Dr. Marisa Cabeza
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Dr. Marisa Cabeza

Professor
Departamento de Sistemas Biológicos, Metropolitan Autonomous University, Mexico City, Distrito Federal, Mexico

Highest Degree
Ph.D. in Basic Biomedical Sciences from Universidad Nacional Autonoma de Mexico, Mexico

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Area of Interest:

Biomedical Sciences
100%
Biochemistry
62%
Physiology
90%
Steroids
75%
Pharmaceutical Sciences
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
138
Abstracts
5

Selected Publications

  1. Franco, K.N.C., G.J.N. Zamudio, E. Bratoeff, M.C. Salinas and G.Y.A. Salazar, 2022. Synthesis, biological evaluation and structure-activity relationships of new steroidal antiandrogens. Latin Am. J. Dev., 4: 967-971.
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  2. Piermattey, J.H., M. Ahumedo, Y. Heuze, J. Soriano and M. Cabeza, 2022. New nonsteroidal molecules as blockers of the steroidogenic pathway. Curr. Enzym Inhib., 18: 19-31.
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  3. Lopez-Lezama, J.C., M. Cabeza, Y. Heuze, A. Sánchez, J. L. Rojas and A. Valencia-Islas, 2021. Synthesis of novel andostane-N-cyclohexyl-17-carboxamides, and their effect on the 5α-reductase isoform 2, the androgen receptor, and androgen-dependent glands. Pharm. Sci., 28: 433-442.
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  4. Pinacho-Garcia, L.M., R.A. Valdez, A. Navarrete, M. Cabeza, J. Segovia and M.C. Romano, 2020. The effect of finasteride and dutasteride on the synthesis of neurosteroids by glioblastoma cells. Steroids, Vol. 155. 10.1016/j.steroids.2019.108556.
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  5. Orozco, M., R.A. Valdez, L. Ramos, M. Cabeza, J. Segovia and M.C. Romano, 2020. Dutasteride combined with androgen receptor antagonists inhibit glioblastoma U87 cell metabolism, proliferation, and invasion capacity: Androgen regulation. Steroids, Vol. 164. 10.1016/j.steroids.2020.108733.
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  6. Cabeza, M. L. Bautista, E. Bratoeff, J. Soriano and Y. Heuze, 2020. In vitro and In vivo Effects of 17β-N-(4-phenylcarbamoyl) androst-4-en-3- one Derivatives as 5a-reductase Inhibitors on Androgen-dependent Glands. Curr. Enzym Inhib., 17: 16-25.
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  7. Cabeza, M. L. Bautista, E. Bratoeff, J. Soriano and Y. Heuze, 2019. Effect of Pregnenolone Derivatives on the Selective Inhibition of 5α-Reductase 2 Activity. Curr. Enzym Inhib., 15: 179-189.
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  8. Cabeza, M., L. Bautista, M.G. Bravo and Y. Heuze, 2018. Molecular interactions of different steroids contributing to sebum production. Review. Curr. Drug Targets, 19: 1855-1865.
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  9. Bratoeff, E., I. Moreno, F. Cortes-Benitez, Y. Heuze, M. Bravo and M. Cabeza, 2018. 17β-N-arylcarbamoylandrost-4-en-3-one derivatives as inhibitors of the enzymes 3α-hydroxysteroid dehydrogenase and 5α-reductase. Curr. Enzyme Inhib., 14: 36-50.
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  10. Arellano, Y., E. Bratoeff, Y. Heuze, M. Bravo, J. Soriano and M. Cabeza, 2018. Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1. Bioorg. Med. Chem., 26: 4058-4064.
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  11. Silva-Ortiz, A.V., E. Bratoeff, T. Ramírez-Apan, Y. Heuze and J. Soriano et al., 2017. Synthesis of new derivatives of 21-imidazolyl-16-dehydropregnenolone as inhibitors of 5α-reductase 2 and with cytotoxic activity in cancer cells. Bioorg. Med. Chem., 25: 1600-1607.
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  12. Sánchez-Márquez, A., Y. Arellano, E. Bratoeff, Y. Heuze, K. Córdova, G. Nieves, J. Soriano and M. Cabeza, 2016. Synthesis and biological evaluation of esters of 16-formyl-17-methoxy-dehydroepiandrosterone derivatives as inhibitors of 5α-reductase type 2. J. Enzyme Inhib. Med. Chem., 31: 1170-1176.
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  13. Sánchez-Márquez, A., A. Silva-Ortíz, E. Bratoeff, Y. Heuze, J. Soriano, Y. Medina and M. Cabeza, 2016. New dehydroepiandrosterone-triazole derivatives identified as inhibitors of 17β.-hydroxysteroid dehydrogenase enzyme in the prostate. Curr. Enzyme Inhib., 12: 145-154.
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  14. Cortés-Benítez, F., M. Cabeza, M.T. Ramírez-Apan, B. Alvarez-Manrique and E. Bratoeff, 2016. Synthesis of 17β-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line. Eur. J. Med. Chem., 121: 737-746.
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  15. Cabeza, M., A. Sánchez-Márquez, M. Garrido, A. Silva and E. Bratoeff, 2016. Recent advances in drug design and drug discovery for androgen-dependent diseases. Curr. Med. Chem., 23: 792-815.
