Dr. Alan Talevi
ProfessorNational Research Council of Argentina, Argentina
Highest Degree
Ph.D. in Biological Sciences from National University of La Plata, Argentina
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National Research Council of Argentina, Argentina
Biography
Dr. Talevi Alan is currently working as Professor in the National Research Council of Argentina (CONICET). He obtained his PhD in Biological Sciences from National University of La Plata in 2007. In past he worked as Doctoral Fellowship holder and Postdoctoral Fellowship holder at the National Research Council of Argentina (CONICET). Dr. Talevi received honors includes, Awarded with the Enrique Herrero Ducloux Award to the best doctoral thesis in the field of Theoretic Chemistry, award given by the Argentinean Chemical Society, and Young Scholar Award from the American Chemical Society at Pacifichem. He has published 37 research papers in referred scientific journals as well as 8 books as author/co author. He also supervised 2 PhD thesis as advisor/ co-adviser, 5 PhD students currently in his supervision.
Area of Interest:
Biomedical Sciences
100%
Cancer Research
62%
Chemotherapies
90%
Bioorganic Reactions
75%
Drug Discovery
55%
Research Publications in Numbers
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Selected Publications
- Ianni, M.E.D., M.E. Gantner, M.E. Ruiz, E.A. Castro, L.E. Bruno-Blanch and A. Talevi, 2015. Systematic comparison of the performance of different 2d and 3d ligand-based virtual screening methodologies to discover anticonvulsant drugs. Comb. Chem. High Throughput Screening, 18: 387-398.
CrossRef | PubMed | Direct Link | - Ianni, M.E.D., A.V. Enrique, M.E.D. Valle, B. Aldana and M.A. Rosella et al., 2015. Is there a relationship between sweet taste and seizures? Anticonvulsant and proconvulsant effects of non-nutritive sweeteners. Comb. Chem. High Throughput Screening, 18: 335-345.
CrossRef | PubMed | Direct Link | - Bellera, C.L., M.L. Sbaraglini, D.E. Balcazar, L. Fraccaroli and M.C. Vanrell et al., 2015. High-throughput drug repositioning for the discovery of new treatments for chagas disease. Mini Rev. Med. Chem., 15: 182-193.
CrossRef | PubMed | Direct Link | - Bellera, C.L., D.E. Balcazar, M.C. Vanrell, A.F. Casassa and P.H. Palestro et al., 2015. Computer-guided drug repurposing: identification of trypanocidal activity of clofazimine, benidipine and saquinavir. Eur. J. Med. Chem., 93: 338-348.
CrossRef | PubMed | Direct Link | - Talevi, A., M.E. Gantner and M.E. Ruiz, 2014. Applications of nanosystems to anticancer drug therapy (Part I. Nanogels, nanospheres, nanocapsules). Recent Patents Anti-Cancer Drug Discovery, 9: 83-98.
PubMed | Direct Link | - Ruiz, M.E., M.E. Gantner and A. Talevi, 2014. Applications of nanosystems to anticancer drug therapy (Part II. Dendrimers, micelles, lipid-based nanosystems). Recent Patents Anti-Cancer Drug Discovery, 9: 99-128.
PubMed | Direct Link | - Di Ianni, M.E. and A. Talevi, 2014. How can network-pharmacology contribute to antiepileptic drug development. Mol. Cell. Epilepsy, 1: 19-25.
CrossRef | Direct Link | - Bellera, C.L., D. Balcazar, L. Alberca, C. Labriola, A. Talevi and C. Carrillo, 2014. Identification of levothyroxine antichagasic activity through computer-aided drug repurposing. Scient. World J., Vol. 2014. 10.1155/2014/279618.
CrossRef | PubMed | Direct Link | - Gantner, M.E., M.E. Di Ianni, M.E. Ruiz, A. Talevi and L.E. Bruno-Blanch, 2013. Development of conformation independent computational models for the early recognition of breast cancer resistance protein substrates. BioMed Res. Int., 10.1155/2013/863592.
