Prof. Giuseppe  Biagini

Prof. Giuseppe Biagini

Associate Professor
University of Modena and Reggio Emilia, Italy


Highest Degree
M.D. in Neurosciences from University of Modena, Italy

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Area of Interest:

Biomedical Sciences
100%
Cerebral Ischemia
62%
Hippocampal Damage
90%
Neuroscience
75%
Central Nervous System
55%

Selected Publications

  1. Testa, F., M. Marchio, M. Belli, S. Giovanella and G. Ligabue et al., 2019. A pilot study to evaluate tolerability and safety of a modified Atkins diet in ADPKD patients. PharmaNutrition, Vol. 9. 10.1016/j.phanu.2019.100154.
    CrossRef  |  Direct Link  |  

  2. Marchio, M., L. Roli, C. Lucchi, A.M. Costa and M. Borghi et al., 2019. Ghrelin plasma levels after 1 year of ketogenic diet in children with refractory epilepsy. Front. Nutr., Vol. 6. 10.3389/fnut.2019.00112.
    CrossRef  |  Direct Link  |  

  3. Marchio, M., L. Roli, C. Giordano, T. Trenti, A. Guerra and G. Biagini, 2019. Decreased ghrelin and des-acyl ghrelin plasma levels in patients affected by pharmacoresistant epilepsy and maintained on the ketogenic diet. Clin. Nutr., 38: 954-957.
    CrossRef  |  

  4. Bresciani, E., E.C. Saletti, N. Squillace, L. Rizzi and L. Molteni et al., 2019. miRNA-218 targets lipin-1 and glucose transporter type 4 genes in 3T3-L1 cells treated with lopinavir/ritonavir. Front. Pharmacol., Vol. 10. 10.3389/fphar.2019.00461.
    CrossRef  |  

  5. Vinet, J., A.M. Costa, M. Salinas-Navarro, G. Leo, L. Moons, L. Arkens and G. Biagini, 2018. A hydroxypyrone-based inhibitor of metalloproteinase-12 displays neuroprotective properties in both status epilepticus and optic nerve crush animal models. Int. J. Mol. Sci., Vol. 19. 10.3390/ijms19082178.
    CrossRef  |  

  6. Molteni, L., L. Rizzi, E. Bresciani, R. Meanti and J.A. Fehrentz et al., 2018. STIM proteins and Orai Ca2+ channels are involved in the intracellular pathways activated by TLQP-21 in RAW264.7 macrophages. Front. Pharmacol., Vol. 9. 10.3389/fphar.2018.01386.
    CrossRef  |  

  7. Meletti, S., C. Lucchi, G. Monti, G. Giovannini and R. Bedin et al., 2018. Evaluation of progesterone and derivatives in cerebrospinal fluid during status epilepticus. J. Neurochem., 147: 275-284.
    CrossRef  |  

  8. Marchio, M., L. Roli, C. Giordano, E. Caramaschi, A. Guerra, T. Trenti and G. Biagini, 2018. High plasma levels of ghrelin and des-acyl ghrelin in responders to antiepileptic drugs. Neurology, 91: e62-e66.
    CrossRef  |  

  9. Trivisano, M., C. Lucchi, C. Rustichelli, A. Terracciano and R. Cusmai et al., 2017. Reduced steroidogenesis in patients with PCDH19-female limited epilepsy. Epilepsia, 58: e91-e95.
    CrossRef  |  

  10. Molteni, L., L. Rizzi, E. Bresciani, R. Possenti and P.P. Passeri et al., 2017. Pharmacological and biochemical characterization of TLQP-21 activation of a binding site on CHO cells. Front. Pharmacol., Vol. 8. 10.3389/fphar.2017.00167.
    CrossRef  |  

  11. Meletti, S., C. Lucchi, G. Monti, G. Giovannini and R. Bedin et al., 2017. Decreased allopregnanolone levels in cerebrospinal fluid obtained during status epilepticus. Epilepsia, 58: e16-e20.
    CrossRef  |  Direct Link  |  

  12. Lucchi, C., M. Marchio, E. Caramaschi, C. Giordano, R. Giordano, A. Guerra and G. Biagini, 2017. Electrographic changes accompanying recurrent seizures under ketogenic diet treatment. Pharmaceuticals, Vol. 10. 10.3390/ph10040082.
    CrossRef  |  

  13. Lucchi, C., A.M. Costa, C. Giordano, G. Curia and M. Piat et al., 2017. Involvement of PPARγ in the anticonvulsant activity of EP-80317, a ghrelin receptor antagonist. Front. Pharmacol., Vol. 8. 10.3389/fphar.2017.00676.
    CrossRef  |  

