Dr. Benny Chung-Ying Zee
Professor and HODThe Chinese University of Hong Kong, Hong Kong
Highest Degree
Ph.D. in Biostatistics from University of Pittsburgh, Pittsburgh, USA
Share this Profile
The Chinese University of Hong Kong, Hong Kong
Biography
Prof. Benny Zee is Assistant Dean of Research for the Faculty of Medicine and also Professor and Director of the Centre for Clinical Research and Biostatistics and Head of the Division of Biostatistics in the JC School of Public Health and Primary Care, Chinese University of Hong Kong (CUHK), and Director of Clinical Trials and Biostatistics Lab in the CU Shenzhen Research Institute (SZRI). He holds honorary appointments in the Department of Clinical Oncology and the Department of Statistics of CUHK. He is also the Chairman of the Joint CUHK-NTEC Clinical Research Ethics Committee since 2006. Professor Zee obtained his Ph.D in Biostatistics from the University of Pittsburgh USA in 1987. He then joined the National Cancer Institute of Canada Clinical Trials Group as Senior Biostatistician, and faculty member in the Department of Community Health and Epidemiology and the Department of Mathematics and Statistics of Queen’s University Canada from 1987-2001. He remains as Adjunct Professor with Queen’s University after he joined CUHK and is actively promoting international academic activities and collaborations.
Professor Zee has strong interest in various aspects of multi-center clinical trials, including statistical methods, data management, drug and medical device development. On the methodological side, he is active in Biostatistics research, especially in the area of clinical trials design, bioinformatics, quality of life, data & safety monitoring and other statistical issues. He has experience in the development of efficient data management procedure using advanced computer technology for “big data”, plus ample experience in working with industry to design and to carry out clinical trials that satisfy both academic interest and industry objectives. He has tremendous experience in the development of hospital infrastructure such as Ethics Committee, GCP Centre and quality assurance team to carry out clinical research in hospitals that satisfies regulatory and international requirements. He is also active in medical devices development such as “automatic retinal imaging analysis(ARIA)” and serves in the Centre for Entrepreneurship of CUHK. He had published more than 180 international peer reviewed journal articles and serves in various committees including advisory committees for drug development and data & safety monitoring committees for international drug trials.
Area of Interest:
Biomedical Sciences
100%
Biostatistics
62%
Clinical Trials
90%
Image Processing
75%
Research
55%
Research Publications in Numbers
Books
0
0
Chapters
0
0
Articles
0
0
Abstracts
0
0
Selected Publications
- Wong, G.K., D.Y. Chan, D.Y. Siu, B.C. Zee, W.S. Poon et al., 2015. High-dose simvastatin for aneurysmal subarachnoid hemorrhage multicenter randomized controlled double-blinded clinical trial. Stroke, 46: 382-388.
CrossRef | Direct Link | - Wong, G.K., A. Wong, B.C. Zee, W.S. Poon, M.T. Chan et al., 2015. Cognitive outcome in acute simvastatin treatment for aneurysmal subarachnoid hemorrhage: A propensity matched analysis. J. Neurol. Scie., 358: 58-61.
CrossRef | Direct Link | - Lai, X and B.C.Y. Zee, 2015. Mixed response and time-to-event endpoints for multistage single-arm phase II design. Trials, 16: 1-10.
Direct Link | - King, A.D., A.C. Vlantis, T.W.C. Yuen, B.K.H. Law and K.S. Bhatia et al., 2015. Detection of nasopharyngeal carcinoma by mr imaging: diagnostic accuracy of mri compared with endoscopy and endoscopic biopsy based on long-term follow-up. Amer. J. Neuroradiol., 10.3174/ajnr.A4456.
CrossRef | Direct Link | - Chong, K.C., W. Goggins, B.C.Y. Zee and M.H. Wang, 2015. Identifying meteorological drivers for the seasonal variations of influenza infections in a subtropical city-hong kong. Int. J. Env. Res. Public Health, 12: 1560-1576.
CrossRef | Direct Link | - Yeo, W., H.M. Lee, A. Chan, E.Y. Chan and M.C. Chan, et al., 2014. Risk factors and natural history of breast cancer in younger chinese women. World J. Clin. Oncol., 5: 1097-1106.
CrossRef | Direct Link | - Wei, X., X. Zhang, J. Yin, J. Walley, R. Beanland et al., 2014. Changes in pulmonary tuberculosis prevalence: evidence from the 2010 population survey in a populous province of china. BMC Infect. Dis., 10.1186/1471-2334-14-21.
