Dr. Yusuke  Shiozawa
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Dr. Yusuke Shiozawa

Research Scientist
University of Michigan School of Dentistry, USA


Highest Degree
Ph.D. in Pediatrics from Juntendo University, Tokyo, Japan

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Biography

Dr. Yusuke Shiozawa is currently working as Assistant Professor at Wake Forest School of Medicine, Winston-Salem, NC Department of Cancer Biology and Comprehensive Cancer Center. He has completed his Ph.D. in Pediatrics from Juntendo University, Tokyo, Japan. He also appointed as Staff Doctor Juntendo University School of Medicine, Tokyo, Japan, Research Fellow at National Research Institute for Child Health and Development, Tokyo, Japan, Postdoctoral Research Fellow and Research Investigator at University of Michigan School of Dentistry, Ann Arbor, MI. Dr. Yusuke received honors includes Pediatric Oncology Research Fellowship, Best Paper Award from the Japan Cytometry Society, and PCF Young Investigator Award. He also delivered number of invited lectures at seminar and conferences. He is member of editorial board and reviewer for several journals. He is member of American Association for Cancer Research, American Society of Hematology, and International Bone and Mineral Society. He also associated with many research projects. He has published 55 research articles, 4 book chapters, and 26 abstracts contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Prostate Cancer
62%
Disseminated Tumor Cells
90%
Hematopoietic Stem Cell
75%
Premetastatic Niche
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Seib, F.P., J.E. Berry, Y. Shiozawa, R.S. Taichman and D.L. Kaplan, 2015. Tissue engineering a surrogate niche for metastatic cancer cells. `Biomaterials, 51: 313-319.
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  2. Jung, Y., J. Wang, E. Lee, S. McGee and J.E. Berry et al., 2015. Annexin 2-CXCL12 interactions regulate metastatic cell targeting and growth in the bone marrow. Mol. Cancer Res., 13: 197-207.
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  3. Yumoto, K., M.R. Eber, J.E. Berry, R.S. Taichman and Y. Shiozawa, 2014. Molecular pathways: Niches in metastatic dormancy. Clin. Cancer Res., 20: 3384-3389.
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  4. Yumoto, K., J.E. Berry, R.S. Taichman and Y. Shiozawa, 2014. A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD. Cytometry, 85 : 548-555.
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  5. Taichman, R.S., L.R. Patel, R. Bedenis, J. Wang and S. Weidner et al., 2013. GAS6 receptor status is associated with dormancy and bone metastatic tumor formation. Plos One, Vol. 8. 10.1371/journal.pone.0061873.
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  6. Shiozawa, Y., S. McGee, M.J. Pienta, N. McGregor and Y. Jung et al., 2013. Erythropoietin supports the survival of prostate cancer, but not growth and bone metastasis. J. Cell. Biochem., 114: 2471-2478.
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  7. Shiozawa, Y., R.S. Taichman and E.T. Keller, 2013. Detection and Isolation of Human Disseminated Tumor Cells in the Murine Bone Marrow Stem Cell Niche. In: Stem cells and Niche: Methods and Protocols, Turksen, K. (Ed.). Humana Press, New York, pp: 207-215.
  8. Shiozawa, Y., B. Nie, K.J. Pienta, T.M. Morgan and R.S. Taichman, 2013. Cancer stem cells and their role in metastasis. Pharmacol. Ther., 138: 285-293.
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  9. Kim, J.K., Y. Jung, J. Wang, J. Joseph and A. Mishra et al., 2013. TBK1 regulates prostate cancer dormancy through mTOR inhibition. Neoplasia, 15: 1064-1074.
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  10. Jung, Y., J.K. Kim, Y. Shiozawa, J. Wang and A. Mishra et al., 2013. Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis. Nature Commun., Vol. 4. 10.1038/ncomms2766.
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  11. Havens, A.M., Y. Shiozawa, Y. Jung, H. Sun and J. Wang et al., 2013. Very Small Embryonic-Like (VSEL) cells generate skeletal structures in vivo. Stem Cells Dev., 22: 622-630.
  12. Havens, A.M., H. Sun, Y. Shiozawa, Y. Jung and J. Wang et al., 2013. Human and murine very small embryonic-like cells represent multipotent tissue progenitors, in vitro and in vivo. Stem Cells Dev., 23: 689-701.
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  13. Yu, C., Y. Shiozawa, R.S. Taichman, L.K. McCauley, K.J. Pienta and E.T. Keller, 2012. Prostate cancer and parasitism of the bone hematopoietic stem cell niche. Crit. Rev. Eukaryot. Gene. Exp., 22: 131-148.
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  14. Sun, H., Y. Jung, Y. Shiozawa, R.S. Taichman and P.H. Krebsbach, 2012. Erythropoietin modulates the structure of bone morphogenetic protein 2-engineered cranial bone. Tissue Eng. Part A, 18: 2095-2105.
