Dr. Antonio  Porcellini
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Dr. Antonio Porcellini

Associate Professor
Universitario di Monte Santangelo, Italy


Highest Degree
Ph.D. in Molecular Oncology from Universita degli studi di Magna Grecia di Catanzaro, Italy

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Biography

Dr. Antonio Porcellini is currently working as Associate Professor at Universitario di Monte Santangelo, Italy. He has completed his Ph.D. in Molecular Oncology from Universita degli studi di Magna Grecia di Catanzaro, Italy. His main area of interest focuses on Biomedical Sciences. His area of expertise includes Signal Trasduction, DNA Damage, DNA Methylation, cAMP-Dependent Protein Kinase, and Epigenetics. He has published 71 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Signal Transduction
62%
Hypertension
90%
Molecular Oncology
75%
Epigenetics
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Feola, A., A. Cimini, F. Migliucci, R. Iorio and C. Zucchegna et al., 2013. The inhibition of p85αPI3KSer83 phosphorylation prevents cell proliferation and invasion in prostate cancer cells. J. Cell. Biochem., 114: 2114-2119.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Costagliola, C., A. Daniele, R. Dell'omo, M.R. Romano and F. Aceto et al., 2013. Aqueous humor levels of vascular endothelial growth factor and adiponectin in patients with type 2 diabetes before and after intravitreal bevacizumab injection. Exp. Eye Res., 110: 50-54.
    PubMed  |  Direct Link  |  
  3. Messina, S., L. Frati and A. Porcellini, 2012. Oxidative stress posttranslationally regulates the expression of Ha-Ras and Ki-Ras in cultured astrocytes. Oxid. Med. Cell. Longev, Vol. 2012. 10.1155/2012/792705.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Lee, B., A. Morano, A. Porcellini and M.T. Muller, 2012. GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair. Nucleic Acids Res., 40: 2481-2493.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Donini, C.F., E. Di Zazzo, C. Zuchegna, M. Di Domenico and S. D'Inzeo et al., 2012. The p85α regulatory subunit of PI3K mediates cAMP-PKA and retinoic acid biological effects on MCF7 cell growth and migration. Int. J. Oncol., 40: 1627-1635.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Dell'Omo, R., M. Cassetta, E. Dell'Omo, A. di Salvatore and J.M. Hughes et al., 2012. Aqueous humor levels of vascular endothelial growth factor before and after intravitreal bevacizumab in type 3 versus type 1 and 2 neovascularization. A prospective, case-control study. Am. J. Ophthalmol., 153: 155-161.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Tartaglia, E., P. Mastrantonio, D. Costa, B. Giugliano, A. Porcellini and C. Costagliola, 2011. Trisomy 1q42-qter associated with monosomy 6q27-qter: A case report. Eur. J. Ophthalmol., 21: 315-319.
    PubMed  |  
  8. Rinaldi, M., E. Buscarini, C. Danesino, F. Chiosi, A. De Benedictis, A. Porcellini and C. Costagliola, 2011. Ocular manifestations in hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease): A case-series. Ophthalmic Genet., 32: 12-17.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Porcellini, A., L. Iacovelli and A. De Blasi, 2011. Viral infection for GPCR expression in eukaryotic cells. Methods Mol. Biol., 746: 39-51.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Messina, S., C. Leonetti, C. Zuchegna, E. Di Zazzo, A. Calogero, L. Frati and A. Porcellini, 2011. Dual-specificity phosphatase DUSP6 has tumor-promoting properties in human glioblastomas. Oncogene, 30: 3813-3820.
