Dr. Ricardo Alberto Gomez Flores
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Dr. Ricardo Alberto Gomez Flores

Professor and Researcher
Autonomous University of New Leon, Mexico

Highest Degree
Ph.D. in Microbiology from Autonomous University of New Leon, Mexico

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Biography

Dr. Ricardo Gomez-Flores obtained Posdoctoral Fellowships in Microbiology and Neuro-endocrinimmunology by the University of Texas M.D. Anderson Cancer Center at Houston, TX, and the University of Illinois College of Medicine at Peoria, IL, respectively. His major research projects are related to evaluating the Immunomodulator, Antibiotic and Antitumor activities of Natural and Synthetic Compounds, and evaluating the Fluorescence Polarized Assay for diagnosis of Human and Animal Brucellosis. He is responsible for the research and publications and the animal facilities at the Immunology and Virology Laboratory, and current Director of the Center for Entrepreneurship Incubation and Technology Transfer at UANL. He is a member of the Mexican Research System level 2, and the Mexican Academy of Sciences. He was awarded the Minority Supplement NIH Fellowship Grant (1997), NIH Research Fellowship (F32) (1998-2001), and travel awards from the National Institute on Drug Abuse. He was also awarded the annual research prize at UANL. He has contributed in the Immunology and Microbiology fields particularly in Demonstrating high effectiveness of antimycobacterial drugs after liposome encapsulation; Reporting a new colorimetric assay based in the reduction of the tetrazolium salt MTT by living microorganisms for measuring their growth in liquid medium; Validating the immunomodulating, antibiotic and antitumoral potential of natural and synthetic compounds; and Exploring the neuroendocrinimmune alterations of morphine and novel non-peptidic opioids administration, and heroin self-administration in the rat. He has published more than 70 peer-reviewed articles and possesses 12 patents; he has presented his results at national and international congresses (more than 180 presentations) and possesses more than 1200 citations to his scientific publications.

Area of Interest:

Biomedical Sciences
100%
Veterinary Sciences
62%
Traditional Medicine
90%
Microbiology
75%
Immunology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Tamayo-Mejia, F., P. Tamez-Guerra, A.W. Guzman-Franco and R. Gomez-Flores, 2015. Can Beauveria bassiana Bals. (Vuill) (Ascomycetes: Hypocreales) and Tamarixia triozae (Burks) (Hymenoptera: Eulophidae) be used together for improved biological control of Bactericera cockerelli (Hemiptera: Triozidae)? Biol. Control, 90: 42-48.
    CrossRef  |  Direct Link  |  
  2. Reyna-Martinez, R., R. Gomez-Flores, U.J. Lopez-Chuken, R. Gonzalez-Gonzalez, S. Fernandez-Delgadillo and I. Balderas-Renteria, 2015. Lipid production by pure and mixed cultures of Chlorella pyrenoidosa and Rhodotorula mucilaginosa isolated in Nuevo Leon, Mexico. Applied Biochem. Biotechnol., 175: 354-359.
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  3. Heredia-Rojas, J.A., L. Villarreal-Trevino, A.O. Rodriguez-De la Fuente, L.I. Herrera-Menchaca, R. Gomez-Flores, B.D. Mata-Cardenas and L.E. Rodriguez-Flores, 2015. Antimicrobial effect of vancomycin electro-transferred water against methicillin-resistant Staphylococcus aureus sp. variant. Afr. J. Tradit. Complement. Altern. Med., 12: 104-108.
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  4. Castillo-Velazquez, U., R. Gomez-Flores, G. Chavez-Gris, L.C. Favila-Humara, R. Soto-Castor, E. Maldonado-Castro and P. Tamez-Guerra, 2015. Presence of paratuberculosis in dairy cows culled in Tizayuca (Hidalgo, Mexico). Revista Colombiana Ciencias Pecuarias, 28: 174-180.
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  5. Tamayo-Mejia, F., P. Tamez-Guerra, A.W. Guzman-Franco, R. Gomez-Flores and L.R. Cruz-Cota, 2014. Efficacy of entomopathogenic fungi (Hypocreales) for Bactericera cockerelli (Sulc.) (Hemiptera: Triozidae) control in the laboratory and field. Southwestern Entomol., 39: 271-283.
