1. Jansen, S.R., W.J. Poppinga, W. de Jager, F. Lezoualch and X. Cheng et al., 2016. Epac1 links prostaglandin E2 to B-catenin-dependent transcription during epithelial-to-mesenchymal transition. Oncotargets, 10.18632/oncotarget.10128.
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2. Han, B., W.J. Poppinga, H. Zuo, A.B. Zuidhof and I.S. Bos et al., 2016. The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease. Sci. Rep., 10.1038/srep26928.
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3. Poppinga, W.J., I.H. Heijink, L.J. Holtzer, P. Skroblin and E. Klussmann et al., 2015. A-kinase anchoring proteins coordinate inflammatory responses to cigarette smoke in airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol., 308: 766-775.
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4. Llancao, P.M., D.R. Henriquez, C. Wilson, F. Bodaleo and E.W. Boddeke et al., 2015. Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J. Neurosci., 35: 11315-11329.
5. Jansen, S.R., R. Holman, I. Hedemann, E. Frankes and C.R. Elzinga et al., 2015. Prostaglandin E2 promoties MYCN non-amplified neuroblastoma cell survival via beta-catenin stabilization. J. Cell. Mol. Med., 19: 210-216.
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6. Tania, N.P., M. Schmidt and R. Gosens, 2014. Activin inflammation in COPD. Eur. Resp. J., 43: 954-955.
7. Poppinga, W.J., P.M. Llancao, C.G. Bilault and M. Schmidt, 2014. Cyclic AMP compartmentalization in chronic pulmonary and neuronal diseases. Br. J. Pharmacol., 171: 5603-5623.
8. Oldenburger, A., W.J. Poppinga, F. Kos, H.G. de Bruin and W.F. Rijks et al., 2014. A-kinase anchoring proteins contribute to loss of E-cadherin and bronchial epithelial barrier by cigarette smoke. Am. J. Physiol., 306: 585-597.
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9. Oldenburger, A., W. Timens, S. Bos, M. Smit and A.V. Smrcka et al., 2014. Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke. FASEB J., 28: 4617-4628.
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10. Kumawat, K., M.H. Menzen, R.M. Slegtenhorst, A.J. Halayko, M. Schmidt and R. Gosens, 2014. TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin. PLoS One, 10.1371/journal.pone.0094801.
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11. Schmidt, M., F. Dekker and H. Maarsingh, 2013. Exchange protein directly activated by cAMP (Epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol. Rev., 65: 670-709.
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12. Schmidt, M. , F. Dekker and H. Maarsingh, 2013. Exchange protein directly activated by cAMP (Epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol. Rev., 65: 670-709.
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13. Kumawat, K., M.H. Menzen, I.S. Bos, H.A. Baarsma and H.A. Borger et al., 2013. Noncanonical WNT-5A signaling regulates TGF-B-induced extracellular matrix production by airway smooth muscle cells. FASEB J., 27: 1631-1643.
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14. Karimian, G., M.B. Homan, M. Schmidt, U.J.F. Tietge and J.F. de Boer et al., 2013. Sphingosine kinase inhibitor protects primary rat hepatocytes against bile acid-induced apoptosis. Biochem. Biophys. Acta, 1832: 1922-1929.
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15. Talaei, F., H.R. Bouma, M.N. Hylkema, A.M. Strijkstra, A.S. Boerema, M. Schmidt and R.H. Henning, 2012. The role of endogenous H2S in reversible remodeling of lung tissue during hibernation in the Syrian hamster. J. Experiment. Biol., 215: 2912-2919.
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16. Schmidt, M., B.G.J. Dekkers and K. Racke, 2012. Distinct PKA and Epac compartmentalization in airway plasticity and function. Pharmacol. Ther., 137: 248-265.
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17. Oldenburger, A., S.S. Roscioni, E. Jansen, M.H. Menzen and A.J. Halayko et al., 2012. Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease. PLoS One, 10.1371/journal.pone.0031574.
