Dr. Jana Dimitrova Tchekalarova
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Dr. Jana Dimitrova Tchekalarova

Associate Professor
Sofia University, Bulgaria

Highest Degree
Ph.D. in Neurobiology from Bulgarian Academy of Sciences, Bulgaria

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Area of Interest:

Biomedical Sciences
100%
Experimental Psychopharmacology
62%
Models of Epilepsy
90%
Circadian Rhythms
75%
Neurobiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. da Conceição Machado, K., M.F.C.J. Paz, J.V. de Oliveira Santos, F.C.C. da Silva, J.D. Tchekalarova and B. Salehi et al., 2020. Anxiety therapeutic interventions of β-caryophyllene: A laboratory-based study. Nat. Prod. Commun., Vol. 15. 10.1177/1934578x20962229.
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  2. Todorov, P., P. Peneva, J. Tchekalarova, S. Georgieva, M. Rangelov and N. Todorova, 2020. Structure-activity relationship study on new hemorphin-4 analogues containing steric restricted amino acids moiety for evaluation of their anticonvulsant activity. Amino Acids, 52: 1375-1390.
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  3. Todorov, P., P. Peneva, J. Tchekalarova and S. Georgieva, 2020. Potential anticonvulsant activity of novel VV-hemorphin-7 analogues containing unnatural amino acids: synthesis and characterization. Amino Acids, 52: 567-585.
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  4. Tchekalarova, J., N. Ivanova, Z. Nenchovska, R. Tzoneva and T. Stoyanova et al., 2020. Evaluation of neurobiological and antioxidant effects of novel melatonin analogs in mice. Saudi Pharm. J., 10.1016/j.jsps.2020.10.004.
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  5. Tchekalarova, J., M. Atanasova, N. Ivanova, N. Boyadjiev, R. Mitreva and K. Georgieva, 2020. Endurance training exerts time-dependent modulation on depressive responses and circadian rhythms of corticosterone and BDNF in the rats with pinealectomy. Brain Res. Bull., 162: 40-48.
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  6. Jana, T., S. Tzveta, N. Zlatina, I. Natasha and A. Dimitrinka et al., 2020. Effect of endurance training on diurnal rhythms of superoxide dismutase activity, glutathione and lipid peroxidation in plasma of pinealectomized rats. Neurosci. Lett., 10.1016/j.neulet.2019.134637.
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  7. Todorov, P., P. Peneva, J. Tchekalarova, M. Rangelov, S. Georgieva and N. Todorova, 2019. Synthesis, characterization and anticonvulsant activity of new series of B-modified analogues of VV-hemorphin-5 with aminophosphonate moiety. Amino Acids, 51: 1527-1545.
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  8. Tchekalarova, J., V.T. Angelova, N. Todorova, P. Andreeva-Gateva and M. Rangelov, 2019. Evaluation of the anticonvulsant effect of novel melatonin derivatives in the intravenous pentylenetetrazol seizure test in mice. Eur. J. Pharmacol., 10.1016/j.ejphar.2019.172684.
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  9. Tchekalarova, J., L. Kortenska, N. Ivanova, M. Atanasova and P. Marinov, 2019. Agomelatine treatment corrects impaired sleep-wake cycle and sleep architecture and increases MT1 receptor as well as BDNF expression in the hippocampus during the subjective light phase of rats exposed to chronic constant light. Psychopharmacology, 237: 503-518.
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  10. Ju00fanior, A.L.G., J.D. Tchekalarova, K.C. Machado, S.W.C. Silva and M.F.C.J. Paz et al., 2019. Antidepressantu2010like effect of anacardic acid in mice via the Lu2010arginine-nitric oxide-serotonergic system. Phytother. Res., 33: 2126-2138.
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  11. Ivanova, N. and J. Tchekalarova, 2019. The potential therapeutic capacity of inhibiting the brain reninu2013angiotensin system in the treatment of co-morbid conditions in epilepsy. CNS Drugs, 33: 1101-1112.
