Dr. Yau-Chi Chan Alex
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Dr. Yau-Chi Chan Alex

Medical Professional/Doctor
The Government of the Hong Kong, Hong Kong


Highest Degree
Ph.D. in Medicine from University of Hong Kong, Hong Kong

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Area of Interest:

Medicine
100%
Human Genetics
62%
Stem Cells
90%
Electrophysiology
75%
Cardiovascular System
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Tse, H.F., C.Y. Ho, S.W. Choi, Y.K. Lee and A.W. Butler et al., 2013. Patient-specific induced pluripotent stem cells derived cardiomycoytes recapitulates the pathogenic phenotypes of dilated cardiomyopathy due to a novel DES mutation identified by whole exome sequencing. Hum. Mol. Genet., 22: 1395-1403.
    CrossRef  |  PubMed  |  Direct Link  |  
  2. Ting, S., M. Lecina, Y.C. Chan, H.F. Tse, S. Reuveny and S.K.W. Oh, 2013. Nutrient supplemented serum-free medium increases cardiomyogenesis efficiency of human pluripotent stem cells. World J. Stem Cells, 5: 86-97.
    CrossRef  |  PubMed  |  Direct Link  |  
  3. Lai, W.H., J.C.Y. Ho, Y.C. Chan, J.H.L. Ng and K.W. Au et al., 2013. Attenuation of hind-limb ischemia in mice with endothelial-like cells derived from different sources of human stem cells. PLoS One, Vol. 8. 10.1371/journal.pone.0057876.
    CrossRef  |  Direct Link  |  
  4. Zhang, J., Y.C. Chan, J.C.Y. Ho, C.W. Siu, Q.Z. Lian and H.F. Tse, 2012. Regulation of cell proliferation of human induced pluripotent stem cell-derived mesenchymal stem cells via ether-a-go-go 1 (hEAG1) potassium channel. Am. J. Physiol.-Cell Physiol., 303: C115-C125.
    CrossRef  |  PubMed  |  Direct Link  |  
  5. Siu, C.W., Y.K. Lee, J.C. Ho, W.H. Lai and Y.C. Chan et al., 2012. Modeling of lamin A/C mutation premature cardiac aging using patient‐specific induced pluripotent stem cells. Aging, 4: 803-822.
    PubMed  |  Direct Link  |  
  6. Liao, S.Y., H.F. Tse, Y.C. Chan, P.M.C. Yip, Y. Zhang, Y. Liu and R.A. Li, 2012. Overexpression of Kir2.1 channel in embryonic stem cell-derived cardiomyocytes attenuates posttransplantation proarrhythmic risk in myocardial infarction. Heart Rhythm, 10: 273-282.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Li, W., X. Wang, W. Fan, P. Zhao and Y.C. Chan et al., 2012. Modeling abnormal early development with induced pluripotent stem cells from aneuploid syndromes. Hum. Mol. Genet., 21: 32-45.
    CrossRef  |  Direct Link  |  
  8. Chan, Y.C., F.P. Leung, X.Y. Tian, L.M. Yung and C.W. Lau et al., 2012. Raloxifene improves vascular reactivity in pressurized septal coronary arteries of ovariectomized hamsters fed cholesterol diet. Pharmacol. Res., 65: 182-188.
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  9. Zhou, T., C. Benda, S. Duzinger, Y. Huang and X. Li et al., 2011. Generation of induced pluripotent stem cells from urine. J. Am. Soc. Nephrol., 22: 1221-1228.
    CrossRef  |  Direct Link  |  
  10. Ng, K.M., Y.K. Lee, W.H. Lai, Y.C. Chan, M.L. Fung, H.F. Tse and C.W. Siu, 2011. Exogenous expression of human apoA-I enhances cardiac differentiation of pluripotent stem cells. PLoS ONE, Vol. 6. 10.1371/journal.pone.0019787.
    CrossRef  |  Direct Link  |  
  11. Ng, K.M., Y.C. Chan, Y.K. Lee, W.H. Lai, M.L. Fung, C.W. Siu and H.F. Tse, 2011. Cobalt chloride pretreatment promotes cardiac differentiation of human embryonic stem cells under atmospheric oxygen level. Cell. Reprogram., 13: 527-537.
    CrossRef  |  Direct Link  |  
  12. Lee, Y.K., K.M. Ng, Y.C. Chan, C.W. Siu, Q.Z. Lian and H.F. Tse, 2011. Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Rev. Rep., 7: 976-986.
    CrossRef  |  Direct Link  |  
  13. Ho, J.C., T. Zhou, W.H. Lai, Y. Huang and Y.C. Chan et al., 2011. Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C. Aging, 3: 380-390.
    PubMed  |  Direct Link  |  
  14. Ng, K.M., Y.K. Lee, Y.C. Chan, W.H. Lai and M.L. Fung et al., 2010. Exogenous expression of HIF-1α promotes cardiac differentiation of embryonic stem cells. J. Mol. Cell. Cardiol., 48: 1129-1137.
