1. Szychowski, K.A., M.L. Leja, D.V. Kaminskyy, U.E. Binduga, R. Pinyazhko, R.B. Lesyk and J. Gminski, 2017. Study of novel anticancer 4-thiazolidinone derivatives. Chemico-Biol. Interact., 262: 46-56.
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2. Lozynskyi, A., V. Matiychuk, O. Karpenko, A.K. Gzella and R. Lesyk, 2017. Tandem hetero-Diels-Alder-hemiacetal reaction in the synthesis of new chromeno [4′,3′:4,5] thiopyrano [2,3-d] thiazoles. Heterocyclic Commun., 23: 1-5.
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3. Zelisko, N., O. Karpenko, V. Muzychenko, A. Gzella, P. Grellier and R. Lesyk, 2017. trans-Aconitic acid-based hetero-Diels-Alder reaction in the synthesis of thiopyrano [2,3-d][1,3] thiazole derivatives. Tetrahedron Lett., 58: 1751-1754.
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4. Malysheva, K.V., N.S. Finiuk, O.K. Pavlenko, D.Y. Havrylyuk, R.B. Lesyk, R.S. Stoika and O.G. Korchynskyi, 2017. 4-Thiazolidinone-based derivatives rescue TNAα-inhibited osteoblast differentiation in mouse mesenchymal precursor cells. Ukrainian Biochem. J., 89: 111-111-122.
5. Ilkiv, I., R. Lesyk and O. Sklyarov, 2017. Evaluation of novel 4-thiazolidinone-based derivatives as possible cytoprotective agents against stress model in rats. J. Applied Pharm. Sci., 7: 199-203.
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6. Halaiev, O., M. Garazd, A. Gzella and R. Lesyk, 2017. Unexpected synthesis of azepino [4,3,2-cd] indoles from 4-aminoindoles. Tetrahedron Lett., 58: 1324-1325.
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7. Golota, S., I. Sydorenko, R. Surma, O. Karpenko, A. Gzella and R. Lesyk, 2017. Facile one-pot synthesis of 5-aryl/heterylidene-2-(2-hydroxyethyl-and 3-hydroxypropylamino)-thiazol-4-ones via catalytic aminolysis. Synthetic Commun., 47: 1071-1076.
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8. Garazd, Y., M. Garazd and R. Lesyk, 2017. Synthesis and evaluation of anticancer activity of 6-pyrazolinylcoumarin derivatives. Saudi Pharm. J., 25: 214-223.
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9. Senkiv, J., N. Finiuk, D. Kaminskyy, D. Havrylyuk and M. Wojtyra et al., 2016. 5-Ene-4-thiazolidinones induce apoptosis in mammalian leukemia cells. Eur. J. Med. Chem., 117: 33-46.
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10. Lozynskyi, A., S. Golota, B. Zimenkovsky, D. Atamanyuk, A. Gzella and R. Lesyk, 2016. Synthesis, anticancer and antiviral activities of novel thiopyrano[2,3-d]thiazole-6-carbaldehydes. Phosphorus Sulfur Silicon Relat. Elem., 191: 1245-1249.
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11. Lozynskyi, A., B. Zimenkovsky, A. Karkhut, S. Polovkovych, A.K. Gzella and R. Lesyk, 2016. Application of the 2(5H) furanone motif in the synthesis of new thiopyrano [2,3-d] thiazoles via the hetero-Diels-Alder reaction and related tandem processes. Tetrahedron Lett., 57: 3318-3321.
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12. Kоbylinska, L.I., N.M. Boiko, R.R. Panchuk, I.I. Grytsyna and L.P. Biletska et al., 2016. Putative anticancer potential of novel 4-thiazolidinone derivatives: Cytotoxicity toward rat C6 glioma in vitro and correlation of general toxicity with the balance of free radical oxidation in rats. Croatian Med. J., 57: 151-163.
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13. Kobylinska, L.I., D.Y. Havrylyuk, N.E. Mitina, A.S. Zaichenko, R.B. Lesyk, B.S. Zimenkovsky and R.S. Stoika, 2016. Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier. Ukrainian Biochem. J., 88: 51-60.
