Dr. Huang   Fang-Ping
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Dr. Huang Fang-Ping

Research Scientist
The University of Hong Kong, Hong Kong


Highest Degree
Ph.D. in Immunology from University of Glasgow, UK

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Biography

Dr. Huang Fang-Ping has received his initial Medical Training in China from University of Shantou Medical College, STU First Teaching Hospital, and was awarded the Li Ka Sheng (LKS) Academic Foundation Fellowship to undertake postgraduate studies in the UK (University of Glasgow, 1987-90). He has subsequently become engaged in active Immunology research and teaching in the University of Glasgow (1990-97), University of Oxford (1997-2000), University of Hong Kong (2000-7) and Imperial College London (2007-14). Currently, he is affiliated to the State Key Laboratory for Liver Research (SKLLR)/Pathology Department, LKS Medical Faculty, HKU. His area of research interest focuses on Immune Regulation in Systemic Autoimmunity, Mucosal Inflammation, and Tumor Immunology. He is also serving as member of editorial board in journals such as European Journal of Immunology, Journal of Leukocyte Biology many others. He also completed 9 research projects as principal investigator and co-investigator. He is also serving as reviewer for number of scientific international journals. He is member of The Royal Society of Medicine UK, American Association of Immunologists, and Hong Kong Society for Immunology and British Society for Immunology. Dr. Huang received honors includes Imperial College Research Excellence Award, UK outstanding Young Scientist, and University of Hong Kong Research Committee Merit Awards. He has published 32 research articles in journals as well as 7 book and book chapters contributed as author/co-author.

Area of Interest:

