Dr. Constance Lay Lay Saw
My Social Links

Dr. Constance Lay Lay Saw

Post-Doctoral Fellow
The State University of New Jersey, USA

Highest Degree
PostDoc. Student in Cancer Chemoprevention from The State University of New Jersey, USA

Share this Profile

Area of Interest:

Pharmacology and Toxicology
100%
Natural Product
62%
Clinical Medicine
90%
Pharmacological Analysis
75%
Pharmacy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
64
Abstracts
0

Selected Publications

  1. Wu, T.Y., T.O. Khor, C.L. Saw, S.C. Loh and A.I. Chen et al., 2011. Anti-inflammatory/anti-oxidative stress activities and differential regulation of Nrf2-mediated genes by non-polar fractions of tea Chrysanthemum zawadskii and Licorice Glycyrrhiza uralensis. Am. Assoc. Pharm. Sei. J. 13: 1-13.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Saw, C.L.L., M. Cintron, T.Y. Wu, Y. Guo, Y. Huang, W.S. Jeong and A.N.T. Kong, 2011. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2‐mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm. Drug Dispos., 32: 289-300.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Saw, C.L., M.T. Huang, Y. Liu, A.H. Conney, T.O. Khor and A.N. Kong, 2011. Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. Mol. Carcinog., 50: 479-486.
    CrossRef  |  PubMed  |  Direct Link  |  
  4. Saw, C.L. and A.N. Kong, 2011. Nrf2 as a therapeutic target in colon cancer. Expert Opin. Ther. Targets, 15: 281-295.
  5. Wang, H., T.O. Khor, C.L. Saw, W. Lin, T. Wu, Y. Huang and A.N. Kong, 2010. Role of Nrf2 in suppressing LPS-induced inflammation in mouse peritoneal macrophages by polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). Mol. Pharm., 7: 2185-2193.
    CrossRef  |  PubMed  |  Direct Link  |  
  6. Saw, C.L., Y. Huang and A.N. Kong, 2010. Synergistic anti-inflammatory effects of low doses of curcumin in combination with polyunsaturated fatty acids: Docosahexaenoic acid or eicosapentaenoic acid. Biochem. Pharmacol., 79: 421-430.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Saw, C.L., Q. Wu and A.N. Kong, 2010. Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways. Chin. Med., 5: 37-42.
    CrossRef  |  PubMed  |  Direct Link  |  
  8. Hu, R., C.L.L. Saw, R. Yu and A.N.T. Kong, 2010. Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory. Antioxid. Redox Signaling, 13: 1679-1698.
    CrossRef  |  PubMed  |  Direct Link  |  
  9. Prawan, A., C.L. Saw, T.O. Khor, Y.S. Keum, S. Yu, L. Hu and A.N. Kong, 2009. Anti-NF-kB and anti-inflammatory activities of synthetic Isothiocyanates: effect of chemical structures and cellular signaling. Chem. Biol. Interact., 179: 202-211.
    CrossRef  |  PubMed  |  Direct Link  |  
  10. Liu, J., Saw, C.L. M. Olivo, S. Thankiah, S. Ahmed, P.W.S. Heng and T. Wohland, 2009. The study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques. Biophys. J., 96: 43-44.
    CrossRef  |  Direct Link  |  
  11. Barve, A., C. Chen, V. Hebbar, J. Desiderio, C.L. Saw and A.N. Kong, 2009. Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats. Biopharm. Drug Dispos., 30: 356-365.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Saw, C.L., P.W.S. Heng and M. Olivo, 2008. Potentiation of the photodynamic action of hypericin. J. Environ. Pathol. Toxicol. Oncol., 27: 23-33.
    PubMed  |  
  13. Saw, C.L., P.W.S. Heng and C.V. Liew, 2008. Chick chorioallantoic membrane as an in situ biological membrane for pharmaceutical formulation development: A review. Drug Dev. Ind. Pharm., 34: 1168-1177.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Chan, L.W., E.L.C. Cheah, C.L. Saw, W.Y. Weng and P.W.S. Heng, 2008. Antimicrobial and antioxidant activities of Cortex Magnoliae officinalis and some other medicinal plants commonly used in South-East Asia. Chin Med. 3: 15-15.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Saw, C.L., M. Olivo, W.W. Chin, K.C. Soo and P.W.S. Heng, 2007. Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model. J. Photochem. Photobiol. B, Biol., 86: 207-218.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Saw, C.L., M. Olivo, T. Wohland, C.Y. Fu, K.W. Kho, K.C. Soo and P.W.S. Heng, 2007. Effects of N-methyl pyrrolidone on the uptake of hypericin in human bladder carcinoma and co-staining with DAPI investigated by confocal microscopy. Technol. Cancer Res. Treat., 6: 383-394.
    PubMed  |  Direct Link  |  
  17. Saw, C.L., P.W.S. Heng, W.W. Chin, K.C. Soo and M. Olivo, 2006. Enhanced photodynamic activity of hypericin by penetration enhancer N-Methyl pyrrolidone formulations in the chick chorioallantoic membrane model. Cancer Lett., 238: 104-110.
    CrossRef  |  PubMed  |  Direct Link  |  
  18. Saw, C.L., M. Olivo, K.C. Soo and P.W.S. Heng, 2006. Spectroscopic characterization and photobleaching kinetics of hypericin-N-methyl pyrrolidone formulations. Photochem. Photobiol. Sci., 5: 1018-1023.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Saw, C.L., M. Olivo, K.C. Soo and P.W.S. Heng, 2006. Delivery of hypericin for photodynamic applications. Cancer Lett., 241: 23-30.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Saw, C.L., M. Olivo, W.W. Chin, K.C. Soo and P.W.S. Heng, 2005. Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment. Biol. Pharm. Bull., 28: 1054-1060.
    PubMed  |  
  21. Chin, W., W. Lau, C.L. Saw, K.W. Kho and M. Olivo, 2004. Photodynamic-induced vascular damage of the chick chorioallantoic membrane model using perylenequinones. Int. J. Oncol., 25: 887-891.
    PubMed  |  Direct Link  |