CrossRef | Direct Link | - Wang, M.H., J. Li, V.S.Y. Yeung, B.C.Y. Zee and R.H.Y. Yu et al., 2014. Four pairs of gene-gene interactions associated with increased risk for type 2 diabetes (CDKN2BAS-KCNJ11), obesity (SLC2A9-IGF2BP2, FTO-APOA5), and hypertension (MC4R-IGF2BP2) in Chinese women. Meta. Gene, 2: 384-391.
CrossRef | Direct Link | - Leung, S.F., K.C.A. Chan, B.B. Ma, E.P. Hui and F. Mo et al., 2014. Plasma epstein-barr viral dna load at midpoint of radiotherapy course predicts outcome in advanced-stage nasopharyngeal carcinoma. Anal. Oncol., 25: 1204-1208.
CrossRef | Direct Link | - King, A.D., B.B. Ma, Y.Y. Yau, B. Zee and S.F. Leung et al., 2014. The impact of 18F-FDG PET/CT on assessment of nasopharyngeal carcinoma at diagnosis. Br. J. Radiol., 81: 291-298.
CrossRef | Direct Link | - He, L., J. Zhao, M.H. Wang, K.K. Siu, and Y.X. Gan, et al., 2014. Interleukin-27 is differentially associated with hiv viral load and cd4+ t cell counts in therapy-naive hiv-mono-infected and hiv/hcv-co-infected chinese. PLoS One, 10.1371/journal.pone.0096792.
CrossRef | Direct Link | - Chong, K.C., H.F. Fong and C.Y. Zee, 2014. Estimating the incidence reporting rates of new influenza pandemics at an early stage using travel data from the source country. Epidemiol. Infect., 142: 955-963.
CrossRef | Direct Link | - Wei, X., G. Zou, W. Gong, J. Yin and Y. Yu et al., 2013. Cardiovascular disease risk reduction in rural China: a clustered randomized controlled trial in Zhejiang. Trials, .
Direct Link | - Lee, J., B. Zee and Q. Li, 2013. Segmentation and texture analysis with multimodel inference for the automatic detection of exudates in early diabetic retinopathy. J. Biomed. Sci. Eng., 6: 298-307.
CrossRef | Direct Link | - Wong, G.K.C., R. Boet, S.C.P. Ng, M. Chan, T. Gin, B. Zee and W.S. Poon, 2012. Ultra-early (within 24 hours) aneurysm treatment after subarachnoid hemorrhage. World Neurosurg., 77: 311-315.
CrossRef | Direct Link | - Lee, A.S., B.C.Y. Zee, F.Y. Cheung, P. Kwong and C.L. Chiang et al., 2012. Randomized phase II study of the x-linked inhibitor of apoptosis (XIAP) antisense AEG35156 in combination with sorafenib in patients with advanced hepatocellular carcinoma (HCC). In Asco Annual Meeting. Amer. J. Clin. Oncol., 10.1097/COC.0000000000000099.
CrossRef | Direct Link | - Chong, K.C and B.C.Y. Zee, 2012. Modeling the impact of air, sea, and land travel restrictions supplemented by other interventions on the emergence of a new influenza pandemic virus. BMC Infect. Dis., 10.1186/1471-2334-12-309.
CrossRef | Direct Link | - King, A.D., A.C. Vlantis, K.S. Bhatia, B.C. Zee and J.K. Woo et al., 2011. Primary nasopharyngeal carcinoma: diagnostic accuracy of MR imaging versus that of endoscopy and endoscopic biopsy. Radiol., 258: 531-537.
CrossRef | Direct Link | - Hui, E.P., L.K. Leung, T.C. Poon, F. Mo and V.T. Chan et al., 2011. Prediction of outcome in cancer patients with febrile neutropenia: a prospective validation of the multinational association for supportive care in cancer risk index in a chinese population and comparison with the talcott model and artificial neural network. Supportive Care Cancer, 19: 1625-1635.
CrossRef | Direct Link | - Hui, E.P., B.B.Y. Ma, A.D. King, F. Mo and S.L. Chan et al., 2011. Hemorrhagic complications in a phase II study of sunitinib in patients of nasopharyngeal carcinoma who has previously received high-dose radiation. Anal. Oncol., 22: 1280-1287.
CrossRef | Direct Link | - Wong, S.C.C., T.C.C. Au, S.C.S. Chan, C.M.L. Chan, M.Y.Y. Lam et al., 2010. Human papillomavirus DNA detection in menstrual blood from patients with cervical intraepithelial neoplasia and condyloma acuminatum. J. Clin. Microbiol., 48: 709-713.
CrossRef | Direct Link | - Wong, G.K.C., W.S. Poon, M.T. Chan, R. Boet, T. Gin, S.C. Ng and B.C. Zee, 2010. Intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage (IMASH) a randomized, double-blinded, placebo-controlled, multicenter phase III trial. Stroke, 41: 921-926.
