Dr. Olga Lavrik
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Dr. Olga Lavrik

Professor
Head of the Laboratory of Bioorganic Chemistry of Enzymes, Institute of Chemical Biology and Fundamental Medicine, Prospekt Lavrentiev, Novosibirsk, Russian Federation

Highest Degree
Ph.D. in Bioorganic Chemistry from Institute of Bioorganic Chemistry, Russia

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Area of Interest:

Chemistry
100%
Enzymes
62%
Cancer Research
90%
Biochemistry
75%
Protein Purification
55%

Research Publications in Numbers

Books
0
Chapters
3
Articles
417
Abstracts
8

Selected Publications

  1. Zakharenko, A.L., O.A. Luzina, A.A. Chepanova, N.S. Dyrkheeva, N.F. Salakhutdinov and O.I. Lavrik, 2023. Natural products and their derivatives as inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24065781.
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  2. Zakharenko, A.L., N.S. Dyrkheeva, O.A. Luzina, A.S. Filimonov and E.S. Mozhaitsev et al., 2023. Usnic acid derivatives inhibit DNA repair enzymes tyrosyl-DNA phosphodiesterases 1 and 2 and act as potential anticancer agents. Genes, Vol. 14. 10.3390/genes14101931.
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  3. Volcho, K.P. and O.I. Lavrik, 2023. Inhibition of DNA repair enzymes as a valuable pharmaceutical approach. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24097954.
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  4. Ukraintsev, A., M. Kutuzov, E. Belousova, M. Joyeau, V. Golyshev, A. Lomzov and O. Lavrik, 2023. PARP3 affects nucleosome compaction regulation. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24109042.
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  5. Makeeva, V.S., N.S. Dyrkheeva, O.I. Lavrik, S.M. Zakian and A.A. Malakhova, 2023. Mutant-huntingtin molecular pathways elucidate new targets for drug repurposing. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms242316798.
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  6. Kovaleva, K.S., O.I. Yarovaya, I.A. Chernyshova, A.L. Zakharenko and S.V. Cheresiz et al., 2023. Synthesis of norabietyl and nordehydroabietyl imidazolidine-2,4,5-Triones and their activity against Tyrosyl-DNA phosphodiesterase 1. Molbank, Vol. 2023. 10.3390/M1743.
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  7. Khomenko, T.M., A.L. Zakharenko, T.E. Kornienko, A.A. Chepanova and N.S. Dyrkheeva et al., 2023. New 5-hydroxycoumarin-based tyrosyl-DNA phosphodiesterase I inhibitors sensitize tumor cell line to topotecan. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24119155.
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  8. Ivankin, D.I., T.E. Kornienko, M.A. Mikhailova, N.S. Dyrkheeva and A.L. Zakharenko et al., 2023. Novel TDP1 inhibitors: Disubstituted thiazolidine-2,4-diones containing monoterpene moieties. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24043834.
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  9. Dyrkheeva, N.S., A.A. Malakhova, A.L. Zakharenko, L.S. Okorokova and D.N. Shtokalo et al., 2023. Transcriptomic analysis of CRISPR/Cas9-mediated PARP1-Knockout cells under the influence of topotecan and TDP1 inhibitor. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24065148.
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  10. Chernyshova, I.A., A.L. Zakharenko, N.N. Kurochkin, N.S. Dyrkheeva and T.E. Kornienko et al., 2023. The lipophilic purine nucleoside-Tdp1 inhibitor-enhances DNA damage induced by topotecan in vitro and potentiates the antitumor effect of topotecan in vivo. Molecules, Vol. 28. 10.3390/molecules28010323.
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  11. Sukhanova, M.V., R.O. Anarbaev, E.A. Maltseva, D. Pastré and O.I. Lavrik, 2022. FUS microphase separation: Regulation by nucleic acid polymers and DNA repair proteins. Int. J. Mol. Sci., Vol. 23. 10.3390/ijms232113200.
