Dr. Jose F. de Celis Ibeas
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Dr. Jose F. de Celis Ibeas

Professor
Centro de Biologia Molecular Severo Ochoa, Spain

Highest Degree
Ph.D. in Science from Centro de Biologia Molecular Severo Ochoa, Spain

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Biography

Dr. Jose F. de Celis Ibeas is currently working as Professor of Research CSIC at Centro de Biologia Molecular Severo Ochoa, Spain. He has completed his Ph.D. in Science from same Institute. His main area of interest focuses on Biomedical Sciences and Molecular Sciences. His area of expertise includes Drosophila, Imaginal Discs, Developmental Genetics, Signaling Pathways, and Transcriptional Regulation. He has published 61 research articles in journals contributed as author/co-author.

Area of Interest:

Molecular Sciences
100%
Drosophila
62%
Genetics
90%
Signalling Pathways
75%
Transcriptional Regulation
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Molnar, C. and J.F. de Celis, 2013. Tay bridge is a negative regulator of EGFR signalling and interacts with Erk and Mkp3 in the Drosophila melanogaster wing. PLoS Genet., Vol. 9 10.1371/journal.pgen.1003982.
    CrossRef  |  
  2. Hevia, C.F. and J.F. de Celis, 2013. Activation and function of TGFβ signalling during Drosophila wing development and its interactions with the BMP pathway. Dev. Biol., 377: 138-153.
  3. De Celis, J.F., 2013. Understanding the determinants of Notch interactions with its ligands. Sci. Signal., Vol. 6 10.1126/scisignal.2004079.
    CrossRef  |  
  4. De Celis, J.F. and A. Garcia-Bellido, 2013. Imaginal Discs. In: Brenner's Encyclopedia of Genetics, Maloy, S. and K. Hughes (Eds.). Chapter 769, Academic Press, New York, USA., ISBN-13: 9780123749840, pp: 19-23.
  5. Organista, M.F. and J.F. De Celis, 2012. The Spalt transcription factors regulate cell proliferation, survival and epithelial integrity downstream of the Decapentaplegic signalling pathway. Biol. Open, 10.1242/​bio.20123038.
    CrossRef  |  
  6. Molnar, C., M. Casado, A. Lopez-Varea, C. Cruz and J.F. de Celis, 2012. Genetic annotation of gain-of-function screens using RNA interference and in situ hybridization of candidate genes in the Drosophila wing. Genetics, 192: 741-752.
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  7. Terriente-Felix, A., C. Molnar, J.L. Gomez-Skarmeta and J.F. de Celis, 2011. A conserved function of the chromatin ATPase Kismet in the regulation of hedgehog expression. Dev. Biol., 350: 382-392.
  8. Resnik-Docampo, M. and J.F. De Celis, 2011. MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster. PloS One, Vol. 6 10.1371/journal.pone.0014528.
    CrossRef  |  
  9. Molnar, C., M. Resnik-Docampo, M.F. Organista, M. Martin, C.F. Hevia and J.F. de Celis, 2011. Signalling Pathways in Development and Human Disease: A Drosophila Wing Perspective. In: Human Genetic Diseases, Plaseska-Karanfilska, D. (Ed.). InTech Publisher, New York, USA., ISBN-13: 9789533079363, pp: 1-37.
  10. Molnar, C., A. Ruiz-Gomez, M. Martin, S. Rojo-Berciano, F. Mayor Jr. and J.F. De Celis, 2011. Role of the Drosophila non-visual β-arrestin kurtz in hedgehog signalling. PLoS Genet., Vol. 7 10.1371/journal.pgen.1001335.
    CrossRef  |  
  11. Glavic, A., A. Lopez-Varea and J.F. de Celis, 2011. The balance between GMD and OFUT1 regulates Notch signaling pathway activity by modulating Notch stability. Biol. Res., 44: 25-34.
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  12. Tortoriello, G., J.F. de Celis and M. Furia, 2010. Linking pseudouridine synthases to growth, development and cell competition. FEBS J., 277: 3249-3263.
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  13. Terriente-Felix, A., A. Lopez-Varea and J.F. de Celis, 2010. Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. Genetics, 185: 671-684.
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  14. De Celis, J.F. and C. Molnar, 2010. A cautionary tale on genetic screens based on a gain-of-expression approach: The case of LanB1. Fly, 4: 24-29.
  15. Urbano, J.M., C.N. Torgler, C. Molnar, U. Tepass and A. Lopez-Varea et al., 2009. Drosophila laminins act as key regulators of basement membrane assembly and morphogenesis. Development, 136: 4165-4176.
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  16. Terriente-Felix, A. and J.F. de Celis, 2009. Osa, a subunit of the BAP chromatin-remodelling complex, participates in the regulation of gene expression in response to EGFR signalling in the Drosophila wing. Dev. Biol., 329: 350-361.
    CrossRef  |  PubMed  |  
  17. Glavic, A., C. Molnar, D. Cotoras and J.F. de Celis, 2009. Drosophila Axud1 is involved in the control of proliferation and displays pro-apoptotic activity. Mech. Dev., 126: 184-197.
