Dr. John  Helliwell
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Dr. John Helliwell

Professor Emeritus
The University of Manchester, United Kingdom


Highest Degree
D.Phil in Molecular Biophysics from University of Oxford, United Kingdom

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Biography

Dr. John Helliwell is currently working as Professor of Structural Chemistry, University of Manchester, England. He obtained his D.Phil in Molecular Biophysics from University of Oxford and DSc in Physics from University of York. He is member of Balliol College, Medical Research Council PDRA at the Laboratory of Molecular Biophysics. In past he worked as Junior Research Fellow at Linacre College, University of Oxford, Lecturer Department of Physics at University of Keele, Senior then Principal Scientific Officer at SERC, Daresbury Laboratory and Honorary, Lecturer in Physics at University of York, Director of SR Science based at Daresbury Laboratory, and Honorary Visiting Scientist STFC Daresbury Laboartory and Science Adviser to STFC CLIK. He has published 52 articles in journals.

Area of Interest:

Physics
100%
Crystallization
62%
Structural Biology
90%
Synchrotron Radiation
75%
Physical Chemistry
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Begum, S., M. Cianci, B. Durbeej, O. Falklof, A. Hadener, J.R. Helliwell and C.I.F. Watt, 2015. On the origin and variation of colors in lobster carapace. Phys. Chem. Chem. Phys., .
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  2. Rhys, N.H., M.C. Wang, T.A. Jowitt, J.R. Helliwell, J.G. Grossmann and C. Baldock, 2011. Deriving the ultrastructure of alpha-crustacyanin using lower-resolution structural and biophysical methods. J. Synchr. Rad., 18: 79-83.
    CrossRef  |  
  3. Fourme, R., J.R. Helliwell, J.E. Johnson, N. Sakabe and N. Yasuoka, 2011. Diffraction structural biology-introductory overview. J. Synchr. Rad., Vol. 18 10.1107/S0909049510044912.
    CrossRef  |  
  4. Polivka, T., H.A. Frank, M.M. Enriquez, D.M. Niedzwiedzki and S. Liaaen-Jensen et al., 2010. X-ray crystal structure and time-resolved spectroscopy of the blue carotenoid violerythrin. J. Phys. Chem. B., 114: 8760-8769.
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  5. Helliwell, M., J.R. Helliwell, V. Kaucic, N.Z. Logar, S.J. Teat, J.E. Warren and E.J. Dodson, 2010. Determination of zinc incorporation in the Zn substituted gallophosphate ZnULM-5 by multiple wavelength anomalous dispersion techniques. Acta Cryst. B: Struct. Sci., 66: 345-357.
    CrossRef  |  
  6. Helliwell, J.R., A.M.T. Bell, P. Bryant, S. Fisher and J. Habash et al., 2010. Time-dependent analysis of K2PtBr6 binding to lysozyme studied by protein powder and single crystal X-ray analysis. Zeitschrift fur Kristallographie Cryst. Mater., 225: 570-575.
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  7. Helliwell, J.R., 2010. The structural chemistry and structural biology of colouration in marine crustacea. Crystallogr. Rev., 16: 231-242.
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  8. Helliwell, J.R. and B. McMahon, 2010. The record of experimental science: Archiving data with literature. Inform. Serv. Use, 30: 31-37.
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  9. Cianci, M., B. Tomaszewski, J.R. Helliwell and P.J. Halling, 2010. Crystallographic analysis of counterion effects on subtilisin enzymatic action in acetonitrile. J. Am. Chem. Soc., 132: 2293-2300.
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  10. Fisher, S.J., J. Wilkinson, R.H. Henchman and J.R. Helliwell, 2009. An evaluation review of the prediction of protonation states in proteins versus crystallographic experiment. Crystallogr. Rev., 15: 231-259.
    CrossRef  |  
  11. Warren, J.E., G. Diakun, G. Bushnell-Wye, S. Fisher, A. Thalal, M. Helliwell and J R Helliwell, 2008. Science experiments via telepresence at a synchrotron radiation facility. J. Synchr. Rad., 15: 191-194.
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  12. Helliwell, M., J.R. Helliwell, N.Z. Logar, G. Mali, N.N. Thsar and V. Kaucic, 2008. Structure characterisation of nanoporous materials using state-of-the-art single-crystal X-ray and neutron diffraction techniques. Acta Chim. Slovenica, 55: 709-718.
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  13. Helliwell, J.R., 2008. Macromolecular crystal twinning, lattice disorders and multiple crystals. Crystallogr. Rev., 14: 189-250.
    CrossRef  |  
  14. Helliwell, J.R. and M. Helliwell, 2008. Unravelling the Chemical Basis of the Bathochromic Shift of the Lobster Carapace Carotenoprotein Crustacyanin. In: Models, Mysteries and Magic of Molecules, Boeyens, J.C.A. and J.F. Ogilvie (Ed.). Springer, New York.
  15. Govada, L., L. Carpenter, P.C. da Fonseca, J.R. Helliwell, P. Rizkallah, E. Flashman and J.M. Squire, 2008. Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy. J. mol. Biol., 378: 387-397.
  16. Fisher, S., J. Helliwell, S. Khurshid, L. Govada, C. Redwood, J. Squire and N. Chayen, 2008. An investigation into the protonation states of the C1 domain of cardiac myosin-binding protein C. Acta Crystallographica Sect. D-Biol. Crystallogr., 64: 658-664.
