Dr. Alessandro  Poggi

Dr. Alessandro Poggi

Head of Academic Department/Faculty
National Institute for Cancer Research, Italy


Highest Degree
PostDoc. in Allergology and Clinical Immunology from University of Genoa, Italy

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Area of Interest:

Biomedical Sciences
100%
Immunology
62%
Experimental Medicine
90%
Cytometry
75%
Cancer
55%

Selected Publications

  1. Zocchi, M.R., D. Costa, R. Venè, F. Tosetti and N. Ferrari,et al 2017. Zoledronate can induce colorectal cancer microenvironment expressing BTN3A1 to stimulate effector γδ T cells with antitumor activity. Oncoimmunology, 10.1080/2162402X.2016.1278099.
    CrossRef  |  PubMed  |  Direct Link  |  

  2. Roncella, S., S. Laurent, V. Fontana, P. Ferro and M.C. Franceschini,et al 2016. CTLA-4 in mesothelioma patients: Tissue expression, body fluid levels and possible relevance as a prognostic factor. Cancer Immunol. Immunother., 65: 909-917.
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  3. Poggi, A. and M. Giuliani, 2016. Mesenchymal stromal cells can regulate the immune response in the tumor microenvironment. Vaccines (Basel). 10.3390/vaccines4040041.
    CrossRef  |  Direct Link  |  

  4. Pereira, R.C., D. Martinelli, R. Cancedda, C. Gentili and A. Poggi, 2016. Human articular chondrocytes regulate immune response by affecting directly t cell proliferation and indirectly inhibiting monocyte differentiation to professional antigen-presenting cells. Front. Immunol., 10.3389/fimmu.2016.00415.
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  5. Penna, I., A. Gigoni, D. Costa, S. Vella and D. Russo,et al 2016. The inhibition of 45A ncRNA expression reduces tumor formation, affecting tumor nodules compactness and metastatic potential in neuroblastoma cells. Oncotarget, 8: 8189-8205.
    CrossRef  |  PubMed  |  Direct Link  |  

  6. Papait, A., R. Cancedda, M. Mastrogiacomo and A. Poggi, 2016. Allogeneic platelet-rich plasma affects monocyte differentiation to dendritic cells causing an anti-inflammatory microenvironment, putatively fostering wound healing. J. Tissue. Eng. Regen. Med., 10.1002/term.2361.
    CrossRef  |  Direct Link  |  

  7. Lasiglie, D., S. Boero, I. Bauer, S. Morando and P. Damonte,et al 2016. Sirt6 regulates dendritic cell differentiation, maturation, and function. Aging (Albany NY). 8: 34-49.
    CrossRef  |  Direct Link  |  

  8. Camodeca, C., E. Nuti, L. Tepshi, S. Boero and T. Tuccinardi,et al 2016. Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin's lymphoma cell models. Eur. J. Med. Chem., 111: 193-201.
    CrossRef  |  Direct Link  |  

  9. Zocchi, M.R., C. Camodeca, E. Nuti, A. Rossello and R. Vene,et al 2015. ADAM10 new selective inhibitors reduce NKG2D ligand release sensitizing Hodgkin lymphoma cells to NKG2D-mediated killing. Oncoimmunology, 10.1080/2162402X.2015.1123367.
    CrossRef  |  Direct Link  |  

  10. Vene, R., F. Tosetti, S. Minghelli, A. Poggi, N. Ferrari and R. Benelli, 2015. Celecoxib increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation. Oncotarget, 6: 12310-12325.
    CrossRef  |  Direct Link  |  

  11. Poggi, A. and M.R. Zocchi, 2015. Mesenchymal stromal cells as regulators of anti-tumour immune response.. Indian J. Med. Res., 141: 139-142.
    Direct Link  |  

  12. Muraglia, A., M.R. Todeschi, A. Papait, A. Poggi and R. Spano,et al 2015. Combined platelet and plasma derivatives enhance proliferation of stem/progenitor cells maintaining their differentiation potential. Cytotherapy, 17: 1793-1806.
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  13. Montecucco, F., S. Lenglet, F. Carbone, S. Boero and G. Pelli,et al 2015. Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response. Vascul. Pharmacol., 72: 197-208.
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  14. Boero, S., A. Morabito, B. Banelli, B. Cardinali and B. Dozin,et al 2015. Analysis of in vitro ADCC and clinical response to trastuzumab: Possible relevance of FcγRIIIA/FcγRIIA gene polymorphisms and HER-2 expression levels on breast cancer cell lines. J. Transl. Med., 13: 324-393.
    CrossRef  |  PubMed  |  Direct Link  |  

  15. Vecchio, D., A. Daga, E. Carra, D. Marubbi and Baio.G et al., 2014. Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019. Int. J. Cancer, 135: 479-491.
    CrossRef  |  PubMed  |  Direct Link  |  

  16. Poggi, A., A. Musso, I. Dapino and M.R. Zocchi, 2014. Mechanisms of tumor escape from immune system: role of mesenchymal stromal cells. Immunol Lett., 159: 55-72.
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  17. Poggi, A. and MR. Zocchi, 2014. Stress immunity in lymphomas: mesenchymal cells as a target of therapy. Front Biosci. (Landmark Ed.), 19: 281-290.
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  18. Musso, A., S. Catellani, P. Canevali, S. Tavella and R. Vene et al., 2014. Aminobisphosphonates prevent the inhibitory effects exerted by lymph node stromal cells on anti-tumor vδ 2 t lymphocytes in non-hodgkin lymphomas. Hematol. J., 99: 131-139.
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  19. Scabini, S., F. Montecucco, A. Nencioni, G. Zoppoli and M. Sartini et al., 2013. The effect of preoperative chemoradiotherapy on lymph nodes harvested in tme for rectal cancer. World J. Surg. Oncol., 11: 292-292.
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  20. Penna, I., I. Vassallo, M. Nizzari, D. Russo and D. Costa et al., 2013. A novel snRNA-like transcript affects amyloidogenesis and cell cycle progression through perturbation of Fe65L1 (APBB2) alternative splicing. Biochim. Biophys. Acta, 1833: 1511-1526.
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  21. Amaro, A., V. Mirisola, G. Angelini, A. Musso and F. Tosetti et al., 2013. Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by gefitinib and cetuximab triggered antibody-dependent cellular cytotoxicity. Eur. J. Cancer, 49: 3353-3365.
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  22. Poggi, A., P. Canevali, M. Contatore and G. Ciprandi, 2012. Higher frequencies of CD161+ circulating T lymphocytes in allergic rhinitis patients compared to healthy donors. Int. Arch. Allergy Immunol., 158: 151-156.
    CrossRef  |  PubMed  |  Direct Link  |  

