Dr. Mark Bryden Cannell
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Dr. Mark Bryden Cannell

Professor
University of Bristol, United Kingdom

Highest Degree
Ph.D. in Physiology from University College London, London, UK

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Biography

Dr. Mark Bryden Cannell is currently working as Professor of Cardiac Cell Biology, University of Bristol. He has completed his Ph.D. in Physiology from University College London, London, UK. Previously he was appointed as Post Doctoral Fellow at American Heart Association, Research Associate, University of Maryland, Assistant Professor, University of Miami, Senior Lecturer, Reader and Professor at St. George’s Hospital Medical School, and Head and Professor at University of Auckland. He has 166 publications in journals, conferences and book chapters contributed as author/co-author. He also received number of research grants and successfully completed several research projects. He also delivered number of invited lectures at seminars and scientific meeting. He successfully supervised several PhD, MSc and undergraduate students in his active supervision. He is also serving as reviewer for journals.

Area of Interest:

Biomedical Sciences
100%
Physiology
62%
Cardiology
90%
Biophysics
75%
Diabetes
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Ju, Y.K., B.H. Lee, S. Trajanovska, G. Hao, D.G. Allen, M. Lei and M.B. Cannell, 2015. The involvement of TRPC3 channels in sinoatrial arrhythmias. Frontiers Physiol., Vol. 6. 10.3389/fphys.2015.00086.
    CrossRef  |  Direct Link  |  
  2. Crossman, D.J., A.A. Young, P.N. Ruygrok, G.P. Nason, D. Baddelely, C. Soeller and M.B. Cannell, 2015. T-tubule disease: Relationship between t-tubule organization and regional contractile performance in human dilated cardiomyopathy. J. Mol. Cell. Cardiol., 84: 170-178.
    CrossRef  |  Direct Link  |  
  3. Chen‐Izu, Y., R.M. Shaw, G.S. Pitt, V. Yarov‐Yarovoy and J.T. Sack et al., 2015. Na+ channel function, regulation, structure, trafficking and sequestration. J. Physiol., 593: 1347-1360.
    CrossRef  |  Direct Link  |  
  4. Shang, W., F. Lu, T. Sun, J. Xu and L.L. Li et al., 2014. Imaging Ca2+ nanosparks in heart with a new targeted biosensor. Circulation Res., 114: 412-420.
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  5. Zhang, L., M.L. Ward, A.R. Phillips, S. Zhang and J. Kennedy et al., 2013. Protection of the heart by treatment with a divalent-copper-selective chelator reveals a novel mechanism underlying cardiomyopathy in diabetic rats. Cardiovasc Diabetol, Vol. 12. .
    Direct Link  |  
  6. Shen, X., M.B. Cannell and M.L. Ward, 2013. Effect of SR load and pH regulatory mechanisms on stretch-dependent Ca2+ entry during the slow force response. J. Mol. Cell. Cardiol., 63: 37-46.
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  7. Laver, D.R., C.H.T. Kong, M.S. Imtiaz and M.B. Cannell, 2013. Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture. J. Mol. Cell. Cardiol., 54: 98-100.
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  8. Kumar, V., T. Kleffmann, M.B. Hampton, M.B. Cannell and C.C. Winterbourn, 2013. Redox proteomics of thiol proteins in mouse heart during ischemia/reperfusion using ICAT reagents and mass spectrometry. Free Radical Biol. Med., 58: 109-117.
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  9. Kong, C.H., D.R. Laver and M.B. Cannell, 2013. Extraction of sub-microscopic Ca fluxes from blurred and noisy fluorescent indicator images with a detailed model fitting approach. PLoS Comput. Biol., Vol. 9. 10.1371/journal.pcbi.1002931.
    CrossRef  |  
  10. Cannell, M.B., C.H.T. Kong, M.S. Imtiaz and D.R. Laver, 2013. Control of sarcoplasmic reticulum Ca2+ release by stochastic RyR gating within a 3D model of the cardiac dyad and importance of induction decay for CICR termination. Biophys. J., 104: 2149-2159.