    CrossRef  |  
  17. Fisher, S. and J. Helliwell, 2008. An investigation into structural changes due to deuteration. Acta Crystallogr.Sect. A., 64: 359-367.
    CrossRef  |  
  18. Cianci, M., J.R. Helliwell and A. Suzuki, 2008. The interdependence of wavelength, redundancy and dose in sulfur SAD experiments. Biol. Crystallogr., 64: 1196-1209.
    CrossRef  |  
  19. Bartalucci, G., J. Coppin, S. Fisher, G. Hall, J. Helliwell, M. Helliwell and S. Liaaen-Jensen, 2007. Unravelling the chemical basis of the bathochromic shift in the lobster carapace; new crystal structures of unbound astaxanthin, canthaxanthin and zeaxanthin. Acta Crystallographica Sect.B-Struct. Sci., 63: 328-337.
    CrossRef  |  
  20. Ahmed, H., M. Blakeley, M. Cianci, D. Cruickshank, J. Hubbard and J. Helliwell, 2007. The determination of protonation states in proteins. Acta Crystallogr. Sect. D-Biol. Crystallogr., 63: 906-922.
    CrossRef  |  
  21. Pasquato, N., R. Berni, C. Folli, S. Folloni, M. Cianci, S. Pantano, J.R. Helliwell and G. Zanotti, 2006. Crystal structure of peach Pru p 3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens. J. Mol. Biol., 356: 684-694.
    CrossRef  |  
  22. Pasquato, N., R. Berni, C. Folli, S. Folloni and M. Cianci et al., 2006. Crystal structure of peach Pru p 3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens. J. Mol. Boil., 356: 684-694.
    CrossRef  |  
  23. Blakeley, M., A.J.K. Gilboa, J. Habash, J.R. Helliwell, D. Myles and J. Raftery, 2006. Neutron Protein Crystallography: Technical Aspects and Some Case Studies at Current Capabilities and Beyond. In: Neutron Scattering in Biology Techniques and Applications, Fitter, J., T. Gutberlet and J. Katsaras (Ed.). Springer, New York.
  24. Maclean, E.J., P.J. Rizkallah and J.R. Helliwell, 2006. Protein crystallography and synchrotron radiation: Current status and future landscape. Eur. Pharm. Rev., 2: 71-76.
  25. Snell, E.H. and J.R. Helliwell, 2005. Macromolecular crystallization in microgravity. Rep. Progr. Phys., 68: 799-853.
    CrossRef  |  
  26. Helliwell, J.R., M. Helliwell and R.H. Jones, 2005. Ab initio structure determination using dispersive differences from multiple wavelength synchrotron-radiation powder diffraction data. Acta Crystallographica Sect. A., 61: 568-574.
    CrossRef  |  
  27. Helliwell, J.R., 2005. Protein crystal perfection and its application. Acta Crystallographica Sect.D: Biol. Crystallogr., 61: 793-798.
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  28. Cianci, M., S. Antonyuk, N. Bliss, M.W. Bailey and S.G. Buffey et al., 2005. A high-throughput structural biology/proteomics beamline at the SRS on a new multipole wiggler. J. Synchr. Rad., 12: 455-466.
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  29. Cianci, J.R., MH. Helliwell, V. Kaucic, N.Z. Logar, G. Mali and N.N. Tusar, 2005. Anomalous scattering in structural chemistry and biology. Crystallogr. Rev., 11: 245-335.
    CrossRef  |  
  30. Carugo, D.K., J.R. Helliwell, H. Stuhrmann and M.S. Weiss, 2005. Softer and soft X-rays in macromolecular crystallography. J. Synchr. Rad., 12: 410-419.
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  31. Jr, H., A.J., Kalb, D.A.A. Myles, M.P. Blakeley, 2004. The 15-K neutron structure of saccharide-free concanavalin A. Proc. National Acad. Sci. U. S., 101: 16405-16410.
  32. Olczak, A., M. Cianci, Q. Hao, P.J. Rizkallah, J. Raftery and J.R. Helliwell, 2003. S-swat (softer single-wavelength anomalous technique): Potential in high-throughput protein crystallography. Acta Crystallographica Sect. A: Found. Crystallogr., 59: 327-334.
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  33. Jr, H.; P.J., Rizkallah, N.E. Chayen and P.F. Zagalsky, 2002. The molecular basis of the coloration mechanism in lobster shell:.beta.-crustacyanin at 3.2-.ANG. Resolution. Proc. National Acad. Sci. U. S. Am., 99: 9795-9800.
  34. Helliwell, J.R., 2002. X-ray crystal structure analysis in Manchester: From W. L. Bragg to the present day. Z. Kristallogr., 217: 385-389.
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  35. Helliwell, J.R., 2002. New opportunities in biological and chemical crystallography. J. Synchr. Rad., 9: 1-8.
    CrossRef  |  
  36. Pratap, J.V., G.M. Bradbrook, G.B. Reddy, A. Surolia, J. Raftery, J.R. Helliwell and M. Vijayan, 2001. The combination of molecular dynamics with crystallography for elucidating protein-ligand interactions: A case study involving peanut lectin complexes with T-antigen and lactose. Acta Crystallographica, Sect. D: Biol. Crystallogr., D57: 1584-1594.
    CrossRef  |  
  37. Kalb A. Gilboa and JR H., 2001. Concanavalin A. Handb. Metalloproteins, .
  38. Bartalucci, G., S. Fisher, J.R Helliwell, M. Helliwell, S. Liaaen-Jensen, J.E. Warren and J. Wilkinson, 2001. X-ray crystal structures of diacetates of 6-s-cis and 6-s-trans astaxanthin and of 7,8-didehydroastaxanthin and 7,8,7',8'-tetradehydroastaxanthin: Comparison with free and protein-bound asta�xanthins. Acta Crystallogr. Section B, 65: 238-247.
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