  14. Bresciani, E., L. Rizzi, L. Molteni, A. Liantonio and D.C. Camerino et al., 2017. JMV 2894, a novel growth hormone secretagogue, antagonizes body weight loss and accelerates body mass recovery in an experimental model of cachexia. Endocrine, 58: 106-114.
    CrossRef  |  

  15. Vinet, J., I.D. Vainchtein, C. Spano, C. Giordano and G. Curia et al., 2016. Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus. Glia, 64: 1350-1362.
    CrossRef  |  

  16. Lippi, G., C.C. Fernandes, L.A. Ewell, D. John and B. Romoli et al., 2016. MicroRNA-101 regulates multiple developmental programs to constrain excitation in adult neural networks. Neuron, 92: 1337-1351.
    CrossRef  |  

  17. Giordano, C., A.M. Costa, C. Lucchi, G. Leo and L. Brunel et al., 2016. Progressive seizure aggravation in the repeated 6-Hz corneal stimulation model is accompanied by marked increase in hippocampal p-ERK1/2 immunoreactivity in neurons. Front. Cell. Neurosci., Vol. 10. 10.3389/fncel.2016.00281.
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  18. Lucchi, C., J. Vinet, S. Meletti and G. Biagini, 2015. Ischemic-hypoxic mechanisms leading to hippocampal dysfunction as a consequence of status epilepticus. Epilepsy Behav., 49: 47-54.
    CrossRef  |  

  19. Kano, T., Y. Inaba, M. D’Antuono, G. Biagini, M. Levesque and M. Avoli, 2015. Blockade of in vitro ictogenesis by low frequency stimulation coincides with increased epileptiform response latency. J. Neurophysiol., 114: 21-28.
    CrossRef  |  

  20. Giordano, C., J. Vinet, G. Curia and G. Biagini, 2015. Repeated 6-Hz corneal stimulation progressively increases FosB/ΔFosB levels in the lateral amygdala and induces seizure generalization to the hippocampus. PLoS One Vol. 10. 10.1371/journal.pone.0141221.
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  21. Biagini, G., M. D’Antuono, Y. Inaba, T. Kano, D. Ragsdale and M. Avoli, 2015. Activity-dependent changes in excitability of perirhinal cortex networks in vitro. Pflugers Arch. (Eur. J. Physiol.), 467: 805-816.
    CrossRef  |  Direct Link  |  

  22. Vainchtein, I.D., J. Vinet, N. Brouwer, S. Brendecke and G. Biagini et al., 2014. In acute experimental autoimmune encephalomyelitis, infiltrating macrophages are immune activated, whereas microglia remain immune suppressed. Glia, 62: 1724-1735.
    CrossRef  |  Direct Link  |  

  23. Giordano, C., M. Marchio, E. Timofeeva and G. Biagini, 2014. Neuroactive peptides as putative mediators of antiepileptic ketogenic diets. Front. Neurol., Vol. 5. 10.3389/fneur.2014.00063.
    CrossRef  |  Direct Link  |  

  24. Curia, G., C. Lucchi, J. Vinet, F. Gualtieri and C. Marinelli et al., 2014. Pathophysiogenesis of mesial temporal lobe epilepsy: Is prevention of damage antiepileptogenic? Curr. Med. Chem., 21: 663-688.
    Direct Link  |  

  25. Pugnaghi, M., G. Monti, G. Biagini and S. Meletti, 2013. Temporal lobe epilepsy exacerbation during pharmacological inhibition of endogenous neurosteroid synthesis. BMJ Case Rep. .
    PubMed  |  Direct Link  |  

  26. Lucchi, C., G. Curia, J. Vinet, F. Gualtieri and E. Bresciani et al., 2013. Protective but not anticonvulsant effects of ghrelin and JMV-1843 in the pilocarpine model of status epilepticus. PLoS One, Vol., 8 .
    PubMed  |  Direct Link  |  

  27. Gualtieri, F., C. Marinelli, D. Longo, M. Pugnaghi, P.F. Nichelli, S. Meletti and G. Biagini, 2013. Hypoxia markers are expressed in interneurons exposed to recurrent seizures. Neuromol. Med., 15: 133-146.
    CrossRef  |  PubMed  |  Direct Link  |  

  28. Curia, G., F. Gualtieri, R. Bartolomeo, R. Vezzali and G. Biagini, 2013. Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout mice. Front. Cell. Neurosci., Vol., 7 10.3389/fncel.2013.00046.
    CrossRef  |  PubMed  |  Direct Link  |  

  29. Curia, G., C. Lucchi, J. Vinet, F. Gualtieri and C. Marinelli et al., 2013. Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic? Curr. Med. Chem. .
    PubMed  |  Direct Link  |  

  30. Biagini, G., M. D'Antuono, R. Benini, P. de Guzman, D. Longo and M. Avoli, 2013. Perirhinal cortex and temporal lobe epilepsy. Front. Cell. Neurosci., Vol., 7 10.3389/fncel.2013.00130.
    CrossRef  |  PubMed  |  Direct Link  |  