CrossRef | Direct Link | - Wong, G.K., W.S. Poon, M.T. Chan, R. Boet, T. Gin, S.C. Ng and B.C. Zee, 2010. Plasma magnesium concentrations and clinical outcomes in aneurysmal subarachnoid hemorrhage patients post hoc analysis of intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage trial. Stroke, 41: 1841-1844.
CrossRef | Direct Link | - Ng, M.H., S.H. Cheng, K.M. Lau, G.M. Leung, U.S. Khoo, B.C. Zee and J.J. Sung, 2010. Immunogenetics in SARS: a case-control study. Hong Kong Med. J., 16: 29-33.
PubMed | - Ng, M.C.Y., V.K.L. Lam, C.H.T. Tam, A.W.H. Chan, W.Y. So et al., 2010. Association of the POU class 2 homeobox 1 gene (POU2F1) with susceptibility to Type 2 diabetes in chinese populations. Diabetic Med., 27: 1443-1449.
CrossRef | Direct Link | - Yeo, W., F.K.F. Mo, J.J.S. Suen, W.M. Ho and S.L. Chan et al., 2009. A randomized study of aprepitant, ondansetron and dexamethasone for chemotherapy-induced nausea and vomiting in chinese breast cancer patients receiving moderately emetogenic chemotherapy. Breast Cancer Res. Treat., 113: 529-535.
CrossRef | Direct Link | - Mak, S.S., W. Yeo, Y.M. Lee, S.M. Tse, F.P. Ho, B. Zee, E. Chan, 2009. Risk factors for the initiation and aggravation of lymphoedema after axillary lymph node dissection for breast cancer. Hong Kong Med. J., 15: 8-12.
- Ma, B.B.Y., E.P. Hui, S.C.C. Wong, S.Y. Tung and K.K. Yuen et al., 2009. Multicenter phase II study of gemcitabine and oxaliplatin in advanced nasopharyngeal carcinoma-correlation with excision repair cross-complementing-1 polymorphisms. Anal. Oncol., 20: 1854-1859.
CrossRef | Direct Link | - Hui, E.P., B.B. Ma, S.F. Leung, A.D. King, F. Mo et al., 2009. Randomized phase II trial of concurrent cisplatin-radiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma. J. Clin. Oncol., 27: 242-249.
CrossRef | Direct Link | - Correa, C., P. Mcgale, C. Taylor, Y. Wang and M. Clarke et al., 2009. Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J. National Cancer Inst. Monogr., 2010: 162-177.
CrossRef | Direct Link | - Zee, B., C. Huang, S. Mak, J. Wong, E. Chan and W. Yeo, 2008. Factors related to sexual health in chinese women with breast cancer in hong kong. Asia-Pac. J. Clin. Oncol., 4: 218-226.
CrossRef | Direct Link | - Wong, A.W., E.K.L. Hon and B. Zee, 2008. Is topical antimycotic treatment useful as adjuvant therapy for flexural atopic dermatitis: randomized, double-blind, controlled trial using one side of the elbow or knee as a control. Int. J. Dermatol., 47: 187-191.
CrossRef | Direct Link | - Ma, B., Hui, E.P., King, A., To, K. F., Mo, F et al., 2008. A phase II study of patients with metastatic or locoregionally recurrent nasopharyngeal carcinoma and evaluation of plasma Epstein-Barr virus DNA as a biomarker of efficacy. Cancer Chemother. Pharmacol., 62: 59-64.
CrossRef | Direct Link | - Ma, B., B.C. Goh, E.H. Tan, K.C. Lam and R. Soo et al., 2008. A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells. Invest. New Drugs, 26: 169-173.
CrossRef | Direct Link | - Lee, J and B. Zee, 2008. Application of wavelet-based neural network on DNA microarray data. Bioinf., 3: 223-229.
Direct Link | - Chiu, R.W., K.A. Chan, Y. Gao, V.Y. Lau and W. Zheng et al., 2008. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc. National Acad. Sci., 105: 20458-20463.
CrossRef | Direct Link | - Benny, Z.C.Y., L.J.W. Jack, W. Nathalie, Y. Winnie, P.L.B. San, M.S.K. Tony and C.T.C. Anthony, 2008. A prognostic model for the combined analysis of gene expression profiling in hepatocellular carcinoma. Bioinf., 2: 395-400.
Direct Link | - Baum, L., C.W.K. Lam, S.K.K. Cheung, T. Kwok and V. Lui et al., 2008. Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with alzheimer disease. J. Clin. Psychopharmacol., 28: 110-113.
