Dr. Baik Lin Seong
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Dr. Baik Lin Seong

Professor
Yonsei University, South Korea


Highest Degree
Ph.D. in Virology from Yonsei University, South Korea

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Biography

Dr. Baik Lin Seong holds a position of Professor at Department of Biotechnology Yonsei University South Korea. He has completed his Ph.D. in Virology from same University. His area of expertise includes Influenza Virus, Chaperone, Pandemic, RNA World, Vaccine, Virus, Protein Folding, and Reverse Genetics. He has published 79 research articles in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Influenza Virus
62%
Vaccine
90%
Protein Folding
75%
Virology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Ye, D., W.J. Shin, N. Li, W. Tang and E. Feng et al., 2012. Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities. Eur. J. Med. Chem., 54: 764-770.
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  2. Shin, W.J., Y.K. Kim, K.H. Lee and B.L. Seong, 2012. Evaluation of the antiviral activity of a green tea solution as a hand-wash disinfectant. Biosci. Biotechnol. Biochem., 76: 581-584.
    PubMed  |  Direct Link  |  
  3. Park, J.K., D.H. Lee, H.N. Youn, M.S. Kim and Y.N. Lee et al., 2012. Protective efficacy of crude virus-like particle vaccine against HPAI H5N1 in chickens and its application on DIVA strategy. Influenza Respi Viruses, 7: 340-348.
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  4. Lee, H.J., Y.N. Lee, H.N. Youn, D.H. Lee and J.H. Kwak et al., 2012. Anti-influenza virus activity of green tea by-products in vitro and efficacy against influenza virus infection in chickens. Poult Sci., 91: 66-73.
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  5. Jang, Y.H., Y.H. Byun, Y.J. Lee, Y.H. Lee, K.H. Lee and B.L. Seong, 2012. Cold-adapted pandemic 2009 H1N1 influenza virus live vaccine elicits cross-reactive immune responses against seasonal and H5 influenza A viruses. J. Virol., 86: 5953-5958.
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  6. Hong, S.H., Y.H. Byun, C.T. Nguyen, S.Y. Kim and B.L. Seong et al., 2012. Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection. Vaccine, 30: 466-474.
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  7. Shim, B.S., Y.K. Choi, C.H. Yun, E.G. Lee and Y.S. Jeon et al., 2011. Sublingual immunization with M2-based vaccine induces broad protective immunity against influenza. PLoS One, Vol. 6. 10.1371/journal.pone.0027953.
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  8. Seo, S.U., H.J. Kwon, H.J. Ko, Y.H. Byun and B.L. Seong et al., 2011. Type I interferon signaling regulates Ly6Chi monocytes and neutrophils during acute viral pneumonia in mice. PLoS Pathog, Vol. 7 10.1371/journal.ppat.1001304.
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  9. Nam, J.S., A.R. Kim, J.C. Yoon, Y. Byun and S.A. Kim et al., 2011. The humoral immune response to the inactivated influenza A (H1N1) 2009 monovalent vaccine in patients with Type 2 diabetes mellitus in Korea. Diabet Med., 28: 815-817.
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  10. Lim, K.H., K.H. Kim, S.I. Choi, E.S. Park and S.H. Park et al., 2011. RPS3a over-expressed in HBV-associated hepatocellular carcinoma enhances the HBx-induced NF-κB signaling via its novel chaperoning function. PLoS One, Vol. 6. 10.1371/journal.pone.0022258.
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  11. Choi, S.I., K.H. Lim and B.L. Seong, 2011. Chaperoning roles of macromolecules interacting with proteins In vivo. Int. J. Mol. Sci., 12: 1979-1990.
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  12. Song, J.M. and B.L. Seong, 2010. Viral membranes: An emerging antiviral target for enveloped viruses? Expert Rev. Anti Infect. Ther., 8: 635-638.
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  13. Shin, W.J., K.H. Lee, M.H. Park and B.L. Seong, 2010. Broad-spectrum antiviral effect of Agrimonia pilosa extract on influenza viruses. Microbiol. Immunol., 54: 11-19.
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  14. Seo, S.U., H.J. Kwon, J.H. Song, Y.H. Byun and B.L. Seong et al., 2010. MyD88 signaling is indispensable for primary influenza A virus infection but dispensable for secondary infection. J. Virol., 84: 12713-12722.