  31. Biagini, G., C. Rustichelli, G. Curia, J. Vinet, C. Lucchi, M. Pugnaghi and S. Meletti, 2013. Neurosteroids and epileptogenesis. J. Neuroendocrinol., 25: 980-990.
    CrossRef  |  Direct Link  |  

  32. Biagini, G., C. Rustichelli, G. Curia, J. Vinet, C. Lucchi, M. Pugnaghi and S. Meletti, 2013. Neurosteroids and epileptogenesis. J. Neuroendocrinol .
    PubMed  |  Direct Link  |  

  33. Gualtieri, F., G. Curia, C. Marinelli and G. Biagini, 2012. Increased perivascular laminin predicts damage to astrocytes in CA3 and piriform cortex following chemoconvulsive treatments. Neuroscience, 218: 278-294.
    CrossRef  |  PubMed  |  Direct Link  |  

  34. Biagini, G., C. Marinelli, G. Panuccio, G. Puia and M. Avoli, 2012. Glia-Neuron Interactions: Neurosteroids and Epileptogenesis. In: Jasper’s Basic Mechanisms of the Epilepsies, Noebels, J.L., M. Avoli, M. Rogawski, R. Olsen and A.V. Delgado-Escueta (Eds.)., 4th Edn., Oxford University Press, New York, ISBN: 9780199842599, pp: 635-647.

  35. Gualtieri, F., A. Torsello, C. Marinelli, E. Bresciani, R. Vezzali, V. Locatelli and G. Biagini, 2011. Anticonvulsant effects of desacyl-ghrelin in a model of temporal lobe epilepsy. Boll. Lega It. Epil., 142: 87-91.

  36. Biagini, G., A. Torsello, C. Marinelli, F. Gualtieri and R. Vezzali et al., 2011. Beneficial effects of desacyl-ghrelin, hexarelin and EP-80317 in models of Status epilepticus. Eur. J. Pharmacol., 670: 130-136.
    CrossRef  |  PubMed  |  Direct Link  |  

  37. Benini, R., D. Longo, G. Biagini and M. Avoli, 2011. Perirhinal cortex hyperexcitability in pilocarpine-treated epileptic rats. Hippocampus, 21: 702-713.
    CrossRef  |  PubMed  |  Direct Link  |  

  38. Panuccio, G., M. D'Antuono, P. de Guzman, L. de Lannoy, G. Biagini and M. Avoli, 2010. In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy. Neurobiol. Dis., 39: 372-380.
    CrossRef  |  PubMed  |  Direct Link  |  

  39. Mantegazza, M., G. Curia, G. Biagini, D.S. Ragsdale and M. Avoli, 2010. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol., 9: 413-424.
    CrossRef  |  

  40. D'Antuono, M., R. Kohling, S. Ricalzone, J. Gotman, G. Biagini and M. Avoli, 2010. Antiepileptic drugs abolish ictal but not interictal epileptiform discharges In vitro. Epilepsia, 51: 423-431.
    CrossRef  |  PubMed  |  Direct Link  |  

  41. Bortel, A., M. Levesque, G. Biagini, J. Gotman and M. Avoli, 2010. Convulsive status epilepticus duration as determinant for epileptogenesis and interictal discharge generation in the rat limbic system. Neurobiol. Dis., 40: 478-489.
    CrossRef  |  PubMed  |  Direct Link  |  

  42. Bortel, A., D. Longo, P. de Guzman, F. Dubeau, G. Biagini and M. Avoli, 2010. Selective changes in inhibition as determinants for limited hyperexcitability in the insular cortex of epileptic rats. Eur. J. Neurosci., 31: 2014-2023.
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  43. Biagini, G., G. Panuccio and M. Avoli, 2010. Neurosteroids and epilepsy. Curr. Opin. Neurol., 23: 170-176.
    PubMed  |  Direct Link  |  

  44. Baldelli, E., G. Leo, N. Andreoli, K. Fuxe, G. Biagini and L.F. Agnati, 2010. Homocysteine potentiates seizures and cell loss induced by pilocarpine treatment. Neuromol. Med., 12: 248-259.
    CrossRef  |  PubMed  |  Direct Link  |  

  45. Inaba, Y., M. D'Antuono, G. Bertazzoni, G. Biagini and M. Avoli, 2009. Dysfunctional presynaptic GABAB receptors in the neocortex of a genetic model of absence epilepsy. Neurosignals, 17: 121-131.