  23. Poggi, A. and M.R. Zocchi, 2012. Imatinib mesylate can help to direct natural immunity toward an anti-leukemic reactivity by acting on the bone marrow microenvironment. Oncoimmunology, 1: 214-216.
    CrossRef  |  PubMed  |  Direct Link  |  

  24. Montecucco, F., I. Bauer, V. Braunersreuther, S. Bruzzone and A. Poggi et al., 2012. Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction. Antioxid Redox Signal, 18: 630-641.
    CrossRef  |  PubMed  |  Direct Link  |  

  25. Magnone, M., I. Bauer, A. Poggi, E. Mannino and L. Sturla et al., 2012. NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes. J. Biol. Chem., 287: 21067-21081.
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  26. Boggio, E., M. Melensi, S. Bocca, A. Chiocchetti and C. Comi et al., 2012. The -346T Polymorphism of the SH2D1A gene is a risk factor for development of autoimmunity/lymphoproliferation in males with defective Fas function. Hum. Immunol., 73: 585-592.
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  27. Bauer, I., A. Grozio, D. Lasiglie, G. Basile and L. Sturla et al., 2012. The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses. J. Biol. Chem., 287: 40924-40937.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Zocchi, M.R. and A. Poggi, 2011. Targeting the microenvironment in hematological malignancies: how to condition both stromal and effector cells to overcome cancer spreading. Curr. Med. Chem., 18: 5172-5173.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Ropolo, M., E. Cappelli, M. Foresta, A. Poggi, L. Proietti-De-Santis and G. Frosina, 2011. Defective resolution of pH2AX foci and enhanced DNA breakage in ionizing radiation-treated Cockayne syndrome B cells. IUBMB Life, 63: 272-276.
    CrossRef  |  PubMed  |  Direct Link  |  

  30. Poggi, A. and M.R. Zocchi, 2011. Modulating mesenchymal stromal cell function with cholesterol synthesis inhibitors. Curr. Med. Chem., 18: 5196-5205.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Mirabella, T., A. Poggi, M. Scaranari, M. Mogni and M. Lituania et al., 2011. Recruitment of host's progenitor cells to sites of human amniotic fluid stem cells implantation. Biomaterials, 32: 4218-4227.
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  32. Ghio M., P. Contini, S. Negrini, C. Mazzei, M.R. Zocchi and A. Poggi, 2011. Down regulation of human Natural Killer cell-mediated cytolysis induced by blood transfusion: Role of transforming growth factor β1 soluble Fasligand and soluble class I human leukocyte antigen. Transfusion, 51: 1567-1673.
    CrossRef  |  PubMed  |  Direct Link  |  

  33. Fenoglio, D., M.R. Zocchi, A. Parodi, P. Durando, G. Gabutitp, R. Gasparini and A. Poggi, 2011. MF-59 adjuvant influence on the functions of gammadelta T cells in HIV-1+ adults immunized with influenza seasonal vaccine. J. Prev. Med. Hyg., 52: 137-141.
    PubMed  |  Direct Link  |  

  34. Poggi, A., M. Zancolli, S. Catellani, S. Boero, A. Musso and M.R. Zocchi, 2010. Differential survival of γδT cells, αβT cells and NK cells upon engagement of NKG2D by NKG2DL-expressing leukemic cells. Int. J. Cancer, 129: 387-396.
    CrossRef  |  PubMed  |  Direct Link  |  

  35. Poggi, A., C. Prevosto, S. Catellani, I. Rocco, A. Garuti and M.R. Zocchi, 2010. Engagement of CD31 delivers an activating signal that contributes to the survival of chronic lymphocytic leukaemia cells. Br. J. Haematol., 151: 252-264.
    CrossRef  |  PubMed  |  Direct Link  |  

  36. Poggi A., A. Musso, S. Boero, P. Canevali and M.R. Zocchi, 2010. Statins as either immunomodulators or anticancer drugs: Functional activities on tumor stromal cells and natural killer cells. CMCAIAA, 9: 82-92.
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  37. Musso, A., M.R. Zocchi and A. Poggi, 2010. Relevance of the mevalonate biosynthetic pathway in the regulation of bone marrow mesenchymal stromal cell-mediated effects on T-cell proliferation and B-cell survival. Haematologica, 96: 16-23.
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  38. Foresta, M., M. Ropolo, P. Degan, I. Pettinati and I.W. Kow et al., 2010. Defective repair of 5-Hydroxy-2'-deoxycytidine in cockayne syndrome cells and its complementation by Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III. Free Radic Biol. Med., 48: 681-690.
    Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III.' target='_blank'>CrossRef  |  Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III.' target='_blank'>PubMed  |  Escherichia coli formamidopyrimidine DNA glycosylase and endonuclease III.' target='_blank'>Direct Link  |  

