Dr. Juan Armendariz Borunda

Dr. Juan Armendariz Borunda

Professor
University of Guadalajara, Mexico


Highest Degree
PostDoc Fellow in Molecular Biology from Centro de Investigacion en Materiales Avanzados, Mexico

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Area of Interest:

Biomedical Sciences
100%
Molecular Biology
62%
Biotechnology
90%
Cell Biology
75%
Biological Sciences
55%

Selected Publications

  1. Rodriguez-Echevarria, R., J. Macias-Barragan, M. Parra-Vargas, J.R. Davila-Rodriguez, E. Amezcua-Galvez and J. Armendariz-Borunda, 2018. Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice. World J. Gastroenterol., 24: 461-474.
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  2. Sanchez-Enriquez, S., I.T. Ballesteros-Gonzalez, J.R. Villafan-Bernal, S. Pascoe-Gonzalez and E.A. Rivera-Leon et al., 2017. Serum levels of undercarboxylated osteocalcin are related to cardiovascular risk factors in patients with type 2 diabetes mellitus and healthy subjects. World J. Diabetes, 8: 11-17.
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  3. Rivera-Valdes, J.J., J. Garcia-Banuelos, A. Salazar-Montes, L. Garcia-Benavides, A. Rosales-Dominguez, J. Armendariz-Borunda and A. Sandoval-Rodriguez, 2017. Human adipose derived stem cells regress fibrosis in a chronic renal fibrotic model induced by adenine. Plos One, Vol. 12. 10.1371/journal.pone.0187907.
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  4. Lopez-Vazquez, A., J.J. Garcia-Banuelos, A.S. Gonzalez-Garibay, P.E. Urzua-Lozano and S. Del Toro-Arreola et al., 2017. IRS-1 pY612 and Akt-1/PKB pT308 phosphorylation and antiinflammatory effect of diindolylmethane in adipocytes cocultured with macrophages. Med. Chem., 13: 727-733.
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  5. Gomez-Meda, B.C., G.M. Zuniga-Gonzalez, L.V. Sanchez-Orozco, A.L. Zamora-Perez and J.P. Rojas-Ramirez et al., 2017. Buccal micronucleus cytome assay of populations under chronic heavy metal and other metal exposure along the Santiago river, Mexico. Environ. Monitor. Assess., Vol. 189. 10.1007/s10661-017-6237-3.
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  6. Gasca-Lozano, L.E., S. Lucano-Landeros, H. Ruiz-Mercado, A. Salazar-Montes and A. Sandoval-Rodriguez et al., 2017. Pirfenidone accelerates wound healing in chronic diabetic foot ulcers: A randomized, double-blind controlled trial. J. Diabetes Res., Vol. 2017. 10.1155/2017/3159798.
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  7. Feustel, S., F. Ayon-Perez, A. Sandoval-Rodriguez, R. Rodriguez-Echevarria, H. Contreras-Salinas, J. Armendariz-Borunda and L.V. Sanchez-Orozco, 2017. Protective effects of moringa oleifera on HBV genotypes C and H transiently transfected Huh7 cells. J. Immunol. Res., Vol. 2017. 10.1155/2017/6063850.
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  8. Zuniga-Gonzalez, G.M., B.C. Gomez-Meda, A.L. Zamora-Perez, M.A. Martinez-Gonzalez and M.A. Bautista-Bejarano et al., 2016. Micronucleated erythrocytes in newborns rats exposed to three different types of ultraviolet-A (UVA) lamps from commonly uses devices. J. Photochem. Photobiol. B: Biol., 165: 141-146.
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  9. Zuniga-Gonzalez, G.M., B.C. Gomez-Meda, A.L. Zamora-Perez, M.A. Martinez-Gonzalez and J. Armendariz-Borunda, 2016. Ultraviolet-a light induces micronucleated erythrocytes in newborn rats. Expert Opin. Environ. Biol., Vol. 5. .
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  10. Pimentel-Gutierrez, H.J., L. Bobadilla-Morales, C.C. Barba-Barba, C. Ortega-De-La-Torre and F.A. Sanchez-Zubieta et al., 2016. Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-κB. Oncol. Lett., 12: 4117-4124.
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  11. Moreno-Ortiz, J.M., M.D.L.L. Ayala-Madrigal, J.R. Corona-Rivera, M. Centeno-Flores and V. Maciel-Gutierrez et al., 2016. Novel mutations in MLH1 and MSH2 genes in Mexican patients with Lynch syndrome. Gastroenterol. Res. Pract., Vol. 2016. 10.1155/2016/5278024.