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  15. Ryu, K., K.H. Kim, S.Y. Yoo, E.Y. Lee and K.H. Lim et al., 2010. Production and characterization of active hepatitis C virus RNA-dependent RNA polymerase. Protein Express. Purificat., 71: 147-152.
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  16. Lee, E.Y., K.H. Lee, E.J. Jung, Y.H. Jang, S.U. Seo, H.A. Kim and B.L. Seong, 2010. Genotyping and screening of reassortant live-attenuated influenza B vaccine strain. J. Virol. Methods, 165: 133-138.
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  17. Kim, K.H., N.D. Kim and B.L. Seong, 2010. Pharmacophore-based virtual screening: A review of recent applications. Exp. Opin. Drug Discov., 5: 205-222.
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  18. Kim, K.H., N.D. Kim and B.L. Seong, 2010. Discovery and development of anti-HBV agents and their resistance. Molecules, 15: 5878-5908.
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  19. Jung, E.J., K.H. Lee and B.L. Seong, 2010. Reverse genetic platform for inactivated and live-attenuated influenza vaccine. Exp. Mol. Med., 42: 116-121.
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  20. Jang, H.C., C.J. Kim, K.H. Kim, K.H. Lee and Y.H. Byun et al., 2010. A randomized, double-blind, controlled clinical trial to evaluate the efficacy and safety of CJ-50300, a newly developed cell culture-derived smallpox vaccine, in healthy volunteers. Vaccine, 28: 5845-5849.
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  21. Uhm, H.S., K.H. Lee and B.L. Seong, 2009. Inactivation of H1N1 viruses exposed to acidic ozone water. Applied Phys. Lett., Vol. 95 10.1063/1.3242338.
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  22. Ryu, K.S., N.D. Kim, S.I. Choi, C.K. Han and J.H. Yoon et al., 2009. Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation. Bioorg Med. Chem., 17: 2975-2982.
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  23. Park, K.S., J. Lee, S.S. Ahn, Y.H. Byun and B.L. Seong et al., 2009. Mucosal immunity induced by adenovirus-based H5N1 HPAI vaccine confers protection against a lethal H5N2 avian influenza virus challenge. Virology, 395: 182-189.
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  24. Kim, H.K., S.I. Choi and B.L. Seong, 2009. 5S rRNA-assisted DnaK refolding. Biochem. Biophys Res. Commun., 291: 1177-1181.
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  25. Choi, S.I., K.S. Ryu and B.L. Seong, 2009. RNA-mediated chaperone type for de novo protein folding. RNA Biol., 6: 21-24.
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  26. Song, J.M., Y.J. Lee, O.M. Jeong, H.M. Kang and H.R. Kim et al., 2008. Generation and evaluation of reassortant influenza vaccines made by reverse genetics for H9N2 avian influenza in Korea. Vet. Microbiol., 130: 268-276.
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  27. Seo, S.U., Y.H. Byun, E.Y. Lee, E.J. Jung and Y.H. Jang et al., 2008. Development and characterization of a live attenuated influenza B virus vaccine candidate. Vaccine, 26: 874-881.
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  28. Ryu, K., C.W. Kim, B.H. Kim, K.S. Han, K.H. Kim, S.I. Choi and B.L. Seong, 2008. Assessment of substrate-stabilizing factors for DnaK on the folding of aggregation-prone proteins. Biochem. Biophys Res. Commun., 373: 74-79.
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  29. Choi, S.I., K.S. Han, C.W. Kim, K.S. Ryu and B.H. Kim et al., 2008. Protein solubility and folding enhancement by interaction with RNA. PLoS One, Vol. 3. 10.1371/journal.pone.0002677.
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  30. Song, J.M., K.D. Park, K.H. Lee, Y.H. Byun and J.H. Park et al., 2007. Biological evaluation of anti-influenza viral activity of semi-synthetic catechin derivatives. Antiviral Res., 76: 178-185.
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  31. Song, J.M. and B.L. Seong, 2007. Tea catechins as a potential alternative anti-infectious agent. Expert. Rev. Anti. Infect. Ther., 5: 497-506.
