Dr. Francisco Eduardo Martinez
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Dr. Francisco Eduardo Martinez

Research Scientist
University Estadual Paulista, Brazil


Highest Degree
Ph.D. in Biology from University Estadual Paulista, Brazil

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Biography

Dr. Francisco Eduardo Martinez is currently working as Professor of Anatomy at Bioscience Institute/UNESP. He obtained his PhD in Department of Anatomy, Bioscience Institute in 1993. In pat he worked as Assistant Teacher and Assistant Professor at Bioscience Institute/UNESP. He has published 5 research articles in journals as well as 3 chapters in books contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Cytology
62%
Structural Biology
90%
Pathology
75%
Cell Biology
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
67
Abstracts
5

Selected Publications

  1. Fioravante, V.C., A.R. Godoi, V.M. de Barros Camargo, P.F.F. Pinheiro, M. Martinez, C.R. Padovani and F.E. Martinez, 2022. Low and high postpubertal ethanol use: Damage on adulthood reproduction and offspring. Reprod. Fertil., 3: 140-151.
    CrossRef  |  Direct Link  |  
  2. Martinez, M., F.A. Milton, P.F.F. Pinheiro, C.C. Almeida-Francia and V.H. Cagnon-Quitete et al., 2016. Chronic ethanol intake leads to structural and molecular alterations in the rat endometrium. Alcohol, 52: 55-61.
    CrossRef  |  Direct Link  |  
  3. Chuffa, L.G.A., M.S. Alves, M. Martinez, I.C.C. Camargo and P.F.F. Pinheiro et al., 2016. Apoptosis is triggered by melatonin in an in vivo model of ovarian carcinoma. Endocrine-Relat. Cancer, 23: 65-76.
    CrossRef  |  Direct Link  |  
  4. Rosa-Toledo, O., L.G. Almeida-Chuffa, M. Martinez, P.F. Felipe-Pinheiro, C.R. Padovani and F.E. Martinez, 2015. Maternal separation on the ethanol-preferring adult rat liver structure. Ann. Hepatol., 14: 910-918.
    Direct Link  |  
  5. Mendes, L.O., W.R. Scarano, S.S. Rochel-Maia, B.A. Fioruci-Fontaneli, L.G. Chuffa, J.A. Anselmo-Franci and F.E. Martinez, 2015. Androgen therapy reverses injuries caused by ethanol consumption in the prostate: Testosterone as a possible target to ethanol-related disorders. Life Sci., 120: 22-30.
    CrossRef  |  Direct Link  |  
  6. Martinez, M., R. Sauce, S.A. Oliveira, L.G. de Almeida Chuffa and M.A. Stefanini et al., 2015. Ethanol intake-induced apoptosis in glial cells and axonal disorders in the cerebellar white matter of UChA rats (voluntary ethanol consumers). Tissue Cell, 147: 389-394.
    CrossRef  |  Direct Link  |  
  7. Fioruci-Fontanelli, B.A., L.G.A. Chuffa, L.O. Mendes, P.F.F. Pinheiro, L.A. Justulin Jr., S.L. Felisbino and F.E. Martinez, 2015. Ethanol modulates the synthesis and catabolism of retinoic acid in the rat prostate. Reprod. Toxicol., 53: 1-9.
    CrossRef  |  Direct Link  |  
  8. Fioruci-Fontanelli, B.A., L.G.A. Chuffa, L.O. Mendes, P.F.F. Pinheiro and F.K. Delella et al., 2015. MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression in the prostatic tissue of two ethanol-preferring rat models. Anal. Cell. Pathol. 10.1155/2015/954548.
    CrossRef  |  Direct Link  |  
  9. Chuffa, L.G., B.A. Fioruci-Fontanelli, L.O. Mendes, F.R.F. Seiva and M. Martinez et al., 2015. Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer. BMC Cancer, Vol. 15. 10.1186/s12885-015-1032-4.
    CrossRef  |  
  10. Oliveira, S.A., L.G.A. Chuffa, B.A. Fioruci-Fontanelli, F.S.L. Neto and P.C. Novais et al., 2014. Apoptosis of purkinje and granular cells of the cerebellum following chronic ethanol intake. Cerebellum, 13: 728-738.
    CrossRef  |  Direct Link  |  
  11. Oliveira, S.A., B.A.F. Fontanelli, M.A. Stefanini, L.G.A. Chuffa and G.R. Teixeira et al., 2014. Interaction of maternal separation on the UCh rat cerebellum. Microsc. Res. Tech., 77: 44-51.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Mendes, L.O., W.R. Scarano, S.S. Rochel-Maia, B.A. Fioruci-Fontaneli and L.G.A. Chuffa et al., 2014. Testosterone therapy differently regulates the anti- and pro-inflammatory cytokines in the plasma and prostate of rats submitted to chronic ethanol consumption (UChB). Am. J. Reprod. Immunol., 72: 317-325.