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  12. Meza-Rios, A., L. Garcia-Benavides, J. Garcia-Banuelos, A. Salazar-Montes, J. Armendariz-Borunda and A. Sandoval-Rodriguez, 2016. Simultaneous administration of ADSCs-based therapy and gene therapy using Ad-huPA reduces experimental liver fibrosis. Plos One, Vol. 11. 10.1371/journal.pone.0166849.
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  13. Gomez-Meda, B.C., A.L. Zamora-Perez, T. Munoz-Magallanes, M.G. Sanchez-Parada and J.G. Banuelos et al., 2016. Nuclear abnormalities in buccal mucosa cells of patients with type I and II diabetes treated with folic acid. Mutat. Res./Genet. Toxicol. Environ. Mutag., 797: 1-8.
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  14. Zuniga-Gonzalez, G.M., B.C. Gomez-Meda, A.L. Zamora-Perez, M.A. Martinez-Gonzalez and I.A.M. de Haro et al., 2015. Micronucleated erythrocytes in newborns of rat dams exposed to ultraviolet-A light during pregnancy; protection by ascorbic acid supplementation. Mutat. Res./Genet. Toxicol. Environ. Mutagen., 782: 36-41.
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  15. Viramontes-Horner, D., F. Marquez-Sandoval, F. Martin-del-Campo, B. Vizmanos-Lamotte and A. Sandoval-Rodriguez et al., 2015. Effect of a symbiotic gel (Lactobacillus acidophilus+ Bifidobacterium lactis+ inulin) on presence and severity of gastrointestinal symptoms in hemodialysis patients. J. Renal Nutr., 25: 284-291.
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  16. Salazar-Montes, A.M., L.D. Hernandez-Ortega, M.S. Lucano-Landeros and J. Armendariz-Borunda, 2015. New gene therapy strategies for hepatic fibrosis. World J. Gastroenterol., 21: 3813-3825.
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  17. Orozco-Perez, J., O. Aguirre-Jauregui, A.M. Salazar-Montes, A.A. Sobrevilla-Navarro, M.S. Lucano-Landeros and J. Armendariz-Borunda, 2015. Pirfenidone prevents rat esophageal stricture formation. J. Surg. Res., 194: 558-564.
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  18. Lyra-Gonzalez, I., L.E. Flores-Fong, I. Gonzalez-Garcia, D. Medina-Preciado and J. Armendariz-Borunda, 2015. MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine. World J. Hepatol., 7: 1530-1540.
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  19. Lopez-de la Mora, D.A., C. Sanchez-Roque, M. Montoya-Buelna, S. Sanchez-Enriquez, S. Lucano-Landeros, J. Macias-Barragan and J. Armendariz-Borunda, 2015. Role and new insights of Pirfenidone in fibrotic diseases. Int. J. Med. Sci., 12: 840-847.
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  20. Leon, E.A.R., B. Palmeros-Sanchez, I.M. Llamas-Covarrubias, S. Fernandez and J. Armendariz-Borunda et al., 2015. Vitamin-D receptor gene polymorphisms (Taql and apal) an circulating osteocalcin in patients with type 2 diabetes and healthy subjets. Endokrynol. Polska, 4: 329-333.
  21. Hernandez-Chan, N.G., M.J. Bannon, C.E. Orozco-Barrios, L. Escobedo and S. Zamudio et al., 2015. Neurotensin-polyplex-mediated brain-derived neurotrophic factor gene delivery into nigral dopamine neurons prevents nigrostriatal degeneration in a rat model of early Parkinson's disease. J. Biomed. Sci., Vol. 22. 10.1186/s12929-015-0166-7.
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  22. Fernandez‐Galindo, D.A., F. Sanchez‐Avila, L. Bobadilla‐Morales, P. Gomez‐Quiroz, M. Bueno‐Topete, J. Armendariz‐Borunda and L.V. Sanchez‐Orozco, 2015. New amino acid changes in drug resistance sites and HBsAg in hepatitis B virus genotype H. J. Med. Virol., 87: 985-992.
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  23. Castro-Torres, R.D., V. Chaparro-Huerta, M.E. Flores-Soto, L. Jave-Suarez and A. Camins et al., 2015. Pirfenidone attenuates microglial reactivity and reduces inducible nitric oxide synthase mRNA expression after kainic acid-mediated excitotoxicity in pubescent rat hippocampus. J. Mol. Neurosci., 56: 245-254.
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  24. Alejandra, M.R., A.B. Juan and S.R. Ana, 2015. Cell therapy for liver diseases: Current medicine and future promises. Expert Rev. Gastroenterol. Hepatol., 9: 837-850.
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  25. Villafan-Bernal, J.R., M.A. Llamas-Covarrubias, J.F. Munoz-Valle, E.A. Rivera-Leon and M.E. Gonzalez-Hita et al., 2014. A cut-point value of uncarboxylated to carboxylated index is associated with glycemic status markers in type 2 diabetes. J. Invest. Med., 62: 33-36.