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  6. Molina-Garza, Z.J., J.L. Rosales-Encina, R. Mercado-Hernandez, D.P. Molina-Garza, R. Gomez-Flores and L. Galaviz-Silva, 2014. Association of Trypanosoma cruzi infection with risk factors and electrocardiographic abnormalities in Northeast Mexico. BMC Infect. Dis., Vol. 14. 10.1186/1471-2334-14-117.
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  7. Castillo-Velazquez, U., R. Gomez-Flores, R. Tamez-Guerra, P. Tamez-Guerra and C. Rodriguez-Padilla, 2014. Corrigendum to Differential responses of macrophages from bovines naturally resistant or susceptible to Mycobacterium bovis after classical and alternative activation [Vet. Immunol. Immunopathol. 154 (1-2) (2013) 8-16]. Vet. Immunol. Immunopathol., 160: 145-146.
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  8. Benavides-Gonzalez, F., R.A. Gomez-Flores, J.G. Sanchez-Martinez, J.L. Rabago-Castro and I.O. Montelongo-Alfaro, 2014. In vitro and in vivo antiparasitic efficacy of praziquantel against monogenean Ligictaluridus floridanus in channel catfish (Ictalurus punctatus). Thai J. Vet. Med., 44: 533-539.
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  9. Rabago-Castro, J.L., R. Gomez-Flores, P. Tamez-Guerra, J.G. Sanchez-Martinez and G. Aguirre-Guzman et al., 2013. Spatial and seasonal variations on Henneguya exilis prevalence on cage intensive cultured channel catfish (Ictalurus punctatus), in Tamaulipas, Mexico. Latin Am. J. Aquat. Res., 41: 194-198.
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  10. Lara-Gonzalez, J.H., R. Gomez-Flores, P. Tamez-Guerra, E. Monreal-Cuevas, R. Tamez-Guerra and C. Rodriguez-Padilla, 2013. In vivo antitumor activity of metal silver and silver nanoparticles in the L5178Y-R murine lymphoma model. Br. J. Med. Med. Res., 3: 1308-1316.
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  11. Gloria-Garza, M.A., R. Gomez-Flores, M.A. De La Garza-Ramos, R. Quintanilla-Licea, R. Tamez-Guerra, P. Tamez-Guerra and C. Rodriguez-Padilla, 2013. In vitro antimicrobial activity of Ruta chalepensis methanol extracts against the cariogenic Streptococcus mutans. Afr. J. Microbiol. Res., 7: 5234-5237.
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  12. Castillo-Velazquez, U., R. Gomez-Flores, R. Tamez-Guerra, P. Tamez-Guerra and C. Rodriguez-Padilla, 2013. Differential responses of macrophages from bovines naturally resistant or susceptible to Mycobacterium bovis after classical and alternative activation. Vet. Immunol. Immunopathol., 154: 8-16.
    CrossRef  |  Direct Link  |  
  13. Rodriguez-Almaraz, G.A., R. Gomez-Flores and J. Rabago-Castro, 2012. First records of Ergasilus cerastes (Copepoda, Poecilostomatoida) on cage-reared Ictalurus from Northeast Mexico. Crustaceana, 85: 607-615.
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  14. Quintanilla-Licea, R., R. Morado-Castillo, R. Gomez-Flores, H. Laatsch and M.J. Verde-Star et al., 2012. Bioassay-guided isolation and identification of cytotoxic compounds from Gymnosperma glutinosum leaves. Molecules, 17: 11229-11241.
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  15. Heredia-Rojas, J.A., R. Gomez-Flores, A.O. Rodriguez-De la Fuente, E. Monreal-Cuevas and A.C. Torres-Flores et al., 2012. Antimicrobial effect of amphotericin B electronically-activated water against Candida albicans. Afr. J. Microbiol. Res., 6: 3684-3689.
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  16. Gomez-Flores, R., R. Reyna-Martinez, P. Tamez-Guerra and R. Quintanilla-Licea, 2012. Antibacterial activity of Oenothera rosea (L'Her) leaf extracts. Br. J. Med. Med. Res., 2: 396-404.
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  17. Gomez‐Flores, R., R. Quintanilla‐Licea, M.J. Verde‐Star, R. Morado‐Castillo and D. Vazquez‐Diaz et al., 2012. Long‐chain alkanes and ent‐labdane‐type diterpenes from Gymnosperma glutinosum with cytotoxic activity against the murine lymphoma L5178Y‐R. Phytother. Res., 26: 1632-1636.