    CrossRef  |  Direct Link  |  
  15. Liao, S.Y., Y. Liu, D.C.W. Siu, Y.L. Zhang and K.W.H. Lai et al., 2010. Proarrhythmic risk of embryonic stem cell-derived cardiomyocyte transplantation in infarcted myocardium. Heart Rhythm, 7: 1852-1859.
    CrossRef  |  PubMed  |  Direct Link  |  
  16. Lee, Y.K., K.M. Ng, Y.C. Chan, W.H. Lai and K.W. Au et al., 2010. Triiodothyronine promotes cardiac differentiation and maturation of embryonic stem cells via the classical genomic pathway. Mol. Endocrinol., 24: 1728-1736.
    CrossRef  |  PubMed  |  Direct Link  |  
  17. Lai, K.W.H., J.C.Y. Ho, Y.K. Lee, K.M. Ng and K.W. Au et al., 2010. ROCK inhibition facilitates the generation of human-induced pluripotent stem cells in a defined, feeder- and serum-free system. Cell. Reprogram., 12: 641-653.
    CrossRef  |  Direct Link  |  
  18. Chan, Y.C., H.F. Tse, C.W. Siu, K. Wang and R.A. Li, 2010. Automaticity and conduction properties of bio-artificial pacemakers assessed in an in vitro monolayer model of neonatal rat ventricular myocytes. Europace, 12: 1178-1187.
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  19. Chan, Y.C., F.P. Leung, W.T. Wong, X.Y. Tian and L.M. Yung et al., 2010. Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation. Arteriosclerosis Thrombosis Vasc. Biol., 30: 992-999.
    CrossRef  |  
  20. Chan, Y.C., K. Wang, K.W. Au, C.P. Lau, H.F. Tse and R.A. Li, 2009. Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels. Pflugers Archiv-Eur. J. Physiol., 459: 25-38.
    CrossRef  |  Direct Link  |  
  21. Chan, Y.C., C.W. Siu, Y.M. Lau, C.P. Lau, R.A. Li and H.F. Tse, 2009. Synergistic effects of inward rectifier (IK1) and pacemaker (If) currents on the induction of bioengineered cardiac automaticity. J. Cardiovasc. Electrophysiol., 20: 1048-1054.
    CrossRef  |  Direct Link  |  
  22. Au, K.W., S.Y. Liao, Y.K. Lee, W.H. Lai and K.M. Ng et al., 2009. Effects of iron oxide nanoparticles on cardiac differentiation of embryonic stem cells. Biochem. Biophys. Res. Commun., 379: 898-903.
    CrossRef  |  Direct Link  |  
  23. Moore, J.C., J. Fu, Y.C. Chan, D. Lin, H. Tran, H.F. Tse and R.A. Li, 2008. Distinct cardiogenic preferences of two Human Embryonic Stem Cell (hESC) lines are imprinted in their proteomes in the pluripotent state. Biochem. Biophys. Res. Commun., 372: 553-558.
    CrossRef  |  Direct Link  |  
  24. Lieu, D.K., Y.C. Chan, C.P. Lau, H.F. Tse, C.W. Siu and R.A. Li, 2008. Overexpression of HCN-encoded pacemaker current silences bioartificial pacemakers. Heart Rhythm, 5: 1310-1317.
    CrossRef  |  PubMed  |  Direct Link  |  
  25. Leung, F.P., S.Y. Tsang, C.M. Wong, L.M. Yung and Y.C. Chan et al., 2007. Raloxifene, tamoxifen and vascular tone. Clin. Exp. Pharmacol. Physiol., 34: 809-813.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Chan, Y.C., F.P. Leung, X.Q. Yao, C.W. Lau, P.M. Vanhoutte and Y. Huang, 2007. Raloxifene modulates pulmonary vascular reactivity in spontaneously hypertensive rats. J. Cardiovasc. Pharmacol., 49: 355-361.
    PubMed  |  
  27. Chan, Y.C., F.P. Leung, X.Q. Yao, C.W. Lau, P.M. Vanhoutte and Y. Huang, 2005. Raloxifene relaxes rat pulmonary arteries and veins: Roles of gender, endothelium and antagonism of Ca2+ influx. J. Pharmacol. Exp. Ther., 312: 1266-1271.
    CrossRef  |  Direct Link  |  
  28. Lau, C.W., Y.C. Chan, X.Q. Yao, F.L. Chan, Z.Y. Chen and Y. Huang, 2004. Nickel inhibits urocortin-induced relaxation in the rat pulmonary artery. Eur. J. Pharmacol., 488: 169-172.
    CrossRef  |  Direct Link  |  
  29. Huang, Y., X.Q. Yao, C.W. Lau, Y.C. Chan, S.Y. Tsang and F.L. Chan, 2004. Urocortin and cardiovascular protection. Acta Pharmacologica Sinica, 25: 257-265.
    PubMed  |  Direct Link  |  
  30. Chan, Y.C., X.Q. Yao, C.W. Lau, F.L. Chan, G.W. He, J.P. Bourreau and Y. Huang, 2004. The relaxant effect of urocortin in rat pulmonary arteries. Regulatory Peptides, 121: 11-18.
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