    CrossRef  |  Direct Link  |  
  11. Ju, Y.K., E.A. Woodcock, D.G. Allen and M.B. Cannell, 2012. Inositol 1, 4, 5-trisphosphate receptors and pacemaker rhythms. J. Mol. Cell. Cardiol., 53: 375-381.
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  12. Jayasinghe, I.D., D.J. Crossman, C. Soeller and M.B. Cannell, 2012. Comparison of the organization of t‐tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium. Clin. Exp. Pharmacol. Physiol., 39: 469-476.
    CrossRef  |  Direct Link  |  
  13. Jayasinghe, I.D., D. Baddeley, C.H. Kong, X.H. Wehrens, M.B. Cannell and C. Soeller, 2012. Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys. J., 102: L19-L21.
    CrossRef  |  Direct Link  |  
  14. Cannell, M.B. and C.H.T. Kong, 2012. Local control in cardiac excitation-contraction coupling. J. Mol. Cell. Cardiol., 52: 298-303.
  15. Ward, M.L., D.J. Crossman and M.B. Cannell, 2011. Mechanisms of reduced contractility in an animal model of hypertensive heart failure. Clin. Exp. Pharmacol. Physiol., 38: 711-716.
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  16. Ju, Y.K., J. Liu, B.H. Lee, D. Lai and E.A. Woodcock et al., 2011. Distribution and functional role of inositol 1,4,5-trisphosphate receptors in mouse sinoatrial node. Circulation Res., 109: 848-857.
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  17. Jayasinghe, I.D., D.J. Crossman, C. Soeller and M.B. Cannell, 2011. Comparison of the organization of t-tubules, sarcoplasmic reticulum and ryanodine receptors in rat and human ventricular myocardium. Proc. Aust. Physiol. Soc., 42: 57-63.
  18. Crossman, D.J., P.N. Ruygrok, C. Soeller and M.B. Cannell, 2011. Changes in the organization of excitation-contraction coupling structures in failing human heart. PloS One, Vol. 6. 10.1371/journal.pone.0017901.
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  19. Baddeley, D., M.B. Cannell and C. Soeller, 2011. Three-dimensional sub-100 nm super-resolution imaging of biological samples using a phase ramp in the objective pupil. Nano Res., 4: 589-598.
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  20. Baddeley, D., D. Crossman, S. Rossberger, J.E. Cheyne and J.M. Montgomery et al., 2011. 4D super-resolution microscopy with conventional fluorophores and single wavelength excitation in optically thick cells and tissues. PloS One, Vol. 6. 10.1371/journal.pone.0020645.
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  21. Ward, M.L., D.J. Crossman, D.S. Loiselle and M.B. Cannell, 2010. Non-steady-state calcium handling in failing hearts from the spontaneously hypertensive rat. Pflugers Archiv-Eur. J. Physiol., 460: 991-1001.
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  22. Li, P., W. Wei, X. Cai, C. Soeller, M.B. Cannell and A.V. Holden, 2010. Computational modelling of the initiation and development of spontaneous intracellular Ca2+ waves in ventricular myocytes. Philosophical Trans. R. Soc. London A: Math. Phys. Eng. Sci., 368: 3953-3965.
  23. Kim, N., M.B. Cannell and P.J. Hunter, 2010. Changes in the calcium current among different transmural regions contributes to action potential heterogeneity in rat heart. Prog. Biophys. Mol. Biol., 103: 28-34.
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  24. Jayasinghe, I.D., D.J. Crossman, C. Soeller and M.B. Cannell, 2010. A new twist in cardiac muscle: dislocated and helicoid arrangements of myofibrillar z-disks in mammalian ventricular myocytes. J. Mol. Cell. Cardiol., 210: 964-971.
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  25. Cooper, P.J., C. Soeller and M.B. Cannell, 2010. Excitation-contraction coupling in human heart failure examined by action potential clamp in rat cardiac myocytes. J. Mol. Cell. Cardiol., 49: 911-917.
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  26. Baddeley, D., M.B. Cannell and C. Soeller, 2010. Visualization of localization microscopy data. Microsc. Microanal., 16: 64-72.