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18. Oldenburger, A., H. Maarsingh and M. Schmidt, 2012. Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung. Pharm., 5: 1291-1331.
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19. Li, X., M. Gao, X. Han, S. Tao and D. Zheng et al., 2012. Disruption of the phospholipase D gene attenuates virulence of Aspergillus fumigatus. Infect. Immun., 80: 429-440.
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20. vom Dorp, F., H. Sanders, C. Boergermann, G. Lummen, H. Rubben, K.H. Jakobs and M. Schmidt, 2011. Inhibition of Rho-kinase abrogrates migration of human transitional cell carcinoma cells: results of an in vitro study. Int. Urol., 86: 220-227.
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21. Talaei, F., M.N. Hylkema, H.R. Bouma, A.S. Boerema, R.H. Henning and M. Schmidt, 2011. Reversible remodeling of lung tissue during hibernation in the syrian hamster. J. Experiment. Biol., 214: 1276-1282.
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22. Talaei, F., M.N. Hylkema, H.R. Bouma, A.S. Boerema, R.H. Henning and M. Schmidt, 2011. Hibernating hamsters reverse lung changes. J. Experiment. Biol., 10.1242/jeb.057687.
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23. Talaei, F., H.R. Bouma, A.C. van der Graaf, A.M. Strijkstra, M. Schmidt and R. Henning, 2011. Serotonin and dopamine protect from cold-induced cell damage through cystathione-synthase induced H2S production. PLoS One, 10.1371/journal.pone.0022568.
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24. Schmidt, M. and M.C. Michel, 2011. How Can 1 + 1 = 3? B2-Adrenergic and Glucocorticoid Receptor Agonist Synergism in Obstructive Airway Diseases. Mol. Pharmacol., 80: 955-958.
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25. Roscioni, S.S., H. Maarsingh, C.R.S. Elzinga, J. Schuur and M. Menzen et al., 2011. Epac as a novel effector of airway smooth muscle relaxation. J. Cell. Mol. Med., 15: 1551-1563.
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26. Roscioni, S.S., B.G.J. Dekkers, A.G. Prins, H. Meurs, M. Schmidt and H. Maarsingh, 2011. cAMP inhibits airway smooth muscle phenotype modulation. Br. J. Pharmacol., 162: 193-209.
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27. Roscioni, S.S., A.G. Prins, B.G.J. Dekkers, C.R.S. Elzinga, A.J. Halayko, H. Meurs and M. Schmidt, 2011. Functional roles of Epac and PKA in human airway smooth muscle phenotype plasticity. Br. J. Pharmacol., 164: 958-969.
28. Han, X., R. Yu, X. Han, L. Ji and D. Zhen et al., 2011. InlB-induced phospholipase D activation in Listeria monocytogenes internalization. Mol. Microbiol., 81: 860-880.
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29. Han, X., R. Yu, D. Zhen, S. Tao and M. Schmidt, 2011. B-1,3-glucan-induced host phospholipase D activation and Aspergillus fumigatus internalization into type II human pneumocyte A549 cells. PLoS One, 10.1371/journal.pone.0021468.
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30. Baarsma, H., H. Meurs, A.J. Halayko, M. Schmidt, H.A.M. Kerstjens and R. Gosens, 2011. Gycogen synthase kinase-3 regulates cigarette smoke extract and IL-1b-induced cytokine secretion by airway smooth muscle. Am. J. Physiol. Lung Cell. Mol. Physiol., 300: 910-919.
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31. Sand, C., C. Borgermann, P.A.O. Weernink, Y. Mahlke, B. Schwindenhammer, A.A. Weber and M. Schmidt, 2010. 8-pCPT-conjugated cyclic AMP analogs exert thromboxane receptor antagonistic properties. Thromb. Haemost., 103: 662-678.