    PubMed  |  Direct Link  |  
  26. Navarro-Palacios, A., E. Garcia-Lopez, A. Meza-Rios, J. Armendariz-Borunda and A. Sandoval-Rodriguez, 2014. Myeloperoxidase enzymatic activity is increased in patients with different levels of dental crowding after initial orthodontic activation. Am. J. Orthodont. Dentofacial Orthoped., 146: 92-97.
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  27. Macias-Barragan, J., A. Caligiuri, J. Garcia-Banuelos, M. Parola, M. Pinzani and J. Armendariz-Borunda, 2014. Effects of alpha lipoic acid and pirfenidone on liver cells antioxidant modulation against oxidative damage. Rev. Med. Chile, 142: 1553-1564.
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  28. Gomez-Meda, B.C., A. Barros-Hernandez, J. Guzman-Barcenas, M. de Lourdes Lemus-Varela and A.L. Zamora-Perez et al., 2014. Effects of blue light phototherapy on DNA integrity in preterm newborns. J. Photochem. Photobiol. B: Biol., 141: 283-287.
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  29. Flores-Contreras, L., A.S. Sandoval-Rodriguez, M.G. Mena-Enriquez, S. Lucano-Landeros and I. Arellano-Olivera et al., 2014. Treatment with pirfenidone for two years decreases fibrosis, cytokine levels and enhances CB2 gene expression in patients with chronic hepatitis C. BMC Gastroenterol., Vol. 14. 10.1186/1471-230X-14-131.
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  30. Castro-Torres, R.D., V. Chaparro-Huerta, M.E. Flores-Soto, J. Banuelos-Pineda and A. Camins et al., 2014. A single dose of pirfenidone attenuates neuronal loss and reduces lipid peroxidation after kainic acid-induced excitotoxicity in the pubescent rat hippocampus. J. Mol. Neurosci., 52: 193-201.
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  31. Veras-Castillo, E.R., L. Cardenas-Camarena, I. Lyra-Gonzalez, J.F. Munoz-Valle and S. Lucano-Landeros et al., 2013. Controlled clinical trial with pirfenidone in the treatment of breast capsular contracture: Association of TGF-β polymorphisms. Ann. Plastic Surg., 7: 16-22.
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  32. Sanchez-Parada, M.G., B.A. Alvarez-Rodriguez, B.C. Gomez-Meda, R. Troyo-Sanroman and L.V. Sanchez-Orozco et al., 2013. Association of genetic polymorphisms with histological grading of necroinflammation, staging of fibrosis and liver function in Mexicans with chronic hepatitis C virus infection. J. Invest. Med., 61: 1088-1096.
    PubMed  |  Direct Link  |  
  33. Ramirez, D.L.L.G.M., O.L.V. Sanchez, L.R. Rodriguez, S. Rodriguez and M.E. Roig et al., 2013. Seroepidemiology of Toxoplasma gondii infection in drivers involved in road traffic accidents in the metropolitan area of Guadalajara, Jalisco, Mexico. Parasites Vectors, Vol. 6, 10.1186/1756-3305-6-294.
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  34. Lyra-Gonzalez, I., L.E. Flores-Fong, I. Gonzalez-Garcia, D. Medina-Preciado and J. Armendariz-Borunda, 2013. Adenoviral gene therapy in hepatocelular carcinoma: A review. Hepatol Int., 7: 48-58.
  35. Gordillo-Bastidas, D., E. Oceguera-Contreras, A. Salazar-Montes, J. Gonzalez-Cuevas, L.D. Hernandez-Ortega and J. Armendariz-Borunda, 2013. Nrf2 and Snail-1 in the prevention of experimental liver fibrosis by caffeine. World J. Gastroenterol., 19: 9020-9033.
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  36. Gonzalez-Garcia, I., I. Lyra-Gonzalez, D. Medina-Preciado, A. Guerrero-Torres, G. Ramos-Gallardo and J. Armendariz-Borunda, 2013. Face transplant: Is it feasible in developing countries? J. Craniof. Surg., 2: 309-312.
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  37. Cantu-Cantu, M.Z., I. Lyra-Gonzalez and J. Armendariz-Borunda, 2013. Coadjuvant treatment with surgery and pirfenidone in severe facial trauma due to dog bite. J. Craniofacial Surg., 24: 675-678.
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  38. Zuniga-Gonzalez, G.M., B.C. Gomez-Meda, M. de Lourdes Lemus-Varela, A.L. Zamora-Perez and J. Armendariz-Borunda et al., 2012. Micronucleated erythrocytes in preterm newborns exposed to phototherapy and/or oxygentherapy. J. Photochem. Photobiol. B: Biol., 107: 79-83.
