Dr. Mathias  Lichterfeld
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Dr. Mathias Lichterfeld

Research Scientist
Massachusetts General Hospital, USA


Highest Degree
Ph.D. in Immunology from Massachusetts General Hospital, USA

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Area of Interest:

Medicine
100%
Immunology
62%
Virology
90%
Infectious Diseases
75%
Gastroenterology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Vigneault, F., M. Woods, M. Buzon, C. Li and F. Pereyra et al., 2011. Transcriptional profiling of CD4 T cells identifies distinct subgroups of HIV-1 elite controllers. J Virol., 85: 3015-3019.
    CrossRef  |  
  2. Chen, H., C. Li, J. Huang, T. Cung and K. Seiss et al., 2011. CD4 T cells from elite controllers resist HIV-1 infection by selective upregulation of p21 (waf-1/cip-1). J. Clin. Invest., 121: 1549-1560.
    CrossRef  |  
  3. Buzon, M.J., K. Seiss, R. Weiss, L.B. Brass and E.S. Rosenberg et al., 2011. Inhibition of HIV-1 integration in ex vivo infected CD4 T cells from elite controllers. J. Virol., 85: 9646-9650.
    CrossRef  |  
  4. Yang, Y., J. Huang, I. Toth, M. Lichterfeld and X.G.Yu et al., 2010.. Mutational escape in HIV-1 CTL epitopes leads to increased binding to inhibitory myelomonocytic MHC class I receptors. PLoS ONE. Vol. 5 10.1371/journal.pone.0015084.
    CrossRef  |  
  5. Williams, K., K. Seiss, J. Beamon, F. Pereyra and E.S. Rosenberg et al., 2010. Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells. AIDS, 24: 1964-1966.
    PubMed  |  
  6. Huang, J., P.S. Burke, T.D. Cung, F. Pereyra and I. Toth et al., 2010. Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers. J. Virol., 84: 9463-9471.
    CrossRef  |  
  7. Huang, J., P. Burke, Y. Yang, K. Seiss and J. Beamon et al., 2010. Soluble HLA-G inhibits myeloid dendritic cell function in HIV-1 infection by interactions with ILT4. J. Virol., 84: 10784-10791.
    CrossRef  |  
  8. Huang, J., J. Goedert, E. Sundberg, T. Cung and P. Burke et al., 2009. HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses. J. Exp. Med., 206: 2959-2966.
    PubMed  |  
  9. Lichterfeld, M., D. Mou, T.D. Cung, K.L. Williams aned M.T. Waring et al., 2008. Telomerase activity of HIV-1-specific CD8+ T cells: Constitutive upregulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood., 112: 3679-3687.
    PubMed  |  
  10. Yu, X.G., M. Lichterfeld, K.L. Williams, P.J. Martinez and B.D.Walker et al., 2007. Random TCR recruitment in HIV-1-specific CD8+ T cells from genetically identical twins infected with the same HIV-1 strain. J. Virol., 81: 12666-12669.
    CrossRef  |  
  11. Xu, G.Y., M. Lichterfeld, S. Chetty, K.L. Williams and S.K. Mui et al., 2007. Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes. J. Virol., 81: 1619-1631.
    PubMed  |  Direct Link  |  
  12. Streeck, H., M. Lichterfeld, G. Alter, A. Meier and N. Teigen et al., 2007. Recognition of a defined region within p24 Gag by CD8+ T cells during primary HIV-1 infection in individuals expressing protective HLA class I alleles. J. Virol., 81: 7725-7731.
    CrossRef  |  
  13. Lichterfeld, M., X.G. Yu, S.K. Mui, K.L. Williams and A. Trocha et al., 2007. Selective depletion of high-avidity HIV-1-specific CD8+ T cells following early HIV-1 infection. J. Virol., 82: 4199-4214.
    PubMed  |  
  14. Lichterfeld, M., D. Kavanagh, K.L. Williams, B. Mosa and S. Mui et al., 2007. A Viral CTL escape mutation leading to ILT4-mediated functional inhibition of myelomonocytic cells. J. Exp. Med., 204: 2813-2824.
    CrossRef  |  
  15. Brainard, D.M., A.M. Tager, J. Misdraji, N. Frahm and M. Lichterfeld et al., 2007. Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction. J. Virol., 81: 8439-8450.
    CrossRef  |  
  16. Vogel, M., M. Lichterfeld, D.E. Kaufmann, S.K. Mui and M. Altfeld et al., 2006. Structured treatment interruptions following immediate initiation of HAART in eight patients with acute HIV-1 seroconversion. Eur. J. Med. Res., 11: 273-278.
    PubMed  |  
  17. Streeck, H., H. Jessen, G. Alter, N. Teigen and M.T. Waring et al., 2006.. Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection. J. Infect. Dis., 194: 734-739.