  46. Curia, G., G. Biagini, E. Perucca and M. Avoli, 2009. Lacosamide: A new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs, 23: 555-568.
    CrossRef  |  PubMed  |  Direct Link  |  

  47. Biagini, G., D. Longo, E. Baldelli, M. Zoli, M.A. Rogawski, G. Bertazzoni and M. Avoli, 2009. Neurosteroids and epileptogenesis in the pilocarpine model: Evidence for a relationship between P450scc induction and length of the latent period. Epilepsia, 50: 53-58.
    CrossRef  |  PubMed  |  Direct Link  |  

  48. Avoli, M., G. Biagini, L. Uva and M. de Curtis, 2009. Network Interactions in the Limbic System and Epileptiform Synchronization. In: The Encyclopedia of Basic Epilepsy Research, Volume 2, Schwartzkroin, P.A. (Ed.)., Academic Press, San Diego, pp: 830-836.

  49. Avoli, M. and G. Biagini, 2009. Thalamocortical Synchronization and Absence Epilepsy. In: The Encyclopedia of Basic Epilepsy Research, Volume 1, Schwartzkroin, P.A. (Ed.)., Academic Press, San Diego, pp: 28-36.

  50. Longo, D., E. Baldelli, L. Manca, G. Gatti, E. Perucca, M. Avoli and G. Biagini, 2008. Pharmacoresistance and hippocampal sclerosis in a model of temporal lobe epilepsy: Evidence for a relationship with lesion of the CA3 region. Boll. Lega It. Epil., 138-139: 103-106.

  51. De Guzman, P., Y. Inaba, E. Baldelli, M. de Curtis, G. Biagini and M. Avoli, 2008. Network hyperexcitability within the deep layers of the pilocarpine-treated rat entorhinal cortex. J. Physiol., 586: 1867-1883.
    CrossRef  |  PubMed  |  Direct Link  |  

  52. Curia, G., D. Longo, G. Biagini, R.S.G. Jones and M. Avoli, 2008. The pilocarpine model of temporal lobe epilepsy. J. Neurosci. Methods, 172: 143-157.
    CrossRef  |  

  53. Biagini, G., E. Baldelli, D. Longo, M.B. Contri and U. Guerrini et al., 2008. Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. J. Neuropathol. Exp. Neurol., 67: 687-701.
    CrossRef  |  PubMed  |  Direct Link  |  

  54. D'Antuono, M., H. Kawasaki, C. Palmieri, G. Curia, G. Biagini and M. Avoli, 2007. Antiepileptic drugs and muscarinic receptor-dependent excitation in the rat subiculum. Neuropharmacology, 52: 1291-1302.
    CrossRef  |  PubMed  |  Direct Link  |  

  55. Inaba, Y., G. Biagini and M. Avoli, 2006. The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission. Neuropharmacology, 51: 681-691.
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  56. De Guzman, P., Y. Inaba, G. Biagini, E. Baldelli, C. Mollinari, D. Merlo and M. Avoli, 2006. Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy. Hippocampus, 16: 843-860.
    CrossRef  |  PubMed  |  Direct Link  |  

  57. D'Antuono, M., Y. Inaba, G. Biagini, G. D'Arcangelo, V. Tancredi and M. Avoli, 2006. Synaptic hyperexcitability of deep layer neocortical cells in a genetic model of absence seizures. Genes Brain Behav., 5: 73-84.
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  58. Biagini, G., E. Baldelli, D. Longo, L. Pradelli, I. Zini, M.A. Rogawski and M. Avoli, 2006. Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy Exp. Neurol., 201: 519-524.
    CrossRef  |  PubMed  |  Direct Link  |  

  59. Baldelli, E., D. Longo, I. Zini, M. Zoli, M. Avoli and G. Biagini, 2006. Neurosteroids and epileptogenesis: Relation between induction of P450scc enzyme and duration of latency period in the pilocarpine model. Boll. Lega It. Epil., 133-134: 45-47.

  60. Avoli, M., G. Biagini and M. de Curtis, 2006. Do interictal spikes sustain seizures and epileptogenesis? Epilepsy Curr., 6: 203-207.
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  61. Stawowy, P., C. Margeta, F. Blaschke, C. Lindschau and C. Spencer-Hansch et al., 2005. Protein kinase C epsilon mediates angiotensin II-induced activation of beta1-integrins in cardiac fibroblasts. Cardiovasc. Res., 67: 50-59.
    CrossRef  |  PubMed  |  Direct Link  |  

  62. Biagini, G., G. D'Arcangelo, E. Baldelli, M. D'Antuono, V. Tancredi and M. Avoli, 2005. Impaired activation of CA3 pyramidal neurons in the epileptic hippocampus. Neuromol. Med., 7: 325-342.
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  63. Baldelli, E., I. Zini, G. Biagini, G. D’Arcangelo, V. Tancredi, M. D’Antuono and M. Avoli, 2004. Hypoactivity of CA3 pyramidal neurons in the pilocarpine model of mesial temporal lobe epilepsy. Boll. Lega It. Epil., 125-126: 129-131.

