Dr. Su Il Do

Dr. Su Il Do

Professor
Ajou University, Korea


Highest Degree
Ph.D. in Biochemistry from University of Georgia, USA

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Area of Interest:

Chemistry
100%
Biochemistry
62%
Molecular Biology
90%
Biological Activity
75%
Bioactive Molecules
55%

Selected Publications

  1. Ryu, I.H., K.Y. Lee and S.I. Do, 2016. Aβ-affected pathogenic induction of S-nitrosylation of OGT and identification of Cys-NO linkage triplet. Biochim. Biophys. Acta (BBA)-Proteins Proteomics, 1864: 609-621.
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  2. Kim, S.M., M.J. Chung, T.J. Ha, H.N. Choi and S.J. Jang et al., 2012. Neuroprotective effects of black soybean anthocyanins via inactivation of ASK1–JNK/p38 pathways and mobilization of cellular sialic acids. Life Sci., 90: 874-882.
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  3. Do, S.I., 2012. Untamed aspects of OGT and O-GlcNAc functionality: Hyperthermal sensing and NO regulation. Trends Comp. Biochem. Physiol., 16: 37-44.
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  4. Ryu, I.H. and S.I. Do, 2011. Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response. Biochem. Biophys. Res. Commun., 408: 52-57.
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  5. Park, S., S. Hyun and J. Yu, 2011. Selective α-glucosidase substrates and inhibitors containing short aromatic peptidyl moieties. Bioorg. Med. Chem. Lett., 21: 2441-2444.
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  6. Kwon, H.Y., S.J. Kim, C.H. Kim, S.W. Son and K.S. Kim et al., 2010. Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells. Exp. Mol. Med., 42: 849-855.
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  7. Do, S.I., 2009. Generation of novel chimeric LacdiNAcS by gene fusion of α-lactalbumin and β1,4-galactosyltransferase 1. Glycoconj. J., 26: 567-575.
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  8. Riu, I.H., I.S. Shin and S.I. Do, 2008. Sp1 modulates ncOGT activity to alter target recognition and enhanced thermotolerance in E. coli. Biochem. Biophys. Res. Commun., 372: 203-209.
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  9. Kwon, H.Y., N.Y. Kang, H.M. Dae, K.S. Kim, C.H. Kim, S.I. Do and Y.C. Lee, 2008. Valproic acid-mediated transcriptional regulation of human GM3 synthase (hST3Gal V) in SK-N-BE(2)-C human neuroblastoma cells. Acta Pharmacol. Sin., 29: 999-1005.
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  10. Lee, D.H., D.B. Koo, K. Ko, K. Ko and S.M. Kim et al., 2007. Effects of daunorubicin on ganglioside expression and neuronal differentiation of mouse embryonic stem cells. Biochem. Biophys. Res. Commun., 362: 313-318.
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  11. Kim, S.M., J.S. Lee, Y.H. Lee, W.J. Kim, S.I. Do, Y.K. Choo and Y.I. Park, 2007. Increased α2,3-sialylation and hyperglycosylation of N-glycans in embryonic rat cortical neurons during camptothecin-induced apoptosis. Mol. Cells, 24: 416-423.
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  12. Alcantara, E.H., D.H. Kim, S.I. Do and S.S. Lee, 2007. Bi-functional activities of chimeric lysozymes constructed by domain swapping between bacteriophage T7 and K11 lysozymes. J. Biochem. Mol. Biol., 40: 539-546.
    PubMed  |  
  13. Kim, S.M., D.H. Kwak, S.M. Kim, J.U. Jung and D.H. Lee et al., 2006. Differential expression of gangliosides in the ovary and uterus of streptozotocin-induced and db/db diabetic mice. Arch. Pharmacal Res., 29: 666-676.
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  14. Sohn, K.C. and S.I. Do, 2005. Transcriptional regulation and O-GlcNAcylation activity of zebrafish OGT during embryogenesis. Biochem. Biophys. Res. Commun., 337: 256-263.
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  15. Ju, E.J., D.H. Kwak, D.H. Lee, S.M. Kim and J.S. Kim et al., 2005. Pathophysiological implication of ganglioside GM3 in early mouse embryonic development through apoptosis. Arch. Pharmacal Res., 28: 1057-1064.
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  16. Sohn, K.C., K.Y. Lee, J.E. Park and S.I. Do, 2004. OGT functions as a catalytic chaperone under heat stress response: A unique defense role of OGT in hyperthermia. Biochem. Biophys. Res. Commun., 322: 1045-1051.