  39. Ropolo, M., A. Daga, F. Griffero, M. Foresta and G.L. Casartelli et al., 2009. A comparative analysis of DNA repair in stem and non-stem glioma cell cultures. Mol. Cancer Res., 7: 383-392.
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  40. Poggi, A., S. Castellani, A. Musso and M.R. Zocchi, 2009. Gammadelta T lymphocytes producing IFNγ and IL-17 in response to Candida albicans or mycobacterial antigens: Possible implications for acute and chronic inflammation. Curr. Med. Chem., 16: 4743-4749.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Fenoglio, D., A. Poggi, S. Catellani, F. Battaglia and Al. Ferrera et al., 2009. Vδ1 T lymphocytes producing IFN-γ and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans. Blood, 113: 6611-6618.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Viale, M., M. Petrillo, M. Taccagno, P. Castagnola and C. Aiello et al., 2008. Sensitivity of different resistant tumour cell lines to the two novel compounds (2Z,4E)-2-methylsulfanyl-5-(1-naphthyl)-4-nitro-2,4-pentadienoate and (1E,3E)-1,4-bis(2-naphthyl)-2,3-dinitro-1,3-butadiene. Eur. J. Pharmacol., 588: 47-51.
    CrossRef  |  PubMed  |  Direct Link  |  

  43. Ponassi, R., B. Biasotti, V. Tomati, S. Bruno and A. Poggi et al., 2008. A novel Bim-BH3-derived Bcl-XL inhibitor: Biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity. Cell. Cycle., 7: 3211-3224.
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  44. Poggi, A., S. Catellani, A. Bruzzone, F. Caligaris-Cappio, M. Gobbi and M.R. Zocchi, 2008. Lack of the Leukocyte-associated Ig-like receptor-1 expression in high-risk chronic lymphocytic leukaemia results in the absence of a negative signal regulating kinase activation and cell division. Leukemia, 22: 980-988.
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  45. Poggi, A. and M.R. Zocchi, 2008. Role of bone marrow stromal cells in the generation of human CD8+ regulatory T cells. Human Immunol., 69: 755-759.
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  46. Patterson, S., A. Chaidos, D.C.A. Neville, A. Poggi and T. Butters et al., 2008. Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer immunoglobulin receptors. J. Immunol., 181: 3268-3276.
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  47. Lombardi, M.L., G. Terrazzano, E. Casentini, L. Gargiulo and A. Risitano et al., 2008. Paroxysmal nocturnal hemoglobinuria: Significant association with specific HLA-A, -B, -C and -DR alleles in an Italian population. Human Immunol., 69: 202-206.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Vene, R., G. Arena, A. Poggi, C. D'Arrigo and M. Mormino et al., 2007. Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: Therapeutic implications. Mol. Cancer Ther., 6: 286-298.
    CrossRef  |  PubMed  |  Direct Link  |  

  49. Ropolo, M., P. Degan, M. Foresta, M. D'errico and D. Lasiglie et al., 2007. Complementation of the oxidatively damaged DNA repair defect in Cockayne syndrome A and B cells by Escherichia coli formamidopyrimidine DNA glycosylase. Free Radic. Biol. Med., 42: 1807-1817.
    CrossRef  |  PubMed  |  Direct Link  |  

  50. Prevosto, C., M. Zancolli, P. Canevali, M.R. Zocchi and A. Poggi, 2007. Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction. Haematologica, 92: 881-888.
    CrossRef  |  PubMed  |  Direct Link  |  

  51. Poggi, A., M. Zancolli, S. Castellani, G. Borsellino, L. Battistini and M.R. Zocchi, 2007. Migratory pathways of γδ T cells and response to CXCR3 and CXCR4 ligands: Adhesion molecules involved and implications for multiple sclerosis pathogenesis. Ann. NY Acad. Sci., 1107: 68-78.
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  52. Poggi, A., C. Prevosto, M. Zancolli, P. Canevali, A. Musso and M.R. Zocchi, 2007. NKG2D and natural cytotoxicity receptors are involved in natural killer cell interaction with self-antigen presenting cells and stromal cells. Ann. NY Acad. Sci., 1109: 47-57.
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  53. Poggi, A., C. Castellani, D. Fenoglio, G. Borsellino, L. Battistini and M.R. Zocchi, 2007. Adhesion molecules and kinases involved in γ δ T cells migratory pathways: Implications for viral and autoimmune diseases. Curr. Med. Chem., 14: 3166-3170.
    CrossRef  |  PubMed  |  Direct Link  |  

  54. Poggi, A. and M.R. Zocchi, 2007. Human natural killer lymphocytes through the engagement of natural cytotoxicity receptors and NKG2D can trigger self-aggression. Autoimmun. Rev., 6: 295-299.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Contini, P., M.R. Zocchi, I. Pierri, A. Albarello and A. Poggi, 2007. In vivo apoptosis of CD8+ lymphocytes in acute myeloid leukemia patients: involvement of soluble HLA-I and Fas ligand. Leukemia, 21: 253-260.
    CrossRef  |  PubMed  |  Direct Link  |  

  56. Catellani, S., A. Poggi, A. Bruzzone, P. Dadati, J.L. Ravetti, M. Gobbi and M.R. Zocchi, 2007. Expansion of Vδ1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16-binding proteins. Blood, 109: 2078-2085.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. Scielzo, C., A. Camporeale, M. Geuna, M. Alessio, A. Poggi, M.R. Zocchi and M. Chilosi, 2006. ZAP-70 is expressed by normal and malignant human B-cell subsets of different maturational stage. Leukemia, 20: 689-695.
    CrossRef  |  PubMed  |  Direct Link  |  