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  39. Navarro-Partida, J., A.B. Martinez-Rizo, J. Gonzalez-Cuevas, G. Arrevillaga-Boni, V. Ortiz-Navarrete and J. Armendariz-Borunda, 2012. Pirfenidone restricts Th2 differentiation in vitro and limits Th2 response in experimental liver fibrosis. Eur. J. Pharmacol., 678: 71-77.
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  40. Martinez-Fong, D., M.J. Bannon, L.E. Trudeau, J.A. Gonzalez-Barrios and M.L. Arango-Rodriguez et al., 2012. NTS-Polyplex: A potential nanocarrier for neurotrophic therapy of Parkinson's disease. Nanomedicine: Nanotechnol. Biol. Med., 8: 1052-1069.
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  41. Hernandez-Ortega, L.D., B.E. Alcantar-Diaz, L.A. Ruiz-Corro, A. Sandoval-Rodriguez, M. Bueno-Topete, J. Armendariz-Borunda and A.M. Salazar-Montes, 2012. Quercetin improves hepatic fibrosis reducing hepatic stellate cells and regulating pro‐fibrogenic/anti‐fibrogenic molecules balance. J. Gastroenterol. Hepatol., 27: 1865-1872.
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  42. Armendariz-Borunda, J., I. Lyra-Gonzalez, D. Medina-Preciado, I. Gonzalez-Garcia and D. Martinez-Fong et al., 2012. A controlled clinical trial with pirfenidone in the treatment of pathological skin scarring caused by burns in pediatric patients. Ann. Plast. Surg., 68: 22-28.
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  43. Alcantar-Diaz, B.E., B.C. Gomez-Meda, G.M. Zuniga-Gonzalez, A.L. Zamora-Perez and J. Gonzalez-Cuevas et al., 2012. Genotoxic evaluation of pirfenidone using erythrocyte rodent micronucleus assay. Food Chem. Toxicol., 50: 2760-2765.
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  44. Vazquez-Valls, E., M.E. Flores-Soto, V. Chaparro-Huerta, B.M. Torres-Mendoza and G. Gudino-Cabrera et al., 2011. HIF-1α expression in the hippocampus and peripheral macrophages after glutamate-induced excitotoxicity. J. Neuroimmunol., 238: 12-18.
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  45. Gonzalez-Cuevas, J., J. Navarro-Partida, A.L. Marquez-Aguirre, M.R. Bueno-Topete, C. Beas-Zarate and J. Armendariz-Borunda, 2011. Ethylenediaminetetraacetic acid induces antioxidant and anti-inflammatory activities in experimental liver fibrosis. Redox Rep., 16: 62-70.
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  46. Galvez-Gastelum, F.J., J.J. Garcia-Banuelos, C. Beas-Zárate, A. Segura-Flores and H. Gonzalez et al., 2011. Combinatorial gene therapy induces regression of hepatic encephalopathy. Gene Ther., 18: 88-94.
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  47. Armendariz-Borunda, J., B.E. Bastidas-Ramirez, A. Sandoval-Rodriguez, J. Gonzalez-Cuevas, B. Gomez-Meda and J. Garcia-Banuelos, 2011. Production of first generation adenoviral vectors for preclinical protocols: Amplification, purification and functional titration. J. Biosci. Bioeng., 112: 415-421.
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  48. Vazquez-Del Mercado, M., C.A. Palafox-Sanchez, J.F. Munoz-Valle, G. Orozco-Barocio and E. Oregon-Romero et al., 2010. High prevalence of autoantibodies to RNA helicase A in Mexican patients with systemic lupus erythematosus. Arthritis Res. Ther., Vol. 12. 10.1186/ar2905.
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  49. Munoz-Valle, J.F., Y. Valle, J.R. Padilla-Gutierrez, I. Parra-Rojas and H. Rangel-Villalobos et al., 2010. The +49A>G CTLA-4 polymorphism is associated with rheumatoid arthritis in Mexican population. Clin. Chim. Acta, 411: 725-728.
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  50. Miranda-Mendez, A., A. Lugo-Baruqui and J. Armendariz-Borunda, 2010. Molecular basis and current treatment for alcoholic liver disease. Int. J. Environ. Res. Public Health, 7: 1872-1888.
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  51. Martinez‐Rizo, A., M. Bueno‐Topete, J. Gonzalez‐Cuevas and J. Armendariz‐Borunda, 2010. Plasmin plays a key role in the regulation of profibrogenic molecules in hepatic stellate cells. Liver Int., 30: 298-310.
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  52. Macias-Barragan, J., A. Sandoval-Rodriguez, J. Navarro-Partida and J. Armendariz-Borunda, 2010. The multifaceted role of pirfenidone and its novel targets. Fibrogenesis Tiss. Repair, Vol. 3. 10.1186/1755-1536-3-16.