Direct Link | - Yeo, W., M. Boyer, H.C. Chung, S.Y.K. Ong and R. Lim et al., 2007. Irofulven as first line therapy in recurrent or metastatic gastric cancer: a phase II multicenter study by the cancer therapeutics research group (ctrg). Cancer Chemother. Pharmacol., 59: 295-300.
CrossRef | Direct Link | - Mok, T.S.K., W. Yeo, P.J. Johnson, P. Hui, W.M. Ho et al., 2007. A double-blind placebo-controlled randomized study of Chinese herbal medicine as complementary therapy for reduction of chemotherapy-induced toxicity. Anal. Oncol., 10.1093/annonc/mdl465.
CrossRef | Direct Link | - Lo, Y.D., F.M. Lun, K.A. Chan, N.B. Tsui and K.C. Chong et al., 2007. Digital PCR for the molecular detection of fetal chromosomal aneuploidy. Proc. National Acad. Sci., 104: 13116-13121.
CrossRef | Direct Link | - Li, C.K., B. Zee, J. Lee, K.W. Chik, Ha, S.Y and V. Lee, 2007. Impact of SARS on development of childhood acute lymphoblastic leukaemia. Leukemia, 21: 1353-1356.
CrossRef | Direct Link | - King, A.D., B. Zee, E.H. Yuen, S.F. Leung and D.K. Yeung et al., 2007. Nasopharyngeal cancers: which method should be used to measure these irregularly shaped tumors on cross-sectional imaging?. Int. J. Radiat. Oncol. Biol. Phys., 69: 148-154.
CrossRef | Direct Link | - Kam, M.K., S.F. Leung, B. Zee, R.M. Chau and J.J. Suen et al., 2007. Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients. J. Clin. Oncol., 25: 4873-4879.
CrossRef | Direct Link | - Ho, S.C., A.S. Chan, Y.P. Ho, E.K. So, A. Sham, B. Zee and J.L. Woo, 2007. Effects of soy isoflavone supplementation on cognitive function in Chinese postmenopausal women: a double-blind, randomized, controlled trial. Menopause, 14: 489-499.
CrossRef | Direct Link | - Baum, L., S.K.K. Cheung, V.C.T. Mok, L.C.W. Lam and V.P.Y. Leung et al., 2007. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol. Res., 56: 509-514.
CrossRef | Direct Link | - Zee, B.C.Y., 2006. Planned equivalence or noninferiority trials versus unplanned noninferiority claims: are they equal?. J. Clin. Oncol., 24: 1026-1028.
CrossRef | Direct Link | - Yeo, W., F.K.F. Mo, J. Koh, A.T.C. Chan and T. Leung et al., 2006. Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma. Ann. Oncol., 17: 1083-1089.
CrossRef | Direct Link | - Wu, J.Y., W.Y. Leung, S. Chang, B. Lee, B. Zee, P.C. Tong and J.C. Chan, 2006. Effectiveness of telephone counselling by a pharmacist in reducing mortality in patients receiving polypharmacy: randomised controlled trial. Br. Med. J., 10.1136/bmj.38905.447118.2F.
CrossRef | Direct Link | - Teo, P.M., S.F. Leung, S.Y. Tung, B. Zee and J.S. Sham et al., 2006. Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (Hknpcsg) Radiother. Oncol., 79: 27-33.
CrossRef | Direct Link | - Ma, B.B., A. King, Y.D. Lo, Y.Y. Yau and B. Zee et al., 2006. Relationship between pretreatment level of plasma Epstein-Barr virus DNA, tumor burden, and metabolic activity in advanced nasopharyngeal carcinoma. Int. J. Radiat. Oncol. Biol. Phys., 66: 714-720.
CrossRef | Direct Link | - Leung, S.F., B. Zee, B.B. Ma, E.P. Hui and F. Mo et al., 2006. Plasma epstein-barr viral deoxyribonucleic acid quantitation complements tumor-node-metastasis staging prognostication in nasopharyngeal carcinoma. J. clin. Oncol., 24: 5414-5418.
CrossRef | Direct Link | - Lee, N., T.H. Rainer, M. Ip, B. Zee and M.H. Ng et al., 2006. Role of laboratory variables in differentiating SARS-coronavirus from other causes of community-acquired pneumonia within the first 72 h of hospitalization. Eur. J. Clin. Microbiol. Infect. Dis., 25: 765-772.
CrossRef | Direct Link | - Yu, K.H., S.F. Leung, S.Y. Tung, B. Zee and D.T. Chua et al., 2005. Survival outcome of patients with nasopharyngeal carcinoma with first local failure: a study by the hong kong nasopharyngeal carcinoma study group. Head Neck, 27: 397-405.