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  16. Arellano, Y., E, Bratoeff, T. Segura, M.E. Mendoza and A. Sánchez-Márquez et al., 2016. Novel dehydroepiandrosterone benzimidazolyl derivatives as 5α-reductase isozymes inhibitors. J. Enzyme Inhib. Med. Chem., 31: 908-914.
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  17. Silva-Ortiz, A.V., E. Bratoeff, T. Ramirez-Apan, Y. Heuze, A. Sanchez, J. Soriano and M. Cabeza, 2015. Synthesis and activity of novel 16-dehydropregnenolone acetate derivatives as inhibitors of type 1 5α-reductase and on cancer cell line SK-LU-1. Bioorg. Med. Chem., 23: 7535-7542.
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  18. Cabeza, M., Y. Heuze, A. Sánchez, M. Garrido and E. Bratoeff, 2015. Recent advances in structure of progestins and their binding to progesterone receptors. J. Enzyme Inhib. Med. Chem., 30: 152-159.
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  19. López-Lezama, J.C., M. Cabeza, I. Mayorga, J. Soriano, T. Sainz and E. Bratoeff, 2014. Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs. Arch. Pharm. Chem. Life Sci., 347: 320-326.
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  20. Bratoeff, E., M. Garrido, T. Ramírez-Apan, Y. Heuze and A. Sánchez et al., 2014. Effect of dehydroepiandrosterone derivatives on the activity of 5α-reductase isoenzymes and on cancer cell line PC-3. Bioorg. Med. Chem., 22: 6233-6241.
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  21. Alali, F.Q., C.S.M. Amrine, T. El-Elimat, A. Alkofahi and K. Tawaha et al., 2014. Bioactive withanolides from Withania obtusifolia. Phytochem. Lett., 9: 96-101.
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  22. Garrido, M., E. Bratoeff, M. García-Lorenzana, Y. Heuze and J. Soriano et al., 2013. Biological evaluation of androstene derivatives. Arch. Pharm. Pharm. Med. Chem., 346: 62-70.
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  23. Bratoeff, E., A. Sánchez, Y. Arellano, Y. Heuze, J. Soriano and M. Cabeza, 2013. In vivo and in vitro effect of androstene derivatives as 5α-reductase type 1 enzyme inhibitors. J. Enzyme Inhib. Med. Chem., 28: 1247-1254.
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  24. Cabeza, M., B. Naranjo, Y. Heuze, A. Sánchez, M. Hernández, T. Sainz and E. Bratoeff, 2012. Molecular interactions of natural and synthetic steroids in female hamsters' flank organs. J. Dermatological Sci., 66: 119-126.
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  25. Garrido, M., E. Bratoeff, D. Bonilla, J. Soriano, Y. Heuze and M. Cabeza, 2011. New steroidal lactones as 5α-reductase inhibitors and antagonists for the androgen receptor. J. Steroid Biochem. Mol. Biol., 127: 367-373.
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  26. Cabeza, M., K.V. Trejo, C. González, P. García, J. Soriano, Y. Heuze and E. Bratoeff, 2011. Steroidal 5α-reductase inhibitors using 4-androstenedione as substrate. J. Enzyme Inhib. Med. Chem., 26: 712-719.
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  27. Arellano, Y., E. Bratoeff, M. Garrido, J. Soriano, Y. Heuze and M. Cabeza, 2011. New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors. Steroids, 76: 1241-1246.
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  28. Soriano-García, M., T. Segura, N. Valencia, E. Bratoeff and M. Cabeza, 2010. Crystal structure and synthesis of three new steroidal derivatives as antiandrogens. J. Chem. Crystallogr., 40: 1119-1124.
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  29. Soriano-García, M., A. Zambrano, M. Cabeza and E. Bratoeff, 2010. Crystal structure and synthesis of 17α-acetoxy-pregn-4,6-diene-3,20-dione. J. Chem. Crystallogr., 40: 1115-1118.
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  30. Cabeza, M., Y. Heuze, H. Quintana and E. Bratoeff, 2010. Comparison between two different hamster models used for the determination of testosterone and finasteride activity. Asian J. Anim. Vet. Adv., 5: 202-209.
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  31. Cabeza, M., M. García-Lorenzana, M. Garcés, I. Heuze, N. Teran and E. Bratoeff, 2010. New-D-homoandrost-4,6-diene derivatives as potent progesterone receptor antagonist. Steroids, 75: 101-108.
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  32. Bratoeff, E., P. García, Y. Heuze, J. Soriano and A. Mejía et al., 2010. Molecular interactions of progesterone derivatives with 5α-reductase types 1 and 2 and androgen receptors. Steroids, 75: 499-505.
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  33. Bratoeff, E., A. Zambrano, I. Heuze, A. Palacios, D. Ramírez and M. Cabeza, 2010. Synthesis and biological activity of progesterone derivatives as 5α-reductase inhibitors, and their effect on hamster prostate weight. J. Enzyme Inhib. Med. Chem., 25: 306-311.
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