholipase C-dependent and -independent mechanisms and requires the integrity of the actin cytoskeleton and participation of p21rho. Biochem. J., 327: 461-472.
    PubMed  |  Direct Link  |  
  149. Rosado, J.A., J.A. Tapia, L.J. Garcia and G.M. Salido, 1996. Histamine-evoked potassium release in the mouse and guinea pig pancreas. Pancreas, 12: 396-400.
    PubMed  |  Direct Link  |  
  150. Alcon, S., J.A. Rosado, L.J. Garcia, J.A. Pariente and G.M. Salidoet al., 1996. Secretin potentiates guinea pig pancreatic response to cholecystokinin by a cholinergic mechanism. Can. J. Physiol. Pharmacol., 74: 1342-1350.
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