  64. Contri, M.B., F. Taparelli, M. Miselli, B. Bacchelli and G. Biagini, 2003. Histomorphometric, biochemical and ultrastructural changes in the aorta of salt-loaded stroke-prone spontaneously hypertensive rats fed a Japanese style diet. Nutr. Metab. Cardiovasc. Dis., 13: 37-45.
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  65. Zanardi, A., G. Leo, G. Biagini and M. Zoli, 2002. Nicotine and neurodegeneration in ageing. Toxicol. Lett., 127: 207-215.
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  66. D'Arcangelo, G., M. D'Antuono, G. Biagini, R. Warren, V. Tancredi and M. Avoli, 2002. Thalamocortical oscillations in a genetic model of absence seizures. Eur. J. Neurosci., 16: 2382-2393.
    CrossRef  |  PubMed  |  Direct Link  |  

  67. D'Antuono, M., R. Benini, G. Biagini, G. D'Arcangelo, M. Barbarosie, V. Tancredi and M. Avoli, 2002. Limbic network interactions leading to hyperexcitability in a model of temporal lobe epilepsy. J. Neurophysiol., 87: 634-639.

  68. Contri, M.B., F. Taparelli, G. Pedrazzi, M. Miselli, B. Bacchelli and G. Biagini, 2002. Dose-dependent prevention of fibrosis in aorta of salt-loaded stroke-prone spontaneously hypertensive rats by combined delapril and indapamide treatment. J. Cardiovasc. Pharmacol., 40: 388-398.
    PubMed  |  Direct Link  |  

  69. Biagini, G. and E.M. Pich, 2002. Corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis. Pharmacol. Biochem. Behav., 73: 95-103.
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  70. Avoli, M., M. D'Antuono, J. Louvel, R. Kohling and G. Biagini et al., 2002. Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system In vitro. Prog. Neurobiol., 68: 167-207.
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  71. D'Antuono, M., G. Biagini, V. Tancredi and M. Avoli, 2001. Electrophysiology of regular firing cells in the rat perirhinal cortex. Hippocampus, 11: 662-672.
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  72. Biagini, G., M. D'Antuono, V. Tancredi, R. Motalli and J. Louvel et al., 2001. Thalamocortical connectivity in a rat brain slice preparation: Participation of the ventrobasal complex to synchronous activities. Thalamus Relat. Syst., 1: 169-179.
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  73. Biagini, G., M. Avoli, J. Marcinkiewicz and M. Marcinkievicz, 2001. Brain-derived neurotrophic factor superinduction parallels anti-epileptic--neuroprotective treatment in the pilocarpine epilepsy model. J. Neurochem., 76: 1814-1822.
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  74. Biagini, G., K. Babinski, M. Marcinkiewicz, M. Avoli and P. Seguela, 2001. Regional and subunit-specific downregulation of acid-sensing ion channels in the pilocarpine model of epilepsy. Neurobiol. Dis., 8: 45-58.
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  75. Tancredi, V., G. Biagini, M. D'Antuono, J. Louvel, R. Pumain and M. Avoli, 2000. Spindle-like thalamocortical synchronization in a rat brain slice preparation. J. Neurophysiol., 84: 1093-1097.
    PubMed  |  Direct Link  |  