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14. Kaminskyy, D., G.J.M. den Hartog, M. Wojtyra, M. Lelyukh, A. Gzella, A. Bast and R. Lesyk, 2016. Antifibrotic and anticancer action of 5-ene amino/iminothiazolidinones. Eur. J. Med. Chem., 112: 180-195.
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15. Havrylyuk, D., O. Roman and R. Lesyk, 2016. Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline-thiazolidine-based hybrids. Eur. J. Med. Chem., 113: 145-166.
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16. Garazd, Y.L., M.M. Garazd and R.B. Lesyk, 2016. Modified coumarins. 38. Synthesis and cytotoxicity of 6-pyrazolinylcoumarins. Chem. Nat. Compd., 52: 782-788.
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17. Devinyak, O.T. and R.B. Lesyk, 2016. 5-year trends in QSAR and its machine learning methods. Curr. Comput.-Aided Drug Des., 12: 265-271.
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18. Zelisko, N., D. Atamanyuk, Y. Ostapiuk, A. Bryhas, V. Matiychuk, A. Gzella and R. Lesyk, 2015. Synthesis of fused thiopyrano[2,3-d][1,3]thiazoles via hetero-Diels-Alder reaction related tandem and domino processes. Tetrahedron, 71: 9501-9508.
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19. Lozynskyi, A., B. Zimenkovsky, A.K. Gzella and R. Lesyk, 2015. Arylidene pyruvic acids motif in the synthesis of new 2H,5H-chromeno[4′,3′:4,5]thiopyrano[2,3-d]thiazoles via tandem hetero-Diels-Alder-hemiacetal reaction. Synth. Commun., 45: 2266-2270.
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20. Lozynskij, A., B. Zimenkovsky, I. Nektegayev and R. Lesyk, 2015. Arylidene pyruvic acids motif in the synthesis of new thiopyrano[2,3-d]thiazoles as potential biologically active compounds. Heterocycl. Commun., 21: 55-59.
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21. Kryshchyshyn, A.P., D.V. Kaminskyy, D.V. Atamanyuk and R.B. Lesyk, 2015. Computer technologies in pharmacy-filling in the gaps in Ukrainian PharmD curriculum. Curr. Pharm. Teach. Learn., 7: 556-559.
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22. Kaminskyy, D., I. Subtel'na, B. Zimenkovsky, O. Karpenko, A. Gzella and R. Lesyk, 2015. Synthesis and evaluation of anticancer activity of 5-ylidene-4-aminothiazol-2(5H)-one derivatives. Med. Chem., 11: 517-530.
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23. Havrylyuk, D., B. Zimenkovsky and R. Lesyk, 2015. Synthesis, biological activity of thiazolidinones bearing indoline moiety and Isatin Based Hybrids. Min. Rev. Org. Chem., 12: 66-87.
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24. Galayev, O., Y. Garazd, M. Garazd and R. Lesyk, 2015. Synthesis and anticancer activity of 6-heteroarylcoumarins. Eur. J. Med. Chem., 105: 171-181.
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25. Zelisko, N., D. Atamanyuk, O. Vasylenko, A. Bryhas, V. Matiychuk, A. Gzella and R. Lesyk, 2014. Crotonic, cynnamic and propiolic acids motifs in the synthesis of thiopyrano[2,3-d][1,3]thiazoles via hetero-Diels-Alder reaction and related tandem processes. Tetrahedron, 70: 720-720.
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26. Nowaczyk, A., M. Kowiel, A. Gzella, L. Fijalkowski ,V. Horishny and R. Lesyk, 2014. Conformational space and vibrational spectra of 2-[(2,4-dimethoxyphenyl)amino]-1,3-thiazolidin-4-one. J. Mol. Modell., 20: 1-9.
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27. Lozynskyi, A., B. Zimenkovsky and R. Lesyk, 2014. Synthesis and Anticancer Activity of New Thiopyrano[2,3-d]thiazoles Based on Cinnamic Acid Amides. Sci. Pharm., 82: 723-733.