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  53. Lugo‐Baruqui, A., J.F. Munoz‐Valle, S. Arevalo‐Gallegos and J. Armendariz‐Borunda, 2010. Role of angiotensin II in liver fibrosis‐induced portal hypertension and therapeutic implications. Hepatol. Res., 40: 95-104.
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  54. Huerta-Olvera, S.G., J. Macias-Barragan, M.E. Ramos-Marquez, J. Armendariz-Borunda, F. Diaz-Barriga and F. Siller-Lopez, 2010. Alpha-lipoic acid regulates heme oxygenase gene expression and nuclear Nrf2 activation as a mechanism of protection against arsenic exposure in HepG2 cells. Environ. Toxicol. Pharmacol., 29: 144-149.
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  55. Galvez-Gastelum, F.J., A.A. Segura-Flores, M.D. Senties-Gomez, J.F. Munoz-Valle and J.S. Armendariz-Borunda, 2010. Combinatorial gene therapy renders increased survival in cirrhotic rats. J. Biomed. Sci., Vol. 17. 10.1186/1423-0127-17-42.
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  56. Arana-Argaez, V.E., V. Delgado-Rizo, O.E. Pizano-Martinez, E.A. Martinez-Garcia and B.T. Martin-Marquez et al., 2010. Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells. J. Biol. Chem., 285: 32824-32833.
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  57. Valle, Y., I.Y. Ledezma-Lozano, N. Torres-Carrillo, J.R. Padilla-Gutierrez and R.E. Navarro-Hernandez et al., 2009. Circulating TNFRI and TNFRII levels correlated with the disease activity score (DAS28) in rheumatoid arthritis. Scand. J. Rheumatol., 38: 332-335.
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  58. Marquez‐Aguirre, A., A. Sandoval‐Rodriguez, J. Gonzalez‐Cuevas, M. Bueno‐Topete and J. Navarro‐Partida et al., 2009. Adenoviral delivery of dominant‐negative transforming growth factor β type II receptor up‐regulates transcriptional repressor SKI‐like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats. J. Gene Med., 11: 207-219.
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  59. Salazar-Montes, A., L. Ruiz-Corro, A. Lopez-Reyes, E. Castrejon-Gomez and J. Armendariz-Borunda, 2008. Potent antioxidant role of pirfenidone in experimental cirrhosis. Eur. J. Pharmacol., 595: 69-77.
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  60. Oregon-Romero, E., M.V. del Mercado, S.L. Ruiz-Quezada, R.E.N. Hernandez and H.R. Villalobos et al., 2008. Tumor necrosis factor a-308 and-238 polymorphism, in rheumatoid artrhitis. Association with messenger RNA expression and sTNF-a. J. Invest. Med., 56: 937-943.
  61. Matias, G., R.C. Luis, S.M. Adriana, R.A. Rosa and A.B. Juan, 2008. Pirfenidone prevents capsular contracture post mammary. Aesthetic Plastic Surg., 32: 32-40.
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  62. Fernandez, T.V., I.J. Garcia‐Gonzalez, C.E. Mason, G. Hernandez‐Zaragoza and V.C. Ledezma‐Rodriguez et al., 2008. Molecular characterization of a patient with 3p deletion syndrome and a review of the literature. Am. J. Med. Genet. Part A, 146: 2746-2752.
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  63. Armendariz-Borunda, J., A.R. Rincon, J.F. Munoz-Valle, M. Bueno-Topete and E. Oregon-Romero et al., 2008. Fibrogenic polymorphisms (TGF-β, PAI-1, AT) in Mexican patients with established liver fibrosis. J. Invest. Med., 56: 944-953.
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  64. Beas-Zarate, C., M.E. Urena-Guerrero, M. Flores-Soto, J. Armendariz-Borunda and D. Ortuno-Sahagun, 2007. The expression and binding of kainate receptors is modified in different brain regions by glutamate neurotoxicity during postnatal rat development. Int. J. Dev. Neurosci., 25: 53-61.
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  65. Salazar-Montes, A., L. Ruiz-Corro, A. Sandoval-Rodriguez, A. Lopez-Reyes and J. Armendariz-Borunda, 2006. Increased DNA binding activity of NF-kB, STAT-3, SMAD3 and AP-1 in acutely damaged liver. World J. Gastroenterol., 12: 5995-6001.
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  66. Gonzalez‐Cuevas, J., M. Bueno‐Topete and J. Armendariz‐Borunda, 2006. Urokinase plasminogen activator stimulates function of active forms of stromelysin and gelatinases (MMP‐2 and MMP‐9) in cirrhotic tissue. J. Gastroenterol. Hepatol., 21: 1544-1554.