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  27. Soeller, C., I.D. Jayasinghe, P. Li, A.V. Holden and M.B. Cannell, 2009. 3D high resolution imaging of cardiac proteins to construct models of intracellular Ca2+ signaling. Exp. Physiol., 94: 496-508.
  28. Li, P., W. Wei, X. Cai, C. Soeller, M.B. Cannell and V. Holden, 2009. Evolution of Calcium Waves from about 10,000 RyR Clusters: Towards Solving a Computationally Daunting Task. In: Fuctional Imaging and Modelling of the Heart, Ayche, N., H. Delingette and M. Seermesant (Eds.). Springer, Berlin, pp: 11-20.
  29. Kumar, V., N. Kitaeff, M.B. Hampton, M.B. Cannell and C.C. Winterbourn, 2009. Reversible oxidation of mitochondrial peroxiredoxin 3 in mouse heart subjected to ischemia and reperfusion. FEBS Lett., 583: 997-1000.
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  30. Jayasinghe, I.D., M.B. Cannell and C. Soeller, 2009. Organization of ryanodine receptors, transverse tubules and sodium-calcium exchanger in rat myocytes. Biophys. J., 97: 2664-2673.
    CrossRef  |  Direct Link  |  
  31. Cannell, M.B., 2009. Pulling on the heart strings a new mechanism within starling's law of the heart? Circulation Res., 104: 715-716.
    CrossRef  |  Direct Link  |  
  32. Baddeley, D., I.D. Jayasinghe, L. Lam, S. Rossberger, M.B. Cannell and C. Soeller, 2009. Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes. Proc. Natl. Acad. Sci., 106: 22275-22280.
    CrossRef  |  Direct Link  |  
  33. Baddeley, D., I.D. Jayasinghe, C. Cremer, M.B. Cannell and C. Soeller, 2009. Light-induced dark states of organic fluochromes enable 30 nm resolution imaging in standard media. Biophys. J., 96: L22-L24.
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  34. Zhang, L., M.B. Cannell, A.R. Phillips, G.J. Cooper and M.L. Ward, 2008. Altered calcium homeostasis does not explain the contractile deficit of diabetic cardiomyopathy. Diabetes, 57: 2158-2166.
    CrossRef  |  Direct Link  |  
  35. Sobie, E.A., M.B. Cannell and J.H. Bridge, 2008. Allosteric activation of Na+-Ca2+ exchange by L-type Ca2+ current augments the trigger flux for SR Ca2+ release in ventricular myocytes. Biophys. J., 94: L54-L56.
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  36. Savio-Galimberti, E., J. Frank, M. Inoue, J.I. Goldhaber, M.B. Cannell, J.H. Bridge and F.B. Sachse, 2008. Novel features of the rabbit transverse tubular system revealed by quantitative analysis of three-dimensional reconstructions from confocal images. Biophys. J., 95: 2053-2062.
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  37. Morton-Jones, R.T., M.B. Cannell and G.D. Housley, 2008. Ca2+ entry via AMPA-type glutamate receptors triggers Ca2+-induced Ca2+ release from ryanodine receptors in rat spiral ganglion neurons. Cell Calcium, 43: 356-366.
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  38. Kong, C.H., C. Soeller and M.B. Cannell, 2008. Increasing sensitivity of Ca2+ spark detection in noisy images by application of a matched-filter object detection algorithm. Biophys. J., 95: 6016-6024.
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  39. Soeller, C., D. Crossman, R. Gilbert and M.B. Cannell, 2007. Analysis of ryanodine receptor clusters in rat and human cardiac myocytes. Proc. Natl. Acad. Sci., 104: 14958-14963.
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  40. Raybould, N.P., D.J. Jagger, R. Kanjhan, D. Greenwood and P. Laslo et al., 2007. TRPC‐like conductance mediates restoration of intracellular Ca2+ in cochlear outer hair cells in the guinea pig and rat. J. Physiol., 579: 101-113.
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  41. Ju, Y.K., Y. Chu, H. Chaulet, D. Lai and O.L. Gervasio et al., 2007. Store-operated Ca2+ influx and expression of TRPC genes in mouse sinoatrial node. Circulation Res., 100: 1605-1614.