  76. Boschi, S., G. Vantaggiato, C. Torri, I. Zini, L.F. Agnati, M. Zoli and G. Biagini, 2000. Protective effects of delapril combined with indapamide or hydrochlorothiazide in spontaneously hypertensive stroke-prone rats: A comparative dose-response analysis. J. Cardiovasc. Pharmacol., 36: 321-328.
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  77. Babinski, K., S. Catarsi, G. Biagini and P. Seguela, 2000. Mammalian ASIC2a and ASIC3 subunits co-assemble into heteromeric proton-gated channels sensitive to Gd3+. J. Biol. Chem., 275: 28519-28525.
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  78. Razzetti, R., S. Bongrani, G. Oberto, R. Ferrari and G. Biagini, 1998. Protective effects of delapril, indapamide and their combination on stroke occurrence and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats. Arzneimittel Forschung, 48: 1083-1087.
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  79. Marzatico, F., L. Bertorelli, O. Pansarasa, P. Guallini, C. Torri, G. Biagini, 1998. Brain oxidative damage following acute immobilization and mild emotional stress. Int. J. Stress Manage., 5: 223-236.
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  80. Biagini, G., E.M. Pich, C. Carani, P. Marrama and L.F. Agnati, 1998. Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field. Int. J. Dev. Neurosci., 16: 187-197.
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  81. Zoli, M., G. Biagini, R. Ferrari, P. Pedrazzi and L.F. Agnati, 1997. Neuron-glia cross talk in rat striatum after transient forebrain ischemia. Adv. Exp. Med. Biol., 429: 55-68.
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  82. Biagini, G., M. Zoli, C. Torri, S. Boschi and G. Vantaggiato et al., 1997. Protective effects of delapril, indapamide and their combination chronically administered to stroke-prone spontaneously hypertensive rats fed a high-sodium diet. Clin. Sci., 93: 401-411.
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  83. Fuxe, K., B. Tinner, M. Zoli, R.F. Pettersson and A. Baird et al., 1996. Computer-assisted mapping of basic fibroblast growth factor immunoreactive nerve cell populations in the rat brain. J. Chem. Neuroanat., 11: 13-35.
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  84. Zoli, M., F. Ferraguti, A. Frasoldati, G. Biagini, L.F. Agnati, 1995. Age-related alterations in tanycytes of the mediobasal hypothalamus of the male rat. Neurobiol. Aging, 16: 77-83.
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  85. Viani, P., I. Zini, G. Cervato, G. Biagini, L.F. Agnati and B. Cestaro, 1995. Effect of endothelin-1 induced ischemia on peroxidative damage and membrane properties in rat striatum synaptosomes. Neurochem. Res., 20: 689-695.
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  86. Kozlov, A.V., G. Biagini, A. Tomasi and I. Zini, 1995. Ex vivo demonstration of nitric oxide in the rat brain: Effects of intrastriatal endothelin-1 injection. Neurosci. Lett., 196: 140-144.
    PubMed  |  Direct Link  |  

  87. Frasoldati, A., M. Zoli, F.F.G. Rommerts, G. Biagini and M.F. Fustini et al., 1995. Temporal changes in sulphated glycoprotein-2 (clusterin) and ornithine decarboxylase mRNA levels in the rat testis after ethane-dimethane sulphonate-induced degeneration of Leydig cells. Int. J. Androl., 18: 46-54.
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  88. Biagini, G., E.M. Pich, A. Frasoldati, L.F. Agnati and P. Marrama, 1995. Changes in glucocorticoid receptor immunoreactivity after adrenalectomy and corticosterone treatment in the rat testis. J. Endocrinol. Invest., 18: 384-390.
    PubMed  |  Direct Link  |  

  89. Biagini, G., D. Sala and I. Zini, 1995. Diethyldithiocarbamate, a superoxide dismutase inhibitor, counteracts the maturation of ischemic-like lesions caused by endothelin-1 intrastriatal injection. Neurosci. Lett., 190: 212-216.
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  90. Fuxe, K., X.M. Li, B. Bjelke, P.B. Hedlund, G. Biagini and L.F. Agnati, 1994. Possible mechanisms for the powerful actions of neuropeptides. Ann. N.Y. Acad. Sci., 739: 42-59.
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  91. Biagini, G., M. Zoli, I. Zini, L. Alboni, A. Frasoldati, E. Valente and L.F. Agnati, 1994. Modulatory Influences on Astroglial Reaction induced by Brain Lesions. In: Recent Advances in the Treatment of Neurodegenerative Disorders and Cognitive Dysfunction, Racagni, C., N. Brunello and S.Z. Langer (Eds.). Karger, Basel, ISBN: 9783805558389, pp: 219-228.

  92. Biagini, G., F. Ferraguti, S. Ponzoni, M. Zoli and L. Alboni et al., 1994. Neurochemical and Behavioural Studies on L-DOPA Toxicity in the Model of Manganese Lesioned Nigrostriatal Pathway in the Rat: Evidence for a Protective Effect of the GM1 Lactone Siagoside. In: Trophic Regulation of the Basal Ganglia, Fuxe, K., L.F. Agnati, B. Bjelke and D. Ottoson (Eds.). Pergamon Press, Oxford, pp: 381-407.

  93. Biagini, G., A. Frasoldati, K. Fuxe and L.F. Agnati, 1994. The concept of astrocyte-kinetic drug in the treatment of neurodegenerative diseases: Evidence for L-deprenyl-induced activation of reactive astrocytes. Neurochem. Int., 25: 17-22.
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  94. Agnati, L.F., P. Cortelli, G. Biagini, B. Bjelke and K. Fuxe, 1994. Different classes of volume transmission signals exist in the central nervous system and are affected by metabolic signals, temperature gradients and pressure waves. Neuroreport, 6: 9-12.
    PubMed  |  Direct Link  |  