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  12. Tchekalarova, J., M. Shishmanova, D. Atanasova, M. Stefanova and L. Alova et al., 2015. Effect of endurance training on seizure susceptibility, behavioral changes and neuronal damage after kainate-induced status epilepticus in spontaneously hypertensive rats. Brain Res., 1625: 39-53.
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  13. Tchekalarova, J., E. Loyens and I. Smolders, 2015. Effects of at1 receptor antagonism on kainate-induced seizures and concomitant changes in hippocampal extracellular noradrenaline, serotonin, and dopamine levels in wistar-kyoto and spontaneously hypertensive rats. Epilepsy Behav., 46: 66-71.
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  14. Ivanova, N.M., D. Atanasova, D.M. Pechlivanova, R. Mitreva and N. Lazarov et al., 2015. Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: effects on epileptogenesis, brain damage, and diurnal behavioral changes. Epilepsy Behav., 51: 1-12.
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  15. Tchekalarova, J.D., N.M. Ivanova, D.M. Pechlivanova, D. Atanasova and N. Lazarov et al., 2014. Antiepileptogenic and neuroprotective effects of losartan in kainate model of temporal lobe epilepsy. Pharmacol. Biochem. Behavior, 127: 27-36.
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  16. Tchekalarova, J.D., H. Kubovu00e1 and P. Mareu0161, 2014. Early caffeine exposure: transient and long-term consequences on brain excitability. Brain Res. Bull., 104: 27-35.
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  17. Tchekalarova, J., N. Ivanova, D. Pechlivanova, K. Ilieva and M. Atanasova, 2014. Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression. Cell. Mol. Neurobiol., 34: 133-142.
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  18. Tchekalaro, J. and R.M. Freitas, 2014. Effect of diterpene phytol on pentlylenetetrazol and maximal electroshock seizure models: possible role of gabaergic mechanism. Pharmacologia, 5: 351-356.
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  19. Tchekalarova, J., Z. Petkova, D. Pechlivanova, S. Moyanova and L. Kortenska et al., 2013. Prophylactic treatment with melatonin after status epilepticus: Effects on epileptogenesis, neuronal damage, and behavioral changes in a kainate model of temporal lobe epilepsy. Epil. Behav., 27: 174-187.
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  20. Tchekalarova, J., H. Kubova and P. Mares, 2013. Effects of caffeine on cortical epileptic afterdischarges in adult rats are modulated by postnatal treatment. Acta Neurol. Belg., 113: 493-500.
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  21. Tchekalarova, J., H. Kubova and P. Mares, 2013. Different effects of postnatal caffeine treatment on two pentylenetetrazole-induced seizure models persist into adulthood. Pharmacol. Rep., 65: 847-853.
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  22. Atanasova, M., Z. Petkova, D. Pechlivanova, P. Dragomirova, A. Blazhev and J. Tchekalarova, 2013. Strain-dependent effects of long-term treatment with melatonin on kainic acid-induced status epilepticus, oxidative stress and the expression of heat shock proteins. Pharmacol. Biochem. Behav., 111: 44-50.
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  23. Pechlivanova, D.M., J.D. Tchekalarova, L.H. Alova, V.V. Petkov, R.P. Nikolov and K.S. Yakimova, 2012. Effect of long-term caffeine administration on depressive-like behavior in rats exposed to chronic unpredictable stress. Behav. Pharmacol., 23: 339-347.
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  24. Atanasova, M., A. Dimitrova, D. Pechlivanova and J. Tchekalarova, 2012. Strain-dependent responses to brain oxidative stress and arterial blood pressure in normotensive and spontaneouysly hypertensive rats. Compt. Rend L'Acad. Bulg. Sci., 65: 549-554.
  25. Tchekalarova, J., H. Kubova and P. Mares, 2011. Transient changes of cortical interhemispheric responses after repeated caffeine administration in immature rats. Physiol. Res., 60: 961-969.