  58. Poggi, A. and M.R. Zocchi, 2006. HIV-1 tat triggers TGF-β production and NK cell apoptosis that is prevented by pertussis toxin B. Clin. Dev. Immunol., 13: 369-372.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Poggi, A. and M.R. Zocchi, 2006. Antigen presenting cells and stromal cells trigger human natural killer lymphocytes to autoreactivity: Evidence for the involvement of Natural Cytotoxicity Receptors (NCR) and NKG2D. Clin. Dev. Immunol., 13: 325-326.
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  60. Zocchi, M.R., P. Contini, M. Alfano and A. Poggi, 2005. Pertussis toxin (PTX) B subunit and the nontoxic PTX mutant PT9K/129G inhibit tat-induced TGF-β production by NK cells and TGF-β-mediated NK cell apoptosis 1. J. Immunol., 174: 6054-6061.
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  61. Zocchi, M.R. and A. Poggi, 2005. Triggering of apoptosis and pro-inflammatory cytokines in NK cells: Regulation by cyclosporin A. Curr. Med. Chem., 4: 115-120.
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  62. Zocchi, M.R. and A. Poggi, 2005. Editorial [Hot topic: Innate immunity and cytokines: How to regulate host response against pathogens avoiding autoreactivity (Guest Editors: M.R. Zocchi and A. Poggi)]. Curr. Med. Chem., 4: 113-114.
    Direct Link  |  

  63. Semino, C., G. Angelini, A. Poggi and A. Rubartelli, 2005. NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the Dc maturation factor HMGB1. Blood, 106: 609-616.
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  64. Poggi, A., S. Negrini, M.R. Zocchi, A.M. Massaro and L. Garbarino, 2005. Patients with paroxysmal nocturnal Hemoglobinuria have a high frequency of peripheral-blood T cells expressing activating isoforms of inhibiting superfamily receptors. Blood, 106: 2399-2408.
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  65. Poggi, A., P. Contini, S. Castellani, M. Setti, G. Murdaca and M.R. Zocchi, 2005. Regulation of γδ T cell survival by soluble HLA-I: Involvement of CD8 and activating killer Ig-like receptors. Eur. J. Immunol., 35: 2670-2678.
    CrossRef  |  PubMed  |  Direct Link  |  

  66. Poggi, A., C. Prevosto, A.M. Massaro, S. Negrini and S. Urbani et al., 2005. Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: Role of NKp30 and NKG2D receptors. J. Immunol., 175: 6352-6360.
    CrossRef  |  PubMed  |  Direct Link  |  

  67. Poggi, A., A.M. Massaro, S. Negrini, P. Contini and M.R. Zocchi, 2005. Tumor-induced apoptosis of human IL-2-activated NK cells: Role of natural cytotoxicity receptors. J. Immunol., 174: 2656-2660.
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  68. Poggi, A. and M.R. Zocchi, 2005. Cyclosporin A regulates human NK cell apoptosis induced by soluble HLA-I or by target cells. Autoimmun. Rev., 4: 532-536.
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  69. Contini, P., M. Ghio, A. Merlo, A. Poggi, F. Indiveri and F. Puppo, 2005. Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas ligand/Fas mediated: Evidence for the involvement of p56lck, calcium calmodulin kinase II and Calcium-Independent Protein Kinase C signaling pathways and for NF-κB and NF-AT nuclear translocation. J. Immunol., 175: 7244-7254.
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  70. Chan, W.L., N. Pejnovic, H. Hamilton, T.V. Liew, D. Popadic, A. Poggi and S.M. Khan, 2005. Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1 NKT and helper T cells. Circ. Res., 96: 675-683.
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  71. Zocchi, M.R. and A. Poggi, 2004. Role of gammadelta T lymphocytes in tumor defense. Frontiers Biosci., 9: 2588-2604.
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  72. Zocchi, M.R. and A. Poggi, 2004. PECAM-1, apoptosis and CD34+ precursors. Leukemia Lymphoma, 45: 2205-2213.
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  73. Ropoli, M., A. Geroldi, O. Rossi, P. Degan, S. Zupo, A. Poggi and G. Frosina, 2004. Expression of the Drosophila melanogaster S3 ribosomal/repair protein in T24 human bladder cells. Anticancer Res., 24: 3811-3818.
    PubMed  |  Direct Link  |  

  74. Poggi, A., C. Venturino, S. Castellani, M. Clavio and M. Miglino et al., 2004. Vδ1 T lymphocytes from B-CLL patients recognize ULBP3 expressed on leukemic B cells and up-regulated by trans-retinoic acid. Cancer Res., 64: 9172-9179.
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  75. Andrei, C., P. Margiocco, A. Poggi, L.V. Lotti, M.R. Torrisi and A. Rubartelli, 2004. Phospholipases C and A2 control lysosome-mediated IL-1β secretion: Implications for inflammatory processes. Proc. Nat. Acad. Sci. USA., 101: 9745-9750.
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  76. Spaggiari, G.M., P. Contini, S. Negrini, A. Dondero and R. Carosio et al., 2003. IFN-γ production in human NK cells through the engagement of CD8 by soluble or surface HLA class I molecules. Eur. J. Immunol., 33: 3049-3059.
    CrossRef  |  PubMed  |  Direct Link  |  

  77. Spaggiari, G.M., P. Contini, M.R. Zocchi and A. Poggi, 2003. Interaction of solubile HLA-I antigens with either CD8 or activating isoform of the inhibitory Receptor Superfamily members induces apoptosis of human NK cells via FasL/Fas interaction. Res. Trends Immunol., 5: 33-43.