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28. Kryshchyshyn, A., D. Kaminskyy, P. Grellier and R. Lesyk, 2014. Trends in research of antitrypanosomal agents among synthetic heterocycles. Eur. J. Med. Chem., 85: 51-64.
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29. Kaminskyy, D., A. Kryshchyshyn, I. Nektegayev, O. Vasylenko, P. Grellier and R. Lesyk, 2014. Isothiocoumarin-3-carboxylic acid derivatives: Synthesis, anticancer and antitrypanosomal activity evaluation. Eur. J. Med. Chem., 75: 57-66.
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30. Kaminskyy, D., A. Gzella and R. Lesyk, 2014. The cyclocondensation of thioamides and haloacetic acid derivatives provides only 4-thiazolidinones; isomeric 5-thiazolidinones were not observed. Synth. Commun., 44: 231-236.
31. Gzella, A.K., M. Kowiel, A. Suseł, M.N. Wojtyra and R. Lesyk, 2014. Heterocyclic tautomerism: reassignment of two crystal structures of 2-amino-1,3-thiazolidin-4-one derivatives. Acta Crystalographica Section, 70: 812-816.
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32. Devinyak, O., D. Havrylyuk, B. Zimenkovsky and R. Lesyk, 2014. Computational Search for Possible Mechanisms of 4-Thiazolidinones Anticancer Activity: The Power of Visualization. Mol. Inf., 33: 216-229.
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33. Devinyak, O., D. Havrylyuk and R. Lesyk, 2014. 3D-MoRSE descriptors explained J. Mol. Graphics Modell., 54: 194-203.
34. Avdieiev, S., L. Gera, D. Havrylyuk, R.S. Hodges and R. Lesyk et al., 2014. Bradykinin antagonists and thiazolidinone derivatives as new potential anti-cancer compounds. Bioorg. Med. Chem., 22: 3815-3823.
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35. Atamanyuk, D., B. Zimenkovsky, V. Atamanyuk and R. Lesyk, 2014. 5-Ethoxymethylidene-4-thioxo-2-thiazolidinone as versatile building block for novel bio-relevant small molecules with thiopyrano[2,3-d][1,3]thiazole core Synth. Commun., 44: 237-244.
36. Polovkovych, S.V., A.I. Karkhut, N.G. Marintsova, R.B. Lesyk, B.S. Zimenkovsky and V.P. Novikov, 2013. Synthesis of New Schiff Bases and Polycyclic fused Thiopyranothiazoles Containing 4,6-Dichloro-1,3,5-Triazine Moiety. J. Heterocycl. Chem., 50: 1419-1424.
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37. Havrylyuk, D., B. Zimenkovsky, O. Vasylenko, C.W. Day, D.F. Smee, P. Grellier and R. Lesyk, 2013. Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones Eur. J. Med. Chem., 66: 228-237.
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38. Harkov, S., D. Havrylyuk, V. Atamanyuk, B. Zimenkovsky and R. Lesyk, 2013. Synthesis and biological activity of isatines bearing thiazolidinone and pyrazoline moieties. Pharm., 60: 8-18.
39. Harkov, S., D. Havrylyuk and R. Lesyk, 2013. Synthesis of 3S-substituted triazino[5,6-b]indoles and 4-thiazolidinone-triazino[5,6-b]indole hybrids with antitumor activity. Chem. Chem. Technol., 7: 237-244.
40. Atamanyuk, D., B. Zimenkovsky, V. Atamanyuk, I. Nektegayev and R. Lesyk, 2013. Synthesis and Biological Activity of New Thiopyrano[2,3-d]thiazoles Containing a Naphthoquinone Moiety Sci. Pharm., 81: 423-436.
41. Zelisko, N., D. Atamanyuk, O. Vasylenko, P. Grellier and R. Lesyk, 2012. Synthesis and antitrypanosomal activity of new 6,6,7-trisubstituted thiopyrano[2,3-d][1,3]thiazoles. Bioorg. Med. Chem., 22: 7071-7074.