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  67. Bueno, M., S. Salgado, C. Beas‐Zarate and J. Armendariz‐Borunda, 2006. Urokinase‐type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down‐regulation and up‐regulation of MMPs, HGF and VEGF. J. Gene Med., 8: 1291-1299.
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  68. Armendariz-Borunda, J., M.C. Islas-Carbajal, E. Meza-Garcia, A.R. Rincon and S. Lucano et al., 2006. A pilot study in patients with established advanced liver fibrosis using pirfenidone. Gut, 55: 1663-1665.
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  69. Rincon-Sanchez, A.R., A. Covarrubias, A.M. Rivas-Estilla, J. Pedraza-Chaverri and C. Cruz et al., 2005. PGE2 alleviates kidney and liver damage, decreases plasma renin activity and acute phase response in cirrhotic rats with acute liver damage. Exp. Toxicol. Pathol., 56: 291-303.
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  70. Islas‐Carbajal, M.C., A. Covarrubias, G. Grijalva, A. Alvarez‐Rodriguez, J. Armendariz‐Borunda and A.R. Rincon‐Sanchez, 2005. Nitric oxide synthases inhibition results in renal failure improvement in cirrhotic rats. Liver Int., 25: 131-140.
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  71. Daneri-Navarro, A., S. Del Toro-Arreola, P.E. Sanchez-Hernandez, M.G. Ramirez-Duenas, J. Armendariz-Borunda and R. Perez-Montfort, 2005. Immunosuppressive activity of proteases in cervical carcinoma. Gynecol. Oncol., 98: 111-117.
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  72. Siller-Lopez, F., A. Sandoval, S. Salgado, A. Salazar and M. Bueno et al., 2004. Treatment with human metalloproteinase-8 gene delivery ameliorates experimental rat liver cirrhosis. Gastroenterology, 126: 1122-1133.
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  73. Rivera‐Cervantes, M.C., J.S. Torres, A. Feria‐Velasco, J. Armendariz‐Borunda and C. Beas‐Zarate, 2004. NMDA and AMPA receptor expression and cortical neuronal death are associated with p38 in glutamate‐induced excitotoxicity in vivo. J. Neurosci. Res., 76: 678-687.
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  74. Ordonez, R.M., A.M. Esinosa, D.J. Sanchez-Gonzalez, J.A. Borunda and J. Berumen, 2004. Enhanced oncogenicity of Asian-American human papillomavirus 16 is associated with impaired E2 repression of E6/E7 oncogene transcription. J. General Virol., 85: 1433-1444.
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  75. Miranda-Daaz, A., A.R. Rincon, S. Salgado, J. Vera-Cruz and J. Galvez et al., 2004. Improved effects of viral gene delivery of human uPA plus biliodigestive anastomosis induce recovery from experimental biliary cirrhosis. Mol. Ther., 9: 30-37.
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  76. Hernandez-Canaveral, I., J. Gonzalez, F. Lopez-Casillas and J. Armendariz-Borunda, 2004. Amplified expression of dominant‐negative transforming growth factor‐beta type II receptor inhibits collagen type I production via reduced Smad‐3 activity. J. Gastroenterol. Hepatol., 19: 380-387.
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  77. Fabre, Y., M.R. Bueno, A.R. Rincon-Sanchez, J. Saldana-Cortes, R. Vargas and J. Armendariz-Borunda, 2004. Mexican infants with extrahepatic biliary atresia display different fibrosis activity. Hepatol. Res., 28: 79-86.
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  78. Vera-Cruz, J.M., E. Magallon-Gastelum, G. Grijalva, A.R. Rincon, C. Ramos-Garcia and J. Armendariz-Borunda, 2003. Molecular diagnosis of Chagas disease and use of an animal model to study parasite tropism. Parasitol. Res., 89: 480-486.
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  79. Munoz‐Valle, J.F., M. Vazquez‐del Mercado, T. Garcia‐Iglesias, G. Orozco‐Barocio and G. Bernard‐Medina et al., 2003. TH1/TH2 cytokine profile, metalloprotease‐9 activity and hormonal status in pregnant rheumatoid arthritis and systemic lupus erythematosus patients. Clin. Exp. Immunol., 131: 377-384.
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  80. Armendariz-Borunda, J., M.C. Islas-Carbajal, E. Meza, A.R. Rincon and A. Alvarez et al., 2003. 314 A pilot study of a novel anti-inflammatory and anti-fibrotic agent, pirfenidone, in patients with liver cirrhosis. Hepatology, Vol. 38. .
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  81. Ramos-Marquez, M.E., G. Grijalva and J. Armendariz-Borunda, 2002. Ductular hyperplasia is characterized by an over expression of c-Myc in bile duct ligation+ furan injured rats: Possible role of interleukin-6. Hepatol. Res., 22: 127-138.