  78. Poggi, A., R. Carosio, D. Fenoglio, S. Brenci and G. Murdaca et al., 2003. Migration of Vδ1 and Vδ2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: Competition by HIV-1 Tat. Blood, 103: 2205-2213.
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  79. Contini, P., M. Ghio, A. Poggi, G. Filaci, F. Indiveri, S. Ferrone and P. Puppp, 2003. Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation. Eur. J. Immunol., 33: 125-134.
    CrossRef  |  PubMed  |  Direct Link  |  

  80. Spaggiari, G.M., P. Contini, R. Carosio, M. Arvigo and M. Ghio et al., 2002. Soluble HLA class I molecules induce natural killer cell apoptosis through the engagement of CD8: Evidence for a negative regulation exerted by members of the inhibitory receptor superfamily. Blood, 99: 1706-1714.
    CrossRef  |  PubMed  |  Direct Link  |  

  81. Spaggiari, G.M., P. Contini, A. Dondero, R. Carosio, F. Puppo, F. Indiveri, M.R. Zocchi and A. Poggi, 2002. Soluble HLA class I induces NK cell apoptosis upon the engagement of killer-activating HLA class I receptors through FasL-Fas interaction. Blood, 100: 4098-4107.
    CrossRef  |  PubMed  |  Direct Link  |  

  82. Poggi, A., R. Carosio, G.M. Spaggiari, C. Fortis and G. Tambussi et al., 2002. NK cell activation by dendritic cells is dependent on LFA-1-mediated induction of calcium-calmodulin kinase II: Inhibition by HIV-1 Tat C-terminal domain. J. Immunol., 168: 95-101.
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  83. Poggi, A., R. Carosio, A. Rubartelli and M.R. Zocchi, 2002. β3-mediated engulfment of apoptotic tumor cells by dendritic cells is dependent on CAMKII: Inhibition by HIV-1 Tat. J. Leukoc Biol., 71: 531-537.
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  84. Poggi, A., M.R. Zocchi, R. Carosio, E. Ferrero and D.F. Angelini et al., 2002. Transendothelial migratory pathways of Vδ1+TCRγδ+ and Vδ2+TCRγδ+ T lymphocytes from healthy donors and multiple sclerosis patients: Involvement of phosphatidylinositol 3 kinase and calcium calmodulin-dependent kinase II. J. Immunol., 168: 6071-6077.
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  86. Ferrarini, M., E. Ferrero, L. Dagna, A. Poggi and M.R. Zocchi, 2002. Human γδ T cells: A nonredundant system in the immune-surveillance against cancer. Trends Immunol., 23: 14-18.
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  87. Zocchi, M.R., F. Pellegatta, I. Pierri, M. Gobbi and A. Poggi, 2001. Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor-dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur. J. Immunol., 31: 3667-3675.
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  88. Spaggiari, G.M., R. Carosio, D. Pende, S. Marcenaro and P. Rivera et al., 2001. NK cell-mediated lysis of autologous antigen-presenting cells is triggered by the engagement of the phosphatidylinositol 3-kinase upon ligation of the natural cytotoxicity receptors NKp30 and NKp46. Eur. J. Immunol., 31: 1656-1665.
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  89. Gardella, S., C. Andrei, L.V. Lotti, A. Poggi, M.R. Torrisi, M.R. Zocchi and A. Rubartelli, 2001. CD8+ T lymphocytes induce polarized exocytosis of secretory lysosomes by dendritic cells with release of interleukin-1β and cathepsin D. Blood, 98: 2152-2159.
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  90. Poggi, A., G.M. Spaggiari, S. Quintino, M. Setti and I. Pierri et al., 2000. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed prevents proliferation and induces apoptosis in human acute myeloid leukemias. Haematologica, 85: 54-54.

  91. Poggi, A., F. Pellegatta, B.E. Leone, L. Moretta and M.R. Zocchi, 2000. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-κB nuclear translocation in human myeloid leukemias. Eur. J. Immunol., 30: 2751-2758.
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  92. Gardella, S., C. Andrei, A. Poggi, M.R. Zocchi and A. Rubartelli, 2000. Control of interleukin-18 secretion by dendritic cells: Role of calcium influxes. FEBS Lett., 481: 245-248.
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  93. Ferrero, E., K. Vettoretto, A. Bondanza, A. Villa, M. Resnati, A. Poggi and M.R. Zocchi, 2000. uPA/uPAR system is active in immature dendritic cells derived from CD14+CD34+ precursors and is down-regulated upon maturation. J. Immunol., 164: 712-718.
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  94. Rubartelli, A., A. Poggi, R. Sitia and M.R. Zocchi, 1999. Reply to reinhold et al. Immunol. Today, 20: 384-385.