Medicine
100%
Immune Regulation
62%
Systemic Autoimmunity
90%
Mucosal Inflammation
75%
Tumor Immunology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Wang, T., X. Sun, J. Zhao, J. Zhang and H. Zhu et al., 2015. Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood. Ann Rheum Dis., 74: 1293-1301.
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  2. Zhao, H., T.J. Davies, J. Ning, Y. Chang and P. Sachamitr et al., 2014. A highly optimized protocol for reprogramming cancer cells to pluripotency using nonviral plasmid vectors. Cell. Reprogramming, 17: 7-18.
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  3. Sun, J., R. Li, J. Guo, Y. Jia and X. Sun et al., 2014. Superior molecularly altered influenza virus hemagglutinin peptide 308-317 inhibits collagen-induced arthritis by inducing CD4+ treg cell expansion. Arthritis Rheum., 64: 2158-2168.
    CrossRef  |  Direct Link  |  
  4. Sattler, S., G.S. Ling, D. Xu, L. Hussaarts and A Romaine et al., 2014. IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut. J. Autoimmunity, 50: 107-122.
    CrossRef  |  Direct Link  |  
  5. Huang, F.P., 2014. Autoimmuno-Anti-Tumour Immunity (AATI)-understanding the immune responses against Self & Altered-self. Front Immunol., 5: 1-2.
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  6. Sattler, S., H.H. Smits, D. Xu and F.P. Huang, 2013. The evolutionary role of the IL-33/ST2 system in host immune defence. Arch. Immunol. Ther. Exp., (Warsz), 61: 107-117.
    CrossRef  |  PubMed  |  
  7. Sattler, S., L.E.P.M. van der Vlugt, L. Hussaarts, H.H. Smits and F.P. Huang, 2012. Regulatory B Cells - Implications in Autoimmune and Allergic Disorders. In: Recent Advances in Immunology to Target Cancer, Inflammation and Infections, Kanwar, J.G., InTech, Europe,.
  8. Ling, G.S., H.T. Cook, M. Botto, Y.L. Lau and F.P. Huang, 2011. An essential protective role of IL-10 in the immunological mechanism underlying resistance vs. susceptibility to lupus induction by dendritic cells and dying cells. Rheumatology, 50: 1773-1784.
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  9. Huang, F.P., Y.X. Chen and C.K. To, 2011. Guiding the misguided-functional conditioning of dendritic cells for the DC-based immunotherapy against tumours. Eur. J. Immunol., 41: 18-25.
    CrossRef  |  PubMed  |  
  10. Huang, F.P., 2011. Autoimmune Disorders: Current concepts & Advances from Bedside to the Mechanistic Insights. InTech, Europe, ISBN: 978-953-307-653-9, Pages: 614.
  11. Huang, F.P. and S. Sattler, 2011. Regulatory T Cell Deficiency in Systemic Autoimmune Disorders - Causal Relationship and Underlying Immunological Mechanisms. In: Autoimmune Disorders - Pathogenetic Aspects, Mavragani, C.P., InTech, Europe, ISBN: 978-953-307-643-0,.
  12. Mok, M.Y., F.P. Huang, W.K. Ip, Y. Lo and F.Y. Wong et al., 2010. Serum levels of IL-33 and soluble ST2 and their association with disease activity in systemic lupus erythematosus. Rheumatology, 49: 520-527.
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  13. Yang, C.H., L. Tian, G.S. Ling, N.J. Trendell-Smith and L. Ma et al., 2008.. Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: roles of IL-2 versus IL-15. Eur. J. Immunol., 38: 1664-1676.
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  14. Chen, Y.X., K. Man, G.S. Ling, Y. Chen and B.S. Sun et al., 2007. A crucial role for dendritic cell (DC) IL-10 in inhibiting successful DC-based immunotherapy: superior antitumor immunity against hepatocellular carcinoma evoked by DC devoid of IL-10. J. Immunol., 179: 6009-6015.
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  15. Chen, Y., V.S. Chan, B. Zheng, K.Y. Chan and X. Xu et al., 2007. A novel subset of putative stem/progenitor CD34+Oct-4+ cells is the major target for SARS coronavirus in human lung. J. Exp. Med., 204: 2529-2536.
    PubMed  |  Direct Link  |  
  16. Ma, L., K.W. Chan, N.J. Trendell-Smit, A. Wu and L. Tian et al., 2005. Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains. Eur. J. Immunol., 35: 3364-3375.
    CrossRef  |  Direct Link  |  
  17. Macpherson, G., S. Milling, U. Yrlid, L. Cousins, E. Turnbull and F.P. Huang, 2004. Uptake of Antigens from the Intestine by Dendritic Cells. Ann. N.Y. Acad. Sci., 1029: 75-82.
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  18. Huang, F.P. and G.G. MacPherson, 2004. Dendritic cells and oral transmission of prion diseases. Adv. Drug Deliv. Rev., 56: 901-913.
    PubMed  |  
  19. Huang, F.P., C.F. Farquhar, N.A. Mabbott, M.E. Bruce and G.G. MacPherson, 2002. Migrating intestinal dendritic cells transport PrP(Sc) from the gut. J. Gen. Virol., 83: 267-271.
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  20. MacPherson, G., M. Wykes, F.P. Huang and C. Jenkins, 2001. Isolation of Dendritic Cells from Rat Lymph and Spleen. In: Dendritic Cell Protocols, Robinson, S.P., A.J. Stagg and N.J. Totowa (Eds.)., Humana Press, USA.
  21. Huang, F.P. and G.G. MacPherson, 2001. Continuing education of the immune system-dendritic cells, immune regulation and tolerance. Curr. Mol. Med., 1: 457-468.
    PubMed  |  
  22. MacPherson, G.G., F.P. Huang and L.M. Liu, 2001. Intestinal Dendritic Cells. In: Dendritic Cells (2nd Edn.) Biology and Clinical Applications, Lotze, M.T. and A.W. Thomson (Eds.)., Harcourt International Academic Press, USA.
  23. Huang, F.P., N. Platt, M. Wykes, J.R. Major, T.J. Powell, C.D. Jenkins and G.G. MacPherson, 2000. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes. J. Exp. Med., 191: 435-444.
    PubMed  |  Direct Link  |  
  24. Huang, F.P. and G.G. MacPherson, 1999. Dendritic cells, mucosal immunity and peripheral tolerance. Mucosal Immunol. Update, 7: 11-15.
  25. Xu, D., W.L. Chan, B.P. Leung, F.P. Huang and R. Wheeler et al., 1998. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J. Exp. Med., 187: 787-794.
    PubMed  |  Direct Link  |  
  26. Huang, F.P., W. Niedbala, X.Q. Wei, D. Xu and G.J. Feng et al., 1998. Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages. Eur. J. Immunol., 28: 4062-4070.
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  27. Huang, F.P., D. Xu, E.O. Esfandiari, W. Sands, X.Q. Wei and F.Y. Liew, 1998. Cutting edge: Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses and enhanced nitric oxide production. J. Immunol., 160: 4143-4147.
    PubMed  |  Direct Link  |  
  28. McInnes, I.B., J. Al-Mughales, M. Field, B.P. Leung and F.P. Huang et al., 1996. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nat. Med., 2: 175-182.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. McInnes, I.B., B.P. Leung, M. Field, X.Q. Wei and F.P. Huang et al., 1996. Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients. J. Exp. Med., 184: 1519-1524.
    PubMed  |  Direct Link  |  
  30. Huang, F.P., G.J. Feng, G. Lindop, D.L. Stott and F.Y. Liew, 1996. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice. J. Exp. Med., 183: 1447-1459.
    PubMed  |  Direct Link  |  
  31. Wei, X.Q., I.G. Charles, A. Smith, J. Ure and G.J. Feng et al., 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature, 375: 408-411.
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  32. Huang, F.P. and D.I. Stott, 1993. Restoration of an early, progressive defect in responsiveness to T-cell activation in lupus mice by exogenous IL-2. Autoimmunity, 15: 19-29.
    PubMed  |  Direct Link  |