    PubMed  |  
  18. Lichterfeld, M., K.L. Williams, S.K. Mui, S.S. Shah and B.R. Mothe et al., 2006. T cell receptor cross-recognition of an HIV-1 CD8+ T cell epitope presented by closely related alleles from the HLA-A3 superfamily. Int. Immunol., 18: 1179-1188.
    PubMed  |  
  19. Frahm, N., P. Kiepiela, S. Adams, C.H. Linde and H.S. Hewitt et al., 2006. Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes. Nat. Immunol., 7: 173-178.
    CrossRef  |  
  20. Altfeld, M., E.T. Kalife, Y. Qi, H. Streeck and M. Lichterfeld et al., 2006. HLA Alleles Associated with delayed progression to aids contribute strongly to the initial CD8 (+) t cell response against HIV-1. PLoS Med. Vol. 3 .
    Direct Link  |  
  21. Yu, X.G., M. Lichterfeld, M.M. Addo and M. Altfeld, 2005. Regulatory and accessory HIV-1 proteins: potential targets for HIV-1 vaccines?. Curr. Med. Chem., 12: 741-747.
    PubMed  |  
  22. Yu, X.G., M. Lichterfeld, B. Perkins, E. Kalife and S. Mui et al., 2005. High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level. AIDS, 19: 1449-1456.
    PubMed  |  
  23. Lichterfeld, M., X.G. Yu, S. Le Gall and M. Altfeld, 2005. Immunodominance of HIV-1-specific CD8(+) T-cell responses in acute HIV-1 infection: At the crossroads of viral and host genetics. Trends Immunol., 26: 166-171.
    PubMed  |  
  24. Lichterfeld, M., S. Haas, H.P. Fischer, E. Voigt and J.K. Rockstroh et al., 2005. Liver histopathology in human immunodeficiency virus-hepatitis C virus co-infected patients with fatal liver disease. J. Gastroenterol Hepatol., 20: 739-745.
    PubMed  |  
  25. Lichterfeld, M., N. Schmeisser, N. Qurishi, M. Vogel and H.H. Brackmann et al., 2005.. Clinical outcomes of HIV-HCV co-infection in a large cohort of hemophiliac patients. J. Infect., 50: 221-228.
    PubMed  |  
  26. Lichterfeld, M., N. Qurishi, C. Hoffmann, B. Hochdorfer and N.H. Brockmeyer et al., 2005. Treatment of HIV-1-associated Kaposi's sarcoma with pegylated liposomal doxorubicin and HAART simultaneously induces effective tumor remission and CD4+ T cell recovery. Infection, 33: 140-147.
    PubMed  |  
  27. Lichterfeld, M., G. Pantaleo and M. Altfeld, 2005. Loss of HIV-1-specific T cell proliferation in chronic HIV-1 infection: Cause or consequence of viral replication?. AIDS., 19: 1225-1227.
    Direct Link  |  
  28. Koibuchi, T., T.M. Allen, M. Lichterfeld, S.K. Mui and K.M. O'Sullivan et al., 2005. Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection. J. Virol., 79: 8171-8181.
    CrossRef  |  PubMed  |  
  29. Frahm, N., S. Adams, P. Kiepiela, C.H. Linde and H.S. Hewitt et al., 2005. HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load. J. Virol., 79: 10218-10225.
    CrossRef  |  Direct Link  |  
  30. Altfeld, M., T.M. Allen, E.T. Kalife, N. Frahm and M.M. Addo et al., 2005. The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: Implications for vaccine design. J. Virol., 79: 5000-5005.
    PubMed  |  
  31. Alter, G., N. Teigen, B.T. Davis, M.M. Addo and T.J. Suscovich et al., 2005. Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection. Blood., 106: 3366-3369.
    CrossRef  |  
  32. Allen, T.M., X.G. Yu, E.T. Kalife, L.L. Reyor and M. Lichterfeld et al., 2005. De novo generation of escape variant-specific CD8+ T-cell responses following cytotoxic T-lymphocyte escape in chronic human immunodeficiency virus type 1 infection. J. Virol., 79: 12952-12960.
    PubMed  |  
  33. Yu, X.G., M.M. Addo, B.A. Perkins, F. Wej and A. Rathod et al., 2004. Differences in the expressed HLA class I alleles effect the differential clustering of HIV type 1-specific T cell responses in infected Chinese and caucasians. AIDS Res. Hum. Retroviruses, 20: 557-564.
    PubMed  |  
  34. Nischalke, H.D., J. Nattermann, M. Lichterfeld, R.P. Woitas and J.K. Rockstroh et al., 2004. Rapid determination of the Delta32 deletion in the human CC-chemokine receptor 5 (CCR5) gene without DNA extraction by lightcycler real-time polymerase chain reaction. AIDS Res. Hum. Retroviruses, 20: 750-754.