    CrossRef  |  PubMed  |  Direct Link  |  
  11. Calogero, A., A. Porcellini, V. Lombari, C. Fabbiano and A. Arcella et al., 2011. Sensitivity to cisplatin in primary cell lines derived from human glioma correlates with levels of EGR-1 expression. Cancer Cell. Int., Vol. 11. 10.1186/1475-2867-11-5.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Bertoni, A., P. Giuliano, M. Galgani, D. Rotoli and L. Ulianich et al., 2011. Early and late events induced by polyq-expanded proteins: Identification of a common pathogenic property of polyq-expanded proteins. J. Biol. Chem., 286: 4727-4741.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Abbondanza, C., C. De Rosa, M.N. Ombra, F. Aceto and N. Medici et al., 2011. Highlighting chromosome loops in DNA-picked chromatin (DPC). Epigenetics, 6: 979-986.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Procaccini, C., V. De Rosa, M. Galgani, L. Abanni and G. Cali et al., 2010. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity, 33: 929-941.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. D'Inzeo, S., A. Nicolussi, A. Ricci, P. Mancini, A. Porcellini, F. Nardi and A. Coppa, 2010. Role of reduced expression of Smad4 in papillary thyroid carcinoma. J. Mol. Endocrinol., 45: 229-244.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Cassano, S., S. Agnese, V. D'amato, M. Papale and C. Garbi et al., 2010. Reactive oxygen species, Ki-Ras, and mitochondrial superoxide dismutase cooperate in nerve growth factor-induced differentiation of PC12 cells. J. Biol. Chem., 285: 24141-24153.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Messina, S., G. Molinaro, V. Bruno, G. Battaglia and P. Spinsanti et al., 2008. Enhanced expression of Harvey ras induced by serum deprivation in cultured astrocytes. J. Neurochem., 106: 551-559.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Fanelli, M., S. Caprodossi, L. Ricci-Vitiani, A. Porcellini and F. Tomassoni-Ardori et al., 2008. Loss of pericentromeric DNA methylation pattern in human Glioblastoma is associated with altered DNA methyltransferases expression and involves the Stem Cell compartment. Oncogene, 27: 358-365.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. De Gregorio, G., A. Coppa, C. Cosentino, S. Ucci and S. Messina et al., 2007. The p85 regulatory subunit of PI3K mediates TSH-cAMP-PKA growth and survival signals. Oncogene, 26: 2039-2047.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Cuozzo, C., A. Porcellini, T. Angrisano, A. Morano and B. Lee et al., 2007. DNA damage, homology-directed repair, and DNA methylation. PLoS Genet., Vol. 3. 10.1371/journal.pgen.0030110.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Cosentino, C., M. Di Domenico, A. Porcellini, C. Cuozzo and G. De Gregorio et al., 2007. p85 regulatory subunit of PI3K mediates cAMP-PKA and estrogens biological effects on growth and survival. Oncogene, 29: 2095-2103.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Cappuccio, I., P. Spinsanti, A. Porcellini, F. Desiderati and T. De Vita et al., 2005. Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells. Neuropharmacology, 49: 196-205.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Messina, S., C. Leonetti, G. De Gregorio, V. Affatigato and G. Ragona et al., 2004. Ras inhibition amplifies cisplatin sensitivity of human glioblastoma. Biochem. Biophys. Res. Commun., 320: 493-500.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Porcellini, A., S. Messina, G. De Gregorio, A. Feliciello and A. Carlucci et al., 2003. The expression of the thyroid-stimulating hormone (TSH) receptor and the cAMP-dependent protein kinase RII β regulatory subunit confers TSH-cAMP-dependent growth to mouse fibroblasts. J. Biol. Chem., 278: 40621-40630.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Pediconi, N., A. Ianari, A. Costanzo, L. Belloni and R. Gallo et al., 2003. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat. Cell Biol., 5: 552-558.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Iacovelli, L., L. Salvatore, L. Capobianco, A. Picascia and E. Barletta et al., 2003. Role of G protein-coupled receptor kinase 4 and β-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases. J. Biol. Chem., 278: 12433-12442.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. De Luca, A., A. Severino, P. De Paolis, G. Cottone and L. De Luca et al., 2003. p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor. Biochem. J., 369: 477-484.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Santelli, G., B.P. Cannada, A. Giuliano, A. Porcellini andA. Mineo et al., 2002. Thymosin β-10 protein synthesis suppression reduces the growth of human thyroid carcinoma cells in semisolid medium. Thyroid, 12: 765-772.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. De Paolis, P., A. Porcellini, C. Savoia, A. Lombardi and B. Gigante et al., 2002. Functional cross-talk between angiotensin II and epidermal growth factor receptors in NIH3T3 fibroblasts. J. Hypertens, 20: 693-699.