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  42. Higgins, E.R., P. Goel, J.L. Puglisi, D.M. Bers, M. Cannell and J. Sneyd, 2007. Modelling calcium microdomains using homogenisation. J. Theoret. Biol., 247: 623-644.
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  43. Travas-Sejdic, J., H. Peng, R.P. Cooney, G.A. Bowmaker, M.B. Cannell and C. Soeller, 2006. Amplification of a conducting polymer-based DNA sensor signal by CdS nanoparticles. Curr. Applied Phys., 6: 562-566.
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  44. Peng, H., C. Soeller, M.B. Cannell, G.A. Bowmaker, R.P. Cooney and J. Travas-Sejdic, 2006. Electrochemical detection of DNA hybridization amplified by nanoparticles. Biosensors Bioelectron., 21: 1727-1736.
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  45. Morton-Jones, R.T., M.B. Cannell, L.H. Jeyakumar, S. Fleischer and G.D. Housley, 2006. Differential expression of ryanodine receptors in the rat cochlea. Neuroscience, 137: 275-286.
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  46. Higgins, E.R., M.B. Cannell and J. Sneyd, 2006. A buffering SERCA pump in models of calcium dynamics. Biophys. J., 91: 151-163.
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  47. Chen-Izu, Y., S.L. McCulle, C.W. Ward, C. Soeller and B.M. Allen et al., 2006. Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys. J., 91: 1-13.
  48. Cannell, M.B., D.J. Crossman and C. Soeller, 2006. Effect of changes in action potential spike configuration, junctional sarcoplasmic reticulum micro-architecture and altered t-tubule structure in human heart failure. J. Muscle Res. Cell Motility, 27: 297-306.
    CrossRef  |  Direct Link  |  
  49. Cannell, M.B., A.J. McMorland and C. Soeller, 2006. Microscopic Image Enhancement by Deconvolution. In: Handbook of Biological Confocal Microscopy, Pawley, J. (Ed.). 3rd Edn., Springer, Berlin, Germany, pp: 488-500.
  50. Cannell, M.B., A. McMorland and C. Soeller, 2006. Practical Tips for 2-Photon Microscopy. In: Handbook of Biological Confocal Microscopy, Pawley, J. (Ed.). 3rd Edn., Springer, Berlin, Germany, pp: 900-905.
  51. Cannell, M.B. and S.H. Cody, 2006. Ion Measurement by Fluorescent Indicators. In: Handbook of Biological Confocal Microscopy, Pawley, J. (Ed.). 3rd Edn., Springer, Berlin, Germany, pp: 736-745.
  52. Travas-Sejdic, J., H. Peng, P.A. Kilmaitin, M.B. Cannell, G.A. Bowmaker, R.P. Cooney and C. Soeller, 2005. DNA sensor based on functionalized polypyrrole. Synthetic Metals, 152: 37-40.
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  53. Peng, H., C. Soeller, N. Vigar, P.A. Kilmartin and M.B. Cannell et al., 2005. Label-free electrochemical DNA sensor based on functionalised conducting copolymer. Biosensors Bioelectron., 20: 1821-1828.
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  54. Cannell, M.B., M.D. Jacobs, P.J. Donaldson and C. Soeller, 2005. Application of two-photon flash photolysis to measure microscopic diffusion and calcium fluxes. Proc. SPIE, 5714: 116-125.
  55. Cannell, M.B., A.J.C. McMorland and C. Soeller, 2005. Imaging Microscopic Calcium Signals in Excitable Cells. In: Imaging in Neuroscience and Development: A Laboratory Manual,Yuste, R. and A. Konnerth (Eds.). Chapter 36, Cold Spring Harbour Press, New York, USA., pp: 299-306.
  56. Soeller, C. and M.B. Cannell, 2004. Analysing cardiac excitation-contraction coupling with mathematical models of local control. Prog. Biophys. Mol. Biol., 85: 141-162.
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  57. Jacobs, M.D., C. Soeller, A.M. Sisley, M.B. Cannell and P.J. Donaldson, 2004. Gap junction processing and redistribution revealed by quantitative optical measurements of connexin46 epitopes in the lens. Invest. Ophthalmol. Visual Sci., 45: 191-199.