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42. Panchuk R.R., V.V. Chumak, M.R. Fil, D.Y. Havrylyuk, B.S. Zimenkovsky, R.B. Lesyk and R.S. Stoika, 2012. Study of molecular mechanisms of proapoptotic action of novel heterocyclic 4-thiazolidone derivatives. Biopolymers Cell, 28: 121-128.
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43. Kryshchyshyn, A., D. Atamanyuk and R. Lesyk, 2012. Fused thiopyrano[2,3-d]thiazole derivatives as potential anticancer agents. Sci. Pharm., 80: 509-529.
44. Kowiel, M., N. Zelisko, D. Atamanyuk, R. Lesyk and A.K. Gzella, 2012. 2-[7-(3,5-Dibromo-2-hydroxyphenyl)-6-ethoxycarbonyl-2-oxo-5H-2,3,6,7-tetrahydrothiopyrano[2,3-d][1,3]thiazol-6-yl]acetic acid ethanol monosolvate. Acta Crystalographica Section, 68: 2721-2721.
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45. Kaminskyy, D., D. Khyluk, O. Vasylenko and R. Lesyk, 2012. An efficient method for the transformation of 5-ylidenerhodanines into 2,3,5-trisubstituted-4-thiazolidinones. Tetrahedron Lett., 53: 557-559.
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46. Kaminskyy, D., B. Bednarczyk-Cwynar, O. Vasylenko, O. Kazakova, B. Zimenkovsky, L. Zaprutko and R. Lesyk, 2012. Synthesis of new potential anticancer agents based on 4-thiazolidinone and oleanane scaffolds. Med. Chem. Res., 21: 3568-3580.
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47. Havrylyuk, D., B. Zimenkovsky, O. Vasylenko, A. Gzella and R. Lesyk, 2012. Synthesis of new 4-thiazolidinone-, pyrazoline-, and isatin-based conjugates with promising antitumor activity J. Med. Chem., 55: 8630-8641.
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48. Devinyak, O., B. Zimenkovsky and R. Lesyk, 2012. Biologically Active 4-Thiazolidinones: A Review of QSAR Studies and QSAR Modeling of Antitumor Activity Curr. Top. Med. Chem., 12: 2763-2784.
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49. Sklyarov, A.Y., R.B. Lesyk, N.B. Panasyuk, I.S. Fomenko and D.Y. Havrylyuk, 2011. Comparison of dual acting and conventional NSAIDs towards parameters of NO-synthase system and oxidative stress in mucosal membrane of large intestine of rats with experimental ulcerative colitis Biopolymers Cell, 27: 147-153.
50. Kaminskyy, D., O. Vasylenko, D. Atamanyuk, A. Gzella and R. Lesyk, 2011. Isorhodanine and thirhodanine motifs in the synthesis of fused thiopyrano[2,3-d][1,3]thiazoles. SYNLETT, 10: 1385-1388.
51. Kaminskyy, D., D. Khyluk, O. Vasylenko, L. Zaprutko and R. Lesyk, 2011. A facile synthesis and anticancer activity evaluation of spiro[thiazolidinone-isatin] conjugates. Sci. Pharm., 79: 763-777.
52. Havrylyuk, D., N. Kovach, B. Zimenkovsky, O. Vasylenko and R. Lesyk, 2011. Snthesis and Anticancer Activity of Isatin-Based Pyrazolines and Thiazolidines Conjugates. Arch. Pharm. Chem. Life Sci., 344: 514-522.
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53. Subtelna, I., B. Zimenkovsky and R. Lesyk, 2010. Synthesis and antitumor activity evaluation of new 2-(alkoxyphenylamino)thiazol-4(5H)-ones derivatives Ann. Universitatis Mariae Curie-Sklodowska. Sect, 3: 321-335.
54. Subtel`na, I., D. Atamanyuk, E. Szymanska, K. Kiec-Kononowicz and B. Zimenkovsky et al., 2010. Synthesis of 5-arylidene-2-amino-4-azolones and evaluation of their anticancer activity. Bioorg. Med. Chem., 18: 5090-5102.