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  18. De los Angeles, S.E.M., A.R. Rocio, C.R. Rocio, G.F. Ricardo, N.R.M. Adriana, A.G.R. Sergio and C.M. Abelardo, 2012. [Antituberculosis activity of a Carya illinoensis extract]. Revista Mexicana Ciencias Farmaceuticas, 43: 36-44, (In Spanish).
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  19. Rabago-Castro, J.L., R. Gomez-Flores, G. Aguirre-Guzman, P. Tamez-Guerra, C. Ramirez-Pfeiffer, J. Loredo-Osti and J.G. Sanchez-Martinez, 2011. Prevalence of henneguya infections on cage-reared channel catfish Ictalurus punctatus (Rafinesque) in Mexico. Thai J. Vet. Med., 41: 471-477.
    Direct Link  |  
  20. Rabago-Castro, J., J.G. Sanchez-Martinez, J. Loredo-Osti, R. Gomez-Flores, P. Tamez-Guerra and C. Ramirez-Pfeiffer, 2011. Temporal and spatial variations of ectoparasites on cage-reared channel catfish, Ictalurus punctatus, in Tamaulipas, Mexico. J. World Aquacult. Soc., 42: 406-411.
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  21. Gomez-Flores, R., R. Gonzalez-Melendez, A. Ceballos-Salobrena, P. Tamez-Guerra and R. Tamez-Guerra et al., 2011. Antimicrobial and antiinflammatory potential of the Swedish herbs extract. Eur. J. Med. Plants, 1: 107-117.
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  22. Gomez-Flores, R., H. Hernandez-Martinez, P. Tamez-Guerra, R. Tamez-Guerra, R. Quintanilla-Licea, E. Monreal-Cuevas and C. Rodriguez-Padilla, 2010. Antitumor and immunomodulating potential of Coriandrum sativum, Piper nigrum and Cinnamomum zeylanicum. J. Nat. Prod., 3: 54-63.
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  23. Franco-Molina, M.A., E. Mendoza-Gamboa, C.A. Sierra-Rivera, R.A. Gomez-Flores and P. Zapata-Benavides et al., 2010. Antitumor activity of colloidal silver on MCF-7 human breast cancer cells. J. Exp. Clin. Cancer Res., Vol. 29. 10.1186/1756-9966-29-148.
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  24. Weber, R.J., R. Gomez-Flores, J.E. Smith and T.J. Martin, 2009. Neuronal adaptations, neuroendocrine and immune correlates of heroin self-administration. Brain Behav. Immunity, 23: 993-1002.
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  25. Gomez-Flores, R., Y. Gracia-Vasquez, M.G. Alanis-Guzman, P. Tamez-Guerra and R. Tamez-Guerra et al., 2009. In vitro antimicrobial activity and polyphenolics content of tender and mature Ebenopsis ebano seeds. Med. Plants-Int. J. Phytomed. Relat. Ind., 1: 11-19.
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  26. Gomez-Flores, R., L. Verastegui-Rodriguez, R. Quintanilla-Licea, P. Tamez-Guerra, E. Monreal-Cuevas, R. Tamez-Guerra and C. Rodriguez-Padilla, 2009. Antitumor properties of Gymnosperma glutinosum leaf extracts. Cancer Invest., 27: 149-155.
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  27. Caballero-Hernandez, D., R. Gomez-Flores, P. Tamez-Guerra, R. Tamez-Guerra and C. Rodriguez-Padilla, 2009. Role of immunogenic fetuin A on L5178Y-R lymphoma tumorigenesis. Cancer Invest., 27: 257-263.
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  28. Tamez-Guerra, P., J.A. Valadez-Lira, J.M. Alcocer-Gonzalez, B. Oppert, R. Gomez-Flores, R. Tamez-Guerra and C. Rodriguez-Padilla, 2008. Detection of genes encoding antimicrobial peptides in Mexican strains of Trichoplusia ni (Hubner) exposed to Bacillus thuringiensis. J. Invertebr. Pathol., 98: 218-227.
