Dr. Kil-Nam  Kim
My Social Links

Dr. Kil-Nam Kim

Research Scientist
Korea Basic Science Institute, Korea


Highest Degree
Ph.D. in Aquatic Life Medicine from Jeju National University, South Korea

Share this Profile

Biography

Dr. Kil-Nam Kim is working at Marine Bio Research Team in Korea Basic Science Institute (KBSI). He obtained his Ph.D. in Aquatic Life Medicine from Jeju National University, South Korea. His area of research interest focuses on Assessment of Biological activities (anti-cancer, anti-oxidant, anti-inflammatory, etc) of natural products and development of functional foods and functional cosmetics using active functional ingredients. He is author and co-author of 60 journal papers and 12 patents.

Area of Interest:

Pharmacology and Toxicology
100%
Cancer
62%
Pharmacology
90%
Molecular Sciences
75%
Chemotherapy
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Yoon, W.J., K.N. Kim, S.J. Heo, S.C. Han and J. Kim et al., 2013. Sargachromanol G inhibits osteoclastogenesis by suppressing the activation NF-κB and MAPKs in RANKL-induced RAW 264.7 cells. Biochem. Biophys. Res. Communi., 434: 892-897.
    PubMed  |  
  2. Kim, K.N., Y.J. Ko, M.C. Kang, H.M. Yang and S.W. Roh et al., 2013. Anti-inflammatory effects of trans-1,3-diphenyl-2,3-epoxypropane-1-one mediated by suppression of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages. Food Chem. Toxicol., 53: 371-375.
    CrossRef  |  
  3. Kim, K.N., Y.J. Ko, H.M. Yang, Y.M. Ham and S.W. Roh et al., 2013. Antiinflmmatory effect of essential oil and its constituents from fingered citron (Citrus medica L. var. Sarcodactylis) through blocking JNK, ERK and NF-κB signaling pathways in LPS-activated RAW264.7 cells. Food Chem. Toxicol., 57: 126-131.
    PubMed  |  
  4. Kim, K.N., H.M. Yang, S.M. Kang, D. Kim, G. Ahn and Y.J. Jeon, 2013. Octaphlorethol A isolated from Ishige foliacea inhibits α-MSH-stimulated induced melanogenesis via ERK pathway in B16F10 melanoma cells. Food Chem. Toxicol., 59: 521-526.
    CrossRef  |  PubMed  |  
  5. Kim, K.N., G. Ahn, S.J. Heo, S.M. Kang and M.C. Kang et al., 2013. Inhibition of tumor growth in vitro and in vivo by fucoxanthin against melanoma B16F10 cells. Environ. Toxicol. Pharmacol., 35: 39-46.
    CrossRef  |  
  6. Kang, M.C., S.M. Kang, G. Ahn, K.N. Kim and N. Kang et al., 2013. Protective effect of a marine polyphenol, diekol against carbon tetrachloride-induced acute liver damage in mouse. Environ. Toxicol. Pharmacol., 35: 517-523.
    CrossRef  |  PubMed  |  
  7. Yang, H.M., Y.M. Ham, W.J. Yoon, S.W. Roh and Y.J. Jeon et al., 2012. Quercitrin protects against ultraviolet B-induced cell death in vitro and in an in vivo zebrafish model. J. Photochem. Photobiol. B, 114: 126-131.
    PubMed  |  
  8. Lee, H.S., Y.J. Lee, J.W. Lee, H.J. Shin and J.S. Lee et al., 2012. Identification of new polyprenyl hydroquinone derivatives from tropical marine sponge Ircinia sp. Heterocycles, 85: 1437-1446.
  9. Ko, S.C., S.H. Lee, G. Ahn, K.N. Kim and S.H. Cha et al., 2012. Effect of enzyme-assisted extract of Sargassum coreanum on induction of apoptosis in HL-60 tumor cells. J. Applied Phycol., 24: 675-684.
    CrossRef  |  
  10. Kim, K.N., Y.M. Ham, J.Y. Moon, M.J. Kim and Y.H. Jung et al., 2012. Acanthoic acid induces cell apoptosis through activation of the p38 MAPK pathway in HL-60 human promyelocytic leukaemia. Food Chem., 135: 2112-2117.
    CrossRef  |  