    CrossRef  |  PubMed  |  Direct Link  |  
  13. Ferreira, G.M., M. Martinez, I.C.C. Camargo, R.F. Domeniconi, F.E. Martinez and L.G.A. Chuffa, 2014. Melatonin attenuates Her-2, p38 MAPK, p-AKT and mTOR levels in ovarian carcinoma of Ethanol-preferring rats. J. Cancer, 5: 728-735.
  14. Fontanelli, B.A.F., L.G.A. Chuffa, G.R. Teixeira, J.P.A. Amorim and L.O. Mendes et al., 2013. Chronic ethanol consumption alters all-Trans-retinoic acid concentration and expression of their receptors on the prostate: a possible link between alcoholism and prostate damage. Alcoholism Clin. Exp. Res., 37: 49-56.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Chuffa, L.G.A., F.R.F. Seiva, W.J. Favaro, J.P.A. Amorim and G.R. Teixeira et al., 2013. Melatonin and ethanol intake exert opposite effects on circulating estradiol and progesterone and differentially regulate sex steroid receptors in the ovaries, oviducts, and uteri of adult rats. Reprod. Toxicol., 39: 40-49.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Chuffa, L.G.A., B.A. Fioruci-Fontanelli, L.O. Mendes, W.J. Favaro, P.F.F. Pinheiro, M. Martinez and F.E Martinez, 2013. Characterization of chemically induced ovarian carcinomas in an ethanol-preferring rat model: Influence of long-term melatonin treatment. PloS One, Vol. 8. 10.1371/journal.pone.0081676.
    CrossRef  |  Direct Link  |  
  17. Teixeira, G.R., W.J. Favaro, P.F.F. Pinheiro, L.G.A. Chuffa and J.P.A. Amorim et al., 2012. Physical exercise on the rat ventral prostate: Steroid hormone receptors, apoptosis and cell proliferation. Scand. J. Med. Sci. Sports, 22: e86-e92.
    CrossRef  |  Direct Link  |  
  18. Teixeira, G.R., L.G.A. Chuffa, O.A. Martins, R. Kremer and P.F.F. Pinheiro et al., 2012. The expression of aquaporins 1 and 9 in adult rat epididymis is pertubed by chronic exposure to ethanol. Tissue Cell, 44: 47-53.
    CrossRef  |  Direct Link  |  
  19. Mendes, L.O., J.P.A. Amorim, G.R. Teixeira, L.G.A. Chuffa and B.A. Fioruci et al., 2011. Mast cells and ethanol consumption: Interactions in the prostate, epididymis and testis of uchb rats. Am. J. Reprod. Immunol., 66: 170-178.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Martinez, M., S.A.D. Oliveira, P.F.F. Pinheiro, C. Almeida-Francia and S. Pereira et al., 2011. IGFR-I expression and structural analysis of the hard palatine mucosa in an ethanol-drinking rat strain (UChA and UChB). Tissue Cell, 43: 101-107.
    CrossRef  |  PubMed  |  Direct Link  |  
  21. Chuffa, L.G.A., J.P.A. Amorim, G.R. Teixeira, L.O. Mendes and B.A. Fioruci et al., 2011. Long-term melatonin treatment reduces ovarian mass and enhances tissue antioxidant defenses during ovulation in the rat Braz. J. Med. Biol. Res., 44: 217-233.
    CrossRef  |  PubMed  |  Direct Link  |  
  22. Chuffa, L.G.A., J.P.A. Amorim, G.R. Teixeira, L.O. Mendes and B.A. Fioruci et al., 2011. Long-term exogenous melatonin treatment modulates overall feed efficiency and protects ovarian tissue against injuries caused by ethanol-induced oxidative stress in adult UChB rats. Alcoholism Clin. Exp. Res., 35: 1498-1508.
    CrossRef  |  PubMed  |  Direct Link  |  
  23. Chuffa, L.G.A., F.R.F. Seiva, W.J. Favaro, G.R. Teixeira and J.P.A. Amorim et al., 2011. Melatonin reduces LH, 17 beta-estradiol and induces differential regulation of sex steroid receptors in reproductive tissues during rat ovulation. Reprod. Biol. Endocrinol., Vol. 9. 10.1186/1477-7827-9-108.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Amorim, J.P.A., L.G.A. Chuffa, G.R. Teixeira, L.O. Mendes and B.A. Fioruci et al., 2011. Variations in maternal care alter corticosterone and 17beta-estradiol levels, estrous cycle and folliculogenesis and stimulate the expression of estrogen receptors alpha and beta in the ovaries of UCh rats. Reprod. Biol. Endocrinol., Vol. 9. 10.1186/1477-7827-9-160.