    PubMed  |  
  35. Lichterfeld, M., X.G. Yu, M.T. Waring, S.K. Mui and M.N. Johnston et al., 2004. HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferongamma and tumor necrosis factor-α. Blood., 104: 487-494.
    Direct Link  |  
  36. Lichterfeld, M., X.G. Yu, D. Cohen, M.M. Addo and J. Malenfant et al., 2004. HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity. AIDS, 18: 1383-1392.
    PubMed  |  
  37. Kaufmann, D.E., P.M. Bailey, J. Sidney, B. Wagner and P.J. Norris et al., 2004. Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. J. Virol., 78: 4463-4477.
    CrossRef  |  Direct Link  |  
  38. Kaufmann, D.E., M. Lichterfeld, M. Altfeld, M.M. Addo and M.N. Johnston et al., 2004. Limited durability of viral control following treated acute HIV infection. PLoS Med., Vol. 1 .
    Direct Link  |  
  39. Alter, G., J.M. Malenfant, R.M. Delabre, N.C. Burgett and X.G. Yu et al., 2004.. Increased natural killer cell activity in viremic HIV-1 infection. J. Immunol., 173: 5305-5311.
    PubMed  |  
  40. Allen, T.M., M. Altfeld, X.G. Yu, K.M. O'Sullivan and M. Lichterfeld et al., 2004. Selection, transmission and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in human immunodeficiency virus type 1 infection. J. Virol., 78: 7069-7078.
    PubMed  |  
  41. Tarrand, J.J., M. Lichterfeld, I. Warraich, M. Luna and X.Y. Han et al., 2003. Diagnosis of invasive septate mold infections. A correlation of microbiological culture and histologic or cytologic examination. Am. J. Clin. Pathol., 119: 854-858.
    PubMed  |  
  42. Lichterfeld, M., H.P. Fischer, U. Spengler and J.K. Rockstroh, 2003. Fatty liver and increased serum lactate in a woman with HIV. Dtsch. Med. Wochenschr, 128: 81-84.
    PubMed  |  
  43. Lichterfeld, M., H.D. Nischalke, J. van Lunzen, J. Sohne and N. Schmeisser et al., 2003. The tandem-repeat polymorphism of the DC-SIGNR gene does not affect the susceptibility to HIV infection and the progression to AIDS. Clin. Immunol., 107: 55-59.
    CrossRef  |  
  44. Lichterfeld, M., A. Wohrmann, N. Schmeisser, G. Fatkenheuer and B. Salzberger et al., 2003. Superior virological efficacy of ritonavir-boosted protease inhibitor regimens compared to single protease inhibitor therapy. Eur. J. Med. Res., 8: 56-60.
    PubMed  |  
  45. Lichterfeld, M. and J.K.Rockstroh, 2003. Antiretroviral treatment of HIV infected patients. Med. Monatsschr Pharm., 26: 111-121.
  46. Spengler, U., M. Lichterfeld and J.K. Rockstroh, 2002. Antiretroviral drug toxicity-a challenge for the hepatologist?. J. Hepatol., 36: 283-294.
    PubMed  |  
  47. Rockstroh, J.K., M. Mudar, M. Lichterfeld, H.D. Nischalke and G. Klausen et al., 2002. Pilot study of interferon alpha high-dose induction therapy in combination with ribavirin for chronic hepatitis C in HIV-co-infected patients. AIDS, 16: 2083-2085.
    PubMed  |  
  48. Lichterfeld, M., L. Leifeld, H.D. Nischalke, J.K. Rockstroh and L. Hess et al., 2002. Reduced CC chemokine receptor (CCR) 1 and CCR5 surface expression on peripheral blood T lymphocytes from patients with chronic hepatitis C infection. J. Infect. Dis., 185: 1803-1807.
    Direct Link  |  
  49. Lichterfeld, M., H.D. Nischalke, F. Bergmann, W. Wiesel and A. Rieke et al., 2002. Long-term efficacy and safety of ritonavir/indinavir at 400/400 mg twice a day in combination with two nucleoside reverse transcriptase inhibitors as first line antiretroviral therapy. HIV Med., 3: 37-43.
    PubMed  |  
  50. Lichterfeld, M., C. Lorenz, H.D. Nischalke, C. Scheurlen and T. Sauerbruch et al., 2002. Decreased prevalence of Helicobacter pylori infection in HIV patients with AIDS defining diseases. Z. Gastroenterol., 40: 11-14.
    PubMed  |  
  51. Lichterfeld, M., S. Martin, L. Burkly, R. Haas and R. Kronenwett et al., 2000. Mobilization of CD34+ haematopoietic stem cells is associated with a functional inactivation of the integrin very late antigen 4. Br. J. Haematol., 110: 71-81.
    PubMed  |