  11. Kim, K.N., M.S. Yang, G.O. Kim, W.J. Lee, N.H. Lee and C.G. Hyun, 2012. Hydroclathrus clathratus induces apoptosis in HL-60 leukaemia cells via caspase activation, upregulation of pro-apoptotic Bax/Bcl-2 ratio and ROS production. J. Med. Plants Res., 6: 1497-1504.
    Direct Link  |  
  12. Kang, S.M., S.J. Heo, K.N. Kim, S.H. Lee, H.M. Yang, A.D. Kim and Y.J. Jeon, 2012. Molecular docking studies of a phlorotannin, dieckol isolated from Ecklonia cava with tyrosinase inhibitory activity. Bioorg. Med. Chem., 20: 311-316.
    CrossRef  |  PubMed  |  
  13. Kang, S.M., K.N. Kim, S.H. Lee and Y.J. Jeon, 2012. Isolation and identification of new compound, 2,7''-phloroglucinol-6,6'-bieckol from brown algae, Ecklonia cava and its antioxidant effect. J. Funct. Foods, 4: 158-166.
    CrossRef  |  Direct Link  |  
  14. Kang, S.M., A.D. Kim, S.J. Heo, K.N. Kim, S.H. Lee, S.C. Ko and Y.J. Jeon, 2012. Induction of apoptosis by diphlorethohydroxycarmalol isolated from brown alga, Ishige okamurae. J. Funct. Foods, 4: 433-439.
    CrossRef  |  Direct Link  |  
  15. Kang, M.C., G. Ahn, X. Yang, K.N. Kim and S.M. Kang et al., 2012. Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice. Food Chem. Toxicol., 50: 1986-1991.
    CrossRef  |  PubMed  |  
  16. Heo, S.J., W.J. Yoon, K.N. Kim, C. Oh and Y.U. Choi et al., 2012. Anti-inflammatory effect of fucoxanthin derivatives isolated from Sargassum siliquastrum in lipopolysaccharide-stimulated RAW 264.7 macrophage. Food Chem. Toxicol., 50: 3336-3342.
    CrossRef  |  PubMed  |  
  17. Heo, S.J., S.H. Cha, K.N. Kim, S.H. Lee and G. Ahn et al., 2012. Neuroprotective effect of phlorotannin isolated from Ishige okamurae against H2O2-induced oxidative stress in murine hippocampal neuronal cells, HT22. Applied Biochem. Biotechnol., 166: 1520-1532.
  18. Ham, Y.M., W.J. Yoon, S.Y. Park, Y.H. Jung and D. Kim et al., 2012. Investigation of the component of Lycopodium serratum extract that inhibits proliferation and mediates apoptosis of human HL-60 leukemia cells. Food Chem. Toxicol., 50: 2629-2634.
    CrossRef  |  PubMed  |  
  19. Ham, Y.M., W.J. Yoon, S.Y. Park, G.P. Song and Y.H. Jung et al., 2012. Quercitrin protects against oxidative stress-induced injury in lung fibroblast cells via up-regulation of Bcl-xL. J. Funct. Foods, 4: 253-262.
    CrossRef  |  Direct Link  |  
  20. Kang, S.M., S.H. Lee, S.J. Heo, K.N. Kim and Y.J. Jeon, 2011. Evaluation of antioxidant properties of a new compound, pyrogallol-phloroglucinol-6,6'-bieckol isolated from brown algae, Ecklonia cava. Nutr. Res. Pract., 5: 495-502.
    Direct Link  |  
  21. Kang, S.M., K.N. Kim, S.H. Lee, G. Ahn and S.H. Cha et al., 2011. Anti-inflammatory activity of polysaccharide purified from AMG-assistant extract of Ecklonia cava in LPS-stilmulated RAW264.7 macrophages. Carbohydrate Polymers, 85: 80-85.
  22. Heo, S.J., K.N. Kim, W.J. Yoon, C. Oh and Y.U. Choi et al., 2011. Chromene induces apoptosis via caspase-3 activation in human leukemia HL-60 cells. Food Chem. Toxicol., 49: 1998-2004.
    CrossRef  |  
  23. Yoon, W.J., S.C. Kang, Y.M. Ham, K.N. Kim and W.H. Yang et al., 2010. Antioxidant and Anti-inflammatory activities of Litsea japonica leaves. J. Korean Soc. Applied Biol. Chem., 53: 27-32.
    Direct Link  |  
  24. Ko, S.C., S.M. Kang, S.H. Lee, G. Ahn and K.N. Kim et al., 2010. Protective effect of enzymatic extracts from Sargassum coreanum on H2O2-induced cell damage. Fish. Aquatic Sci.. 13: 26-35.