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55. Kryshchyshyn, A., B. Zimenkovsky and R. Lesyk, 2010. Synthesis of novel fused thiopyrano[2,3-d]thiazole derivatives as potential anticancer drugs. Ann. Universitatis Mariae Curie-Sklodowska. Sect., 3: 163-167.
56. Kaminskyy, D.V. and R.B. Lesyk, 2010. Structure - anticancer activity relationship among 4-azolidone-3-carboxylic acids derivatives Biopolymers Cell, 26: 136-136.
57. Havrylyuk, D., L. Mosula, B. Zimenkovsky, O. Vasylenko, A. Gzella and R. Lesyk, 2010. Synthesis and anticancer activity evaluation of 4-thiazolidinones containing benzothiazole moiety. Eur. J. Med. Chem., 45: 5012-5021.
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58. Havrylyuk, D., B. Zimenkovsky, N. Kovach and R. Lesyk, 2010. Synthesis of new 4-azolidinones with 3,5-diaryl-4,5-dihydropyrazole moiety and evaluation of their antitumor activity in vitro. Ann. Universitatis Mariae Curie-Sklodowska. Sect., 3: 173-177.
59. Senthilraja, M., V.V. Atamanyuk, R.B. Lesyk, D.V. Atamanyuk, O.R. Pinyazhko, I.O. Nektegayev and B.S. Zimenkovsky, 2009. Development of rational strategy for selective COX-2 inhibitors searching as potential anticancer drugs. Fabad J. Pharm. Sci., 34: 127-136.
    Direct Link  |  
60. Olender, D., J. Zwawiak, V. Lukianchuk, R. Lesyk, A. Kropacz, A. Fojutowski and L. Zaprutko, 2009. Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents. Eur. J. Med. Chem., 44: 645-652.
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61. Mosula, L., B. Zimenkovsky, D. Havrylyuk, A. Missir, I.C. Chirita and R. Lesyk, 2009. Synthesis and antitumor activity of novel 2-thioxo-4-thiazolidinones with benzothiazole moieties. Farmacia, 57: 321-330.
62. Kaminskyy, D., B. Zimenkovsky and R. Lesyk, 2009. Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives. Eur. J. Med. Chem., 44: 3627-3636.
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63. Havrylyuk, D., B. Zimenkovsky, O. Vasylenko, L. Zaprutko, A. Gzella and R. Lesyk, 2009. Synthesis of novel thiazolone-based compounds containing pyrazoline moiety and evaluation of their anticancer activity. Eur. J. Med. Chem., 44: 1396-1404.
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64. Artemenko, A.G., E.N. Muratov, D.V. Atamanyuk, V.E. Kuzmin, A.I. Hromov, R.V. Kutsyk and R.B. Lesyk, 2009. QSAR analysis of antimicrobial activity of 4-thiazolidone derivatives QSAR Comb. Sci., 28: 194-205.
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65. Matiychuk, v., R. Lesyk, M. Obushak, A. Gzella, D. Atamanyuk, Yu. Ostapiuk and A. Kryshchyshyn, 2008. A new domino-Knoevenagel-hetero-Diels-Alder reaction. Tetrahedron Lett., 49: 4648-4648.
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66. Kryshchyshyn, A., B. Zimenkovsky and R. Lesyk, 2008. Synthesis and anticancer activity of isothiochromeno[3,4-d]thiazole derivatives. Ann. Universitatis Mar. Curie-Sklodowska. Sect., 1: 247-251.
67. Atamanyuk, D., B. Zimenkovsky and R. Lesyk, 2008. Synthesis and anticancer activity of novel thiopyrano[2.3-d]thiazole-based compounds containing norbornane moiety. J. Sulfur Chem., 29: 151-162.
68. Sanotsky, Y., R. Lesyk, L. Fedoryshyn, I. Komnatska, Yu. Matvienko and S. Fahn, 2007. Manganic encephalophathy due to ephedrone abuse. Mov. disorders, 22: 1337-1343.