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32. Ostroveanu, A., E. van der Zee, U.L.M. Eisle, M. Schmidt and I. Nijholt, 2010. Exchange protein directly activated by cyclic AMP2 (Epac2) plays a specific and time-limited role in memory retrieval. Hippocampus, 20: 1018-1026.
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33. Grandoch, M., S.S. Roscioni and M. Schmidt, 2010. Epac: novel cAMP mediators in inflammatory pulmonary and neuronal dysfunction. Br. J. Pharmacol., 159: 265-284.
34. van Wijk, B., G. van den Berg, R.A. Issa, S. van der Velden and M. Schmidt et al., 2009. Epicardial cells separate from the myocardial lineage under influence of FGF-signaling via Mek1/2. Cir. Res., 105: 431-441.
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35. Roscioni, S.S., L.E.M. Kistemaker, M. Menzen, C.R.S. Elzinga and R. Gosens et al., 2009. PKA and Epac cooperate to augment bradykinin-induced interleukin-8 release from human airway smooth muscle. Resp. Res., 10.1186/1465-9921-10-88.
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36. Grandoch, M., V. Bujok, D. Fleckenstein, M. Schmidt, J.W. Fischer and A.A. Weber, 2009. Epac inhibits apoptosis of human leukocytes. J. Leuk. Biol., 86: 847-849.
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37. Grandoch, M., P.A.O. Weernink, A.A. Weber, K.H. Kajobs and M. Schmidt, 2009. B cell receptor-induced growth arrest and apoptosis in WEHI-231 cells immature B lymphoma cells involve cyclic AMP and Epac proteins. Cell. Signal., 21: 609-621.
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38. Grandoch, M., A. Rose, M. ter Braak, V. Jendrossek and H. Rubben et al., 2009. Epac inhibits migration and proliferation of human prostate carcinoma cells. Br. J. Cancer, 101: 2038-2042.
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39. Gkoumassi, E., B.G.J. Dekkers, M.J. Droge, C.R.S. Elzinga and R.E. Hasenbosch et al., 2009. Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells. Naunyn-Schmiedebergs Arch. Pharmacol., 380: 67-77.
40. Schaafsma, D., S.S. Roscioni, H. Meurs and M. Schmidt, 2008. Monomeric G proteins as signal transducers in airway pathophysiology. Cell. Signal., 20: 1705-1714.
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41. Roscioni, S.S., C.R.S. Elzinga and M. Schmidt, 2008. Epac: effectors and biological functions. Naunyn-Schmiedebergs Arch. Pharmacol., 377: 345-357.
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42. Nunes, R.O., M. Schmidt, G. Dueck, H. Baarsma and A.J. Halayko et al., 2008. The GSK-catenin signaling axis in airway smooth muscle: Role in mitogenic signaling. Am. J. Physiol. Lung Cell Mol. Physiol., 294: 1110-1118.
43. Nijholt, I., A.M. Dolga, T. Vieth, A. Ostroveanu and M. de Bruyn et al., 2008. Neuronal AKAP150 coordinates PKA and Epac mediated PKB/Akt phosphorylation. Cell. Signal., 20: 1715-1724.
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44. Gosens, R., S.S. Roscioni, B.G. Dekkers, T. Pera and M. Schmidt et al., 2008. Pharmacology of airway smooth muscle proliferation. Eur. J. Pharmacol., 585: 385-397.
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45. Gosens, R., H. Meurs and M. Schmidt, 2008. The GSK-3/beta-catenin axis in smooth muscle and its relationship with remodelling. Naunyn-Schmiedebergs Arch. Pharmacol., 378: 345-357.
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46. Weernink, P.A.O., M.L. de Jesus and M. Schmidt, 2007. Phospholipase D signaling: orchestration by PIP2 and small GTPases. Naunyn-Schmiedebergs Arch. Pharmacol., 374: 399-411.