CrossRef | PubMed | Direct Link | - Bellera, C.L., M.E. Gantner, M.E. Ruiz and A. Talevi, 2013. Recent advances on nanotechnology applications to cancer drug therapy. J. Cancer Res. Updates, 2: 151-185.
Direct Link | - Bellera, C.L., D.E. Balcazar, L. Alberca, C.A. Labriola, A. Talevi and C. Carrillo, 2013. Application of Computer-aided drug repurposing in the search of new cruzipain inhibitors: Discovery of amiodarone and bromocriptine inhibitory effects. J. Chem. Inform. Model., 53: 2402-2408.
CrossRef | PubMed | Direct Link | - Talevi, A., E.A. Castro and L.E. Bruno-Blanch, 2012. Recent Studies on Similarity Measures and its Applications to Chemoinformatics and Drug Design. In: Recent Trends QSAR Pharmaceutical Perceptions, Khan, M.T.H. (Ed.). Bentham Science Publishers, USA., ISBN: 9781608053797, pp: 272-297.
CrossRef | Direct Link | - Talevi, A., C.L. Bellera, M. di Ianni, P.R. Duchowicz, L.E. Bruno-Blanch and E.A. Castro, 2012. An integrated drug development approach applying topological descriptors. Curr. Comput.-Aided Drug Design, 8: 172-181.
CrossRef | PubMed | Direct Link | - Talevi, A., C.L. Bellera, M. di Ianni, M. Gantner, L.E. Bruno-Blanch and E.A. Castro, 2012. CNS drug Development-lost in translation? Mini Rev. Med. Chem., 12: 959-970.
CrossRef | Direct Link | - Talevi, A., A.V. Enrique and L.E. Bruno-Blanch, 2012. Anticonvulsant activity of artificial sweeteners: a structural link between Sweet-taste receptor T1R3 and brain glutamate receptors. Bioorganic Med. Chem. Lett., 22: 4072-4074.
CrossRef | PubMed | Direct Link | - Esperanza Ruiz, M., A. Gregorini, A. Talevi and M.G. Volonite, 2012. Dissolution studies of generic medications: New evidence of deviations from the transitivity principle. Dissolut. Technol., 19: 13-24.
CrossRef | Direct Link | - Di Ianni, M.E., A.V. Enrique, P.H. Palestro, L. Gavernet, A. Talevi and L.E. Bruno-Blanch, 2012. Several new diverse anticonvulsant agents discovered in a virtual screening campaign aimed at novel antiepileptic drugs to treat refractory epilepsy. J. Chem. Inform. Model., 52: 3325-3330.
CrossRef | PubMed | Direct Link | - Talevi, A., M. Goodarzi, E.V. Ortiz, P.R. Duchowicz and C.L. Bellera et al., 2011. Prediction of drug intestinal absorption by new linear and Non-linear QSPR. Eur. J. Med. Chem., 46: 218-228.
CrossRef | PubMed | Direct Link | - Pizzo, C., C. Saiz, A. Talevi, L. Gavernet and P. Palestro et al., 2011. Synthesis of 2-Hydrazolyl-4-thiazolidinones based on multicomponent reactions and biological evaluation against Trypanosoma cruzi. Chem. Biol. Drug Design, 77: 166-172.
CrossRef | PubMed | Direct Link | - Di Ianni, M., A. Talevi, E.A. Castro and L.E. Bruno-Blanch, 2011. Development of a highly specific ensemble of topological models for early identification of P-glycoprotein substrates. J. Chemometrics, 25: 313-322.
CrossRef | Direct Link | - Talevi, A., C.L. Bellera, E.A. Castro and L.E. Bruno-Blanch, 2010. Optimal partition of datasets of QSPR studies: A sampling problem. MATCH Commun. Math. Comput. Chem., 63: 585-599.