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69. Roman, O. and R. Lesyk, 2007. Synthesis and anticancer activity in vitro of some 2-thioxo-4-thiazolidone derivatives. Farmacia, 6: 640-648.
70. Lesyk, R., O. Vladzimirska, S. Holota, L. Zaprutko and A. Gzella, 2007. New 5-substituted thiazolo[2,3-d][1,2,4]triazol-6-ones. Synthesis and anticancer evaluation. Eur. J. Med. Chem., 42: 641-648.
71. Zimenkovskii, B.S., R.V. Kutsyk, R.B. Lesyk, V.S. Matyichuk, N.D. Obushak and T.I. Klyufinska, 2006. Synthesis and antimicrobial activity of 2,4-dioxothiazolidine-5-acetic acid amides. Pharm. Chem. J., 40: 303-306.
    CrossRef  |  Direct Link  |  
72. Lesyk, R., B. Zimenkovsky, D. Kaminsky, S. Holota and D. Atamanyuk et al., 2006. Anticancer potential of 4-azolidones and related heterocycles. Ann. Universitatis Mariae Curie-Sklodowska. Sect., 1: 107-107.
73. Lesyk, R., B. Zimenkovsky, D. Atamanyuk, F. Jensen, K. Kiec-Kononowicz and A. Gzella, 2006. Anticancer thiopyrano[2,3-d]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies. Bioorg. Med. Chem., 14: 5230-5240.
74. Obniska, J., R. Lesyk, D. Atamanyuk and K. Kaminski, 2005. Synthesis and anticonvulsant activity of a series N-substituted bicycle[2.2.1]hept-5-ene-2,3-dicaboximides. Acta Poloniae Pharm. Drug Res., 3: 213-219.
75. Lesyk, R., B. Zimenkovsky, G. Kazmirchuk, L. Zaprutko, A. Paraskiewicz and E. Melzer, 2005. New 5-arylidene-4-thiazolidones and their anticancer activity. Ann. the Pol. Chemi. Soci., 1: 69-72.
76. Lesyk, R. and B. Zimenkovsky, 2004. 4-Thiazolidones: Centenarian History, Current Status and Perspectives for Modern Organic and Medicinal Chemistry. Curr. Org. Chem., 8: 1547-1578.
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77. Lesyk, R., B. Zimenkovsky, V. Lukyanchuk, D. Atamanyuk and O. Vovk, 2003. Chemistry and pharmacology of 4-thiazolidone derivatives. Ann. Pol. Chem. Soci., 2: 293-298.
78. Lesyk, R., B. Zimenkovsky, I. Subtelna, I. Nektegayev and G. Kazmirchuk, 2003. Synthesis and antinflammatory activity of some 2-arylamino-2-thiazoline-4-ones Acta Poloniae Pharm. Drug Res., 6: 457-466.
    Direct Link  |  
79. Lesyk, R., O. Vladzimirska, B. Zimenkovsky, S. Golota, I. Nektegayev, O. Cherpak, M. Lebyak and O. Kozak, 2002. Synthesis and antiinflammatory activity of novel 3-(2,3-dimethyl-1-phenyl-4-pyrazon-5-yl)-4-thiazolidones. Bolletino Chimico Pharm., 141: 197-201.
80. Lesyk, R., B. Zimenkovsky, N. Trocko and G. Kazmirchuk, 2002. Synthesis of 5-arylidene-2,4-thiazolidin-3-yl alkanoic acids. Ann. Universitatis Mar. Curie-Sklodowska, 5: 39-45.
81. Nektegayev, I. and R. Lesyk, 1999. 3-Oxyaryl-2-thionethiazolidones-4 and their choleretic activity. Sci. Pharma., 67: 227-230.
82. Lesyk, R., O. Vladzimirska, B. Zimenkovsky, V. Horishny, I. Nektegayev, V. Solyanyk and O. Vovk, 1998. New thiazolidones-4 with pyrazolone-5 substituent as the potential NSAIDs. Bolletino Chimico Pharma., 137: 210-217.
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