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  95. Poggi, A., M.R. Zocchi, P. Costa, E. Ferrero and G. Borsellino et al., 1999. IL-12-mediated NKRP1A up-regulation and consequent enhancement of endothelial transmigration of Vδ 2+ TCRγδ+ T lymphocytes from healthy donors and multiple sclerosis patients. J. Immunol., 162: 4349-4354.
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  96. Gardella, S., C. Andrei, S. Costigliolo, A. Poggi, M.R. Zocchi and A. Rubartelli, 1999. Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells. J. Leukoc. Biol., 66: 237-241.
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  97. Zocchi, M.R., A. Rubartelli, P. Morgavi and A. Poggi, 1998. HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels. J. Immunol., 161: 2938-2943.
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  98. Rubartelli, A., A. Poggi, R. Sitia and M.R. Zocchi, 1998. HIV-1 Tat: A polypeptide for all seasons. Immunol. Today, 19: 543-545.
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  99. Poggi, A., P. Costa, E. Tomasello and L. Moretta, 1998. IL-12-induced up-regulation of NKRP1A expression in human NK cells and consequent NKRP1A- mediated down-regulation of NK cell activation. Eur. J. Immunol., 28: 1611-1616.
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  100. Poggi, A., E. Tomasello, E. Ferrero, M.R. Zocchi and L. Moretta, 1998. p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor. Eur. J. Immunol., 28: 2086-2091.
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  101. Poggi, A., A. Rubartelli and M.R. Zocchi, 1998. Involvement of dihydropyridine-sensitive calcium channels in human dendritic cell function. Competition by HIV-1 Tat. J. Biol. Chem., 273: 7205-7209.
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  102. Ferrero, E., M. Fabbri, A. Poggi, G. Galati, S. Bernasconi and M.R. Zocchi, 1998. Tumor-driven matrix invasion by infiltrating lymphocytes: Involvement of the α1 integrin I-domain. Eur. J. Immunol., 28: 2530-2536.
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  103. Ferrero, E., A. Bondanza, B.E. Leone, S. Manici, A. Poggi and M.R. Zocchi, 1998. CD14+ CD34+ peripheral blood mononuclear cells migrate across endothelium and give rise to immunostimulatory dendritic cells. J. Immunol., 160: 2675-2683.
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  104. Zocchi, M.R., A. Poggi and A. Rubartelli, 1997. The RGD-containing domain of exogenous HIV-1 Tat inhibits the engulfment of apoptotic bodies by dendritic cells. AIDS, 11: 1227-1235.
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  105. Rubartelli, A., A. Poggi and M.R. Zocchi, 1997. The selective engulfment of apoptotic bodies by dendritic cells is mediated by the αvβ3 integrin and requires intracellular and extracellular calcium. Eur. J. Immunol., 27: 1893-1900.
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  106. Poggi, A., P. Costa, M.R. Zocchi and L. Moretta, 1997. Phenotypic and functional analysis of CD4+ NKRP1A+ human T lymphocytes. Direct evidence that the NKRP1A molecule is involved in transendothelial migration. Eur. J. Immunol., 27: 2345-2350.
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  107. Poggi, A., P. Costa, M.R. Zocchi and L. Moretta, 1997. NKRP1A molecule is involved in transendothelial migration of CD4+ human T lymphocytes. Immunol. Lett., 57: 121-123.
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  108. Poggi, A., E. Tomasello, V. Revello, L. Nanni, P. Costa and L. Moretta, 1997. p40 molecule regulates NK cell activation mediated by NK receptors for HLA class I antigens and TCR-mediated triggering of T lymphocytes. Int. Immunol., 9: 1271-1279.
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  109. Poggi, A., E. Tomasello and P. Costa, 1997. NKRP1A and p40 molecules are involved in regulation of activation and maturation of human NK cells. Res. Immunol., 148: 179-184.
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  110. Poggi, A., A. Rubartelli, L. Moretta and M.R. Zocchi, 1997. Expression and function of NKRP1A molecule on human monocytes and dendritic cells. Eur. J. Immunol., 27: 2965-2970.
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  111. Moretta, L., A. Poggi, L. Nanni, C. Bottino, G. Melioli, R. Biassoni and A. Moretta, 1997. Natural Killer Cell Antigens: Section Report. In: Leukocyte Typing VI, Kishimoto, T. (Ed.). Garland Publishing, New York, pp: 265-267.