CrossRef | Direct Link | - Yeo, W., T.S. Mok, B. Zee, T.W. Leung and P.B. Lai et al., 2005. A randomized phase III study of doxorubicin versus cisplatin/interferon α-2b/doxorubicin/fluorouracil (PIAF) combination chemotherapy for unresectable hepatocellular carcinoma. J. National Cancer Inst., 97: 1532-1538.
CrossRef | Direct Link | - Poon, T.C., C.H. Chiu, P.B. Lai, T.S. Mok and B. Zee et al., 2005. Correlation and prognostic significance of beta-galactoside alpha-2, 6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma. World J. Gastroenterol., 11: 6701-6706.
CrossRef | Direct Link | - Osoba, D., A. Bezjak, M. Brundage, B. Zee, D. Tu and J. Pater, 2005. Analysis and interpretation of health-related quality-of-life data from clinical trials: basic approach of the national cancer institute of canada clinical trials group. Eur. J. Cancer, 41: 280-287.
CrossRef | Direct Link | - Mok, T.S., W. Yeo, S. Yu, P. Lai and H.L. Chan et al., 2005. An intensive surveillance program detected a high incidence of hepatocellular carcinoma among hepatitis B virus carriers with abnormal alpha-fetoprotein levels or abdominal ultrasonography results. J. Clin. Oncol., 23: 8041-8047.
CrossRef | Direct Link | - Mok, T.S., K.C. Lam, C. Lee, L. Zhang and H. Wong et al., 2005. Phase II randomized study comparing the toxicity profile of gemcitabine plus cisplatin with gemcitabine plus oral etoposide in the treatment of advanced non-small cell lung cancer. Oncol., 68: 485-492.
CrossRef | Direct Link | - Mak, S.S., C.Y. Zee, A. Molassiotis, S.J. Chan, S.F. Leung, K.F. Mo and P.J. Johnson, 2005. A comparison of wound treatments in nasopharyngeal cancer patients receiving radiation therapy. Cancer Nursing, 28: 436-545.
Direct Link | - Lee, A.W., W.M. Sze, J.S. Au, S.F. Leung and T.W. Leung et al., 2005. Treatment results for nasopharyngeal carcinoma in the modern era: the Hong Kong experience. Int. J. Radiat. Oncol. Biol. Phys., 61: 1107-1116.
CrossRef | Direct Link | - Davis, A.M., B. O'Sullivan, R. Turcotte, R. Bell and C. Catton et al., 2005. Late radiation morbidity following randomization to preoperative versus postoperative radiotherapy in extremity soft tissue sarcoma. Radiother. Oncol., 75: 48-53.
CrossRef | Direct Link | - Chua, M.S.T., T.S. Mok, W.H. Kwan, W. Yeo and B. Zee, 2005. Knowledge, perceptions, and attitudes of Hong Kong Chinese women on screening mammography and early breast cancer management. Breast J., 11: 52-56.
CrossRef | Direct Link | - Chan, A.T., S.F. Leung, R.K. Ngan, P.M. Teo and W.H. Lau et al., 2005. Overall survival after concurrent cisplatin-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma. J. National Cancer Inst., 97: 536-539.
CrossRef | Direct Link | - Zhong, S., W. Yeo, C. Schroder, P.K.S. Chan and W.L. Wong et al., 2004. High hepatitis B virus (HBV) DNA viral load is an important risk factor for HBV reactivation in breast cancer patients undergoing cytotoxic chemotherapy. J. Viral Hepatitis, 11: 55-5910.1046/j.1352-0504.2003.00467.x.
Direct Link | - Zee, B.C.Y and T.S. Mok, 2004. Methodology for quality-of-life assessment: a critical appraisal. Thoracic Surg. Clin., 14: 305-315.
CrossRef | Direct Link | - Yeo, W., P.K. Chan, W.M. Ho, B. Zee and K.C. Lam et al., 2004. Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis B s-antigen seropositive cancer patients undergoing cytotoxic chemotherapy. J. Clin. Oncol., 22: 927-934.
CrossRef | Direct Link | - Yeo, W., K.C. Lam, B. Zee, P.S.K. Chan and F.K.F. Mo et al., 2004. Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy. Anal. Oncol., 15: 1661-1666.
CrossRef | Direct Link | - Yeo, W., B. Zee, S. Zhong, P.K.S. Chan and W.L. Wong et al., 2004. Comprehensive analysis of risk factors associating with Hepatitis B virus (HBV) reactivation in cancer patients undergoing cytotoxic chemotherapy. Br. J. Cancer, 90: 1306-1311.