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  32. Seo, S.U., K.H. Lee, Y.H. Byun, M.N. Kweo and B.L. Seong, 2007. Immediate and broad-spectrum protection against heterologous and heterotypic lethal challenge in mice by live influenza vaccine. Vaccine, 25: 8067-8076.
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  33. Park, S.A., E.S. Song, Y.J. Cho, B.Y. Ahn and S.H. Ha et al., 2007. Immune responses of mice to influenza subunit vaccine in combination with CIA07 as an adjuvant. Microbiol. Immunol., 51: 1099-1107.
    PubMed  |  
  34. Nojima, H., R.H. Park, J.H. Kwon, I. Suh and J. Jeon et al., 2007. Novel atmospheric pressure plasma device releasing atomic hydrogen: Reduction of microbial contaminants and OH radicals in the air. J. Phys. D: Appl. Phys., 40: 501-501.
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  35. Kim, C.W., K.S. Han, K.S. Ryu, B.H. Kim and K.H. Kim et al., 2007. N-terminal domains of native multidomain proteins have the potential to assist de novo folding of their downstream domains in vivo by acting as solubility enhancers. Protein Sci., 16: 635-643.
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  36. Kim, K., M. Lee, H. Park, J.H. Kim and S. Kim et al., 2006. Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. J. Am. Chem. Soc., 128: 3490-3491.
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  37. Kim do, Y., K.H. Kim, N.D. Kim, K.Y. Lee and C.K. Han et al., 2006. Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin. J. Med. Chem., 49: 5664-5670.
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  38. Ha, S.H., H.A. Kim, Y.H. Kim, J.S. Kim and K.H. Lee et al., 2006. A multiplex RT-PCR method for screening of reassortant live influenza vaccine virus strains. J. Virol. Meth., 134: 154-163.
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  39. Song, J.M., K.H. Lee and B.L. Seong, 2005. Antiviral effect of catechins in green tea on influenza virus. Antiviral Res., 68: 66-74.
    CrossRef  |  PubMed  |  Direct Link  |  
  40. Park, K.S., W. Seol, H.Y. Yang, S.I. Lee and S.K. Kim et al., 2005. Identification and use of zinc finger transcription factors that increase production of recombinant proteins in yeast and mammalian cells. Biotechnol. Prog., 21: 664-670.
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  41. Lee, K.H., S.U. Seo, J.M. Song, C.M. Lee and H.A. Kim et al., 2005. Characterization of live influenza vaccine donor strain derived from cold-adaptation of X-31 virus. Vaccine, 24: 1966-1974.
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  42. Han, K.S., S.I. Kim, S.I. Choi and B.L. Seong, 2005. N-Glycosylation of secretion enhancer peptide as influencing factor for the secretion of target proteins from Saccharomyces cerevisiae Biochem. Biophys. Res. Commun., 18: 557-562.
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  43. Kim, K.H., K.H. Lee, H.Y. Chang, S.H. Ahn and S. Tong et al., 2003. Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy. J. Med. Virol., 71: 367-375.
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  44. Kim, K.H. and B.L. Seong, 2003. Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal EMBO. J., 22: 2104-2116.
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  45. Song, H.W., S.I. Choi and B.L. Seong, 2002. Engineered recombinant enteropeptidase catalytic subunit: effect of N-terminal modification. Arch. Biochem. Biophys, 400: 1-6.
    PubMed  |  
  46. Park, K.S., Y. Ahn, J.A. Kim, M.S. Yun and B.L. Seong et al., 2002. Extracellular zinc stimulates ERK-dependent activation of p21(Cip/WAF1) and inhibits proliferation of colorectal cancer cells. Br. J. Pharmacol., 137: 597-607.
    PubMed  |  
  47. Lee, K.Y., J.H. Hyeok Yoon, M. Kim, S. Roh and Y.S. Lee et al., 2002. A dipalmitoyl peptide that binds SH3 domain, disturbs intracellular signal transduction, and inhibits tumor growth in vivo. Biochem. Biophys. Res. Commun., 296: 434-442.
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  48. Lee, K.Y., E. Chun and B.L. Seong, 2002. Investigation of antigen delivery route in vivo and immune-boosting effects mediated by pH-sensitive liposomes encapsulated with Kb-restricted CTL epitope. Biochem. Biophys. Res. Commun., 292: 682-688.