  95. Zoli, M., I. Zini, R. Grimaldi, G. Biagini and L.F. Agnati, 1993. Effects of polyamine synthesis blockade on neuronal loss and astroglial reaction after transient forebrain ischemia. Int. J. Dev. Neurosci., 11: 175-187.
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  96. Zoli, M., E.M. Pich, F. Ferraguti, G. Biagini, K. Fuxe and L.F. Agnati, 1993. Indole-pyruvic acid treatment reduces damage in striatum but not in hippocampus after transient forebrain ischemia in the rat. Neurochem. Int., 23: 139-148.
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  97. Biagini, G., M. Zoli, K. Fuxe and L.F. Agnati, 1993. L-deprenyl increases GFAP immunoreactivity selectively in activated astrocytes in rat brain. Neuroreport, 4: 955-958.
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  98. Biagini, G., E.M. Pich, C. Carani, P. Marrama, J.A. Gustafsson, K. Fuxe and L.F. Agnati, 1993. Indole-pyruvic acid, a tryptophan ketoanalogue, antagonizes the endocrine but not the behavioral effects of repeated stress in a model of depression. Biol. Psychiatry, 33: 712-719.
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  99. Agnati, L.F., M. Zoli, G. Biagini, B. Bjelke, K. Fuxe and F. Benfenati, 1993. Neurophysiological aspects of pain. Anaesthetic Pharmacol. Rev., 1: 101-113.

  100. Pich, E.M., R. Grimaldi, M. Zoli, G. Biagini and V. Solfrini et al., 1992. Siagoside selectively attenuates morphological and functional striatal impairments induced by transient forebrain ischemia in rats. Stroke, 23: 234-241.
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  101. Pich, E.M., B. Messori, M. Zoli, F. Ferraguti and P. Marrama et al., 1992. Feeding and drinking responses to neuropeptide Y injections in the paraventricular hypothalamic nucleus of aged rats. Brain Res., 575: 265-271.
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  102. Fuxe, K., L.F. Agnati, P. Hedlund, S.O. Ogren, F. Bortolotti, C. Carani and G. Biagini, 1992. Failure of Integrative Mechanisms in the Aging Brain. In: Treatment of Age-Related Cognitive Dysfunction: Pharmacological and Clinical Evaluation, Racagni, G. and J. Mendlewicz (Eds.)., Karger, Basel, ISBN: 9783805555517, pp: 1-18.

  103. Cocilovo, L., V.G. Colonna, M. Zoli, G. Biagini, B.P. Settembrini, E.E. Muller and D. Cocchi, 1992. Central mechanisms subserving the impaired growth hormone secretion induced by persistent blockade of NMDA receptors in immature male rats. Neuroendocrinology, 55: 416-421.
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  104. Biagini, G. and V. Solfrini, 1992. "Manganism" in experimental animals and its enhancement by L-DOPA treatment. Neurosci. Facts, 3: 91-92.

  105. Agnati, L.F., M. Zoli, G. Biagini, F. Benfenati, G. Toffano and K. Fuxe, 1992. Involvement of Gangliosides in Neuroplasticity of the Central Nervous System in Physiological and Pathological Conditions. In: Current Aspects of the Neurosciences, Osborne N.N. (Ed.)., Palgrave, London, ISBN: 978-1-349-12275-2, pp: 33-86.

  106. Agnati, L.F., M. Zoli, G. Biagini and K. Fuxe, 1992. Neuronal plasticity and ageing processes in the frame of the 'Red Queen Theory'. Acta Physiol. Scand., 145: 301-309.
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  107. Agnati, L.F., F. Benfenati, V. Solfrini, G. Biagini and K. Fuxe et al., 1992. Brain aging and neuronal plasticity. Ann. N.Y. Acad. Sci., 673: 180-186.

  108. Agnati, L.F., A. Cintra, G. Biagini, M. Zoli and P. Marrama et al., 1992. Central Glucocorticoid Receptors, Dopamine and their Involvement in Stress Responses in Postnatal Rats. In: Stress: Neuroendocrine and Molecular Approaches, Kvetnansky, R. (Ed.)., Gordon and Breach Science Publisher, New York, ISBN: 9782881245060, pp: 751-763.

  109. Zoli, M., F. Ferraguti, G. Biagini, A. Cintra, K. Fuxe and L.F. Agnati, 1991. Corticosterone treatment counteracts lesions induced by neonatal treatment with monosodium glutamate in the mediobasal hypothalamus of the male rat. Neurosci. Lett., 132: 225-228.
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  110. Pich, E.M., G. Biagini, M. Vecchi, C. Carani and M.F Fustini et al., 1991. Perinatal Stress and Puberty: Preliminary Results on the Effects of Neonatal Corticosterone Treatment on Pubertal Development and Glucocorticoid Receptor Levels in the Testis of the Rat. In: Andrology in Latin Countries, Isidori, A., L. di Luigi and G. D'Ottavio (Eds.). Ares-Serono Symposia, Rome, pp: 303-310.

