Dr. Koichi  Othaki
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Dr. Koichi Othaki

Associate Professor
Hokkaido University of Science, Japan

Highest Degree
Ph.D. in Pharmacology from Hokkaido University, Japan

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Area of Interest:

Pharmacology and Toxicology
Pharmaceutical Analysis
Drugs Bioavailability
Neuro Pharmacology

Research Publications in Numbers


Selected Publications

  1. Iwayama, K., J. Kimura, A. Mishima, A. Kusakabe, K.I. Ohtaki, Y. Tampo and N. Hayase, 2018. Low concentrations of clarithromycin upregulate cellular antioxidant enzymes and phosphorylation of extracellular signal-regulated kinase in human small airway epithelial cells. J. Pharm. Health Care Sci., Vol. 4. 10.1186/s40780-018-0120-4.
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  2. Iwayama, K., A. Kusakabe, K. Ohtsu, T. Nawano and R. Tatsunami et al., 2017. Long-term treatment of clarithromycin at a low concentration improves hydrogen peroxide-induced oxidant/antioxidant imbalance in human small airway epithelial cells by increasing Nrf2 mRNA expression. BMC Pharmacol. Toxicol., Vol. 18. 10.1186/s40360-017-0119-8.
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  3. Tasaki, Y., J. Yamamoto, T. Omura, T. Sakaguchi and N. Kimura et al., 2012. Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model. Neurosci. Lett., 521: 15-19.
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  4. Iwayama, K., Y. Takashima, K.I. Ohtaki, K. Endoh, Y. Tampo and N. Hayase, 2012. Protective effects of clarithromycin, a lipophilic 14-membered macrolide, on hemolysis induced by lysophosphatidylcholine in human erythrocytes. Japanese J. Pharm. Health Care Sci., 38: 617-627.
  5. Suno, M., T. Ono, S. Iida, N. Umetsu and K.I. Ohtaki et al., 2007. Improved high-performance liquid chromatographic detection of paclitaxel in patient's plasma using solid-phase extraction and semi-micro-bore C18 separation and UV detection. J. Chromatography B, 860: 141-144.
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  6. Matsubara, K., K. Shimizu, M. Suno, K. Ogawa and T. Awaya et al., 2006. Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions. Brain Res., 1112: 126-133.
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  7. Awaya, T., K.I. Ohtaki, T. Yamada, K. Yamamoto and T. Miyoshi et al., 2005. Automation in drug inventory management saves personnel time and budget. Yakugaku Zasshi, 125: 427-432.
  8. Ohtaki, K., K. Matsubara, S. Fujimaru, K. Shimizu and T. Awaya et al., 2004. Cefoselis, a β-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release. J. Neural Transmission, 111: 1523-1535.
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  9. Shimizu, K., K. Matsubara, K.I. Ohtaki and H. Shiono, 2003. Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neurosci. Res., 46: 523-532.
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  10. Shimizu, K., K. Matsubara, K. Ohtaki, S. Fujimaru, O. Saito and H. Shiono, 2003. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain Res., 976: 243-252.
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  11. Shimizu, K., K. Ohtaki, K. Matsubara, K. Aoyama and T. Uezono et al., 2001. Carrier-mediated processes in blood-brain barrier penetration and neural uptake of paraquat. Brain Res., 906: 135-142.
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  12. Matsubara, K., T. Senda, T. Uezono, S. Fukushima and S. Ohta et al., 1998. Structural significance of azaheterocyclic amines related to Parkinson's disease for dopamine transporter. Eur. J. Pharmacol., 348: 77-84.
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  13. Matsubara, K., T. Gonda, H. Sawada, T. Uezono and Y. Kobayashi et al., 1998. Endogenously occurring β‐carboline induces parkinsonism in nonprimate animals: A possible causative protoxin in idiopathic Parkinson's disease. J. Neurochem., 70: 727-735.
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