    PubMed  |  Direct Link  |  
  30. Angiolillo, A., G. Russo, A. Porcellini, S. Smaldone, F. D'Alessandro and C. Pietropaolo, 2002. The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts. Gene, 284: 169-178.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Squitieri ,F., M. Cannella, A. Porcellini, L. Brusa, M. Simonelli and S. Ruggieri, 2001. Short-term effects of olanzapine in huntington disease. Neurops. Neuropsychol. Behav. Neurol., 14: 69-72.
    PubMed  |  Direct Link  |  
  32. Sorrentino, R., A. Porcellini, D. Spalletti-Cernia, V. Lombari, G. Vecchio and P. Laccetti, 2001. Inhibition of MAPK activity, cell proliferation, and anchorage-independent growth by N-Ras antisense in an N-ras-transformed human cell line. Antisense Nucl. Acid Drug Dev., 11: 349-358.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Quadro, L., O. Fattoruso, M.P. Cosma, U. Verga, A. Porcellini, A. Libroia and V. Colantuoni, 2001. Loss of heterozygosity at the RET protooncogene locus in a case of multiple endocrine neoplasia type 2A. J. Clin. Endocrinol. Metab., 86: 239-244.
    CrossRef  |  PubMed  |  Direct Link  |  
  34. Calogero, A., A. Arcella, G. De Gregorio, A. Porcellini and D. Mercola et al., 2001. The early growth response gene EGR-1 behaves as a suppressor gene that is down-regulated independent of ARF/Mdm2 but not p53 alterations in fresh human gliomas. Clin. Cancer Res., 7: 2788-2796.
    PubMed  |  Direct Link  |  
  35. Feliciello, A., A. Gallo, E. Mele, A. Porcellini and G. Troncone et al., 2000. The localization and activity of camp-dependent protein kinase affect cell cycle progression in thyroid cells. J. Biol. Chem., 275: 303-311.
    CrossRef  |  PubMed  |  Direct Link  |  
  36. Enea, I., P. De Paolis, A. Porcellini, O. Piras and C. Savoia et al., 2000. Defective suppression of the aldosterone biosynthesis during stroke permissive diet in the stroke-prone phenotype of the spontaneously hypertensive rat. Basic Res. Cardiol., 95: 84-92.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Tassi, V., A. Di Cerbo, A. Porcellini, E. Papini and C. Cisternino et al., 1999. Screening of thyrotropin receptor mutations by fine-needle aspiration biopsy in autonomous functioning thyroid nodules in multinodular goiters. Thyroid, 9: 353-357.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Paolillo, M., A. Feliciello, A. Porcellini, C. Garbi and M. Bifulco et al., 1999. The type and the localization of cAMP-dependent protein kinase regulate transmission of cAMP signals to the nucleus in cortical and cerebellar granule cells. J. Biol. Chem., 274: 6546-6552.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. De Paolis, P., A. Porcellini, B. Gigante, R. Giliberti and A. Lombardi et al., 1999. Modulation of the AT2 subtype receptor gene activation and expression by the AT1 receptor in endothelial cells. J. Hypertens, 17: 1873-1877.
    PubMed  |  Direct Link  |  
  40. Normanno, N., A. De Luca, A. Castaldo, A. Casamassimi and A. Di Popolo et al., 1998. Apolipoprotein A-I reverse transcriptase-polymerase chain reaction analysis for detection of hematogenous colon cancer dissemination. Int. J. Oncol., 13: 443-447.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Gigante, B., O. Piras, P. De Paolis, A. Porcellini, A. Natale and M. Volpe, 1998. Role of the angiotensin II AT2-subtype receptors in the blood pressure-lowering effect of losartan in salt-restricted rats. J. Hypertens, 16: 2039-2043.
    PubMed  |  Direct Link  |  
  42. Casamassimi, A., M.G. Miano, A. Porcellini, G. De Vita and F. de Nigris et al., 1998. p53 genes mutated in the DNA binding site or at a specific COOH-terminal site exert divergent effects on thyroid cell growth and differentiation. Cancer Res., 58: 2888-2894.
    PubMed  |  Direct Link  |  
  43. Zhang, L., M.L. Martelli, C. Battaglia, F. Trapasso and D. Tramontano et al., 1997. Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase. Exp. Cell Res., 235: 62-70.