  111. Pich, E.M., G. Biagini, L.F. Agnati and P. Marrama, 1991. Evidence that Neonatal Corticosterone Administration Advances Puberty and Increases Glucocorticoid Receptor Levels in the Testis of the Male Rat. In: Stress and Related Disorders from Adaptation to Dysfunction, Genazzani, A.R., G. Nappi, F. Petraglia and E. Martignoni (Eds.)., Parthenon Publication, Carnforth, ISBN: 9781850703587, pp: 353-361.

  112. Fuxe, K., L.F. Agnati, M. Zoli, G. Biagini, A. Cintra and P. Eneroth, 1991. Regulatory Peptides in the Neuroendocrine System. Aspects of the Communicational and Computational Processes in Peptidergic Neurons and their Steroidal Regulation. In: Brain Endocrinology, Motta M. (Ed.)., 2nd Edn., Raven Press, New York, ISBN: 9780881677683, pp: 31-69.

  113. Carani, C., E.M. Pich, A.R.M. Granata, M. Vecchi and C. Garau et al., 1991. Environmental Perturbances and Andrological Diseases: Stress, Sexual Behaviour and Reproductive Function. In: Andrologia, Pisani, E. and E. Austoni (Eds.). Monduzzi, Bologna, pp: 637-640.

  114. Biagini, G., M. Zoli, E.M. Pich, P. Marrama and L.F. Agnati, 1991. Different Stressful Neonatal Treatments Modulate Glucocorticoid Receptor Immunoreactivity in the Hippocampal CA1 Region and Affect Exploratory Behavior in the Adult Rat. In: Stress and Related Disorders from Adaptation to Dysfunction, Genazzani, A.R., G. Nappi, F. Petraglia and E. Martignoni (Eds.)., Parthenon Publication, Carnforth, ISBN: 9781850703587, pp: 139-149.

  115. Agnati, L.F., M. Zoli, M. Kurosawa, F. Benfenati and G. Biagini et al., 1991. A new model of focal brain ischemia based on the intracerebral injection of endothelin-I. Ital. J. Neurol. Sci., 2: 49-53.
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  116. Agnati, L.F., M. Tiengo, F. Ferraguti, G. Biagini and F. Benfenati et al., 1991. Pain, analgesia and stress: An integrated view. Clin. J. Pain, 1: S23-S37.
    PubMed  |  Direct Link  |  

  117. Zoli, M., L.F. Agnati, K. Fuxe, F. Ferraguti, G. Biagini, A. Cintra and J.A. Gustafsson, 1990. Long-lasting reduction of glucocorticoid receptor immunoreactivity in the hippocampal field CA1 but not in the dentate gyrus after neonatal treatment with corticosterone in the rat Acta Physiol. Scand., 138: 577-579.
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  118. Zini, I., M. Zoli, R. Grimaldi, E.M. Pich, G. Biagini, K. Fuxe and L.F. Agnati, 1990. Evidence for a role of neosynthetized putrescine in the increase of glial fibrillary acid protein immunoreactivity induced by a mechanical lesion in the rat brain. Neurosci. Lett., 120: 13-16.

  119. Pich, E.M., V. Solfrini, G. Biagini, K. Fuxe and L.F. Agnati, 1990. Effects of indole-pyruvic acid on sleep and food intake in the rat. Acta Physiol. Scand., 139: 583-589.
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  120. Grimaldi, R., I. Zini, G. Biagini, G. Toffano and L.F. Agnati et al., 1990. Effects of centrally administered clonidine and neuropeptide Y on arterial blood pressure in the rat after transient forebrain ischemia. J. Auton. Nerv. Syst., 30: S67-S70.
    PubMed  |  Direct Link  |  

  121. Biagini, G., E.M. Pich, P. Marrama, K. Fuxe, L.F. Agnati and J.A. Gustafsson, 1990. Evidence for Different Types of Glucocorticoid Receptor Immunoreactive Cell Populations in the Rat Testis with Differential Sensitivity to Neonatal Corticosterone Treatment. In: Hormonal Communicating Events in the Testis, Isidori, A., A. Fabbri and M.L. Dufau (Eds.). Raven Press, New York, ISBN: 9780881676495, pp: 127-136.

  122. Biagini, G. and L.F. Agnati, 1990. Analgesia enocicezione. Doctor, 6: 43-47.

  123. Grimaldi, R., I. Zini, M. Zoli, G. Biagini, M. Goldstein, K. Fuxe and L.F. Agnati, 1989. Related Responses between Dopamine Synapses and Astrocytes in the Rat Striatum after Global Cerebral Ischemia: A Morphometric and Microdensitometric Study. In: Cerebral Ischemia and Calcium, Hartmann, A. and W. Kuschinsky (Eds.)., Springer-Verlag, Berlin, ISBN: 978-3-642-85863-5, pp: 105-110.