Dr. Da-Yong  Shi
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Dr. Da-Yong Shi

Research Scientist
Chinese Academy of Sciences, China


Highest Degree
Ph.D. in Chemistry from Chinese Academy of Sciences, China

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Area of Interest:

Chemistry
100%
Medicinal Chemistry
62%
Marine Chemistry
90%
Natural Product Chemistry
75%
Chemical Synthesis
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Wang, L.J., B. Jiang, N. Wu, S.Y. Wang and D. Shi, 2015. Natural and semisynthetic Protein Tyrosine Phosphatase 1B (PTP1B) inhibitors as anti-diabetic agents. RSC Adv., 5: 48822-48834.
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  2. Shi, D., S. Guo, B. Jiang, C. Guo, T. Wang, L. Zhang and J. Li, 2013. HPN, a synthetic analogue of bromophenol from red alga Rhodomela confervoides: Synthesis and anti-diabetic effects in C57BL/KsJ-db/db mice. Mar. Drugs, 11: 350-362.
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  3. Jiang, B., S. Guo, D. Shi, C. Guo and T. Wang, 2013. Discovery of novel bromophenol 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(isobutoxymethyl)benzyl)benzene-1,2-diol as protein tyrosine phosphatase 1B inhibitor and its anti-diabetic properties in C57BL/KsJ-db/db mice. Eur. J. Med. Chem., 64: 129-136.
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  4. Shi, D., J. Li, B. Jiang, S. Guo, H. Su and T. Wang, 2012. Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties. Bioorg. Med. Chem. Lett., 22: 2827-2832.
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  5. Jiang, B., D. Shi, Y. Cui and S. Guo, 2012. Design, synthesis and biological evaluation of bromophenol derivatives as protein tyrosine phosphatase 1B inhibitors. Archiv Pharmazie, 345: 444-453.
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  6. Shi, D., S. Guo and X. Fan, 2011. A new ketosteroid from red alga Acanthophora spicifera. Chin. J. Oceanol. Limnol., 29: 674-678.
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  7. Guo, S., J. Li, T. Li, D. Shi and L. Han, 2011. Synthesis of three bromophenols from red algae as PTP1B inhibitors. Chin. J. Oceanol. Limnol., 29: 68-74.
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  8. Cui, Y., D. Shi and Z. Hu, 2011. Synthesis and protein tyrosine phosphatase 1B inhibition activities of two new synthetic bromophenols and their methoxy derivatives. Chin. J. Oceanol. Limnol., 29: 1237-1242.
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  9. Shi, D., X. Li, J. Li, S. Guo, H. Su and X. Fan, 2010. Antithrombotic effects of bromophenol, an alga-derived thrombin inhibitor. Chin. J. Oceanol. Limnol., 28: 96-98.
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  10. Su, H., Z.H. Yuan, J. Li, S.J. Guo and L.P. Deng et al., 2009. Two new bromoindoles from red alga Laurencia similis. Chin. Chem. Lett., 20: 456-458.
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  11. Su, H., Z.H. Yuan, J. Li, S.J. Guo and L.P. Deng et al., 2009. Sesquiterpenes from the marine red alga Laurencia saitoi. Helvetica Chimica Acta, 92: 1291-1297.
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  12. Su, H., D.Y. Shi, J. Li, S.J. Guo, L.L. Li, Z.H. Yuan and X.B. Zhu, 2009. Sesquiterpenes from Laurencia similis. Molecules, 14: 1889-1897.
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  13. Shi, D., J. Li, S. Guo, H. Su and X. Fan, 2009. The antitumor effect of bromophenol derivatives in vitro and Leathesia nana extract in vivo. Chin. J. Oceanol. Limnol., 27: 277-282.
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  14. Shi, D., X. Fan, J. Sun, L. Han and J. Shi, 2008. Steroids from green alga Chaetomorpha basiretorsa Setchell. Chin. J. Oceanol. Limnol., 26: 415-418.
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  15. Shi, D., F. Xu, J. He, J. Shi, X. Fan and L. Han, 2008. Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell. Acta Oceanologica Sinica, 27: 147-151.
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  16. Li, J., S.J. Guo, H. Su, L.J. Han and D.Y. Shi, 2008. Total synthesis of bis-(2,3-dibromo-4,5-dihydroxyphenyl)-methane as potent PTP1B inhibitor. Chin. Chem. Lett., 19: 1290-1292.
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