1. Mello-Vieira, J., T. Sousa, A. Coutinho, A. Fedorov and S.D. Lucas et al., 2013. Cytotoxic bile acids but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations. Biochim. Biophys. Acta, 1828: 2152-2163.
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2. Dosa, P.I., T. Ward, R.E. Castro, C.M. Rodrigues and C.J. Steer, 2013. Synthesis and evaluation of water-soluble prodrugs of ursodeoxycholic acid (UDCA), an anti-apoptotic bile acid. Chem. Med. Chem., 8: 1002-1011.
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3. Castro, R.E., D.M. Ferreira, M.B. Afonso, P.M. Borralho, M.V. Machado, H. Cortez-Pinto and C.M.P. Rodrigues, 2013. MiR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J. Hepatol., 58: 119-125.
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4. Machado, M.V., D.M.S. Ferreira, R.E. Castro, A.R. Silvestre and T. Evangelista et al., 2012. Liver and muscle in morbid obesity: The interplay of fatty liver and insulin resistance. PLoS One, Vol. 7. 10.1371/journal.pone.0031738.
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5. Castro, R.E. and C.M.P. Rodrigues, 2012. Targeting miR-506 in primary biliary cirrhosis to support the HCO3- umbrella. Clin. Res. Hepatol. Gastroenterol., 36: 402-404.
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6. Ferreira, D.M., R.E. Castro, M.V. Machado, T. Evangelista and A. Silvestre et al., 2011. Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. Diabetologia, 54: 1788-1798.
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7. Borralho, P.M., A.E.S. Simoes, S.E. Gomes, R.T. Lima and T. Carvalho et al., 2011. MiR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation. PLoS One, Vol. 6. 10.1371/journal.pone.0023787.
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8. Castro, R.E., M.M. Santos, P.M. Gloria, C.J. Ribeiro and D.M. Ferreira et al., 2010. Cell death targets and potential modulators in Alzheimer's disease. Curr. Pharm. Des., 16: 2851-2864.
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9. Castro, R.E., D.M.S. Ferreira, X. Zhang, P.M. Borralho and A.L. Sarver et al., 2010. Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid. Am. J. Physiology-Gastrointestinal Liver Physiol., 299: 887-897.
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10. Amaral, J.D., R.E. Castro, S. Sola, C.J. Steer and C.M.P. Rodrigues, 2010. Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53. Biochem. Biophys. Res. Commun., 400: 649-654.
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11. Viana, R.J., A.F. Nunes, R.E. Castro, R.M. Ramalho and J. Meyerson et al., 2009. Tauroursodeoxycholic acid prevents E22Q Alzheimer's Aβ toxicity in human cerebral endothelial cells. Cell. Mol. Life Sci., 66: 1094-1104.
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12. Santos, D.M., M.M. Santos, R.J. Viana, R.E. Castro, R. Moreira and C.M.P. Rodrigues, 2009. Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents. Chem. Biol. Interact., 180: 175-182.
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13. Borralho, P.M., B.T. Kren, R.E. Castro, I.B. da Silva, C.J. Steer and C.M. Rodrigues, 2009. MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells. FEBS J., 276: 6689-6700.
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14. Amaral, J.D., R.E. Castro, C.J. Steer and C.M.P. Rodrigues, 2009. p53 and the regulation of hepatocyte apoptosis: Implications for disease pathogenesis. Trends Mol. Med., 15: 531-541.
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15. Ramalho, R.M., R.J. Viana, R.E. Castro, C.J. Steer, W.C. Low and C.M.P. Rodrigues, 2008. Apoptosis in transgenic mice expressing the P301L mutated form of human tau. Mol. Med., 14: 309-317.
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16. Rivard, A.L., C.J. Steer, B.T. Kren, C.M.P. Rodrigues, R.E. Castro, R.W. Bianco and W.C. Low, 2007. Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat. Am. J. Chinese Med., 35: 279-295.