  25. Ko, S.C., S.M. Kang, G. Ahn, H.P. Yang, K.N. Kim and Y.J. Jeon, 2010. Antioxidant activity of enzymatic extract from Sargassum coreanum. J. Korean Soc. Food Sci. Nutr., 39: 494-499.
    Direct Link  |  
  26. Kim, K.N., Y.M. Ham, M.S. Yang, D.S. Kim, W.J. Lee, N.H. Lee and C.G. Hyun, 2010. Molecular mechanisms of apoptosis induced by Scytosiphon gracilis in HL-60 cells. Int. J. Pharmacol., 6: 249-256.
  27. Kim, K.N., S.J. Heo, W.J. Yoon, S.M. Kang, G. Ahn, T.H. Yi and Y.J. Jeon, 2010. Fucoxanthin inhibits the inflammatory response by suppressing the activiation of NF-κB and MAPKs in lipopolysaccharide-induced RAW 264.7 macrophages. Eur. J. Pharmacol., 649: 369-375.
  28. Kim, K.N., S.J. Heo, S.M. Kang, G. Ahn and Y.J. Jeon, 2010. Fucoxanthin induces apoptosis in human leukemia HL-60 cells through a ROS-mediated Bcl-xL pathway. Toxicol. In vitro, 24: 1648-1654.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Heo, S.J., W.J. Yoon, K.N. Kim, G.N. Ahn and S.M. Kang et al., 2010. Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages. Food Chem. Toxicol., 48: 2045-2051.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Ham, Y.M., K.N. Kim, W.J. Lee, N.H. Lee and C.G. Hyun, 2010. Chemical constituents from Sargassum micracanthum and antioxidant activity. Int. J. Pharmacol., 6: 147-151.
    CrossRef  |  Direct Link  |  
  31. Choi, H.M., K.N. Kim and Y.H. Jung, 2010. Anticancer activities of various extracts from native plant in Jeju Island, Korea. J. Food Natural Prod. Sci., 1: 27-32.
  32. Yang, E.J., S.S. Kim, T.H. Oh, G. Song, K.N. Kim, J.Y. Kim, N.H. Lee and C.G. Hyun, 2009. Peucedanum japonicum and Citrus unshiu essential oils inhibit the growth of antibiotic-resistant skin pathogens. Ann. Microbiol., 59: 623-628.
    Direct Link  |  
  33. Kim, S.S., G. Song, T.H. Oh, K.N. Kim and E.J. Yang et al., 2009. Antimicrobial effect of Lindera erythrocarpa essential oil against antibiotic-resistant skin pathogens. J. Pure Applied Microbiol., 3: 429-434.
    Direct Link  |  
  34. Kim, K.N., Y.M. Ham, J.Y. Moon, M.J. Kim and D.S. Kim et al., 2009. In vitro cytotoxic activity of Sargassum thunbergii and Dictyopteris divaricata (Jeju Seaweeds) on the HL-60 tumour cell line. Int. J. Pharmacol., 9: 298-306.
    CrossRef  |  Direct Link  |  
  35. Kim, J.Y., K.N. Kim, J.G. Kim, S.C. Kim, W.J. Lee and C.G. Hyun, 2009. In vitro antimicrobial and antioxidant activities of chitosan oligosaccharides. J. Applied Biol. Chem., 52: 84-87.
  36. Siriwardhana, N., K.N. Kim, K.W. Lee, S.H. Kim and J.H. Ha et al., 2008. Optimisation of hydrophilic antioxidant extraction from Hizikiafusiformis by integrating treatments of enzymes, heat and pH control. Int. J. Food Sci. Technol., 43: 587-596.
    CrossRef  |  Direct Link  |  
  37. Kim, K.N., S.H. Kim, W.S. Kim, S.M. Kang and K.W. Lee et al., 2008. Antitumor activites of sea staghorn (Codium fragile) against CT-26 cells. Food Sci. Biotechnol., 75: 976-982.
    Direct Link  |  
  38. Kim, K.N., S.B. Kim, W.J. Yoon, K.S. Yang and S.Y. Park, 2008. Induction of apoptosis by Scolopendra subspinipes mutilans in human leukemia HL-60 cells through Bcl-xL regulation. J. Korean Soc. Food Sci. Nutr., 37: 1408-1414.
    Direct Link  |  
  39. Yoon, W.J., J.A. Lee, K.N. Kim, J.Y. Kim and S.Y. Park, 2007. In vitro antiinflammatory activity of the Artemisia fukudo extracts in murine macrophage RAW 264.7 cells. Korean J. Food Sci. Technol., 39: 464-469.