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  15. Shiozawa, Y. and R.S. Taichman, 2012. Getting blood from bone: An emerging understanding of the role that osteoblasts play in regulating hematopoietic stem cells within their niche. Exp. Hematol., 40: 685-694.
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  16. Shiozawa, Y. and R.S. Taichman, 2012. Cancer stem cells and the bone marrow microenvironment. BoneKey Rep., Vol. 1. .
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  17. Pedersen, E.A., Y. Shiozawa, K.J. Pienta and R.S. Taichman, 2012. The prostate cancer bone marrow niche: More than just fertile soil. Asian J. Androl., 14: 423-427.
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  18. Pedersen, E.A., Y. Shiozawa, A. Mishra and R.S. Taichman, 2012. Structure and function of the solid tumor niche. Frontiers Biosci., 4: 1-15.
  19. Mishra, A., J. Wang, Y. Shiozawa, S. McGee and J. Kim et al., 2012. Hypoxia stabilizes GAS6/Axl signaling in metastatic prostate cancer. Mol. Cancer Res., 10: 703-712.
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  20. McGee, S.J., A.M. Havens, Y. Shiozawa, Y. Jung and R.S. Taichman, 2012. Effects of erythropoietin on the bone microenvironment. Growth Factors, 30: 22-28.
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  21. Kim, J., Y. Jung, H. Sun, J. Joseph and A. Mishra et al., 2012. Erythropoietin mediated bone formation is regulated by mTOR signaling. J. Cell. Biochem., 113: 220-228.
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  22. Jung, Y., Y. Shiozawa, J. Wang, N. McGregor and J. Dai et al., 2012. Prevalence of prostate cancer metastases following intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment. Neoplasia, 14: 429-439.
  23. Joseph, J., Y. Shiozawa, Y. Jung, J.K. Kim and E. Pedersen et al., 2012. Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype. Mol. Cancer Res., 10: 282-292.
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  24. D'Souza, S., N. Kurihara, Y. Shiozawa, J. Joseph, R. Taichman, D.L. Galson and G.D. Roodman, 2012. Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironment. Blood, 119: 1888-1896.
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  25. Shiozawa, Y., K.J. Pienta and R.S. Taichman, 2011. Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors. Clin. Cancer Res., 17: 5553-5558.
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  26. Shiozawa, Y., E.A. Pedersen, A.M. Havens, Y. Jung and A. Mishra et al., 2011. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow. J. Clin. Invest., 121: 1298-1312.
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  27. Patel, L.R., D.F. Camacho, Y. Shiozawa, K.J. Pienta and R.S. Taichman, 2011. Mechanisms of cancer cell metastasis to the bone: A multistep process. Future Oncol., 7: 1285-1297.
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  28. Mishra, A., Y. Shiozawa, K.J. Pienta and R.S. Taichman, 2011. Homing of cancer cells to the bone. Cancer Microenviron., 4: 221-235.
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  29. Jung, Y., Y. Shiozawa, J. Wang, L.R. Patel and A.M. Havens et al., 2011. Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche. Exp. Hematol., 39: 151-166.
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  30. Taichman, R.S., Z. Wang, Y. Shiozawa, Y. Jung and J. Song et al., 2010. Prospective identification and skeletal localization of cells capable of multilineage differentiation in vivo. Stem Cells Dev., 19: 1557-1570.
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  31. Shiozawa, Y., Y. Jung, A.M. Ziegler, E.A. Pedersen and J. Wang et al., 2010. Erythropoietin couples hematopoiesis with bone formation. Plos One, Vol. 5. 10.1371/journal.pone.0010853.
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  32. Shiozawa, Y., E.A. Pedersen, L.R. Patel, A.M. Ziegler and A.M. Havens et al., 2010. GAS6/AXL axis regulates prostate cancer invasion, proliferation and survival in the bone marrow niche. Neoplasia, 12: 116-127.
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  33. Shiozawa, Y., E.A. Pedersen and R.S. Taichman, 2010. GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche. Exp. Hematol., 38: 132-140.
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  34. Shiozawa, Y. and R.S. Taichman, 2010. Dysfunctional niches as a root of hematopoietic malignancy. Cell Stem Cell, 6: 399-400.
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  35. Pedersen, E.A., Y. Shiozawa and R.S. Taichman, 2010. Hematopoietic stem cells, cancer stem cells and the hematopoietic stem cell niche. IBMS BoneKEy, 7: 32-46.
  36. Jung, Y., Y. Shiozawa, J. Wang, J. Wang and Z. Wang et al., 2009. Expression of PGK1 by prostate cancer cells induces bone formation. Mol. Cancer Res., 7: 1595-1604.
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  37. Havens, A.M., Y. Shiozawa and R.S. Taichman, 2009. Blood-Bone Axis and Bone Marrow Microenvironment. In: Bone and Cancer, Bronner, F. and M.C. Farach-Carson (Eds.). Springer, London, pp: 1-17.