    CrossRef  |  PubMed  |  Direct Link  |  
  44. Volpe, M., B. Gigante, I. Enea, A. Porcellini and R. Russo et al., 1997. Role of tissue renin in the regulation of aldosterone biosynthesis in the adrenal cortex of nephrectomized rats. Circulation Res., 81: 857-864.
    CrossRef  |  PubMed  |  Direct Link  |  
  45. Porcellini, A., G. Ruggiano, S. Pannain, I. Ciullo, G. Amabile, G. Fenzi and E.V. Avvedimento, 1997. Mutations of thyrotropin receptor isolated from thyroid autonomous functioning adenomas confer TSH-independent growth to thyroid cells. Oncogene, 15: 781-789.
    PubMed  |  Direct Link  |  
  46. Porcellini, A., G. Fenzi and E.V. Avvedimneto, 1997. Mutations of thyrotropin receptor gene. J. Mol. Med., 75: 567-575.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Gigante, B., S. Rubattu, R. Russo, A. Porcellini and I. Enea et al., 1997. Opposite feedback control of renin and aldosterone biosynthesis in the adrenal cortex by angiotensin II AT1-subtype receptors. Hypertension, 30: 563-568.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Ventra, C., A. Porcellini, A. Feliciello, A. Gallo and M. Paolillo et al., 1996. The differential response of protein kinase A to cyclic AMP in discrete brain areas correlates with the abundance of regulatory subunit II. J. Neurochem., 66: 1752-1761.
    CrossRef  |  PubMed  |  Direct Link  |  
  49. Grieco, D., A. Porcellini, V.E. Avvedimento and M.E. Gottesman, 1996. Requirement for cAMP-PKA pathway activation by M phase-promoting factor in the transition from mitosis to interphase. Science, 271: 1718-1723.
    CrossRef  |  PubMed  |  Direct Link  |  
  50. Feliciello, A., P. Giuliano, A. Porcellini, C. Garbi and S. Obici et al., 1996. The v-Ki-Ras oncogene alters cAMP nuclear signaling by regulating the location and the expression of cAMP-dependent protein Kinase IIβ. J. Biol. Chem., 271: 25350-25359.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Cassano, S., A. Gallo, V. Buccigrossi, A. Porcellini, R. Cerillo, M.E. Gottesman and E.V. Avvedimento, 1996. Membrane localization of cAMP-dependent protein kinase amplifies cAMP signaling to the nucleus in PC12 cells. J. Biol. Chem., 271: 29870-29875.
    CrossRef  |  PubMed  |  Direct Link  |  
  52. Volpe, M., S. Rubattu, B. Gigante, D. Ganten and A. Porcellini et al., 1995. Regulation of aldosterone biosynthesis by adrenal renin is mediated through AT1 receptors in renin transgenic rats. Circ. Res., 77: 73-79.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Ventra, C., O. Meucci, M. Grimaldi, A. Scorziello, A. Porcellini and G. Schettini, 1995. Absence of D2S dopamine receptor in the prolactin-secreting MMQ pituitary clone: Characterization of a wild D2L receptor coupled to native transduction mechanisms. J. Mol. Endocrinol., 14: 375-389.
    CrossRef  |  PubMed  |  Direct Link  |  
  54. Rubattu, S., R. Russo, B. Gigante, A. Porcellini, L. Finizia, B. Trimarco and M. Volpe, 1995. Regulation of 11 beta-hydroxylase cytochrome P450 expression by cholesterol in spontaneously hypertensive rats. J. Hypertens., 13: 1253-1258.
    PubMed  |  
  55. Rigoli, L., G. Raimondo, A. Di Benedetto, G. Romano and A. Porcellini et al., 1995. Apolipoprotein AI-CIII-AIV genetic polymorphisms and coronary heart disease in type 2 diabetes mellitus. Acta Diabetol., 32: 251-256.
    CrossRef  |  PubMed  |  Direct Link  |  
  56. Porcellini, A., I. Ciullo, S. Pannain, G. Fenzi and V.E. Avvedimento, 1995. Somatic mutations in the VI transmembrane segment of the thyrotropin receptor constitutively activate cAMP signalling in thyroid hyperfunctioning adenomas. Oncogene, 11: 1089-1093.
