Dr. Ivanka  I. Dimova
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Dr. Ivanka I. Dimova

Medical University of Sofia, Bulgaria

Highest Degree
Ph.D. in Medical Sciences from Medical University of Sofia, Bulgaria

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Area of Interest:

Biomedical Sciences
Medical Genetics

Research Publications in Numbers


Selected Publications

  1. Dimova, I. and I. Kremensky, 2018. LAMA2 congenital muscle dystrophy: A novel pathogenic mutation in bulgarian patient. Case Rep. Genet., Vol. 2018. 10.1155/2018/3028145.
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  2. Yordanova, A., I. Dimova and M. Koprinarova, 2017. Cytotoxic effect of aloe-emodin on cancer and endothelial human cells. Comptes Rendus Acad. Bulgare Sci., 70: 229-236.
  3. Trpchevska, N., I. Dimova, T. Arabadji, T. Milachich and S. Angelova et al., 2017. A family study of complex chromosome rearrangement involving chromosomes 1, 8, and 11 and its reproductive consequences. J. Assisted Reprod. Genet., 34: 659-669.
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  4. Rizov, M., P. Andreeva and I. Dimova, 2017. Molecular regulation and role of angiogenesis in reproduction. Taiwanese J. Obstet. Gynecol., 56: 127-132.
  5. Miglena, K., K. Stefan, D. Ivan, A. Petya and N. Dragomira et al., 2017. Association of HPV cervical dysplasia progression with DNA methylation of genes. Connected to cellular stress and oncogenesis. J. Oncol. Stud., Vol. 1. .
  6. Gazdic, M., A. Arsenijevic, B.S. Markovic, A. Volarevic and I. Dimova et al., 2017. Mesenchymal stem cell-dependent modulation of liver diseases. Int. J. Biol. Sci., 13: 1109-1117.
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  7. Dimova, I., S. Danova, E. Nikolova and M. Koprinarova, 2017. Aloe-emodin triggers ROS and Ca2+ production and decreases the levels of mitochondrial membrane potential of human brain capillary endothelial cells. Int. J. Phytomed., 9: 511-517.
  8. Milanov, I., K. Kmetska, B. Popivanova, I. Dimova, T. Kadyiska, E. Naseva and V. Grozeva, 2016. HLA-G 14bp deletion/insertion polymorphisms in multiple sclerosis. Eur. J. Med., 11: 19-24.
  9. Grozdanov, P., S. Hadjidekova, I. Dimova, I. Nikolova and D. Toncheva et al., 2016. Characterization of genomic changes in the cervical pre-cancerous lesions and tumors induced by different types of human papillomaviruses. Virusdisease, 27: 271-276.
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  10. Dimitrova-Dikanarova, D.K., V.V. Lazarov, R. Tafradjiiska-Hadjiolova, I.I. Dimova, N.U. Petkova and Z.A. Krastev, 2016. Association between Helicobacter pylori infection and the presence of anti-sperm antibodies. Biotechnol. Biotechnol. Equip., 31: 1-8.
  11. An, M., I. Dimova, T. Koller, B. Styp-Rekowska and V. Djonov, 2016. Dynamics of the developing chick chorioallantoic membrane assessed by stereology, allometry, immunohistochemistry and molecular analysis. Plos One, Vol. 5. .
  12. Staneva, R.G., L. Balabanski, I. Dimova, B. Rukova et al., 2015. Genetic, genomic and epigenomic studies of Balkan Endemic Nephropathy (BEN). Prilozi, 36: 101-108.
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  13. Penchev, V., E. Marinova, M. Rizov, I. Antonova and D. Gulenova et al., 2015. The role of +405 G/C VEGF A polymorphism in women with recurrent implantation failure, endometriosis and miscarriages after ICSI-ET cycles. EC Gynaecol., 1: 105-111.
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  14. Karachanak-Yankova, S., R. Dimova, D. Nikolova, D. Nesheva and M. Koprinarova et al., 2015. Epigenetic alterations in patients with type 2 diabetes. BJMG., 18: 15-24.
  15. Dimova, I., R. Tafradzhiska-Hadzhiolova, S. Maslyankov, D. Nesheva and D. Toncheva, 2015. Whole genome microarray analysis in invasive ductal breast cancer revealed the most significant changes affect chromosomes 1, 8, 17 and 20. Int. J. Sci., 4: 8-17.