    PubMed  |  Direct Link  |  
  26. Tchekalarova, J., D. Pechlivanova, T. Atanasova, P. Markova, V. Lozanov and A. Stoynev, 2011. Diurnal variations in depression-like behavior of Wistar and spontaneously hypertensive rats in the kainate model of temporal lobe epilepsy. Epil. Behav., 20: 277-285.
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  27. Pechlivanova, D.M., A.G. Stoynev and J.D. Tchekalarova, 2011. The effects of chronic losartan pretreatment on restraint stress-induced changes in motor activity, nociception and pentylenetetrazol generalized seizures in rats. Folia Med. (Plovdiv), 53: 69-73.
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  28. Pechlivanova, D., J. Tchekalarova, Z. Рetkova, R. Nikolov and K. Yakimova, 2011. Effect of long-term caffeine administration in chronic unpredictable stress model of depression in rats. Compt. Rend L'Acad. Bulg. Sci., 64: 1193-1198.
  29. Tchekalarova, J., H. Kubova and P. Mares, 2010. Postnatal period of caffeine treatment and time of testing modulate the effect of acute caffeine on cortical epileptic afterdischarges in rats. Brain Res., 1356: 121-129.
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  30. Tchekalarova, J., H. Kubova and P. Mares, 2010. Effects of early postnatal caffeine exposure on seizure susceptibility of rats are age- and model-dependent. Epilepsy Res., 88: 231-238.
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  31. Tchekalarova, J., D. Pechlivanova, D. Itzev, N. Lazarov, P. Markova and A. Stoynev, 2010. Diurnal rhythms of spontaneous recurrent seizures and behavioral alterations of Wistar and spontaneously hypertensive rats in the kainate model of epilepsy. Epil. Behav., 17: 23-32.
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  32. Tchekalarova, J., D. Pechlivanova, C. Atanasova, P. Markova and A. Stoynev, 2010. Study of diurnal rhythms of depressive state in kainate model of epilepsy in normotensive and spontaneous hypertensive rats. Compt. Rend L'Acad. Bulg. Sci., 63: 1691-1700.
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  33. Pechlivanova, D., J. Tchekalarova, R. Nikolov and K. Yakimova, 2010. Dose-dependent effects of caffeine on behavior and thermoregulation in a chronic unpredictable stress model of depression in rats. Behav. Brain Res., 209: 205-211.
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  34. Tchekalarova, J., H. Kubova and P. Mares, 2009. Postnatal caffeine treatment affects differently two pentylenetetrazol seizure models in rats. Seizure, 18: 463-469.
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  35. Tchekalarova, J., D. Pechlivanova, P. Markova and A. Stoynev, 2009. Behavioural alterations in Wistar and spontaneously hypertensive rats in kainate model of epilepsy. Compt. Rend L'Acad. Bulg. Sci., 62: 767-772.
  36. Pehlivanova, D., K. Yakimova, L. Tancheva, R. Nikolov, V.V. Petkov and Y. Chekalarova, 2009. Effect of caffeine on body temperature of rats in norm and depression. Pharmacy, 56: 10-14.
  37. Pechlivanova, D., J. Tchekalarova, V.V. Petkov, L. Tancheva, R. Nikolov and K. Yakimova, 2009. Dose-dependent effects of caffeine in a chronic mild stress model of depression in ICR mice. Compt. Rend L'Acad. Bulg. Sci., 62: 773-778.
  38. Tchekalarova, J., H. Kubova and P. Mares, 2007. Effects of postnatal caffeine exposure on seizure susceptibility in developing rats. Brain Res., 1150: 32-39.
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  39. Tchekalarova, J. and D. Albrecht, 2007. Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels. Neurosci. Lett., 415: 68-72.
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  40. Tchekalarova, J., H. Kubova and P. Mares, 2006. Biphasic effect of chronic postnatal caffeine treatment on cortical epileptic afterdischarges during ontogeny in rats. Brain Res., 1082: 43-49.
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  41. Tchekalarova, J. and V. Georgiev, 2006. Effect of acute versus chronic theophylline administration on acute restraint stress-induced increase of pentylenetetrazol seizure threshold in mice. Brain Res. Bull., 68: 464-468.