    CrossRef  |  Direct Link  |  
  25. Montico, F., W.J. Favaroa, E.M. Candido, M. Martinez and P.F.F. Pinheiro et al., 2010. Alcoholism and coagulating gland: Androgen and insulin like growth factor-1 receptor features. Tissue Cell, 42: 203-210.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Martinez, M., S. Macera, G.F. de Assis, P.F.F. Pinheiro and C.C.D. Almeida et al., 2009. Structural evaluation of the effects of chronic ethanol ingestion on the testis of calomys callosus. Tissue Cell, 41: 199-205.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Chuff, L.G.A., C.R. Padovani and F.E. Martinez, 2009. Ovarian structure and hormonal status of the UChA and UChB adult rats in response to ethanol. Maturitas, 62: 21-29.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Martinez, M., G.S. Reis, P.F.F. Pinheiro, C.C.D. Almeida and V.H.A. Cagnon et al., 2008. Evaluation of the ethanol intake on the Calomys callosus seminal vesicle structure. Micron, 39: 587-592.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Pinheiro, P.F.F., T.M. Segatelli, C.C.D.A. Francia, M. Martinez and C.R. Padovani et al., 2007. Morphologic changes in the urethral epithelium in an ethanol-drinking rat strain (UChA and UChB). Micron, 38: 734-746.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Candido, E.M., C.A.F. Carvalho, F.E. Martinez and V.H.A. Cagnon, 2007. Experimental alcoholism and pathogenesis of prostatic diseases in UChB rats. Cell Biol. Int., 31: 459-472.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Pereira, S., M. Martinez, F.E. Martinez and W.M. Junior, 2006. Repercussions of castration and vasectomy on the ductal system of the rat ventral prostate. Cell Biol. Int., 30: 169-174.
    CrossRef  |  PubMed  |  Direct Link  |  
  32. Martinez, M., F.A. Milton, S.A. de Oliveira, G.S. Reis and S. Pereira et al., 2006. Morphological alterations on the prostate of calomys callosus submitted to chronic ethanol ingestion. J. Submicroscopic Cytol. Pathol., 38: 117-123.
    PubMed  |  Direct Link  |  
  33. Martinez, M., F.A. Milton, S.A. de Oliveira, N.F. de Lima and T.M. Segatelli et al., 2005. Ultrastructural changes on the hard palatine mucosa of calomys callosus after 120 days of experimental chronic alcoholism. J. Submicroscopic Cytol. Pathol., 37: 59-65.
    PubMed  |  
  34. Segatelli, T.M., L.R. Franca, P.F.F. Pinheiro, C.C.D. Alemida and M. Martinez et al., 2004. Spermatogenic cycle length and spermatogenic efficiency in the gerbil (Meriones unguiculatus). J. Andrology, 25: 872-880.
    CrossRef  |  PubMed  |  Direct Link  |  
  35. Rissato, J.H., M.V. Ietsugu, C.C. Almeida, P.F. Pinheiro and T.M. Segatelli et al., 2003. Morphology of the vas deferens in an ethanol-drinking strain of rats (UChA and UChB). J. Submicroscopic Cytol. Pathol., 35: 331-341.
    PubMed  |  
  36. Pinheiro, P.F.F., C.C.D. Almeida, T.M. Segatelli, M. Martinez and C.R. Padovani et al., 2003. Ultrastructure of the urethra of the Mongolian gerbil. World J. Urol., 20: 378-384.
    CrossRef  |  PubMed  |  Direct Link  |  
  37. Pinheiro, P.F.F., C.C.D. Almeida, T.M. Segatelli, M. Martinez and C.R. Padovani et al., 2003. Structure of the pelvic and penile urethra-relationship with the ducts of the sex accessory glands of the Mongolian gerbil (Meriones unguiculatus). J. Anat., 202: 431-444.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Martinez, M., M.A. Stefanini, F.E. Martinez, H.L. Guida and P.F.F. Pinheiro et al., 2003. Morphological study of the tongue of budgerigar (Melopsittacus undulatus). Int. J. Morphol., 21 : 117-122.
    CrossRef  |  Direct Link  |  
  39. Laura, I.A., F.E. Martinez, C.R. Padovani and M. Martinez, 2003. Ultrastructural and morphometric analysis on the ovary of wistar rats after chronic ethanol ingestion. J. Submicroscopic Cytol. Pathol., 20: 167-176.