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  29. Ramirez-Pfeiffer, C., E. Diaz-Aparicio, R. Gomez-Flores, C. Rodriguez-Padilla, A. Morales-Loredo and G. Alvarez-Ojeda, 2008. Use of the Brucella melitensis native hapten to diagnose brucellosis in goats by a rapid, simple and specific fluorescence polarization assay. Clin. Vaccine Immunol., 15: 911-915.
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  30. Ramirez-Pfeiffer, C., E. Diaz-Aparicio, C. Rodriguez-Padilla, A. Morales-Loredo, G. Alvarez-Ojeda and R. Gomez-Flores, 2008. Improved performance of Brucella melitensis native hapten over Brucella abortus OPS tracer on goat antibody detection by the fluorescence polarization assay. Vet. Immunol. Immunopathol., 123: 223-229.
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  31. Gomez-Flores, R., L. Verastegui-Rodriguez, R. Quintanilla-Licea, P. Tamez-Guerra, R. Tamez-Guerra and C. Rodriguez-Padilla, 2008. In vitro rat lymphocyte proliferation induced by Ocinum basilicum, Persea americana, Plantago virginica and Rosa spp. extracts. J. Med. Plant Res., 2: 5-10.
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  32. Gomez-Flores, R., C. Arzate-Quintana, R. Quintanilla-Licea, P. Tamez-Guerra, R. Tamez-Guerra, E. Monreal-Cuevas and C. Rodriguez-Padilla, 2008. Antimicrobial activity of Persea americana Mill (Lauraceae) (Avocado) and Gymnosperma glutinosum (Spreng.) Less (Asteraceae) leaf extracts and active fractions against Mycobacterium tuberculosis. Am.-Eurasian J. Scient. Res., 3: 188-194.
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  33. Ramirez-Pfeiffer, C., K. Nielsen, P. Smith, F. Marin-Ricalde, C. Rodriguez-Padilla and R. Gomez-Flores, 2007. Application of the fluorescence polarization assay for detection of caprine antibodies to Brucella melitensis in areas of high prevalence and widespread vaccination. Clin. Vaccine Immunol., 14: 299-303.
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  34. Weber, R.J., R. Gomez-Flores, I. Sora and G. Uhl, 2006. Loss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in μ-opioid receptor knockout mice. Am. J. Immunol., 2: 35-39.
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  35. Tamez-Guerra, P., G. Damas, M.M. Iracheta, B. Oppert, R. Gomez-Flores and C. Rodriguez-Padilla, 2006. Differences in susceptibility and physiological fitness of Mexican field Trichoplusia ni strains exposed to Bacillus thuringiensis. J. Econ. Entomol., 99: 937-945.
    CrossRef  |  
  36. Ramirez-Pfeiffer, C., K. Nielsen, F. Marin-Ricalde, C. Rodriguez-Padilla and R. Gomez-Flores, 2006. Comparison of fluorescence polarization assay with card and complement fixation tests for the diagnosis of goat brucellosis in a high-prevalence area. Vet. Immunol. Immunopathol., 110: 121-127.
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  37. Quintanilla-Licea, R., J.F. Colunga-Valladares, A. Caballero-Quintero, N. Waksman, R. Gomez-Flores, C. Rodriguez-Padilla and R. Tamez-Guerra, 2006. 5,5'-Biindole. Molbank. 10.3390/M474.
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  38. Gomez-Flores, R., P. Tamez-Guerra, R. Tamez-Guerra, C. Rodriguez-Padilla and E. Monreal-Cuevas et al., 2006. In vitro antibacterial and antifungal activities of Nopalea cochenillifera pad extracts. Am. J. Infect. Dis., 2: 1-8.
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  39. Gomez-Flores, R., K.R. Vietti, W.J. Dunn III, R. Tamez-Guerra and R.J. Weber, 2006. Selective lymphocyte activation and inhibition of in vitro tumor cell growth by novel morphinans. Am. J. Immunol., 2: 1-7.
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  40. Weber, R. and R. Gomez, 2005. Modulation of Immune Function by Novel Opioid Receptor Ligands. In: Infectious Diseases and Substance Abuse, Friedman, H., T.W. Klein and M. Bendinelli (Eds.). Springer, New York, USA., ISBN-13: 978-0-306-48688-3, pp: 149-158.