  112. Moretta, A., R. Biassoni, C. Bottino, D. Pende and M. Vitale et al., 1997. Major histocompatibility complex class I-specific receptors on human natural killer and T lymphocytes. Immunol. Rev., 155: 105-117.
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  113. Davodeau, F., M.A. Peyrat, A. Necker, R. Dominici and F. Blanchard et al., 1997. Close phenotypic and functional similarities between human and murine αβ T cells expressing invariant TCR α-chains. J. Immunol., 158: 5603-5611.
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  114. Poggi, A., P. Costa, L. Morelli, C. Cantoni and N. Pella et al., 1996. Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity. Eur. J. Immunol., 26: 1266-1272.
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  115. Poggi, A., N. Pella, C. Cantoni, M.R. Zocchi and L. Moretta, 1996. Physical and functional association of CD45 and CD3-TCR complex on CD1+ human thymocytes. Evidence that the engagement of CD45 molecules can prevent CD1+ thymocytes from apoptosis. Int. Immunol., 8: 1947-1953.
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  116. Poggi, A., M.C. Panzeri, L. Moretta and M.R. Zocchi, 1996. CD31-triggered rearrangement of the actin cytoskeleton in human natural killer cells. Eur. J. Immunol., 26: 817-824.
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  117. Poggi, A., F. Spada, P. Costa, E. Tomasello and V. Revello et al., 1996. Dissection of lymphocyte function-associated antigen 1-dependent adhesion and signal transduction in human natural killer cells shown by the use of cholera or pertussis toxin. Eur. J. Immunol., 26: 967-975.
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  118. Mingari, M.C., A. Cambiaggi, C. Vitale, F. Schiavetti, R. Bellomo and A. Poggi, 1996. Effect of superantigens on human thymocytes: Selective proliferation of V beta 2+ cells in response to toxic shock syndrome toxin-1 and their deletion upon secondary stimulation. Int. Immunol., 8: 203-209.
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  119. Han, D., C. Pottin-Clemenceau, M.A. Imro, M. Scudeletti and C. Doucet et al., 1996. IL2 triggers a tumor progression process in a melanoma cell line MELP derived from a patient whose metastasis increased in size during IL2/INFα biotherapy. Oncogene, 12: 1015-1023.
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  120. Biassoni, R., C. Cantoni, M. Falco, S. Verdiani and C. Bottino et al., 1996. The human leukocyte antigen (HLA)-C-specific ''activatory'' or ''inhibitory'' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med., 183: 645-650.
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  121. Zocchi, M.R. and A. Poggi, 1995. Human gamma delta T lymphocytes use N-CAM to interact with the subendothelial matrix. J. Natl. Cancer Inst., 87: 846-847.
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  122. Poggi, A., N. Pella, L. Morelli, F. Spada and V. Revello, et al., 1995. P40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur. J. Immunol., 25: 369-376.
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  123. Poggi, A. and M.C. Mingari, 1995. Development of human NK cells from the immature cell precursors. Semin. Immunol., 7: 61-66.
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  124. Mingari, M.C., C. Vitale, A. Cambiaggi, F. Schiavetti, G. Melioli, S. Ferrini and A. Poggi, 1995. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int. Immunol., 7: 697-703.
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  125. Zocchi, M.R., E. Ferrero, E. Toninelli, P. Castellani, A. Poggi and C. Rugarli, 1994. Expression of N-CAM by human renal cell carcinomas correlates with growth rate and adhesive properties. Exp. Cell Res., 214: 499-509.
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  126. Poggi, A., J.F. Demarest, P. Costa, R. Biassoni and N. Pella et al., 1994. Expression of a wide T cell receptor V beta repertoire in human T lymphocytes derived in vitro from embryonic liver cell precursors. Eur. J. Immunol., 24: 2258-2261.
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  127. Moretta, L., E. Ciccone, A. Poggi, M.C. Mingari and A. Moretta, 1994. Origin and functions of human natural killer cells. Int. J. Clin. Lab. Res., 24: 181-186.
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  128. Moretta, L., E. Ciccone, A. Poggi, M.C. Mingari and A. Moretta, 1994. Ontogeny, specific functions and receptors of human natural killer cells. Immunol. Lett., 40: 83-88.
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  129. Ferrini, S., S. Sforzini, A. Cambiaggi, A. Poggi and R. Meazza, et al., 1994. The LFA-1/ICAM cell adhesion pathway is involved in tumor-cell lysis mediated by bispecific monoclonal-antibody-targeted T lymphocytes. Int. J. Cancer, 56: 846-852.
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  130. Cantoni, C., A. Cambiaggi, S. Sforzini, A. Poggi, M. Viale, R. Biassoni and S. Ferrini, 1994. Characterization of a cyclosporin A-sensitive activation pathway in cultured T and natural killer cells. Scand J. Immunol., 39: 373-379.
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  131. Zocchi, M.R., M. Vidal and A. Poggi, 1993. Involvement of CD56/N-CAM molecule in the adhesion of human solid tumor cell lines to endothelial cells. Exp. Cell. Res., 204: 130-135.
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  132. Zocchi, M.R., A. Poggi, F. Crosti, S. Tongiani and C. Rugarli, 1993. Signal transduction in human tumor infiltrating lymphocytes. Arch. Immunol. Ther. Exp. (Warsz), 41: 33-39.
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  133. Zocchi, M.R. and A. Poggi, 1993. NCAM and lymphocyte adhesion in leucocyte adhesion deficiency (LAD) syndrome. Immunol. Today, 14: 94-95.
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  134. Zocchi, M.R. and A. Poggi, 1993. Lymphocyte-endothelial cell adhesion molecules at the primary tumor site in human lung and renal cell carcinomas. J. Natl. Cancer. Inst., 85: 246-247.
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  135. Tripodi, G., A. Poggi, A.M. Orengo, N. Pella and M. Vitale et al., 1993. Identification of a new surface molecule involved in the mechanism of cell to cell adhesion between human NK and tumor target cells. Cytotechnology, 1: S109-S111.
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  136. Poggi, A., R. Pardi, N. Pella, L. Morelli and S. Sivori et al., 1993. CD45-mediated regulation of LFA1 function in human natural killer cells. Anti-CD45 monoclonal antibodies inhibit the calcium mobilization induced via LFA1 molecules. Eur. J. Immunol., 23: 2454-2463.
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  137. Poggi, A., M. Sargiacomo, R. Biassoni, N. Pella and S. Sivori et al., 1993. Extrathymic differentiation of T lymphocytes and natural killer cells from human embryonic liver precursors. Proc. Natl. Acad. Sci. USA., 90: 4465-4469.
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  138. Zocchi, M.R., A. Poggi, F. Crosti, S. Tongiani and C. Rugarli, 1992. Signalling in human tumour infiltrating lymphocytes: The CD28 molecule is functional and is physically associated with the CD45R0 molecule. Eur. J. Cancer, 28: 749-754.
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  139. Zocchi, M.R. and A. Poggi, 1992. NCAM is Involved in the Adhesion of Human LFA1 Negative Thymic and Peripheral Lymphocytes to Endothelial Cells. In: Recent Advances in Cellular and Molecular Biology, Wegmann, R.J. and M.A. Wegmann (Eds.). Peeters Press, Leuven, Belgium, pp: 121-127.