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  49. Lee, K.Y., B.L. Seong and K. Kim, 2002. Soluble factor-mediated differentiation of CD4+CD8+ thymocytes to single positives in vitro. Differentiation, 70: 410-421.
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  50. Lee KY, E. Chun, N.Y. Kim and B.L. Seong, 2002. Characterization of HLA-A2.1-restricted epitopes, conserved in both Hantaan and Sin Nombre viruses, in Hantaan virus-infected patients. J. Gen. Virol., 83: 1131-1136.
    PubMed  |  Direct Link  |  
  51. Lee, K.H., J.W. Youn, H.J. Kim and B.L. Seong, 2001. Identification and characterization of mutations in the high growth vaccine strain of influenza virus. Arch. Virol., 146: 369-377.
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  52. Choi, S.I., H.W. Song, J.W. Moon and B.L. Seong, 2001. Recombinant enterokinase light chain with affinity tag: Expression from Saccharomyces cerevisiae and its utilities in fusion protein technology. Biotechnol. Bioeng, 75: 718-724.
    CrossRef  |  PubMed  |  Direct Link  |  
  53. Lee, S.W., J.W. Youn, B.L. Seong and Y.C. Sung, 1999. IL-6 induces long-term protective immunity against a lethal challenge of influenza virus. Vaccine, 17: 490-496.
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  54. Lee, J., S.I. Choi, J.S. Jang, K. Jang and J.W. Moon et al., 1999. Novel secretion system of recombinant Saccharomyces cerevisiae using an N-terminus residue of human IL-1 beta as secretion enhancer. Biotechnol. Prog., 15: 884-890.
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  55. Cheong, H.K., C. Cheong, Y.S. Lee, B.L. Seong and B.S. Choi, 1999. Structure of influenza virus panhandle RNA studied by NMR spectroscopy and molecular modeling. Nucleic Acids Res., 27: 1392-1397.
    PubMed  |  Direct Link  |  
  56. Lee, Y.S. and B.L. Seong, 1998. Nucleotides in the panhandle structure of the influenza B virus virion RNA are involved in the specificity between influenza A and B viruses. J. Gen. Virol., 79: 673-681.
    PubMed  |  Direct Link  |  
  57. Lee, K.H. and B.L. Seong, 1998. The position 4 nucleotide at the 3' end of the influenza virus neuraminidase vRNA is involved in temporal regulation of transcription and replication of neuraminidase RNAs and affects the repertoire of influenza virus surface antigens. J. Gen. Virol., 79: 1923-1934.
    PubMed  |  Direct Link  |  
  58. Bae, C.S., D.S. Yang, K.R. Chang, B.L. Seong and J. Lee, 1998. Enhanced secretion of human granulocyte colony-stimulating factor directed by a novel hybrid fusion peptide from recombinant Saccharomyces cerevisiae at high cell concentration. Biotechnol. Bioeng., 57: 600-609.
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  59. Kim, H.J., E. Fodor, G.G. Brownlee and B.L. Seong, 1997. Mutational analysis of the RNA-fork model of the influenza A virus vRNA promoter in vivo. J. Gen. Virol., 78: 353-357.
    PubMed  |  Direct Link  |  
  60. Lee, Y.S. and B.L. Seong, 1996. Mutational analysis of influenza B virus RNA transcription in vitro. J. Virol., 70: 1232-1236.
    PubMed  |  Direct Link  |  
  61. Pritlove, D.C., E. Fodor, B.L. Seong and G.G. Brownlee, 1995. In vitro transcription and polymerase binding studies of the termini of influenza A virus cRNA: Evidence for a cRNA panhandle. J. Gen. Virol., 76: 2205-2213.
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  62. Seong, B.L., 1993. Influencing the influenza virus: Genetic analysis and engineering of the negative-sense RNA genome. Infect. Agents Dis., 2: 17-24.
    PubMed  |  
  63. Fodor, E., B.L. Seong and G.G. Brownlee, 1993. Photochemical cross-linking of influenza A polymerase to its virion RNA promoter defines a polymerase binding site at residues 9 to 12 of the promoter. J. Gen. Virol., 74: 1327-1333.