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47. Vogt, A., S. Lutz, U. Rumenapp, L. Han, K.H. Jakobs, M. Schmidt and T. Wieland, 2007. Regulators of G protein signalling 3 redirects prototypical Gi-coupled receptors from Rac to Rho activation. Cell. Signal., 19: 1229-1237.
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48. Schmidt, M., C. Sand, K.H. Jakobs, M.C. Michel and P.A.O. Weernink, 2007. Epac and the cardiovascular system. Curr. Opin. Pharmacol., 7: 193-200.
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49. Gkoumassi, E., M.J. Droge, B.G.J. Dekkers, C.R.S. Elzinga and M. Schmidt et al., 2007. Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells. Br. J. Pharmacol., 151: 1041-1048.
    CrossRef  |  Direct Link  |  
50. Weernink, P.A.O., L. Han, K.H. Jakobs and M. Schmidt, 2006. Dynamic phospholipid signaling by G protein-coupled receptors. Biochim. Biophys. Acta, 1768: 888-900.
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51. Peters, S.L.M., M. Schmidt and M.C. Michel, 2006. Rho kinase: a target for treating urinary incontinence. Trends Pharmacol. Sci., 27: 492-497.
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52. Hennenberg, M., E. Biecker, J. Trebicka, K. Jochem and Q. Zhou et al., 2006. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Gastroenterol., 130: 838-854.
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53. De Jesus, M.L., M.B. Stope, P.A.O. Weernink, C. Borgermann and V.N. Ananaba et al., 2006. Cyclic AMP-dependent and Epac-mediated Activation of R-Ras by G Protein-coupled Receptors Leads to Phospholipase D Stimulation. J. Biol. Chem., 281: 21837-21847.
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54. Lutz, S., A.F. Blomquist, Y. Yang, U. Rumenapp, K.H. Jakobs, M. Schmidt and T. Wieland, 2005. The guanine nucleotide exchange factor p63RhoGEF a specific link between Gq/11-coupled receptor signaling and RhoA. J. Biol. Chem., 280: 11134-11139.
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55. Weernink, P.A.O., M. Schmidt and K.H. Jakobs, 2004. Regulation and cellular roles of phosphoinositide 5-kinases. Eur. J. Pharmacol., 500: 87-99.
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56. Weernink, P.A.O., K. Meletiadis, S. Hommeltenberg, M. Hinz, H. Ishihara, M. Schmidt and K.H. Jakobs, 2004. Activation of type I phosphatidylinositol-4-phosphate 5-kinase isoforms by the Rho GTPases, RhoA, Rac1, and Cdc42. J. Biol. Chem., 279: 7840-7849.
    CrossRef  |  Direct Link  |  
57. Stope, M.B., F. Dorp, D. Szatkowski, A. Bohm and M. Keiper et al., 2004. Rap2B-dependent stimulation of phospholipase C-Src phosphorylation of RasGRP3. Cell. Mol. Biol., 24: 4664-4676.
    CrossRef  |  Direct Link  |  
58. Lutz, S., A.F. Blomquist, U. Rumenapp, M. Schmidt, K.H. Jakobs and T. Wieland, 2004. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. Naunyn Schmiedebergs Arch. Pharmacol., 369: 540-546.
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59. Keiper, M., M.B. Stope, D. Szatkowski, A. Bohm and K. Tysack et al., 2004. Epac- and Ca2+-controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J. Biol. Chem., 279: 46497-46508.
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60. Dorp, F., A.Y. Sari, H. Sanders, M. Keiper, P.A.O. Weernink, K.H. Jakobs and M. Schmidt, 2004. Inhibition of phospholipase C- i-coupled receptors. Cell. Signal., 16: 921-928.
61. Stope, M.B., C. Kunkel, C. Kories, M. Schmidt and M.C. Michel, 2003. Differential agonist-induced regulation of human M2 and M3 muscarinic receptors. Biochem. Pharmacol., 66: 2099-2105.