  18. Garcia-Bellido, A. and J.F. de Celis, 2009. The complex tale of the Achaete-scute complex: A paradigmatic case in the analysis of gene organization and function during development. Genetics, 182: 631-639.
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  19. De Celis, J.F. and R. Barrio, 2009. Regulation and function of Spalt proteins during animal development. Int. J. Dev. Biol., 53: 1385-1398.
    CrossRef  |  PubMed  |  
  20. Cruz, C., A. Glavic, M. Casado and J.F. de Celis, 2009. A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Genetics, 183: 1005-1026.
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  21. Ruiz-Gomez, A., C. Molnar, H. Holguin, F. Mayor Jr. and J.F. de Celis, 2007. The cell biology of Smo signalling and its relationships with GPCRs. Bioch. Biophys. Acta, 1768: 901-912.
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  22. Molnar, C., H. Holguin, F. Mayor Jr., A. Ruiz-Gomez and J.F. de Celis, 2007. The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc. Natl. Acad. Sci., 104: 7963-7968.
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  23. Barrio, R., A. Lopez-Varea, M. Casado and J.F. de Celis, 2007. Characterization of dSnoN and its relationship to Decapentaplegic signaling in Drosophila. Dev. Biol., 306: 66-81.
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  24. Sotillos, S. and J.F. de Celis, 2006. Regulation of Decapentaplegic expression during Drosophila wing veins pupal development. Mech. Dev., 123: 241-251.
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  25. Molnar, C., C. Cruz, A. Terrientey and J.F. de Celis, 2006. Drosophila as a model organism in genetic research. Recent Res. Dev. Entomol., 5: 69-93.
  26. Molnar, C., A. Lopez-Varea, R. Hernandez and J.F. de Celis, 2006. A gain-of-function screen identifying genes required for vein formation in the Drosophila melanogaster wing. Genetics, 174: 1635-1659.
    CrossRef  |  Direct Link  |  
  27. Molnar, C. and J.F. de Celis, 2006. Independent roles of Drosophila Moesin in imaginal disc morphogenesis and hedgehog signalling. Mech. Dev., 123: 337-351.
    CrossRef  |  Direct Link  |  
  28. Sotillos, S. and J.F. De Celis, 2005. Interactions between the Notch, EGFR and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development. Dev. Dyn., 232: 738-752.
    CrossRef  |  Direct Link  |  
  29. Gomez, A.R., A. Lopez‐Varea, C. Molnar, E. de la Calle‐Mustienes, M. Ruiz‐Gomez, J.L. Gomez‐Skarmeta and J.F. de Celis, 2005. Conserved cross‐interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual‐specificity phosphatase MKP3. Dev. Dyn., 232: 695-708.
    CrossRef  |  Direct Link  |  
  30. De Celis, J.F., 2004. The Notch Signalling Module. In: Modularity in Development and Evolution, Schlosser, G. and G.P. Wagner (Eds.). The University of Chicago Press, Chicago, IL., USA., pp: 81-100.
  31. Barrio, R. and J.F. de Celis, 2004. Regulation of Spalt expression in the Drosophila wing blade in response to the Decapentaplegic signaling pathway. Proc. Natl. Acad. Sci. USA., 101: 6021-6026.
    CrossRef  |  
  32. Villa-Cuesta, E., J. de Navascues, M. Ruiz-Gomez, R.D. del Corral, M. Dominguez, J.F. de Celis and J. Modolell, 2003. Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila. Genetics, 163: 1403-1412.
    Direct Link  |  
  33. De Celis, J.F., 2003. Pattern formation in the Drosophila wing: The development of the veins. Bioessays, 25: 443-451.
    CrossRef  |  PubMed  |  Direct Link  |  
  34. De Celis, J.F. and F.J. Diaz-Benjumea, 2003. Developmental basis for vein pattern variations in insect wings. Int. J. Dev. Biol., 47: 653-664.
  35. Mollereau, B., M. Dominguez, R. Webel, N. Jo Colley, B. Keung, J.F. de Celis and C. Desplan, 2001. Two-step process for photoreceptor formation in Drosophila. Nature, 414: 911-913.
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  36. De Celis, J.F. and S. Bray, 2000. The Abruptex domain of Notch regulates negative interactions between Notch, its ligands and Fringe. Development, 127: 1291-1302.
    PubMed  |  Direct Link  |  
  37. De Celis, J.F. and R. Barrio, 2000. Function of the spalt/spalt-related gene complex in positioning the veins in the Drosophila wing. Mechanism Dev., 91: 31-41.
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  38. Baonza, A., J.F. de Celis and A. Garcia-Bellido, 2000. Relationships between extramacrochaetae and Notch signalling in Drosophila wing development. Development, 127: 2383-2393.
    Direct Link  |  
  39. De Celis, J.F., R. Barrio and F.C. Kafatos, 1999. Regulation of the spalt/spalt-related gene complex and its function during sensory organ development in the Drosophila thorax. Development, 126: 2653-2662.
    PubMed  |  Direct Link  |  