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  12. Singatulina, A.S., M.V. Sukhanova, B. Desforges, V. Joshi, D. Pastré and O.I. Lavrik, 2022. PARP1 activation controls stress granule assembly after oxidative stress and DNA damage. Cells, Vol. 11. 10.3390/cells11233932.
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  13. Salomatina, O.V., N.S. Dyrkheeva, I.I. Popadyuk, A.L. Zakharenko and E.S. Ilina et al., 2022. New deoxycholic acid derived Tyrosyl-DNA phosphodiesterase 1 inhibitors also inhibit tyrosyl-DNA phosphodiesterase 2. Molecules, Vol. 27. 10.3390/molecules27010072.
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  14. Munkuev, A.A., N.S. Dyrkheeva, T.E. Kornienko, E.S. Ilina and D.I. Ivankin et al., 2022. Adamantane-monoterpenoid conjugates linked via heterocyclic linkers enhance the cytotoxic effect of topotecan. Molecules, Vol. 27. 10.3390/molecules27113374.
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  15. Krasikova, Y.S., O.I. Lavrik and N.I. Rechkunova, 2022. The XPA protein-life under precise control. Cells, Vol. 11. 10.3390/cells11233723.
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  16. Dyrkheeva, N.S., I.A. Chernyshova, G.A. Ivanov, Y.B. Porozov and A.A. Zenchenko et al., 2022. In vitro and in silico studies of human Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibition by stereoisomeric forms of lipophilic nucleosides: The role of carbohydrate stereochemistry in ligand-enzyme interactions. Molecules, Vol. 27. 10.3390/molecules27082433.
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  17. Alemasova, E.E. and O.I. Lavrik, 2022. Poly(ADP-ribose) in condensates: The PARtnership of phase separation and site-specific interactions. Int. J. Mol. Sci., Vol. 23. 10.3390/ijms232214075.
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  18. Vasil’eva, I., N. Moor, R. Anarbaev, M. Kutuzov and O. Lavrik, 2021. Functional roles of PARP2 in assembling protein-protein complexes involved in base excision DNA repair. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms22094679.
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  19. Munkuev, A.A., E.S. Mozhaitsev, A.A. Chepanova, E.V. Suslov and D.V. Korchagina et al., 2021. Novel Tdp1 inhibitors based on adamantane connected with monoterpene moieties via heterocyclic fragments. Molecules, Vol. 26. 10.3390/molecules26113128.
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  20. Krasikova, Y., N. Rechkunova and O. Lavrik, 2021. Nucleotide excision repair: From molecular defects to neurological abnormalities. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms22126220.
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  21. Kovaleva, K., O. Yarovaya, K. Ponomarev, S. Cheresiz and A. Azimirad et al., 2021. Design, synthesis, and molecular docking study of new Tyrosyl-DNA phosphodiesterase 1 (Tdp1) inhibitors combining resin acids and adamantane moieties. Pharmaceuticals, Vol. 14. 10.3390/ph14050422.
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  22. Gladkova, E.D., A.A. Chepanova, E.S. Ilina, A.L. Zakharenko and J. Reynisson et al., 2021. Discovery of novel sultone fused berberine derivatives as promising Tdp1 inhibitors. Molecules, Vol. 26. 10.3390/molecules26071945.
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  23. Dyrkheeva, N.S., A.S. Filimonov, O.A. Luzina, K.A. Orlova and I.A. Chernyshova et al., 2021. New hybrid compounds combining fragments of usnic acid and thioether are inhibitors of human enzymes TDP1, TDP2 and PARP1. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms222111336.
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  24. Dyrkheeva, N.S., A.S. Filimonov, O.A. Luzina, A.L. Zakharenko and E.S. Ilina et al., 2021. New hybrid compounds combining fragments of usnic acid and monoterpenoids for effective Tyrosyl-DNA phosphodiesterase 1 Inhibition. Biomolecules, Vol. 11. 10.3390/biom11070973.
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