CrossRef | Direct Link | - Ng, M.H.L., K.M. Lau, S.H. Cheng, W.Y. Chan and P.K. Hui et al., 2004. Association of HLA Class I (B703) and Class II (DRB1*0301) genotypes with susceptibility and resistance to the development of Severe Acute Respiratory Syndrome (SARS). J. Infect. Dis., 190: 515-518.
- Ma, B.B., S.F. Leungm, E.P. Hui, F. Mo and W.H. Kwan et al., 2004. Prospective validation of serum CYFRA 21-1, β-2-microglobulin, and ferritin levels as prognostic markers in patients with nonmetastatic nasopharyngeal carcinoma undergoing radiotherapy. Cancer, 101: 776-781.
CrossRef | Direct Link | - Leung, S.F., J.S. Tam, A.T. Chan, B. Zee and L.Y. Chan et al., 2004. Improved accuracy of detection of nasopharyngeal carcinoma by combined application of circulating Epstein-Barr virus DNA and anti-Epstein-Barr viral capsid antigen IgA antibody. Clin. Chem., 50: 339-345.
CrossRef | Direct Link | - Lee, A.W.M., J.S.K. Au, P.M.L. Teo, T.W. Leung and D.T.T. Chua et al., 2004. Staging of nasopharyngeal carcinoma: suggestions for improving the current UICC/AJCC staging system. Clin. Oncol., 16: 269-276.
CrossRef | Direct Link | - King, A.D., M.K. Gary, E.H. Yuen, E.W. To and A.C. Vlantis et al., 2004. Comparison of CT and MR imaging for the detection of extranodal neoplastic spread in metastatic neck nodes. Eur. J. Radiol., 52: 264-270.
CrossRef | Direct Link | - Kam, M.K., P.M. Teo, R.M. Chau, K.Y. Cheung and P.H. Choi et al., 2004. Treatment of nasopharyngeal carcinoma with intensity-modulated radiotherapy: the Hong Kong experience. Int. J. Radiat. Oncol. Biol. Phys., 60: 1440-1450.
CrossRef | Direct Link | - Hui, E.P., S.F. Leung, J.S. Au, B. Zee and S. Tung et al., 2004. Lung metastasis alone in nasopharyngeal carcinoma: A relatively favorable prognostic group. Cancer, 101: 300-306.
CrossRef | Direct Link | - Chan, A.T., B.B. Ma, Y.D. Lo, S.F. Leung and W.H. Kwan et al., 2004. Phase II study of neoadjuvant carboplatin and paclitaxel followed by radiotherapy and concurrent cisplatin in patients with locoregionally advanced nasopharyngeal carcinoma: therapeutic monitoring with plasma Epstein-Barr virus DNA. J. Clin. Oncol., 22: 3053-3060.
CrossRef | Direct Link | - Butler, L., M. Bacon, M. Carey, B. Zee, D. Tu and A. Bezjak, 2004. Determining the relationship between toxicity and quality of life in an ovarian cancer chemotherapy clinical trial. J. Clin. Oncol., 22: 2461-2468.
CrossRef | Direct Link | - Blazeby, J.M., E. Currie, B.C. Zee, W.C. Chie, R.T. Poon, O.J. Garden, 2004. Development of a questionnaire module to supplement the EORTC QLQ-C30 to assess quality of life in patients with hepatocellular carcinoma, the EORTC QLQ-HCC18. Eur. J. Cancer, 40: 2439-2444.
CrossRef | Direct Link | - Bezjak, A., D. Tu, M. Bacon, D. Osoba and B. Zee et al., 2004. Quality of life in ovarian cancer patients: comparison of paclitaxel plus cisplatin, with cyclophosphamide plus cisplatin in a randomized study.. J. Clin. Oncol., 22: 4595-4603.
CrossRef | Direct Link | - Yee, K.W., J.L. Pater, L. Pho, B. Zee and L.L. Siu, 2003. Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier?. J. clin. Oncol., 21: 1618-1623.
CrossRef | Direct Link | - Piccart, M.J., K. Bertelsen, G. Stuart, J. Cassidy and C. Mangioni et al., 2003. Long-term follow-up confirms a survival advantage of the paclitaxel-cisplatin regimen over the cyclophosphamide-cisplatin combination in advanced ovarian cancer. Int. J. Gynecological Cancer, 13: 144-148.
CrossRef | Direct Link | - Moore, M.J., J. Hamm, J. Dancey, P.D. Eisenberg and M. Dagenais et al., 2003. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the national cancer institute of canada clinical trials group. J. Clin. Oncol., 21: 3296-3302.