  40. De Celis, J.F., 1999. The function of vestigial in Drosophila wing development: How are tissue-specific responses to signalling pathways specified? BioEssays, 21: 542-545.
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  41. Barrio, R., J.F. de Celis, S. Bolshakov and F.C. Kafatos, 1999. Identification of regulatory regions driving the expression of the Drosophila spalt complex at different developmental stages. Dev. Biol., 215: 33-47.
    CrossRef  |  PubMed  |  Direct Link  |  
  42. Dominguez, M. and J.F. de Celis, 1998. A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye. Nature, 396: 276-278.
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  43. De Celis, J.F., D.M. Tyler, J. de Celis and S. Bray, 1998. Notch signalling mediates segmentation of the Drosophila leg. Development, 125: 4617-4626.
    Direct Link  |  
  44. De Celis, J.F., 1998. Positioning and differentiation of veins in the Drosophila wing. Int. J. Dev. Biol., 42: 335-344.
    PubMed  |  
  45. De Celis, J.F., S. Bray and A. Garcia-Bellido, 1997. Notch signalling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development, 124: 1919-1928.
    PubMed  |  Direct Link  |  
  46. De Celis, J.F., 1997. Expression and function of decapentaplegic and thick veins during the differentiation of the veins in the Drosophila wing. Development, 124: 1007-1018.
    PubMed  |  Direct Link  |  
  47. De Celis, J.F. and S. Bray, 1997. Feed-back mechanisms affecting Notch activation at the dorsoventral boundary in the Drosophila wing. Development, 124: 3241-3251.
    PubMed  |  Direct Link  |  
  48. De Celis, J.F., R. Barrio and F.C. Kafatos, 1996. A gene complex acting downstream of dpp in Drosophila wing morphogenesis. Nature, 381: 421-424.
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  49. De Celis, J.F., J. de Celis, P. Ligoxygakis, A. Preiss, C. Delidakis and S. Bray, 1996. Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: The E(spl) genes mediate only a subset of Notch activities during imaginal development. Development, 122: 2719-2728.
    PubMed  |  Direct Link  |  
  50. De Celis, J.F., A. Garcia-Bellido and S.J. Bray, 1996. Activation and function of Notch at the dorsal-ventral boundary of the wing imaginal disc. Development, 122: 359-369.
    PubMed  |  Direct Link  |  
  51. De Celis, J.F., M. Llimargas and J. Casanova, 1995. Ventral veinless, the gene encoding the Cf1a transcription factor, links positional information and cell differentiation during embryonic and imaginal development in Drosophila melanogaster. Development, 121: 3405-3416.
    PubMed  |  Direct Link  |  
  52. De Celis, J.F., A. Baonza and A. Garcia-Bellido, 1995. Behavior of extramacrochaetae mutant cells in the morphogenesis of the Drosophila wing. Mechanisms Dev., 53: 209-221.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. De Celis, J.F. and M. Ruiz-Gomez, 1995. Groucho and hedgehog regulate engrailed expression in the anterior compartment of the Drosophila wing. Development, 121: 3467-3476.
    PubMed  |  Direct Link  |  
  54. De Celis, J.F. and A. Garcia-Bellido, 1994. Roles of the Notch gene in Drosophila wing morphogenesis. Mechanism Dev., 46: 109-122.
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  55. De Celis, J.F. and A. Garcia-Bellido, 1994. Modifications of the Notch function by Abruptex mutations in Drosophila melanogaster. Genetics, 136: 183-194.
    PubMed  |  Direct Link  |  
  56. De Celis, J.F., R. Barrio, A. del Arco and A. Garcia-Bellido, 1993. Genetic and molecular characterization of a Notch mutation in its Delta- and Serrate-binding domain in Drosophila. Proc. Natl. Acad. Sci. USA, 90: 4037-4041.
    CrossRef  |  PubMed  |  Direct Link  |  
  57. Garcia-Bellido, A. and J.F. de Celis, 1992. Developmental genetics of the venation pattern of Drosophila. Ann. Rev. Genet., 26: 277-304.
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  58. Mari-Befa, M., J.F. de Celis and A. Garcia-Bellido, 1991. Genetic and developmental analysis of the chaetae pattern formation in Drosophilaterguites. Roux's Arch. Dev. Biol., 200: 132-142.
  59. De Celis, J.F., M. Mari-Beffa and A. Garcia-Bellido, 1991. Function of trans-acting genes of the achaete-scute complex in sensory organ patterning in the mesonotum of Drosophila. Roux's Arch. Dev. Biol., 200: 64-76.
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  60. De Celis, J.F., M. Mari-Beffa and A. Garcia-Bellido, 1991. Cell-autonomous role of Notch, an epidermal growth factor homologue, in sensory organ differentiation in Drosophila. Proc. Natl. Acad. Sci. USA, 88: 632-636.
    PubMed  |  Direct Link  |  
  61. Cubas, P., J.F. de Celis, S. Campuzano and J. Modolell, 1991. Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev., 5: 996-1008.
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