    PubMed  |  
  57. Pacifico, F., L. Laviola, L. Ulianich, A. Porcellini, C. Ventra, E. Consiglio and V.E. Avvedimento, 1995. Differential expression of the asyaloglycoprotein receptor in discrete brain areas, in kidney and thyroid. Biochem. Biophys. Res. Commun., 210: 138-144.
    CrossRef  |  PubMed  |  Direct Link  |  
  58. Indolfi, C., G. Esposito, E. Di Lorenzo, A. Rapacciuolo and A. Feliciello et al., 1995. Smooth muscle cell proliferation is proportional to the degree of balloon injury in a rat model of angioplasty. Circulation, 92: 1230-1235.
    CrossRef  |  PubMed  |  Direct Link  |  
  59. Quaresima, B., M.T. Tiano, A. Porcellini, P. D'Agostino and M.C. Faniello et al., 1994. PCR analysis of the H ferritin multigene family reveals the existence of two classes of processed pseudogenes. PCR Methods Appl., 4: 85-88.
    PubMed  |  Direct Link  |  
  60. Porcellini, A., I. Ciullo, L. Laviola, G. Amabile, G. Fenzi and V.E. Avvedimento, 1994. Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy. J. Clin. Endocrinol. Metab., 79: 657-661.
    CrossRef  |  PubMed  |  Direct Link  |  
  61. Pianese, L., A. Porcellini, V.E. Avvedimento, F. D'Esposito and A. Feliciello et al., 1994. A novel thyroid transcript negatively regulated by TSH. Mol. Biol., 13: 75-83.
  62. Faraonio, R., G. Minopoli, A. Porcellini, F. Costanzo, F. Cimino and T. Russo, 1994. The DNA sequence encompassing the transcription start site of a TATA-less promoter contains enough information to drive neuron-specific transcription. Nucleic Acids Res., 22: 4876-4883.
    CrossRef  |  PubMed  |  Direct Link  |  
  63. Tortora, G., S. Pepe, A.M. Cirafici, F. Ciardiello and A. Porcellini et al., 1993. Thyroid-stimulating hormone-regulated growth and cell cycle distribution of thyroid cells involve type I isozyme of cyclic AMP-dependent protein kinase. Cell Growth Differ., 4: 359-365.
    PubMed  |  Direct Link  |  
  64. Marasco, O., F. Melina, E. Mele, B. Quaresima and A. Zingone et al., 1993. Linkage disequilibrium of three polymorphic RFLP markers in the apolipoprotein AI-CIII gene cluster on chromosome 11. Hum. Genet., 91: 169-174.
    CrossRef  |  PubMed  |  Direct Link  |  
  65. Feliciello, A., A. Porcellini, I. Ciullo, G. Bonavolonta, E.V. Avvedimento and G. Fenzi, 1993. Expression of thyrotropin-receptor mRNA in healthy and Graves' disease retro-orbital tissue. Lancet, 342: 337-338.
    CrossRef  |  PubMed  |  Direct Link  |  
  66. Cocozza, S., A. Antonelli, G. Campanella, F. Cavalcanti and G. De Michele et al., 1993. Evidence of a genetic marker associated with early onset in Friedreich's ataxia. J. Neurol., 240: 254-256.
    CrossRef  |  PubMed  |  Direct Link  |  
  67. Porcellini, A., S. Cocozza, A. Monticelli, L. Pianese, G. Riccardi, A. Ferrara and S. Varrone, 1992. Mutations in insulin-receptor gene: Val996 allele in white NIDDM patients. Diabetes Care, 15: 591-592.
    CrossRef  |  PubMed  |  Direct Link  |  
  68. Cocozza, S., A. Porcellini, G. Riccardi, A. Monticelli and G. Condorelli et al., 1992. NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene. Diabetes, 41: 521-526.
    CrossRef  |  PubMed  |  Direct Link  |  
  69. Cavalcanti, F., S. Cocozza, A. Filla, G. De Michele, L. Pianese et al., 1992. Friedreich's disease. A linkage study in southern and central Italy. Acta Neurol., 14: 519-523.
    PubMed  |