  58. Hanley, P.J., H.E. Ter Keurs and M.B. Cannell, 2004. Excitation-contraction coupling in the heart and the negative inotropic action of volatile anesthetics. Anesthesiology, 101: 999-1014.
  59. Cannell, M.B., M.D. Jacobs, P.J. Donaldson and C. Soeller, 2004. Probing microscopic diffusion by 2-photon flash photolysis: measurement of isotropic and anisotropic diffusion in lens fiber cells. Microscopy Res. Tech., 63: 50-57.
  60. Cannell, M.B., 2004. Functional imaging: Gaining new insight from biophotonic imaging. Clin. Exp. Pharmacol. Physiol., 31: 883-884.
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  61. Zhang, H., D. Noble, M. Cannell, C.H. Orchard and M. Lancaster et al., 2003. Dynamics of cardiac intracellular Ca2+ handling-from experiments to virtual cells. Int. J. Bifurcation Chaos, 13: 3535-3560.
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  62. Ward, M.L., A.J. Pope, D.S. Loiselle and M.B. Cannell, 2003. Reduced contraction strength with increased intracellular [Ca2+] in left ventricular trabeculae from failing rat hearts. J. Physiol., 546: 537-550.
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  63. Wang, J.C.C., N.P. Raybould, L. Luo, A.F. Ryan, M.B. Cannell, P.R. Thorne and G.D. Housley, 2003. Noise induces up-regulation of P2X2 receptor subunit of ATP-gated ion channels in the rat cochlea. Neuroreport, 14: 817-823.
    Direct Link  |  
  64. Soeller, C., M.D. Jacobs, P.J. Donaldson, M.B. Cannell, K.T. Jones and G.C.R. Ellis-Davies, 2003. Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements. J. Biomed. Optics, 8: 418-427.
  65. Jacobs, M.D., P.J. Donaldson, M.B. Cannell and C. Soeller, 2003. Resolving morphology and antibody labeling over large distances in tissue sections. Microsc. Res. Tech., 62: 83-91.
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  66. Soeller, C. and M.B. Cannell, 2002. Estimation of the Sarcoplasmic Reticulum Ca2+ release fluxunderlying Ca2+ sparks. Biophys. J., 82: 2396-2414.
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  67. Cannell, M.B. and C. Soeller, 2002. A mode of thought in E-C coupling. Biophys. J., 83: 1-2.
  68. Wan, H., H.L. Winton, C. Soeller, G.W. Taylor and D.C. Gruenert et al., 2001. The transmembrane protein occludin of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clin. Exp. Allergy, 31: 279-294.
  69. Jacobs, M.D., C. Soeller, M.B. Cannell and P.J. Donaldson, 2001. Quantifying changes in gap junction structure as a function of lens fiber cell differentiation. Cell Commun. Adhesion, 8: 349-353.
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  70. Cordeiro, J.M., K.W. Spitzer, W.R. Giles, P.E. Ershler, M.B. Cannell and J.H.B. Bridge, 2001. Location of the initiation site of calcium transients and sparks in rabbit heart Purkinje cells. J. Physiol., 531: 301-314.
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  71. Wan, H., H.L. Winton, C. Soeller, G.A. Stewart and P.J. Thompson et al., 2000. Tight junction properties of the immortalized human bronchial epithelial cell lines Calu-3 and 16HBE14o. Eur. Respirat. J., 15: 1058-1068.
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  72. Wan, H., H.L. Winton, C. Soeller, D.C. Gruenert and P.J. Thompson et al., 2000. Quantitative structural and biochemical analyses of tight junction dynamics following exposure of epithelial cells to house dust mite allergen Der p 1. Clin. Exp. Allergy, 30: 685-698.
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  73. Hollingworth, S., C. Soeller, S.M. Baylor and M.B. Cannell, 2000. Sarcomeric Ca2+ gradients during activation of frog skeletal muscle fibres imaged with confocal and two‐photon microscopy. J. Physiol., 526: 551-560.