    PubMed  |  Direct Link  |  
  40. Segatelli, T.M., C.C.D. Almeida, P.F.F. Pinheiro, M. Martinez, C.R. Padovani and F.E. Martinez, 2002. Kinetics of spermatogenesis in the mongolian gerbil (Meriones unguiculatus). Tissue Cell, 34: 7-13.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Martinez, M., F.E. Martinez, M.R. da Cunha, T.M. Segatelli and P.F. Pinheiro et al., 2002. Morphological effects on the hard palatine mucosa of Calomys callosus submitted to experimental chronic alcoholism. J. Submicroscopic Cytol. Pathol., 34: 77-83.
    PubMed  |  
  42. Martinez, M., P.J. Garcia, V.H. Cagnon, W. Mello-Junior and C.R. Padovani et al., 2001. Effects of chronic experimental alcoholism on the epithelium of the uterine horn of rats (Rattus norvegicus Albinus). J. Submicroscopic Cytol. Pathol., 33: 107-115.
    PubMed  |  
  43. Martinez, M., E.C. Mattos, W.J. Mello, V.H. Cagnon and F.E. Martinez, 2001. Morphology of the seminal vesicle of calomys callosus submitted to experimental chronic alcoholism. J. Submicroscopic Cytol. Pathol., 33: 453-461.
    PubMed  |  Direct Link  |  
  44. Martinez, F.E., I.A. Laura, M. Martinez, C.R. Padovani and E. Bustos-Obregon, 2001. Morphology of the ventral lobe of the prostate and seminal vesicles in an ethanol-drinking strain of rats (UChA and UChB). J. Submicroscopic Cytol. Pathol., 33: 99-106.
    PubMed  |  Direct Link  |  
  45. Cagnon, V.H.A, F.M Tomazini, P.J Garcia, F.E Martinez and M. Martinez et al., 2001. Structure and ultrastructure of the ventral prostate of isogenic mice (C57B1/6J) submitted to chronic alcohol ingestion. Tissue Cell, 33: 354-360.
    CrossRef  |  PubMed  |  Direct Link  |  
  46. Almeida, C.C.D., P.F.F. Pinheiro, T.M. Segatelli, M. Martinez and C.R. Padovani et al., 2001. Estrous cycle, anatomy and histology of the uterine tube of the mongolian gerbil (Meriones unguiculatus). Rev. chil. Anatomia, 19 : 191-196.
    CrossRef  |  Direct Link  |  
  47. Segatelli, T.M., C.C.D. Almedia, P.F.F. Pinheiro, M. Martinez and C.R. Padovani et al., 2000. Ultrastructural study of acrosomeformation in mongolian gerbil (Meriones unguiculatus). Tissue Cell, 32: 508-517.
    CrossRef  |  PubMed  |  Direct Link  |  
  48. Martinez, M., F.E. Martinez, P.F.F. Pinheiro, C.C.D. Almeida and T.M. Segatelli et al., 2000. Scanning electron microscopic study of the tongue of chinchila (Chinchilla laniger). Rev. chil. Anatomia, 18 : 53-59.
    CrossRef  |  Direct Link  |  
  49. Martinez, F.E., M. Martinez, C.R. Padovani and E. Bustos-Obregon, 2000. Morphology of testis and epididymis in an ethanol-drinking rat strain (UChA and UChB). J. Submicroscopic Cytol. Pathol., 32: 175-184.
    PubMed  |  Direct Link  |  
  50. Cagnon, V.H.A., A.M. Camargo, R.M. Rosa, R. Fabiani and C.R. Padovani et al., 2000. Ultrastructural study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57BL/6J). Tissue Cell, 32: 275-283.
    CrossRef  |  PubMed  |  Direct Link  |  
  51. Martinez, M., H.L. Guida, R.J.S. Domingues, F.D. Cassel and E.P.A. Filho et al., 1999. Morphological study of the larynx of chinchilla (Chinchilla laniger). Rev. chil. Anatomia, 17 : 39-45.
    CrossRef  |  Direct Link  |  
  52. Martinez, M., F.E. Martinez, P.J. Garcia, V.H. Cagnon and M.W. Junior et al., 1999. Morphometric analysis of the endometrial epithelium of rats (Rattus norvegicus Albinus) submitted to chronic experimental alcoholism. J. Submicroscopic Cytol. Pathol., 31: 469-475.
    PubMed  |  
  53. Martinez, M., A.C.B. Junior, V.H. Cagnon, M.W. Junior and P.J. Garcia et al., 1999. Ultrastructural changes on the epithelial cells of uterine tubes of wistar rats after chronic ethanol ingestion. J. Submicroscopic Cytol. Pathol., 31: 273-278.