  40. Kim, K.N., J.A. Lee, W.J. Yoon, J.Y. Kim, G.P. Song and S.Y. Park, 2007. The cytotoxicity of Artemisia fukudo extract against HL-60 cells. J. Korean Soc. Food Sci. Nutr., 36: 819-824.
    Direct Link  |  
  41. Kim, J.Y., J.A. Lee, K.N. Kim, W.J. Yoon, W.J. Lee and S.Y. Park, 2007. Antioxidative and antimicrobial activities of Sargassum muticum extracts. J. Korean Soc. Food Sci. Nutr., 36: 663-669.
    CrossRef  |  Direct Link  |  
  42. Kim, J.Y., J.A. Lee, K.N. Kim, G.P. Song and S.Y. Park, 2007. Antioxidative and antimicrobial activities of Euphorbia helioscopia extract. J. Korean Soc. Food Sci. Nutr., 36: 1106-1112.
  43. Aktas, Z., G. Gurelok, N. Akyurek, M. Onol and B. Hasanreisoglu, 2007. Neuroprotective effect of topically applied Brimonidine tartrate 0.2% in endothelin-1 induced optic nerve ischaemia model. Clin. Exp. Ophthalmol., 35: 527-534.
    PubMed  |  
  44. Ahn, G.N., K.N. Kim, S.H. Cha, C.B. Song and J. Lee et al., 2007. Antioxidant activities of phlorotanins purified from Ecklonia cava on freeradical scavenging using ESR and H2O2-mediated DNA damage. Eur. Food Res. Technol., 226: 71-79.
    Direct Link  |  
  45. Lee, S.H., K.N. Kim, S.H. Cha, G.N. Ahn and Y.J. Jeon, 2006. Comparison of antioxidant activities of enzymatic and mehanolic extracts from Ecklonia cava stem and leave. J. Korean Soc. Food Sci. Nutr., 35: 1139-1145.
  46. Kim, K.N., S.J. Heo, S.H. Cha and Y.J. Jeon, 2006. Evaluation of DPPH radical scavenging activity of Jeju seaweeds using High Throughput Screening (HTS) technique. J. Marine Biosci. Biotechnol., 1: 170-177.
  47. Kim, K.N., S.J. Heo, C.B. Song, J. Lee and M.S. Heo et al., 2006. Protective effect of Ecklonia cava enzymatic extracts on hydrogen peroxide-induced cell damage. Process Biochem., 41: 2393-2401.
    CrossRef  |  
  48. Kim, K.N., K.W. Lee, C.B. Song, C.B. Ahn and Y.J. Jeon, 2006. Cytotoxic activities of red algae collected from Jeju Island against our tumor cell line. J. Food Sci. Nutr., 11: 17-24.
  49. Kim, K.N., K.W. Lee, C.B. Song and Y.J. Jeon, 2006. Cytotoxic activities of green and brown seaweeds collected from Jeju Island against four tumor cell lines. J. Food Sci. Nutr., 11: 17-24.
    Direct Link  |  
  50. Kang, K.A., K.H. Lee, R. Zhang, M. Piao and S. Chae et al., 2006. Caffeic acid protects hydrogen peroxide induced cell damage in WI-38 human lung fibroblast cells. Biol. Pharm. Bull., 29: 1820-1824.
    PubMed  |  
  51. Cha, S.H., G.N. Ahn, S.J. Heo, K.N. Kim and K.W. Lee et al., 2006. Screening of extracts from marine green and brown algae in Jeju for potential marine Angiotensin-Converting Enzyme (ACE) inhibitory activity. J. Korean Soc. Food Sci. Nutr., 35: 307-314.
  52. Athukorala, Y., K.N. Kim and Y.J. Jeon, 2006. Antiproliferative and antioxidant properties of an enzymatic hydrolysate from brown alga, Ecklonia cava. Food Chem. Toxicol., 44: 1065-1074.
    Direct Link  |  
  53. Kim, K.N., S.K. Kim and Y.J. Jeon, 2005. Effects of chitosan on cholesterol level and hepatic morphology in ethanol-treated rats. J. Korean Soc. Food Sci. Nut., 34: 814-820.
  54. Kim, K.N., E.S. Joo, K.I. Kim, S.K. Kim and H.P. Yang et al., 2005. Effect of chitosan oligosaccharides on cholesterol level and antioxidant enzyme activities in hypercholesterolemic rat. J. Korean Soc. Food Sci. Nut., 34: 36-41.
    Direct Link  |