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  74. Wan, H., H.L. Winton, C. Soeller, E.R. Tovey and D.C. Gruenert et al., 1999. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J. Clin. Invest., 104: 123-133.
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  75. Soeller, C. and M.B. Cannell, 1999. Examination of the transverse tubular system in living cardiac rat myocytes by 2-photon microscopy and digital image-processing techniques. Circulat. Res., 84: 266-275.
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  76. Soeller, C. and M.B. Cannell, 1999. Two-photon microscopy: Imaging in scattering samples and three-dimensionally resolved flash photolysis. Microsc. Res. Techn., 47: 182-195.
  77. Housley, G.D., R. Kanjhan, N.P. Raybould, D. Greenwood and S.G. Salih et al., 1999. Expression of the P2X2 receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission. J. Neurosci., 19: 8377-8388.
    Direct Link  |  
  78. Cannell, M.B. and C. Soeller, 1999. Mechanisms underlying calcium sparks in cardiac muscle. J. Gen. Physiol., 113: 373-376.
  79. Bridge, J.H., P.R. Ershler and M.B. Cannell, 1999. Properties of Ca2+ sparks evoked by action potentials in mouse ventricular myocytes. J. Physiol., 518: 469-478.
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  80. Winton, H.L., H. Wan, M.B. Cannell, P.J. Thompson and D.R. Garrod et al., 1998. Class specific inhibition of house dust mite proteinases which cleave cell adhesion, induce cell death and which increase the permeability of lung epithelium. Br. J. Pharmacol., 124: 1048-1059.
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  81. Thompson, J., 1998. Cell lines of pulmonary and non‐pulmonary origin as tools to study the effects of house dust mite proteinases on the regulation of epithelial permeability. Clin. Exp. Allergy, 28: 1273-1285.
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  82. McSheehy, P.M., S.P. Robinson, A.S. Ojugo, E.O. Aboagye and M.B. Cannell et al., 1998. Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: A magnetic resonance study in vivo. Cancer Res., 58: 1185-1194.
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  83. Jones, K.T., C. Soeller and M.B. Cannell, 1998. The passage of Ca2+ and fluorescent markers between the sperm and egg after fusion in the mouse. Development, 125: 4627-4635.
  84. Gordienko, D.V., T.B. Bolton and M.B. Cannell, 1998. Variability in spontaneous subcellular calcium release in guinea‐pig ileum smooth muscle cells. J. Physiol., 507: 707-720.
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  85. Cannell, M.B. and C. Soeller, 1998. Sparks of interest in cardiac excitation-contraction coupling. Trends Pharmacol. Sci., 19: 16-20.
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  86. Soeller, C. and M.B. Cannell, 1997. Numerical simulation of local calcium movements during L-type calcium channel gating in the cardiac diad. Biophys. J., 73: 97-111.
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  87. Main, M.J., C.J. Grantham and M.B. Cannell, 1997. Changes in subsarcolemmal sodium concentration measured by Na-Ca exchanger activity during Na-pump inhibition and β-adrenergic stimulation in guinea-pig ventricular myocytes. Pflugers Archiv, 435: 112-118.
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  88. Gomez, A.M., H.H. Valdivia, H. Cheng, M.R. Lederer and L.F. Santana et al., 1997. Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failure. Science, 276: 800-806.
  89. Evans, A.M. and M.B. Cannell, 1997. The role of L-type Ca2+ current and Na+ current-stimulated Na/Ca exchange in triggering SR calcium release in guinea-pig cardiac ventricular myocytes. Cardiovasc. Res., 35: 294-302.
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  90. Cannell, M.B., 1997. New insights into cardiac excitation-contraction coupling in normal and hypertension/failure animal models. J. Hum. Hyperten., 11: 555-558.
  91. Cannell, M.B. and C. Soeller, 1997. Optical sectioning in fluorescence microscopy by confocal and 2-photon imaging techniques. Microsc. Today, 5: 12-15.
  92. Cannell, M.B. and C. Soeller, 1997. Numerical analysis of ryanodine receptor activation by L-type channel activity in the cardiac muscle diad. Biophys. J., 73: 112-122.