  16. Dimov, D., R. Hadjiolova, K. Kanev, R. Tomova and A. Michova et al., 2015. Cardiac and renal nitrosative-oxidative stress after acute poisoning by a nerve agent Tabun. J. Environ. Sci. Health, Part A, 50: 824-829.
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  17. Chaveeva, P., N. Persico, R. Maslarska, T. Georgiev, I. Dimova and A. Shterev, 2015. Second stage in mininvasive fetal surgery for severe congenital diaphragmatic hernia. Case report. Akush Ginekol (Sofiia), 54: 40-44.
  18. Al Zeyadi, M., I. Dimova, V. Ranchich, B. Rukova and D. Nesheva et al., 2015. Whole genome microarray analysis in non-small cell lung cancer. Biotechnol. Biotechnol. Equip., 29: 111-118.
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  19. Toncheva, D., M. Mihailova-Hristova, R. Vazharova, R. Staneva and S. Karachanak et al., 2014. NGS nominated CELA1, HSPG2 and KCNK5 as candidate genes for predisposition to Balkan endemic nephropathy. BioMed Res. Int., Vol. 2014. .
  20. Stoynev, N., I. Dimova, B. Rukova, S. Hadjidekova, D. Nikolova, D. Toncheva and T. Tankova, 2014. Gene expression in peripheral blood of subjects with hypertension and subjects with type 2 diabetes. J. Cardiovasc. Med. (Hagerstown), 15: 702-709.
  21. Maslyankov, S., G. Trifonov, D. Kyoseva, I. Fidoshev and D. Tzoneva et al., 2014. Peutz-Jeghers syndrome: A rare case and a literature review. Khirurgiia, 1: 43-48.
  22. Makanya, A., B. Styp-Rekowska, I. Dimova and V. Djonov, 2014. Avian Area Vasculosa and CAM as Rapid In Vivo Pro- and Anti-Angiogenic Models. In: Methods in Molecular Biology: Vascular Morphogenesis: Methods and Protocols Ribatti, D. and J.M. Walker (Eds.)., Humana Press, USA.
  23. Ivanka, D., H. Radka, N. Emanuil, N. Desislava and T. Draga, 2014. Genomic markers for glioblastoma multiforme, revealed by array CGH analysis. Br. J. Applied Sci. Technol., 4: 1540-1553.
  24. Dimova, I., S. Lalchev, M. Malinov, V. Djonov and D. Toncheva, 2014. New generation genomic platforms in investigation of complex diseases and BEN. Prilozi, 35: 25-33.
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  25. Dimova, I., G. Popivanov and V. Djonov, 2014. Angiogenesis in cancer-general pathways and their therapeutic implications. J. Buon, 19: 15-21.
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  26. Balabanski, L., G. Antov, I. Dimova, S. Ivanov and M. Nacheva et al., 2014. Next‑generation sequencing of BRCA1 and BRCA2 in breast cancer patients and control subjects. Mol. Clin. Oncol., 2: 435-439.
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  27. Staneva, R., B. Rukova, S. Hadjidekova, D. Nesheva and O. Antonova et al., 2013. Whole genome methylation array analysis reveals new aspects in Balkan endemic nephropathy etiology. BMC Nephrol., Vol. 14. 10.1186/1471-2369-14-225.
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  28. Dimova, I., R. Hlushchuk, A. Makanya, B. Styp-Rekowska and A. Ceausu et al., 2013. Inhibition of Notch signalling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells. Angiogenesis, 16: 921-937.
  29. Dimova, I., A. Yosifova, B. Zaharieva, S. Raitcheva, N. Doganov and D. Toncheva, 2013. Association of 20q13.2 copy number changes with the advanced stage of ovarian cancer-tissue microarray analysis. Eur. J. Obstet. Gynecol. Reprod. Biol., 118: 81-85.
  30. Dimova, I. and D. Toncheva, 2013. Genetic aspects of hypertension in early age. Clin. Paediat., Vol. 2013. .
  31. Damyanova, V., I. Dimova, A. Savov, D. Nesheva and S. Hadjidekova et al., 2013. Comprehensive genomic study in patients with idiopathic azoospermia and oligoasthenoteratozoospermia. Biotechnol. Biotechnol. Equip., 27: 3529-3533.