CrossRef | Direct Link | - Ma, B.B., T.C. Poon, T.C. To, K.F., Zee and B. Mo et al., 2003. Prognostic significance of tumor angiogenesis, Ki 67, p53 oncoprotein, epidermal growth factor receptor and HER2 receptor protein expression in undifferentiated nasopharyngeal carcinoma-a prospective study. Head Neck, 25: 864-872.
CrossRef | Direct Link | - Leung, S.F., A.T. Chan, B. Zee, B. Ma, L. Chan, P.J. Johnson and L.Y.M. Dennis, 2003. Pretherapy quantitative measurement of circulating Epstein-Barr virus DNA is predictive of posttherapy distant failure in patients with early-stage nasopharyngeal carcinoma of undifferentiated type. Cancer, 98: 288-291.
CrossRef | Direct Link | - Hui, E.P., T.C. Poon, P.M. Teo, F. Mo, B. Zee and S.F. Leung et al., 2003. A prospective study of pre-treatment cell kinetics and clinical outcome in nasopharyngeal carcinoma. Radiother. Oncolo., 69: 53-62.
CrossRef | Direct Link | - Bacon, M., K. James and B. Zee, 2003. A comparison of the incidence, duration, and degree of the neurologic toxicities of cisplatin-paclitaxel (PT) and cisplatin-cyclophosphamide (PC). Int. J. Gynecol. Cancer, 13: 428-434.
CrossRef | Direct Link | - Tozer, R.G., S. Burdette-Radoux, K. Berlanger, M.L. Davis and R.C. Lohmann et al., 2002. A randomized phase ii study of two schedules of bryostatin-1 (nsc339555) in patients with advanced malignant melanoma-a national cancer institute of canada clinical trials group study. Invest. New Drugs, 20: 407-412.
CrossRef | Direct Link | - Shepherd, F.A., G. Giaccone, L. Seymour, C. Debruyne and A. Bezjak et al., 2002. Prospective, randomized, double-blind, placebo-controlled trial of marimastat after response to first-line chemotherapy in patients with small-cell lung cancer: a trial of the national cancer institute of canada-clinical trials group and the european organization for research and treatment of cancer. J. Clin. Oncol., 20: 4434-4439.
CrossRef | Direct Link | - Roche, K., N. Paul, B. Smuck, M. Whitehead and B. Zee et al., 2002. Factors affecting workload of cancer clinical trials: results of a multicenter study of the national cancer institute of canada clinical trials group. J. Clin. Oncol., 20: 545-556.
CrossRef | Direct Link | - O`Sullivan, B., A.M. Davis, R. Turcotte, R. Bell and C. Catton et al., 2002. Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial. Lancet, 359: 2235-2241.
CrossRef | Direct Link | - Mok, T.S., H. Wong, B. Zee, K.H. Yu and T.W. Leung et al., 2002. A phase I-II study of sequential administration of topotecan and oral etoposide (toposiomerase I and II inhibitors) in the treatment of patients with small cell lung carcinoma. Cancer, 95: 1511-1519.
CrossRef | Direct Link | - Mok, T.S and B. Zee, 2002. Adequate lymph node staging is fundamental to comparative study on resectable non-small-cell lung cancer. J. Clin. Oncol., 20: 2604-2605.
Direct Link | - Leung, T.W., A.M. Tang, B. Zee, W.Y. Lau and P. Lai et al., 2002. Construction of the chinese university prognostic index for hepatocellular carcinoma and comparison with the tnm staging system, the okuda staging system, and the cancer of the liver italian program staging system. Cancer, 94: 1760-1769.
CrossRef | Direct Link | - Leung, T.W., A.M. Tang, B. Zee, S.C. Yu, P. Lai, W.Y. Lau and P.J. Johnson, 2002. Factors predicting response and survival in 149 patients with unresectable hepatocellular carcinoma treated by combination cisplatin, interferon-alpha, doxorubicin and 5-fluorouracil chemotherapy. Cancer, 94: 421-427.
CrossRef | Direct Link | - Leung, S.F., Y. Zheng, C.Y. Choi, S.S. Mak and S.K. Chiu et al., 2002. Quantitative measurement of post-irradiation neck fibrosis based on the young modulus. Cancer, 95: 656-662.
CrossRef | Direct Link | - Hui, E.P., A.T. Chan, F. Pezzella, H. Turley and K.F. To et al., 2002. Coexpression of hypoxia-inducible factors 1α and 2α, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival. Clin. Cancer Res., 8: 2595-2604.
Direct Link | - Freidlin, B., J. Dancey, E.L. Korn, B. Zee and E. Eisenhauer, 2002. Multinomial phase II trial designs. J. Clin. Oncol., 20: 599-599.