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  93. Cannell, M.B. and C. Soeller, 1997. High resolution imaging using confocal and 2-photon molecular excitation microscopy. Proc. R. Microsc. Soc., 32: 3-8.
  94. Soeller, C. and M.B. Cannell, 1996. Construction of a two-photon microscope and optimisation of illumination pulse duration. Pflugers Archiv, 432: 555-561.
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  95. Santana, L.F., H. Cheng, A.M. Gomez, M.B. Cannell and W.J. Lederer, 1996. Relation between the sarcolemmal Ca2+ current and Ca2+ sparks and local control theories for cardiac excitation-contraction coupling. Circulation Res., 78: 166-171.
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  96. Lederer, W.J., S. He, S. Luo, W. DuBell and P. Kofuji et al., 1996. The molecular biology of the Na+‐Ca2+ exchanger and its functional roles in heart, smooth muscle cells, neurons, glia, lymphocytes and nonexcitable cellsa. Ann. N. Y. Acad. Sci., 779: 7-17.
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  97. Grantham, C.J. and M.B. Cannell, 1996. Ca2+ influx during the cardiac action potential in guinea pig ventricular myocytes. Circulation Res., 79: 194-200.
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  98. Cheng, H., M.R. Lederer, W.J. Lederer and M.B. Cannell, 1996. Calcium sparks and [Ca2+] i waves in cardiac myocytes. Am. J. Physiol. Cell Physiol., 270: C148-C159.
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  99. Nichols, C.G., M.B. Cannell and A.N. Lopatin, 1995. Cell-Free Ion-Channel Recording. In: Neuromethods Vol. 26: Patch Clamp Applications and Protocols, Boulton, A., G. Baker and W. Walz (Eds.). Humana Press, New York, USA., pp: 89-121.
  100. Cheng, H., W.J. Lederer and M.B. Cannell, 1995. Partial inhibition of calcium current by D600 reveals spatial non-uniformities in [Ca2+]i during excitation-contraction coupling in cardiac myocytes. Circulation Res., 76: 236-241.
  101. Cannell, M.B., H. Cheng and W.J. Lederer, 1995. The control of calcium release in heart muscle. Science, 268: 1045-1049.
  102. Grantham, C.J., M.J. Main and M.B. Cannell, 1994. Fluspirilene block of N‐type calcium current in NGF‐differentiated PC 12 cells. Br. J. Pharmacol., 111: 483-488.
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  103. Cheng, H., M.B. Cannell and W.J. Lederer, 1994. Propagation of excitation-contraction coupling into ventricular myocytes. Pflugers Archiv, 428: 415-417.
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  104. Cannell, M.B., H. Cheng and W.J. Lederer, 1994. Spatial non-uniformities in [Ca2+] i during excitation-contraction coupling in cardiac myocytes. Biophys. J., 67: 1942-1956.
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  105. Cannell, M.B. and M.V. Thomas, 1994. Intracellular Ion Measurement with Fluorescent Indicators. In: Microelectrode Techniques, Ogden, D. (Ed.). The Company of Biologists, Cambridge, UK., pp: 317-346.
  106. Cheng, H., W.J. Lederer and M.B. Cannell, 1993. Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscle. Science, 262: 740-744.
  107. Laskey, R.E., D.J. Adams, M. Cannell and C. van Breemen, 1992. Calcium entry-dependent oscillations of cytoplasmic calcium concentration in cultured endothelial cell monolayers. Proc. Natl Acad. Sci., 89: 1690-1694.
  108. Chen, Q., M. Cannell and C.V. Breemen, 1992. The superficial buffer barrier in vascular smooth muscle. Can. J. Physiol. Pharmacol., 70: 509-514.
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  109. Sage, S.O., C. van Breemen and M.B. Cannell, 1991. Sodium‐calcium exchange in cultured bovine pulmonary artery endothelial cells. J. Physiol., 440: 569-580.
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  110. Nichols, C.G., W.J. Lederer and M.B. Cannell, 1991. ATP dependence of KATP channel kinetics in isolated membrane patches from rat ventricle. Biophys. J., 60: 1164-1177.