Direct Link | - Talevi, A., 2010. Towards responsible, safe self-medication. Curr. Drug Safety, 5: 314-314.
CrossRef | PubMed | Direct Link | - Talevi, A., 2010. The new patient and responsible Self-medication practices: A critical review. Curr. Drug Safety, 5: 342-353.
CrossRef | PubMed | Direct Link | - Talevi, A., L. Gavernet and L.E. Bruno-Blanch, 2009. Combined virtual screening strategies. Curr. Comput.-Aided Drug Design, 5: 23-37.
CrossRef | Direct Link | - Talevi, A. and L.E. Bruno-Blanch, 2009. Virtual screening: An efficient tool for the development of new drugs in Latin America. Latin Am. J. Pharm., 28: 141-150.
Direct Link | - Nounou, B., M.E. Cattaneo, R. Salmon, L. Palasezze and J. Boccaleri et al., 2009. A study regarding consumption and Self-medication with antibiotics in the city of La Plata (Buenos Aires, Argentina). Latin Am. J. Pharm., 28: 544-551.
- Talevi, A., E.A. Castro and L.E. Bruno Blanch, 2008. Generation of new QSAR model for anticonvulsant activity and application in virtual screening. Int. J. Applied Chem., 4: 99-118.
Direct Link | - Gavernet, L., A. Talevi, E.A. Castro and L.E. Bruno-Blanch, 2008. A combined virtual screening 2D and 3D QSAR methodology for the selection of new anticonvulsant candidates from a natural product library. QSAR Comb. Sci., 27: 1120-1129.
CrossRef | Direct Link | - Duchowicz, P.R., A. Talevi, L.E. Bruno-Blanch and E.A. Castro, 2008. New QSPR study for the prediction of aqueous solubility of drug-like compounds. Bioorganic Med. Chem., 16: 7944-7955.
CrossRef | PubMed | Direct Link | - Talevi, A., M.S. Cravero, E.A. Castro and L.E. Bruno-Blanch, 2007. Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis. Bioorganic Med. Chem. Lett., 17: 1684-1690.
CrossRef | PubMed | Direct Link | - Talevi, A., J.J. Prieto, L.E. Bruno-Blanch and E.A. Castro, 2007. New similarity-based algorithm and its application to classification of anticonvulsant compounds. J. Enzyme Inhibit. Med. Chem., 22: 253-265.
CrossRef | PubMed | Direct Link | - Talevi, A., C.L. Bellera, E.A. Castro and L.E. Bruno-Blanch, 2007. A successful virtual screening application: Prediction of anticonvulsant activity in MES test of widely used pharmaceutical and food preservatives methylparaben and propylparaben. J. Comput.-Aided Mol. Design, 21: 527-538.
CrossRef | PubMed | Direct Link | - Duchowicz, P.R., A. Talevi, C. Bellera, L.E. Bruno-Blanch and E.A. Castro, 2007. Application of descriptors based on Lipinski's rules in the QSPR study of aqueous solubilities. Bioorganic Med. Chem., 15: 3711-3719.
CrossRef | PubMed | Direct Link | - Castronuovo, C., F. Chiclana, L. Giosso, G. Pensa and M. Prario et al., 2007. Automedicacion en estudiantes de la Universidad Nacional de La Plata (Argentina). Latin Am. J. Pharm., 26: 937-944.
Direct Link | - Bellera, C.L., A. Talevi and L.E. Bruno-Blanch, 2007. Application of linear discriminant analysis in the search of antiepileptogenic drugs. Latin Am. J. Pharm., 26: 244-252.
Direct Link | - Prieto, J.J., A. Talevi and L.E. Bruno-Blanch, 2006. Application of linear discriminant analysis in the virtual screening of antichagasic drugs through trypanothione reductase inhibition. Mol. Diversity, 10: 361-375.
CrossRef | PubMed | Direct Link |