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17. Ferreira-Dias, G., L. Mateus, A.S. Costa, S. Sola, R.M. Ramalho, R.E. Castro and C.M.P. Rodrigues, 2007. Progesterone and caspase-3 activation in equine cyclic corpora lutea. Reprod. Domest. Anim., 42: 380-386.
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18. Castro, R.E., J.D. Amaral, S. Sola, B.T. Kren, C.J. Steer and C.M.P. Rodrigues, 2007. Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes. Am. J. Physiol. Gastrointestinal Liver Physiol., 293: G327-G334.
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19. Amaral, J.D., R.E. Castro, S. Sola, C.J. Steer and C.M.P. Rodrigues, 2007. p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis. J. Biol. Chem., 282: 34250-34259.
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20. Sola, S., J.D. Amaral, P.M. Borralho, R.M. Ramalho and R.E. Castro et al., 2006. Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid β-peptide-induced apoptosis. Mol. Endocrinol., 20: 2292-2303.
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21. Ramalho, R.M., P.M. Borralho, R.E. Castro, S. Sola, C.J. Steer and C.M.P. Rodrigues, 2006. Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells. J. Neurochem., 98: 1610-1618.
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22. Ramalho, R.M., H. Cortez-Pinto, R.E. Castro, S. Sola and A. Costa et al., 2006. Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis. Eur. J. Gastroenterol. Hepatol., 18: 21-29.
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23. Sola, S., J.D. Amaral, R.E. Castro, R.M. Ramalho and P.M. Borralho et al., 2005. Nuclear translocation of ursodeoxycholic acid via the glucocorticoid receptor is required to reduce TGF-β1-induced apoptosis in rat hepatocytes. Hepatology, 42: 925-934.
24. Castro, R.E., S. Sola, X. Ma, R.M. Ramalho, B.T. Kren, C.J. Steer and C.M.P. Rodrigues, 2005. Distinct gene expression profile associated with ursodeoxycholic acid treatment of primary rat hepatocytes using microarray analysis. J. Hepatol., 42: 897-906.
25. Sola, S., R.E. Castro, B.T. Kren, C.J. Steer and C.M.P. Rodrigues, 2004. Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-β-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. Biochemistry, 43: 8429-8438.
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26. Ribeiro, P.S., H. Cortez-Pinto, S. Sola, R.E. Castro and R.M. Ramalho et al., 2004. Hepatocyte apoptosis, expression of death receptors and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. Am. J. Gastroenterol., 99: 1708-1717.
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27. Ramalho, R.M., P.S. Ribeiro, S. Sola, R.E. Castro, C.J. Steer and CM.P. Rodrigues, 2004. Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid β-peptide-induced apoptosis of PC12 cells. J. Neurochem., 90: 567-575.
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28. Castro, R.E., S. Sola, R.M. Ramalho, C.J. Steer and C.M.P. Rodrigues, 2004. The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons. J. Pharmacol. Exp. Ther., 311: 845-852.
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29. Sola, S., X. Ma, R.E. Castro, B.T. Kren, C.J. Steer and C.M.P. Rodrigues, 2003. Ursodeoxycholic acid modulates E₂F-1 and p53 Expression through a caspase-independent mechanism in transforming growth factor β1-induced apoptosis of rat hepatocytes. J. Biol. Chem., 278: 48831-48838.
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30. Sola, S., R.E. Castro, P.A. Laires, C.J. Steer and C.M.P. Rodrigues, 2003. Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. Mol. Med., 9: 226-234.
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31. Rodrigues, C.M., S. Sola, Z. Nan, R.E. Castro, P.S. Ribeiro, W.C. Low and C.J. Steer, 2003. Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats. Proc. National Acad. Sci. USA., 100: 6087-6092.
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32. Rodrigues, C.M., S. Sola, R.E. Castro, P.A. Laires, D. Brites, J.J. Moura, 2002. Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis. J. Lipid Res., 43: 885-894.
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