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62. Schmidt, M., P.A.O. Weernink, F. vom Dorp, M.B. Stope and K.H. Jakobs, 2003. Mammalian phospholipase C. Adv. Mol. Cell Biol., 33: 431-450.
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63. Genth, H., M. Schmidt, R. Gerhard, K. Aktories and I. Just, 2003. Activation of phospholipase D1 by ADP-ribosylated RhoA. Biochem. Biophys. Res. Commun., 302: 127-132.
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64. Wilde, C., H. Barth, P. Sehr, L. Han, M. Schmidt, I. Just and K. Aktories, 2002. Interaction of the Rho-ADP-ribosylating C3 exoenzyme with RalA. J. Biol. Chem., 277: 14771-14776.
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65. Vahid, M.F., N. Gosau, C. Michalek, L. Han and K.H. Jakobs et al., 2002. Distinct signaling pathways mediate cardiomyocyte phospholipase D stimulation by endothelin-1 and thrombin. J. Mol. Cell Cardiol., 34: 441-453.
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66. Heneweer, C., L.H. Kruse, F. Kindhauser, M. Schmidt, K.H. Jakobs, H.W. Denker and M. Thie, 2002. Adhesiveness of human uterine epithelial RL95-2 cells for trophoblast: Rho protein regulation. Mol. Hum. Reprod., 8: 1014-1022.
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67. Gosau, N., M.F. Vahid, C. Michalek, M. Schmidt and T. Wieland, 2002. Signalling components involved in the coupling of a1-adrenoceptors to phospholipase D in neonatal rat cardiac myocytes. Naunyn-Schmiedebergs Arch. Pharmacol., 365: 468-476.
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68. Fetscher, C., M. Fleichmann, M. Schmidt, S. Krege and M.C. Michel, 2002. M3 muscarinic receptors mediate contraction of human urinary bladder. Br. J. Pharmacol., 136: 641-644.
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69. Evellin, S., J. Nolte, K. Tysack, F. Dorp and M. Thiel et al., 2002. Stimulation of phospholipase C-3 muscarinic acetycholine receptor mediated by cyclic AMP and the GTPase Rap2B. J. Biol. Chem., 277: 16805-16813.
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70. Schmidt, M., S. Evellin, P.A.O. Weernink, F. Dorp, H. Rehmann, J.W. Lomasney and K.H. Jakobs, 2001. A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase. Nat. Cell Biol., 3: 1020-1024.
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71. Rumenapp, U., M. Asmus, H. Schablowski, M. Woznicki and L. Han et al., 2001. The M3 muscarinic acetylcholine receptor expressed in HEK-293 cells signals to phospholipase D via G12 but not Gq type G proteins. Regulators of G proteins as tools to dissect pertussis toxin-resistant G proteins in receptor-effector coupling. J. Biol. Chem., 276: 2474-2479.
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72. Weernink, P.A.O., Y. Guo, C. Zhang, M. Schmidt, C.E. Streiber and K.H. Jakobs, 2000. Control of cellular phosphatidylinositol 4,5-bisphosphate levels by adhesion signals and Rho GTPases in NIH 3T3 fibroblasts. Eur. J. Biochem., 267: 5237-5246.
    CrossRef  |  Direct Link  |  
73. Weernink, P.A.O., P. Schulte, Y. Guo, J. Wetzel and M. Amano et al., 2000. Stimulation of phosphatidyl-inositol- 4-phosphate 5-kinase by Rho-kinase. J. Biol. Chem., 275: 10168-10174.
    CrossRef  |  Direct Link  |  
74. Schmidt, M., M. Frings, M.L. Mono, Y. Guo and P.A.O. Weernink et al., 2000. G protein-coupled receptor-induced sensitization of phospholipase C stimulation by receptor tyrosine kinases. J. Biol. Chem., 275: 32603-32610.
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