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  42. Tchekalarova, J. and V. Georgiev, 2006. Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: Possible involvement of noradrenergic mechanism. Neuropeptides, 40: 339-348.
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  43. Tancheva, L., V.V. Petkov, G. Karamukova, Y. Chekalarova and S. Aberova et al., 2006. Neuropharmacological activity of newly synthesized peptides derivates of L-valine. Bulg. Chem. Commun., 38: 54-57.
  44. Tchekalarova, J., H. Kubova and P. Mares, 2005. Postnatal caffeine exposure: Effects on motor skills and locomotor activity during ontogenesis. Behav. Brain Res., 160: 99-106.
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  45. Tchekalarova, J., E. Sotiriou, V. Georgiev, G. Kostopoulos and F. Angelatou, 2005. Up-regulation of adenosine A1 receptor binding in pentylenetetrazol kindling in mice: Effects of angiotensin IV. Brain Res., 1032: 94-103.
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  46. Tchekalarova, J. and V. Georgiev, 2005. Angiotensin peptides modulatory system: how is it implicated in the control of seizure susceptibility? Life Sci., 76: 955-970.
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  47. Tchekalarova, J., E. Sotiriou and F. Angelatou, 2004. Down-regulation of dopamine D1 and D2 receptors in the basal ganglia of PTZ kindling model of epilepsy: Effects of angiotensin IV. Brain Res., 1024: 159-166.
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  48. Tchekalarova, J., D. Pechlivanova, T. Kambourova, J. Matsoukas and V. Georgiev, 2003. The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception. Regul. Pept., 111: 191-197.
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  49. Tchekalarova, J., T. Kambourova and V. Georgiev, 2002. Interaction of angiotensin II and III with adenosine A1 receptor-related drugs in passive avoidance conditioning in rats. Behav. Brain Res., 129: 61-64.
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  50. Tchekalarova, J. and V. Georgiev, 2002. Effects of Angiotensin II, III and IV on Memory Retention of Rat: Interaction with Adenosine A1 Receptor Related Ligands. In: Drug Discovery and Design: Medical Aspects, Matsoukas, J. and T. Mavromoustakos (Eds.). IOS Press, The Netherlands, pp: 267-271.
  51. Tchekalarova, J., T. Kambourova and V. Georgiev, 2001. Interaction between angiotensin IV and adenosine A1 receptor related drugs in passive avoidance conditioning in rats. Behav. Brain Res., 123: 113-116.
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  52. Tchekalarova, J., T. Kambourova and V. Georgiev, 2001. Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): Interaction with adenosine A1 receptors. Brain Res. Bull., 56: 87-91.
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  53. Kambourova, T., J. Tchekalarova and V. Georgiev, 2001. Influence of adenosine modulatory system on the effects of angiotensin III and angiotensin IV on pentylenetetrazole seizure threshold in mice. Bulg. Chem. Commun., 33: 101-105.
  54. Tchekalarova, J., T. Kambourova and V. Georgiev, 2000. Long-term theophylline treatment changes the effects of angiotensin II and adenosinergic agents on the seizure threshold. Brain Res. Bull., 52: 13-16.
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  55. Tchekalarova, J. and V. Georgiev, 1999. Adenosine-angiotensin II interactions in pentylenetetrazol seizure threshold in mice. J. Physiol. Paris, 93: 191-197.
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  56. Tchekalarova, J. and V. Georgiev, 1998. Further evidence for interaction between angiotensin II and dopamine receptors (experiments on apomorphine stereotypy). Methods Find. Exp. Clin. Pharmacol., 20: 419-424.
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  57. Georgiev, V.P. and J.D. Tchekalarova, 1998. Interaction of angiotensin II and adenosine receptors in pentylenetetrazol-induced kindling in mice. Brain Res., 779: 259-261.
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  58. Georgiev, V., J.M. Matsoukas, D. Georgieva, J. Tchekalarova and I. Todorov, 1996. Influence of sarmesin on some dopamine-related types of behaviour. Lett. Pept. Sci., 3: 185-190.
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