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  17. Park, J.E., S.I. Do, K.S. Lee and S.S. Lee, 2004. A mutagenic study of β-1,4-galactosyltransferases from Neisseria meningitidis. BMB Rep., 37: 597-602.
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  18. Kim, H.G., S.M. Yang, Y.C. Lee, S.I. Do, I.S. Chung and J.M. Yang, 2003. High-level expression of human glycosyltransferases in insect cells as biochemically active form. Biochem. Biophys. Res. Commun., 305: 488-493.
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  19. Park, J.E., K.Y. Lee, S.I. Do and S.S. Lee, 2002. Expression and characterization of β-1,4-galactosyltransferase from Neisseria meningitidis and Neisseria gonorrhoeae. BMB Rep., 35: 330-336.
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  20. Lee, K.Y., H.G. Kim, M.R. Hwang, J.I. Chae and J.M. Yang et al., 2002. The hexapeptide inhibitor of Galβ1,3GalNAc-specific α2,3-sialyltransferase as a generic inhibitor of sialyltransferases. J. Biol. Chem., 277: 49341-49351.
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  21. Lee, Y.I., S. Kang-Park, S.I. Do and Y.I. Lee, 2001. The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem., 276: 16969-16977.
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  22. Lee, K.Y. and S.I. Do, 2001. Differential and cell-type specific microheterogeneity of high mannose-type Asn-linked oligosaccharides of human transferrin receptor. Mol. Cells, 12: 239-243.
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  23. Do, S.I., K.Y. Lee and H.N. Kim, 2000. Novel induction of α-lactalbumin-mediated lacdiNAc-R expression in vivo. Biochem. J., 348: 229-234.
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  24. Kang, S.S., T. Kwon and S.I. Do, 1999. Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J. Biol. Chem., 274: 13085-13090.
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  25. Lee, Y.C., Y.J. Kim, K.Y. Lee, K.S. Kim and B.U. Kim et al., 1998. Cloning and expression of cDNA for a human Siaα2,3Galβ1,4GlcNA:α2,8-sialyltransferase (hST8Sia III). Arch. Biochem. Biophys., 360: 41-46.
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  26. Do, S.I. and K.Y. Lee, 1998. Jacalin interacts with Asn‐linked glycopeptides containing multi-antennary oligosaccharide structure with terminal α-linked galactose. FEBS Lett., 421: 169-173.
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  27. Yan, L., P.P. Wilkins, G. Alvarez-Manilla, S.I. Do, D.F. Smith and R.D. Cummings, 1997. Immobilized Lotus tetragonolobus agglutinin binds oligosaccharides containing the Lex determinant. Glycoconj. J., 14: 45-55.
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  28. Do, K.Y., S.I. Do and R.D. Cummings, 1997. Differential expression of LacdiNAc sequences (GalNAcβ1-4GlcNAc-R) in glycoproteins synthesized by Chinese hamster ovary and human 293 cells. Glycobiology, 7: 183-194.
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  29. Do, K.Y., S.I. Do and R.D. Cummings, 1995. α-Lactalbumin induces bovine milk β1,4-galactosyltransferase to utilize UDP-GalNAc. J. Biol. Chem., 270: 18447-18451.
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  30. Do, S.I. and R.D. Cummings, 1992. The hamster transferrin receptor contains Ser/Thr-linked oligosaccharides: Use of a lectin-resistant CHO cell line to identify glycoproteins containing these linkages. J. Biochem. Biophys. Methods, 24: 153-165.
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  31. Do, S.I. and R.D. Cummings, 1992. Presence of O-linked oligosaccharide on a threonine residue in the human transferrin receptor. Glycobiology, 2: 345-353.
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  32. Enns, C.A., E.M. Clinton, C.L. Reckhow, B.J. Root, S.I. Do and C. Cook, 1991. Acquisition of the functional properties of the transferrin receptor during its biosynthesis. J. Biol. Chem., 266: 13272-13277.
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  33. Do, S.I., C. Enns and R.D. Cummings, 1990. Human transferrin receptor contains O-linked oligosaccharides. J. Biol. Chem., 265: 114-125.
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