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  32. Ceausu, R.A., A.M. Cimpean, I. Dimova, R. Hlushchuk, V. Djonov, P.N. Gaje and M. Raica, 2013. Everolimus dual effects of an area vasculosa angiogenesis and lymphangiogenesis. In Vivo, 27: 61-66.
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  33. Betcheva, E.T., A.G. Yosifova, T. Mushiroda, M. Kubo and A. Takahashi et al., 2013. Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiat. Genet., 23: 11-19.
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  34. Wooding, S.P., S. Atanasova, H.C. Gunn, R. Staneva, I. Dimova and D. Toncheva, 2012. Association of a bitter taste receptor mutation with Balkan Endemic Nephropathy (BEN). BMC Med. Genet., Vol. 13. 10.1186/1471-2350-13-96.
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  35. Velizarova, M., I. Dimova, E. Hadzhiev and K. Tsatchev, 2012. BCR/ABL molecular testing by fluorescence in situ hybridization in untreated adult acute leukaemia. Acta Med. Bulgarica, 32: 82-88.
  36. Velizarova, M., E. Hadzhiev, I. Dimova, D. Toncheva and K. Tsatchev, 2012. High incidence of unfavorable cytogenetic aberrations and low remission rate in adults over 60 with acute myeloid leukemia. Acta Med. Bulgarica, 32: 29-36.
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  37. Velizarova, M., D. Popova, E. Hadjiev, N. Dimitrova, I. Dimova, D. Toncheva and K. Tsachev, 2012. Evaluation of molecular-cytogenetic aberrations and overall survival in myeloid antigen positive adult acute lymphoblastic leukemia. Acta Med. Bulgarica, 1: 40-46.
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  38. Hadzhiev, E., K. Alexandrova, M. Velizarova, I. Dimova and D. Toncheva, 2012. Association of 13q14 deletion with clinico-laboratory parameters in B-cell chronic lymphocytic leukemia (B-CLL). Acta Med. Bulgarica, 32: 73-81.
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  39. Dimov, D., K. Kanev and I. Dimova, 2012. Correlation between butyrylcholinesterase variants and sensitivity to soman toxicity. Acta Biochim. Polonica, 59: 313-316.
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  40. Yosifova, A., T. Mushiroda, M. Kubo, A. Takahashi and Y. Kamatani et al., 2011. Genome‐wide association study on bipolar disorder in the Bulgarian population. Genes Brain Behav., 10: 789-797.
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  41. Velizarova, M.G., E.A. Hadjiev, K.V. Alexandrova, I.I. Dimova, D.I. Toncheva and N.E. Dimitrova, 2011. Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia. Turk. J. Hematol., 28: 176-185.
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  42. Metodieva, S.N., D.N. Nikolova, R.V. Cherneva, I.I. Dimova, D.B. Petrov and D.I. Toncheva, 2011. Expression analysis of angiogenesis-related genes in Bulgarian patients with early-stage non-small cell lung cancer. Tumori J., 97: 86-94.
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  43. Angelova, S., M. Jordanova, B. Spassov, V. Shivarov and M. Simeonova et al., 2011. Amplification of c-MYC and MLL genes as a marker of clonal cell progression in patients with myeloid malignancy and trisomy of chromosomes 8 or 11. Balkan J. Med. Genet., 14: 17-24.
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  44. Templin, C., M. Meyer, M.F. Muller, V. Djonov and R. Hlushchuk et al., 2010. Coronary Optical Frequency Domain Imaging (OFDI) for in vivo evaluation of stent healing: Comparison with light and electron microscopy. Eur. Heart J., 31: 1792-1801.
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  45. Stoynev, N., B. Rukova, I. Dimova, S. Hadjidekova, D. Nikolova, D. Toncheva and T. Tankova, 2010. Altered expression of genes associated with atherosclerosis in peripheral blood of subjects with hypertension and type 2 diabetes mellitus: pp. 21.336. J. Hyperten., Vol. 28. 10.1097/01.hjh.0000379262.16454.8c.