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  82. Garcia-Banuelos, J., F. Siller-Lopez, A. Miranda, L.K. Aguilar, E. Aguilar-Cordova and J. Armendariz-Borunda, 2002. Cirrhotic rat livers with extensive fibrosis can be safely transduced with clinical-grade adenoviral vectors. Evidence cirrhosis reversion. Gene Ther., 9: 127-134.
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  83. Garcia, L., I. Hernandez, A. Sandoval, A. Salazar and J. Garcia et al., 2002. Pirfenidone effectively reverses experimental liver fibrosis. J. Hepatol., 37: 797-805.
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  84. Beas-Zarate, C., M.E. Flores-Soto and J. Armendariz-Borunda, 2002. NMDAR-2C and 2D subunits gene expression is induced in brain by neonatal exposure of monosodium L-glutamate to adult rats. Neurosci. Lett., 321: 9-12.
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  85. Abbas, A., L. Aguilar, E. Aguilar-Cardova, J. Armendariz and M. Brenner et al., 2002. Cabo II: Immunology and gene therapy. Mol. Ther., 5: 486-491.
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  86. Nieto, N., J.A., Dominguez‐Rosales, L. Fontana, A. Salazar, J. Armendariz‐Borunda, P. Greenwel and M. Rojkind, 2001. Rat hepatic stellate cells contribute to the acute‐phase response with increased expression of α1 (I) and α1 (IV) collagens, tissue inhibitor of metalloproteinase‐1 and matrix‐metalloproteinase‐2 messenger RNAs. Hepatology, 33: 597-607.
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  87. Beas-Zarate, C., S.V. Rivera-Huizar, A. Martinez-Contreras, A. Feria-Velasco and J. Armendariz-Borunda, 2001. Changes in NMDA-receptor gene expression are associated with neurotoxicity induced neonatally by glutamate in the rat brain. Neurochem. Int., 39: 1-10.
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  88. Siller-Lopez, F., J. Garcia-Banuelos, K.A. Hasty, J. Segura and M. Ramos-Marquez et al., 2000. Truncated active matrix metalloproteinase-8 gene expression in HepG2 cells is active against native type I collagen. J. Hepatol., 33: 758-763.
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  89. Salgado, S., J. Garcia, J. Vera, F. Siller and M. Bueno et al., 2000. Liver cirrhosis is reverted by urokinase-type plasminogen activator gene therapy. Mol. Ther., 6: 545-551.
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  90. Salazar-Montes, A., V. Delgado-Rizo and J. Armendariz-Borunda, 2000. Differential gene expression of pro-inflammatory and anti-inflammatory cytokines in acute and chronic liver injury. Hepatol. Res., 16: 181-194.
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  91. Bueno, M.R., A. Daneri and J. Armendariz-Borunda, 2000. Cholestasis-induced fibrosis is reduced by interferon α-2a and is associated with elevated liver metalloprotease activity. J. Hepatol., 33: 915-200.
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  92. Aguilar, L.K., E. Aguilar-Cordova, D. Ando, J. Armendariz-Borunda and P.R. Burd et al., 2000. A prescription for Gene Therapy. The first Cabo gene therapy working group. Mol. Ther., 1: 385-388.
  93. Salazar-Montes, A., A.R. Rincon, A. Panduro and J. Armendariz-Borunda, 1999. Chemically induced liver regeneration is characterized by specific IL-6 gene expression. Hepatol. Res., 15: 10-21.
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  94. Rincon, A.R., A. Covarrubias, J. Pedraza-Chaverri, J.L. Poo, J. Armendariz-Borunda and A. Panduro, 1999. Differential effect of CCl4 on renal function in cirrhotic and non-cirrhotic rats. Exp. Toxicol. Pathol., 51: 199-205.
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  95. Mercado, M.V.D., V. Delgado-Rizo, J.F. Mu oz-Valle, J. Orozco-Alcala, H.D. Volk and J. Armendariz-Borunda, 1999. Expression of interleukin-1β, tumor necrosis factor α, interleukins-6,-10, and-4 and metalloproteases by freshly isolated mononuclear cells from early never-treated and non-acute treated rheumatoid arthritis patients. Clin. Exp. Rheumatol., 17: 575-583.
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  96. Fafutis-Morris, M., V.C. Guillen, F.S. Navarro and J. Armendariz-Borunda, 1999. Serum IL-1RA is elevated in lepromatous leprosy patients. Int. J. Leprosy, 67: 287-291.
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  97. Fafutis-Morris, M., C.M. Guillen-Vargas, S. Navarro-Fierros, F. Alfaro-Bustamante and G. Zaitzeva-Petrovna et al., 1999. Addition of anti-CD28 antibodies restores PBMC proliferation and IFN-γ production in lepromatous leprosy patients. J. Interferon Cytokine Res., 19: 1237-1243.