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  64. Dyson, M.R., C.P. Lee, N. Mandal, B.L. Seong, U. Varshney and U.L. RajBhandary, 1993. Identity of a Prokaryotic Initiator tRNA. In: The Translational Apparatus, Nierhaus, K.H., F. Franceschi, A.R. Subramanian, V.A. Erdmann and B. Wittmann-Liebold (Eds.). Plenum Press, New York, USA., pp: 23-33.
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  65. Seong, B.L., M. Kobayashi, K. Nagata, G.G. Brownlee and A. Ishihama, 1992. Comparison of two reconstituted systems for in vitro transcription and replication of influenza virus. J. Biochem., 111: 496-499.
    PubMed  |  Direct Link  |  
  66. Seong, B.L. and G.G. Brownlee, 1992. Nucleotides 9 to 11 of the influenza A virion RNA promoter are crucial for activity in vitro. J. Gen. Virol., 73: 3115-3124.
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  67. Seong, B.L. and G.G. Brownlee, 1992. A new method for reconstituting influenza polymerase and RNA in vitro: A study of the promoter elements for cRNA and vRNA synthesis in vitro and viral rescue in vivo. Virology, 186: 247-260.
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  68. Varshney, U., C.P. Lee, B.L. Seong and U.L. RajBhandary, 1991. Mutants of initiator tRNA that function both as initiators and elongators. J. Biol. Chem., 266: 18018-18024.
    PubMed  |  Direct Link  |  
  69. Lee, C.P., B.L. Seong and U.L. RajBhandary, 1991. Structural and sequence elements important for recognition of Escherichia coli formylmethionine tRNA by methionyl-tRNA transformylase are clustered in the acceptor stem. J. Biol. Chem., 266: 18012-18017.
    PubMed  |  Direct Link  |  
  70. Seong, B.L., C.P. Lee and U.L. RajBhandary, 1989. Suppression of amber codons in vivo as evidence that mutants derived from Escherichia coli initiator tRNA can act at the step of elongation in protein synthesis. J. Biol. Chem., 246: 6504-6508.
    PubMed  |  Direct Link  |  
  71. Seong, B.L. and U.L. RajBhandary, 1987. Mutants of Escherichia coli formylmethionine tRNA: A single base change enables initiator tRNA to act as an elongator in vitro. Proc. Natl. Acad. Sci., 84: 8859-8863.
    PubMed  |  Direct Link  |  
  72. Seong, B.L. and U.L. RajBhandary, 1987. Escherichia coli formylmethionine tRNA: mutations in GGGCCC sequence conserved in anticodon stem of initiator tRNAs affect initiation of protein synthesis and conformation of anticodon loop. Proc. Natl. Acad. Sci., 84: 334-338.
    PubMed  |  Direct Link  |  
  73. Mheen, T.L., M.H. Han, Y.H. Park, H.J. Sohn and B.L. Seong, 1985. Enzymatic oxidation of rifamycins by a microorganism of the genus Humicola. J. Ferment. Technol., 63: 515-522.
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  74. Han, M.H., B.L. Seong, H.J. Son and T.I. Mheen, 1983. Rifamycin B oxidase from Monocillium spp., a new type of diphenol oxidase. FEBS Lett., 151: 36-40.
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  75. Son, H.J., T.I. Mheen, B.L. Seong and M.H. Han, 1982. Studies on microbial penicillin amidase (IV) Production of penicillin amidase from a partially constitutive mutant of Bacillus megaterium. J. Gen. Applied Microbiol., 28: 281-291.
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  76. Seong, B.L. and M.H. Han, 1982. A facile preparation of rifamycin derivatives by use of manganese dioxide. Chem. Lett., 5: 627-628.
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  77. Park, J.M., C.Y. Choi, B.L. Seong and M.H. Han, 1982. The production of 6-aminopenicillanic acid by a multistage tubular reactor packed with immobilized penicillin amidase. Biotechnol. Bioeng, 24: 1623-1637.
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  78. Park, J.M., C.Y. Choi, B.L. Seong and M.H. Han, 1982. Effect of mass transfer in a recirculation batch reactor system for immobilized penicillin amidase. Biotechnol. Bioeng, 24: 2215-2226.
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  79. Seong, B.L., M.H. Han, J.M. Park and C.Y. Choi, 1981. A graphical method of determining external diffusion free Michaelis-Menten constant for immobilized enzyme in a packed bed reactor. Biotechnol. Lett., 3: 607-607.