Direct Link | - Davis, A.M., B. O`sullivan, R.S. Bell, R. Turcotte and C.N. Catton et al., 2002. Function and health status outcomes in a randomized trial comparing preoperative and postoperative radiotherapy in extremity soft tissue sarcoma. J. Clin. Oncol., 20: 4472-4477.
CrossRef | Direct Link | - Chan, A.T.C., P.M.L. Teo, R.K. Ngan, T.W. Leung and W.H. Lau et al., 2002. Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of a phase III randomized trial. J. Clin. Oncol., 20: 2038-2044.
CrossRef | Direct Link | - Chan, A.T., Y.D. Lo, B. Zee, L.Y. Chan and B.B. Ma et al., 2002. Plasma epstein-barr virus dna and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma. J. National Cancer Inst., 94: 1614-1619.
CrossRef | Direct Link | - Speirs, A.D., C.F. Small, J.T. Bryant, D.R. Pichora and B.Y. Zee, 2001. Three-dimensional metacarpophalangeal joint kinematics using two markers on the phalanx. J. Eng. Med., 215: 415-419.
CrossRef | Direct Link | - Pritchard, K.I., A.H. Paterson, S. Fine, N.A. Paul and B. Zee et al., 2001. Application of a new multinomial phase II stopping rule using response and early progression. J. Clin. Oncol., 19: 785-791.
Direct Link | - Poon, T.W., A.T.C. Chan, B. Zee, S.W. Ho and T.K. Mok et al., 2001. Application of classification tree and neural network algorithms to the identification of serological liver marker profiles for the diagnosis of hepatocellular carcinoma. Oncol., 61: 275-283.
CrossRef | Direct Link | - Myeloma, T.C.G., 2001. Interferon as therapy for multiple myeloma: an individual patient data overview of 24 randomized trials and 4012 patients. Br. J. Haematol., 113: 1020-1034.
CrossRef | Direct Link | - Chiu, R.W., M.F. Murphy, C. Fidler, B.C. Zee, J.S. Wainscoat and Y.D. Lo, 2001. Determination of RhD zygosity: comparison of a double amplification refractory mutation system approach and a multiplex real-time quantitative PCR approach. Clin. Chem., 47: 667-672.
Direct Link | - Yeo, W., P.K. Chan, S. Zhong, W.M. Ho and J.L. Steinberg et al., 2000. Frequency of hepatitis B virus reactivation in cancer patients undergoing cytotoxic chemotherapy: a prospective study of 626 patients with identification of risk factors. J. Med. Virol., 62: 299-307.
CrossRef | Direct Link | - Teo, P.M.L., S.F. Leung, W.Y. Lee and B. Zee, 2000. Intracavitary brachytherapy significantly enhances local control of early T-stage nasopharyngeal carcinoma: the existence of a dose-tumor-control relationship above conventional tumoricidal dose. Int. J. Radiat. Oncol. Biol. Phys., 46: 445-458.
CrossRef | Direct Link | - Teo, P.M.L., S.F. Leung, J. Fowler, T.W. Leung, Y. Tung, W.Y. Lee and B. Zee, 2000. Improved local control for early T-stage nasopharyngeal carcinoma-a tale of two hospitals. Radiother. Oncol., 57: 155-166.
CrossRef | Direct Link | - Piccart, M.J., K. Bertelsen, K. James, J. Cassidy and C. Mangioni et al., 2000. Randomized intergroup trial of cisplatin-paclitaxel versus cisplatin-cyclophosphamide in women with advanced epithelial ovarian cancer: three-year results. J. National Cancer Inst., 92: 699-708.
CrossRef | Direct Link | - Mok, T.S., B. Zee, A.T. Chan, W. Yeo and W.T. Yang et al., 2000. A phase II study of gemcitabine plus oral etoposide in the treatment of patients with advanced nonsmall cell lung carcinoma. Cancer, 89: 543-550.
CrossRef | Direct Link | - Kirkbride, P., A. Bezjak, J. Pater, B. Zee and M.J. Palmer et al., 2000. Dexamethasone for the prophylaxis of radiation-induced emesis: a national cancer institute of canada clinical trials group phase iii study. J. Clin. Oncol., 18: 1960-1966.
Direct Link | - Geels, P., E. Eisenhauer, A. Bezjak, B. Zee and A. Day, 2000. Palliative effect of chemotherapy: objective tumor response is associated with symptom improvement in patients with metastatic breast cancer. J. Clin. Oncol., 18: 2395-2405.
Direct Link | - Dent, S.F., D. Klaassen, J.L. Pater, B. Zee and M. Whitehead, 2000. Second primary malignancies following the treatment of early stage ovarian cancer: Update of a study by the national cancer institute of canada-clinical trials group (ncic-ctg). Anal. Oncol., 11: 65-68.
Direct Link |