  38. Havens, A.M. E.A. Pedersen, Y. Shiozawa and R.S. Taichman, 2009. Innovative mouse models for metastatic disease. Drug Discovery Today: Dis. Models, 6: 27-31.
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  39. Wang, J., Y. Shiozawa, J. Wang, Y. Wang and Y. Jung et al., 2008. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J. Biol. Chem., 283: 4283-4294.
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  40. Sun, Y.X., E.A. Pedersen, Y. Shiozawa, A.M. Havens and Y. Jung et al., 2008. CD26/dipeptidyl peptidase IV regulates prostate cancer metastasis by degrading SDF-1/CXCL12. Clin. Exp. Metastasis, 25: 765-776.
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  41. Shiozawa, Y., S. Sakaguchi, O. Sakakibara, K. Yagishita, M. Saito and Y. Yamashiro, 2008. Urolithiasis in an acute lymphoblastic leukemia child during induction chemotherapy. Pediatric Hematol.-Oncol., 25: 359-363.
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  42. Shiozawa, Y., H. Takenouchi, T. Taguchi, M. Saito and Y.U. Katagiri et al., 2008. Human osteoblasts support hematopoietic cell development in vitro. Acta Haematol., 120: 134-145.
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  43. Shiozawa, Y., A.M. Havens, Y. Jung, A.M. Ziegler and E.A. Pedersen et al., 2008. Annexin II/Annexin II receptor axis regulates adhesion, migration, homing and growth of prostate cancer. J. Cell. Biochem., 105: 370-380.
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  44. Shiozawa, Y., A.M. Havens, K.J. Pienta and R.S. Taichman, 2008. The bone marrow niche: Habitat to hematopoietic and mesenchymal stem cells and unwitting host to molecular parasites. Leukemia, 22: 941-950.
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  45. Jung, Y., J. Song, Y. Shiozawa, J. Wang and Z. Wang et al., 2008. Hematopoietic stem cells regulate mesenchymal stromal cell induction into osteoblasts thereby participating in the formation of the stem cell niche. Stem Cells, 26: 2042-2051.
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  46. Havens, A.M., E.A. Pedersen, Y. Shiozawa, C. Ying and Y. Jung et al., 2008. An in vivo mouse model for human prostate cancer metastasis. Neoplasia, 10: 371-379.
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  47. Havens, A.M., E. Chiu, M. Taba Jr., J. Wang and Y. Shiozawa et al., 2008. Stromal-derived factor-1α (CXCL12) levels increase in periodontal disease. J. Periodontol., 79: 845-853.
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  48. Taguchi, T., H. Takenouchi, Y. Shiozawa, J. Matsui and N. Kitamura et al., 2007. Interleukin-7 contributes to human Pro-B-cell development in a mouse stromal Cell-dependent culture system. Exp. Hematol., 35: 1398-1407.
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  49. Jung, Y., J. Wang, J. Song, Y. Shiozawa and J. Wang et al., 2007. Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing and engraftment following transplantation. Blood, 110: 82-90.
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  50. Taguchi, T., H. Takenouchi, J. Matsui, W.R. Tang and M. Itagaki et al., 2006. Involvement of Insulin-like growth Factor-I and Insulin-like growth factor binding proteins in Pro-B-cell development. Exp. Hematol., 34: 508-518.
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  51. Shiozawa, Y., N. Kiyokawa, M. Saito, J. Fujimoto, J.I. Hata and Y. Yamashiro, 2005. Granulocytic sarcoma of the spine in a child without bone marrow involvement: A case report and literature review. Eur. J. Pediatrics, 164: 616-620.
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  52. Shiozawa, Y., N. Kiyokawa, J. Fujimura, K. Suzuki and Y. Yarita et al., 2005. Primary malignant lymphoma of the central nervous system in an immunocompetent child: A case report. J. Pediatric Hematol. /Oncol., 27: 561-564.
  53. Matsui, J., N. Kiyokawa, H. Takenouchi, T. Taguchi and K. Suzuki et al., 2005. Dietary bioflavonoids induce apoptosis in human leukemia cells. Leukemia Res., 29: 573-581.
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  54. Taguchi, T., N. Kiyokawa, H. Takenouch, J. Matsui and W.R. Tang et al., 2004. Deficiency of BLNK hampers PLC-gamma2 phosphorylation and Ca2+ influx induced by the pre-B-cell receptor in human pre-B cells. Immunology, 112: 575-582.
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  55. Shiozawa, Y., H. Fujita, J. Fujimura, K. Suzuki and H. Sato et al., 2004. A fetal case of transient abnormal myelopoiesis with severe liver failure in Down syndrome: Prognostic value of serum markers. Pediatric Hematol.-Oncol., 21: 273-278.
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