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  111. Cannell, M.B. and C.G. Nichols, 1991. Diffusion limitations in the rate of solution changes in excised patch clamp experiments. Biophys. J., 60: 1156-1163.
  112. Crespo, L.M., C.J. Grantham and M.B. Cannell, 1990. Kinetics, stoichiometry and role of the Na-Ca exchange mechanism in isolated cardiac myocytes. Nature, 345: 618-621.
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  113. Berlin, J.R., M.A. Wozniak, M.B. Cannell, R.J. Bloch and W.J. Lederer, 1990. Measurement of intracellular Ca2+ in BC3H-1 muscle cells with Fura-2: Relationship to acetylcholine receptor synthesis. Cell Calcium, 11: 371-384.
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  114. Lederer, W.J., M.B. Cannell, N.M. Cohen and J.R. Berlin, 1989. Excitation-contraction coupling in heart muscle. Mol. Cell. Biochem., 89: 115-119.
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  115. Cannell, M.B. and S.O. Sage, 1989. Bradykinin-evoked changes in cytosolic calcium and membrane currents in cultured bovine pulmonary artery endothelial cells. J. Physiol., 419: 555-568.
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  116. Berlin, J.R., M.B. Cannell and W.J. Lederer, 1989. ITI in single rat cardiac ventricular cells: Relationship to fluctuations in intracellular calcium. Circulation Res., 65: 115-126.
  117. Wier, W.G., M.B. Cannell, J.R. Berlin, E. Marban and W.J. Lederer, 1987. Fura-2 fluorescence imaging reveals cellular and sub-cellular heterogeneity of [Ca2+ 1i in single heart cells. Science, 235: 325-328.
  118. Cannell, M.B. and W.J. Lederer, 1987. Effect of membrane potential changes on the calcium transient in single rat cardiac muscle cells. Science, 238: 1419-1423.
  119. Berlin, J.R., M.B. Cannell and W.J. Lederer, 1987. Regulation of twitch tension in sheep cardiac Purkinje fibers during calcium overload. Am. J. Physiol. Heart Circulatory Physiol., 253: H1540-H1547.
  120. Lederer, W.J., R.D. Vaughan-Jones, D.A. Eisner, S.S. Sheu and M.B. Cannell, 1986. The Regulation of Tension in Heart Muscle by Intracellular Sodium. In: Cardiac Muscle: The Regulation of Excitation and Contraction, Nathan, F. (Ed.). John Wiley and Sons, New York, USA., pp: 217-236.
  121. Cannell, M.B., D.A. Eisner, W.J. Lederer and M. Valdeolmillos, 1986. The effects of membrane potential on intracellular calcium concentration in sheep cardiac purkinje fibers in Na-free solutions. J. Physiol., 381: 193-203.
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  122. Cannell, M.B., 1986. Effect of tetanus duration on the free calcium during the relaxation of frog skeletal muscle fibres. J. Physiol., 376: 203-218.
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  123. Cannell, M.B. and W.J. Lederer, 1986. The arrhythmogenic current ITI in the absence of electrogenic sodium‐calcium exchange in sheep cardiac Purkinje fibres. J. Physiol., 374: 201-219.
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  124. Cannell, M.B. and W.J. Lederer, 1986. A novel experimental chamber for single-cell voltage-clamp and patch-clamp applications with low electrical noise and excellent temperature and flow control. Pflugers Archiv, 406: 536-539.
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  125. Cannell, M.B., R.D. Vaughan-Jones and W.J. Lederer, 1985. Ryanodine block of calcium oscillations in heart muscle and the sodium-tension relationship. Federat. Proc., 44: 2964-2969.
    Direct Link  |  
  126. Cannell, M.B. and D.G. Allen, 1984. Model of calcium movements during activation in the sarcomere of frog skeletal muscle. Biophys. J., 45: 913-925.
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  127. Cannell, M.B. and D.G. Allen, 1983. A photomultiplier tube assembly for the detection of low light levels. Pflugers Archiv, 398: 165-168.
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  128. Arnold, L., J. Page, D. Attwell, M. Cannell and D.A. Eisner, 1982. The dependence on heart rate of the human ventricular action potential duration. Cardiovasc. Res., 16: 547-551.
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