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  46. Ivanka, D., D. Vera, N. Desislava, H. Savina and V. Ilia et al., 2010. Array Comparative Genomic Hybridization (CGH) analysis of sperm DNA to detect copy number variations in infertile men with idiopathic azoospermia. J. Clin. Med. Res., 2: 42-48.
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  47. Hadjidekova, S.P., D.M.A. Tsavela, I.I. Dimova, B.B. Rukova and D.V. Nesheva et al., 2010. Unclear malformative syndrome-tools for modern diagnostics. Pediatrics, 1: 30-32.
  48. Gladilova, A.S., S.P. Hadjidekova, I.D. Dimova, B.B. Rukova, D.M. Avdjieva-Tzavella and D.I. Toncheva, 2010. Expression profile of the immune response factors in patients with bronchial asthma. Biotechnol. Biotechnol. Equip., 24: 1858-1861.
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  49. Dimova, I., R. Hlushchuk, A. Makanya and V. Djonov, 2010. Notch inhibition destroys vessel stability and induces intussusception by recruiting mononuclear cells. Cardiovasc. Res., Vol. 87. .
  50. Cherneva, R., O. Georgiev, I. Dimova, B. Rukova, D. Petrov and D. Toncheva, 2010. EGFR and hTERT expression as a diagnostic approach for non-small cell lung cancer in high risk groups. Biomarkers Cancer, Vol. 2. 10.4137/BIC.S3383.
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  51. Yosifova, A., T. Mushiroda, D. Stoianov, R. Vazharova and I. Dimova et al., 2009. Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population. J. Affect. Disord., 117: 87-97.
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  52. Nikolova, D.N., N. Doganov, R. Dimitrov, K. Angelov and S.K. Low et al., 2009. Genome-wide gene expression profiles of ovarian carcinoma: Identification of molecular targets for the treatment of ovarian carcinoma. Mol. Med. Rep., 2: 365-384.
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  53. Naydenov, E., C. Tzekov, K. Minkin, S. Hadjidekova and I. Dimova et al., 2009. Clinical, histopathological and cytogenetical findings in six cases with primary glioblastoma multiforme. Khirurgiia, 2-3: 49-55.
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  54. Dimova, I., S. Raicheva, R. Dimitrov, N. Doganov and D. Toncheva, 2009. Coexistence of copy number increases of c-Myc, ZNF217, CCND1, ErbB1 and ErbB2 in ovarian cancers. Oncol. Res. Treatment, 32: 405-410.
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  55. Dimova, I., B. Orsetti, V. Negre, C. Rouge and L. Ursule et al., 2009. Genomic markers for ovarian cancer at chromosomes 1, 8 and 17 revealed by array CGH analysis. Tumori J., 95: 357-366.
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  56. Dimova, I., B. Orsetti, C. Theillet, R. Dimitrov and D. Toncheva, 2009. Copy number changes in 1q21. 3 and 1q23. 3 have different clinical relevance in ovarian tumors. Balkan J. Med. Genet., 12: 29-37.
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  57. Cherneva, R.V., O.B. Georgiev, D.B. Petrov, I.I. Dimova and D.I. Toncheva, 2009. Expression levels of p53 messenger RNA detected by real time PCR in tumor tissue, lymph nodes and peripheral blood of patients with non-small cell lung cancer-new perspectives for clinicopathological application. Biotechnol. Biotechnol. Equipment, 23: 1247-1249.
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  58. Betcheva, E.T., T. Mushiroda, A. Takahashi, M. Kubo and S.K. Karachanak et al., 2009. Case-control association study of 59 candidate genes reveals the DRD2 SNP rs6277 (C957T) as the only susceptibility factor for schizophrenia in the Bulgarian population. J. Hum. Genet., 54: 98-107.
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  59. Velizarova, M.G., E.A. Hadjiev, K.V. Alexandrova, D.N. Popova, I. Dimova, B.M. Zaharieva and D. Toncheva, 2008. Significance of molecular-cytogenetic aberrations for the achievement of first remission in de novo acute myeloid leukemia. Turk. J. Hematol., 25: 190-194.
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  60. Petrova, D.T., A.R. Asif, V.W. Armstrong, I. Dimova and S. Toshev et al., 2008. Expression of chloride intracellular channel protein 1 (CLIC1) and tumor protein D52 (TPD52) as potential biomarkers for colorectal cancer. Clin. Biochem., 41: 1224-1236.