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  98. Campollo, O., R. Cortez, A. Odor, R.M. Munoz, J. Armendariz-Borunda and J. Alvarez-Tostado, 1999. A novel sodium benzoate analog (CH-1) decreases blood ammonia levels in experimental hyperammonemia. Hepatol. Res., 15: 104-109.
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  99. Maria, R.E.A., S.L. Veronica, M. Osmar, C. Octavio, A.B. Juan, S.O.J. Enrique and A. Panduro, 1998. Identification of Hepatitis C Virus (HCV) genotypes in infected patients from the West of Mexico. Hepatol. Res., 12: 121-130.
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  100. Delgado-Rizo, V.A., A. Salazar, A. Panduro and J. Armendariz-Borunda, 1998. Treatment with Anti-TGFbeta antibodies influences an altered pattern of cytokine gene expression in injured rat liver. Biochim. Biophys. Acta, 1442: 20-27.
  101. Aldana, L., E.G. de Mejıa, A. Craigmill, V. Tsutsumi, J. Armendariz-Borunda, A. Panduro and A.R. Rincon, 1998. Cypermethrin increases apo A-1 and apo B mRNA but not hyperlipidemia in rats. Toxicol. Lett., 95: 31-39.
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  102. Wall, C.D., P.B. Conley, J. Armendariz-Borunda, C. Sudarshan, J.E. Wagner, R. Raghow and L.K. Jennings, 1997. Expression of αIIbβ3 integrin (GPIIb-IIIa) in myeloid cell lines and normal CD34+/CD33+ bone marrow cells. Blood Cells Mol. Dis., 23: 361-376.
  103. Armendariz-Borunda, J., L. LeGros, Jr., O. Campollo, A. Panduro and A.R. Rincon, 1997. Antisense S-oligodeoxynucleotides down-regulate TGFβ-production by Kupffer cells from CCl4-injured rat livers. Biochim. Biophys. Acta (BBA)-Gene Struct. Exp., 1353: 241-252.
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  104. Armendariz-Borunda, J., R.O. Endres, L.R. Ballou and A.E. Postlethwaite, 1996. Transforming growth factor-beta inhibits interferon-gamma-induced HLA-DR expression by cultured human fibroblasts. Int. J. Biochem. Cell Biol., 28: 1107-1116.
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  105. Martinez‐Fong, D., J.E. Mullersman, A.F. Purchio, J. Armendariz‐Borunda and A. Martinez‐Hernandez, 1994. Nonenzymatic glycosylation of poly‐l‐lysine: A new tool for targeted gene delivery. Hepatology, 20: 1602-1608.
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  106. Armendariz-Borunda, J., C.P. Simkevich, N. Roy, R. Raghow, A.H. Kang and J.M. Seyer, 1994. Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression. Biochem. J., 304: 817-824.
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  107. Katayama, K., J. Armendariz-Borunda, R. Raghow, A.H. Kang and J.M. Seyer, 1993. A pentapeptide from type I procollagen promotes extracellular matrix production. J. Biol. Chem., 268: 9941-9944.
  108. Armendariz-Borunda, J., H. Katai, C.M. Jones, J.M. Seyer, A.H. Kang and R. Raghow, 1993. Transforming growth factor beta gene expression is transiently enhanced at a critical stage during liver regeneration after CCl4 treatment. Lab. Invest.; J. Tech. Meth. Pathol., 69: 283-294.
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  109. Armendariz-Borunda, J., K. Katayama and J.M. Seyer, 1992. Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1 beta, tumor necrosis factor alpha and transforming growth factor beta in Ito cells. J. Biol. Chem., 267: 14316-14321.
  110. Armendariz‐Borunda, J., J.M. Seyer, A.E. Postlethwaite and A.H. Kang, 1991. Kupffer cells from carbon tetrachloride–injured rat livers produce chemotactic factors for fibroblasts and monocytes: The role of tumor necrosis factor‐α. Hepatology, 14: 895-900.
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  111. Armendariz-Borunda, J., J.M. Seyer, A.H. Kang and R. Raghow, 1990. Regulation of TGF beta gene expression in rat liver intoxicated with carbon tetrachloride. FASEB J., 4: 215-221.
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  112. Armendariz-Borunda, J., P. Greenwel and M. Rojkind, 1984. Kupffer cells from CC14-treated rat livers induce skin fibroblast and liver fat-storing cell proliferation in culture. Matrix, 9: 150-158.
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  113. Armendariz-Borunda, J. and M. Rojkind, 1984. A simple quantitative method for collagen typing in tissue samples: Its application to human liver with schistosomiasis. Collagen Related Res., 4: 35-47.
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