  140. Vidal, M.J., M.R. Zocchi, A. Poggi, F. Pellegatta and S.L. Chierchia, 1992. Involvement of nitric oxide in tumor cell adhesion to cytokine-activated endothelial cells. J. Cardiovasc. Pharmacol., 12: S155-S159.
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  141. Poggi, A., 1992. The Leukocyte Common Antigen Regulates The [Ca++]I Increase Mediated Via the Lymphocyte Function Associated Antigen-1 in CD3-CD16+ Peripheral Lymphocytes. In: Recent Advances in Cellular and Molecular Biology, Wegmann, R.J. and M.A. Wegmann (Eds.). Peeters Press, Leuven, Belgium, pp: 63-69.

  142. Poggi, A. and M.R. Zocchi, 1992. Cultured human thymocytes lacking CD2 and CD11a/CD18 antigens are functional and adhere to endothelial cells via CD56 or CDw49d molecules. Cell Immunol., 140: 319-330.
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  143. Poggi, A. and M.R. Zocchi, 1992. Antigen-independent pathways of T-cell activation are functional in human immature thymocytes. Int. J Clin. Lab. Res., 21: 304-309.
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  144. Mingari, M.C., A. Poggi, R. Bellomo, N. Pella and L. Moretta, 1992. Thymic origin of some natural killer cells: clonal proliferation of human CD3-16+ cells from CD3-4-8- thymocyte precursors requires the presence of H9 leukemic cells. Int. J. Clin. Lab. Res., 21: 176-178.
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  145. Zocchi, M.R., M. Fabbri, A. Poggi and E. Gianazza, 1991. Biochemical characterization by two-dimensional electrophoresis of lymphocyte antigens involved in cell-to-cell or cell-to-matrix adhesion. Electrophoresis, 12: 527-535.
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  146. Zocchi, M.R. and A. Poggi, 1991. Activation of CD3/TCR negative human thymocytes via CD28 molecule. Cell Immunol., 136: 105-112.
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  147. Moretta, A., A. Poggi, D. Pende, G. Tripodi and A.M. Orengo et al., 1991. CD69-mediated pathway of lymphocyte activation: Anti-CD69 monoclonal antibodies trigger the cytolytic activity of different lymphoid effector cells with the exception of cytolytic T lymphocytes expressing T cell receptor alpha/beta. J. Exp. Med., 174: 1393-1398.
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  148. Mingari, M.C., A. Poggi, R. Biassoni, R. Bellomo and E. Ciccone et al., 1991. In vitro proliferation and cloning of CD3- CD16+ cells from human thymocyte precursors. J. Exp. Med., 174: 21-26.
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  149. Zocchi, M.R., F. Marelli and A. Poggi, 1990. Simultaneous cytofluorometric analysis for the expression of cytoplasmic antigens and DNA content in CD3- human thymocytes. Cytometry, 11: 883-887.
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  150. Zocchi, M.R., A. Poggi, S. Heltai, A. Villa and L. Inverardi et al., 1990. Signal requirements for activation of leukaemic T cells from a chronic lymphocytic leukaemia (T-CLL). Clin. Exp. Immunol., 82: 108-113.
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  151. Zocchi M.R., F. Marelli and A. Poggi, 1990. CD1+ thymocytes proliferate and give rise to functional cells after stimulation with monoclonal antibodies recognizing CD3, CD2 or CD28 surface molecules. Cell Immunol, 129: 394-403.
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  152. Poggi, A., R. Biassoni, N. Pella, F. Paolieri and R. Bellomo et al., 1990. In vitro expansion of CD3/TCR- human thymocyte populations that selectively lack CD3 delta gene expression: A phenotypic and functional analysis. J. Exp. Med., 172: 1409-1418.
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  153. Poggi, A., E. Maggi, R. Biagiotti, M.G. Giudizi and F. Almerigogna et al., 1990. A novel pathway of human B cell activation initiated by CK226 surface antigen. Eur. J. Immunol., 20: 1161-1165.
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  154. Heltai, S., A. Poggi, M.G. Sabbadini and M.R. Zocchi, 1990. Evaluation of cytotoxic cell-target cell conjugates. Comparison between flow cytometric analysis and 51Cr binding assay. Haematologica, 75: 191-193.
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  155. Ferrarini, M., E. Ferrero, C. Fortis, A. Poggi and M.R. Zocchi, 1990. LAK1 antigen defines two distinct subsets among human tumour infiltrating lymphocytes. Br. J. Cancer, 62: 754-757.
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  156. De Maria, A.F., M.S. Malnati, A. Poggi, D. Pende, F. Cottafava and L. Moretta, 1990. Clonal analysis of joint fluid T lymphocytes in patients with juvenile rheumatoid arthritis. J. Rheumatol., 17: 1073-1078.
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  157. Zocchi, M.R., S. Heltai and A. Poggi, 1989. Dual-parameter flow cytometric analysis of an early lymphocyte activation antigen (CK226) and DNA content. Cytometry, 10: 762-771.
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  158. Zocchi, M.R., A. Poggi, S. Mariani, E. Gianazza and C. Rugarli, 1989. Identification of a new surface molecule expressed by human LGL and LAK cells: Production of a specific monoclonal antibody and comparison with other NK/LAK markers. Cell. Immunol., 124: 144-157.
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  159. Zocchi, M.R. and A. Poggi, 1989. LAK1 and LAK2 Monoclonal Antibodies Identified two different Molecules Expressed on Large Granular Lymphocytes and Lymphokine Activated Killer Cells. In: Leukocyte Typing IV, Knapp, W. (Ed.). Oxford University Press, Oxford, UK., pp: 727-728.

  160. Poggi, A., M.R. Zocchi, L. Moretta and A. Moretta, 1989. CK226: A novel surface molecule involved in human T cell activation. Eur. J. Immunol., 19: 2069-2074.
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  161. Poggi, A. and M.R. Zocchi, 1989. Activation and Proliferation of Human T and B Lymphocytes through a Novel Surface Structure Defined by the Monoclonal Antibody CK226. In: Leukocyte Typing IV, Knapp, W. (Ed.). Oxford University Press, Oxford, UK., pp: 375-376.

  162. Pantaleo, G., M.R. Zocchi, S. Ferrini, A. Poggi and G. Tambussi et al., 1988. Human cytolytic cell clones lacking surface expression of T cell receptor alpha/beta or gamma/delta. Evidence that surface structures other than CD3 or CD2 molecules are required for signal transduction. J. Exp. Med., 168: 13-24.
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  163. Poggi, A., C. Bottino, M.R. Zocchi, G. Pantaleo and E. Ciccone et al., 1987. CD3+ WT31 peripheral T lymphocytes lack T44 (CD28), a surface molecule involved in activation of T cells bearing the α/β heterodimer. Eur. J. Immunol., 17: 1065-1068.
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  164. Pantaleo, G., D. Olive, M.R. Zocchi, A. Poggi, C. Bottino and A. Moretta, 1987. Signal Transducing Mechanisms in Human T Cell Activation. In: Genotypic and Functional Aspects of Haematopoiesis, Grignani, F., M.F. Martelli and D.Y. Mason (Eds.). Raven Press, New York, USA., pp: 197-204.

  165. Pantaleo, G., D. Olive, A. Poggi, W.J. Kozumbo, L. Moretta and A. Moretta, 1987. Transmembrane signalling via the T11-dependent pathway of human T cell activation. Evidence for the involvement of 1,2-diacylglycerol and inositol phosphates. Eur. J. Immunol., 17: 55-60.
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