  41. Gomez-Flores, R., D. Caballero-Hernandez, R.J. Weber, R. Tamez-Guerra, P. Tamez-Guerra and C. Rodriguez-Padilla, 2005. In vitro activation of human and rat lymphocyte and macrophage functions by norepinephrine. Am. J. Immunol., 1: 148-153.
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  42. Gomez-Flores, R., D. Caballero-Hernandez, R. Tamez-Guerra, C. Rodriguez-Padilla and P. Tamez-Guerra et al., 2005. Increased survival of tumor-bearing mice by the delta opioid SNC 80. Anticancer Res., 25: 4563-4567.
    PubMed  |  Direct Link  |  
  43. Caballero, H.D., R.J. Weber, M.E. Hicks, R. Tamez-Guerra and C.R. Padilla et al., 2005. Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids. Int. Immunopharmacol., 5: 1271-1278.
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  44. Weber, R.J., R. Gomez-Flores, J.E. Smith and T.J. Martin, 2004. Immune, neuroendocrine and somatic alterations in animal models of human heroin abuse. J. Neuroimmunol., 147: 134-137.
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  45. Tamez-Guerra, P., M.M. Iracheta, B. Pereyra-Alferez, J. Galan-Wong, R. Gomez-Flores, R.S. Tamez-Guerra and C. Rodriguez-Padilla, 2004. Characterization of Mexican Bacillus thuringiensis strains toxic for lepidopteran and coleopteran larvae. J. Invertebr. Pathol., 86: 7-18.
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  46. Solis-Maldonado, S., R. Quintanilla-Licea, R. Tamez-Guerra, C. Rodrı́guez-Padilla and R. Gomez-Flores, 2003. Differential effects of synthetic indoloquinolizines on in vitro rat lymphocyte and macrophage functions. Int. Immunopharmacol., 3: 1261-1271.
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  47. Ordaz-Sanchez, I., R.J. Weber, K.C. Rice, X. Zhang and C. Rodriguez-Padilla et al., 2003. Chemotaxis of human and rat leukocytes by the delta-selective non-peptidic opioid SNC 80. Rev. Latinoam. Microbiol., 45: 16-23.
    PubMed  |  Direct Link  |  
  48. Franco-Molina, M., R. Gomez-Flores, P. Tamez-Guerra, R. Tamez-Guerra, L. Castillo-Leon and C. Rodriguez-Padilla, 2003. In vitro immunopotentiating properties and tumour cell toxicity induced by Lophophora williamsii (peyote) cactus methanolic extract. Phytother. Res., 17: 1076-1081.
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  49. Quintanilla-Licea, R., J.F. Colunga-Valladares, A. Caballero-Quintero, C. Rodriguez-Padilla, R. Tamez-Guerra, R. Gomez-Flores and N. Waksman, 2002. NMR detection of isomers arising from restricted rotation of the C-N amide bond of N-formyl-o-toluidine and N,N'-bis-formyl-o-tolidine. Molecules, 7: 662-673.
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  50. Liang-Suo, J., R. Gomez-Flores and R.J. Weber, 2002. Immunosuppression induced by central action of morphine is not blocked by mifepristone (RU 486). Life Sci., 71: 2595-2602.
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  51. Jacobi-Elizondo, J.S., R. Gomez-Flores, R. Tamez-Guerra, C. Rodriguez-Padilla and J.A. Heredia-Rojas, 2001. Acute effects of 60-Hz electromagnetic fields on ex vivo murine lymphocyte and macrophage functions, and in vitro tumor cell growth. Rev. Latinoam. Microbiol., 43: 130-134.
    PubMed  |  Direct Link  |  
  52. Hicks, M.E., R. Gomez-Flores, C. Wang, H.I. Mosberg and R.J. Weber, 2001. Differential effects of the novel non-peptidic opioid 4-tyrosylamido-6-benzyl-1,2,3,4 tetrahydroquinoline (CGPM-9) on in vitro rat t lymphocyte and macrophage functions. Life Sci., 68: 2685-2694.
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  53. Gomez-Flores, R., K.C. Rice, X. Zhang and R.J. Weber, 2001. Increased tumor necrosis factor-α and nitric oxide production by rat macrophages following in vitro stimulation and intravenous administration of the δ-opioid agonist SNC 80. Life Sci., 68: 2675-2684.
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