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  61. Dimova I., R. Vazharova, D. Nikolova, R. Tincheva, D. Nesheva and D. Toncheva, 2008. Whole genome analysis by array-based comparative genomic hybridization in patients with congenital anomalies. Balkan J. Med. Genet., 11: 33-40.
  62. Dimova, I. and D. Toncheva, 2007. Genomic medicine in modern neonatology and pediatrics. Pract. Pediat., 6: 21-23.
  63. Velizarova, M., D. Popova, E. Hadjiev, K. Aleksandrova and I. Dimova et al., 2006. Molecular-cytogenetic aberrations in B-cell adult acute lymphoblastic leukemia (B-ALL)-frequency and correlation with immunophenotype. Turk. J. Hematol., 23: 151-157.
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  64. Velizarova, M. and I. Dimova, 2006. Genetic mechanisms of leukemogenesis. Med. Rev., 1: 40-43.
  65. Petrova, D., R. Jankova, A. Yosifova, V. Tzenova, I. Dimova and D. Toncheva, 2006. Tissue microarray analysis of EGFR gene amplification and gain in Bulgarian patients with colorectal cancer. Onkologie, 29: 198-200.
  66. Krystev, K., I. Dimova and M. Odgakova, 2006. Molecular basis of congenital heart malformations. Pract. Pediat., 9: 8-12.
  67. Dimova, I., S.Wieczorek V. Dimitrova, A. Krasteva, S. Lalchev and D. Toncheva, 2006. The implication of the first prenatal diagnosis for Huntington disease in Bulgaria after predictive testing. Facta Univ., 13: 74-77.
  68. Dimova, I., S. Raitcheva, R. Dimitrov, N. Doganov and D. Toncheva, 2006. Correlations between c-myc copy number increases and clinicopathological parameters of ovarian tumors-tissue microarray analysis. Eur. J. Cancer, 42: 674-679.
  69. Dimova, I., B. Zaharieva, S. Raitcheva, R. Dimitrov, N. Doganov and D. Toncheva, 2006. Tissue microarray analysis of Her1 (EGFR) and Her2 (c-erbB-2) copy number changes in ovarian tumors. Int. J. Gynecol. Cancer, 16: 145-151.
  70. Cherneva, R. and I. Dimova, 2006. Genetic aspects of lung cancer. BJMG, 9: 9-17.
  71. Velizarova, М., B. Zaharieva, I. Dimova, D. Nikolova and S. Atanasova et al., 2005. Molecular monitoring of himerism after bone marrow transplantation in Bulgarian patients. Balkan J. Med. Genet., 8: 37-41.
  72. Velizarova, M., D. Popova, E. Hadjiev, K. Aleksandrova and I. Dimova et al., 2005. FISH detection of specific chromosomal aberrations and clonality in adult acute leukaemia. Haema, 8: 255-261.
  73. Dimova, I., 2005. Array comparative genomic hybridization-A new genomic approach for high resolution analysis of copy number changes. BJMG, Vol. 8. .
  74. Buzhkov. B.T.S., R. Vuzharova, V. Dimitrova, I. Dimova and I. Turnev et al., 2005. First facioscapulohumeral muscular dystrophy prenatal diagnosis in a Bulgarian family. Akush Ginekol., 44: 30-33.
  75. Toncheva, D., D. Petrova, V. Tzenova, I. Dimova and R. Yankova et al., 2004. Tissue microarray analysis of cyclin D1 gene amplification and gain in colorectal carcinomas. Tumour Biol., 25: 157-160.
  76. Dimova, I., B. Zaharieva, S. Racheva, I. Milev and R. Dimitrov et al., 2004. Association of CyclinD1 copy number changes with histological type in ovarian tumors. Acta Oncol., 43: 675-679.
  77. Dimova, I., 2003. Genetic aspects of ovarian cancer. Med. Rev., 1: 11-15.
  78. Dimova I., S. Lalchev, B. Zaharieva and D. Toncheva, 2003. Balanced translocation t (5;13)(q11;q12) in a woman with malformed child. Facta Univ., 1: 127-130.