    PubMed  |  Direct Link  |  
  54. Garcia, P.J., V.H.A. Cagnon, W.M. Jr., M. Martinez and F.E. Martinez, 1999. Ultrastructural observations of the dorsal lobe of the prostate of rats (Rattus norvegicus) submitted to experimental chronic alcohol ingestion. Rev. chil. Anatomia, 17: 153-159.
    CrossRef  |  Direct Link  |  
  55. Tirapelli, L.F., O.J. Tamega and F.E. Martinez, 1998. Ultrastructural changes of the choroid plexus of the lateral ventricles of rats (Rattus norvegicus) submitted to experimental chronic alcoholism, followed by alcohol withdrawal. Rev. chil. Anatomia, 16: 229-235.
    CrossRef  |  Direct Link  |  
  56. Martinez, M., F.E. Martinez, P.F.F. Pinheiro, C.C.D. Almeida and H.L. Guida et al., 1998. Light and scanning electron microscopic study of the vallate papillae of the opossum (Didelphis albiventris). Rev. chil. Anatomia, 16: 67-73.
    CrossRef  |  Direct Link  |  
  57. Martinez, M., F.E. Martinez and I.S. Watanabe, 1998. Light and scanning electron microscopic study of the palatine mucosa of nine-banded armadillo (Dasypus novemcinctus). Eur. J. Morphol., 36: 97-104.
    PubMed  |  
  58. Martinez, M., F.E. Martinez and I. Watanabe, 1998. Morphological changes on the hard palatine mucosa of rats (Rattus norvegicus albinus) after chronic alcohol consumption. J. Submicroscopic Cytol. Pathol., 30: 379-384.
    PubMed  |  
  59. Cagnon, V.H., P.J. Garcia, G.J. Filho, F.E. Martinez and M.W. Jr et al., 1998. Ultrastructural study of the lateral lobe of the prostate of wistar rats submitted to experimental chronic alcohol ingestion. J. Submicroscopic Cytol. Pathol., 30: 77-84.
    PubMed  |  
  60. Novelli, E.L.B., N.L. Rodrigues, C.X.C. Santos, F.E. Martinez and J.L.V.B. Novelli, 1997. Toxic effects of alcohol intake on prostate of rats. Prostate, 31: 37-41.
    PubMed  |  Direct Link  |  
  61. Martinez, M., I.S. Watanabe, M.F. Eduardo, N.A. Basso and O. Ribeiro et al., 1997. Scanning electron microscopic study of the hard palatine mucosa of opossum (Didelphis albiventris). Rev. Chil. Anatomia, 15: 13-18.
    CrossRef  |  Direct Link  |  
  62. Martinez, F.E., P.J. Garcia, C.R. Padovani, V.H. Cagnon and M. Martinez, 1997. A morphometric ultrastructural study of the seminal vesicle of rats submitted to experimental chronic alcoholism. J. Submicroscopic Cytol. Pathol., 29: 537-542.
    PubMed  |  
  63. Martinez, F.E., M. Martinez, V.H.A. Cagnon, M.W. Junior and C.R. Padovani et al., 1997. Effects of experimental chronic alcoholism on the seminal vesicle and testis weight of adult rats (Rattus norvegicus). Rev. chil. Anatomia, 15: 121-126.
    CrossRef  |  Direct Link  |  
  64. Junior, M.W., P.J. Garcia, V.H. Cagnon, M. Martinez and F.E. Martinez, 1997. Morphologic changes in the vesical transition epithelium of alcoholic rats. J. Submicroscopic Cytol. Pathol., 29: 393-399.
    PubMed  |  Direct Link  |  
  65. Cagnon, V.H.A., P.J. Garcia, F.E. Martinez, M. Martinez and C.R. Padovani, 1996. Ultrastructural study of the coagulating gland of Wistar rats submitted to experimental chronic alcohol ingestion. Prostate, 28: 341-346.
    PubMed  |  Direct Link  |  
  66. Martinez, M., I.S. Watanabe, F.E. Martinez and R.A. Lopes, 1995. Ultrastructural study of the palatine mucosa of the opossum (Didelphis albiventris). Braz. J. Morphological Sci., 12: 115-120.
    Direct Link  |  
  67. Martinez, F.E., P.J. Garcia, C.R. Padovani, V.H.A. Cagnon and M. Martinez, 1993. Ultrastructural study of the ventral lobe of the prostate of rats submitted to experimental chronic alcoholism. Prostate, 22: 317-324.
    CrossRef  |  PubMed  |  Direct Link  |