Biography

I am a structural DNA nanotechnology expert and a nucleic acid biochemist with years of experience in applying designer DNA nanostructures to address challenges in biological and biomedical research fields.I have years of training as a biochemist in the field of structural DNA nanotechnology,working first on the molecular programming of DNA nanostructures & devices in vitro,and then on the self-assembly of these structures in vivo.To further my vision in molecular programming from synthetic DNA to the genome level in vivo,I have conducted my postdoctoral research to gain quantifications and experience in RNA-mediated genome programming and engineering in ciliate Oxytricha trifallax.My interdisciplinary background in both chemistry and biology allows me to appreciate the capability of designer DNA nanostructures to address complex biological problems, which further leads to the research interests in my own lab at RPI.

Area of Interest:

Chemistry

100%

Nanotechnology

62%

Molecular Structure

90%

RNA Structure

75%

Genetics

55%

Research Publications in Numbers

Books
0

Chapters
0

Articles
0

Abstracts
0

Selected Publications

Deng, Y., M. Kizer, M. Rada, J. Sage, X. Wang, D.J. Cheon and A.J. Chung., 2018. Intracellular delivery of nanomaterials via an inertial microfluidic cell hydroporator. Nano lett., 10.1021/acs.nanolett.8b00704.
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Anderson, N.T., P.H. Dinolfo and X. Wang, 2018. Synthesis and characterization of porphyrin-dna constructs for the self-assembly of modular energy transfer arrays. J. Mater. Chem. C., 6: 2452-2459.
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Halvorsen, K., M.E. Kizer, X. Wang, A.R. Chandrasekaran and M. Basanta-Sanchez, 2017. Shear dependent LC purification of an engineered DNA nanoswitch and implications for DNA origami. Anal. Chem., 89: 5673-5677.
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Chandrasekaran, A.R., N. Anderson, M. Kizer, K. Halvorsen and X. Wang, 2016. Beyond the fold: Emerging biological applications of DNA origami. Chem. Bio. Chem., 17: 1081-1089.
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Bracht, J.R., X. Wang, K. Shetty, X. Chen and G.J. Uttarotai et al., 2016. Chromosome fusions triggered by noncoding RNA. RNA Biol., 10.1080/15476286.2016.1195940.
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Ohayon, Y.P., R. Sha, O. Flint, W. Liu and B. Chakraborty et al., 2015. Covalent linkage of one-dimensional DNA arrays bonded by paranemic cohesion. ACS Nano, 9: 10304-10312.
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Ohayon, Y.P., R. Sha, O. Flint, A.R. Chandrasekaran and H.O. Abdallah et al., 2015. Topological linkage of DNA tiles bonded by paranemic cohesion. ACS Nano, 9: 10296-10303.
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Khurana, J.S., X. Wang, X. Chen, D.H. Perlman and L.F. Landweber, 2014. Transcription-independent functions of an RNA polymerase II subunit, Rpb2, during genome rearrangement in the ciliate, Oxytricha trifallax. Genetics, 197: 839-849.
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Fang, W., X. Wang, J.R. Bracht, M. Nowacki and L.F. Landweber, 2012. Piwi-interacting RNAs protect DNA against loss during Oxytricha genome rearrangement. Cell, 151: 1243-1255.
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Wang, X., X. Zhang, C. Mao and N.C. Seeman, 2010. Double-stranded DNA homology produces a physical signature. Proc. Natl. Acad. Sci. U.S.A., 107: 12547-12552.
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Liu, W., X. Wang, T. Wang, R. Sha and N.C. Seeman, 2008. PX DNA triangle oligomerized using a novel three-domain motif. Nano Lett., 8: 317-322.
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Lin, C., S. Rinker, X. Wang, Y. Liu, N.C. Seeman and H. Yan, 2008. In vivo cloning of artificial DNA nanostructures. Proc. Natl. Acad. Sci. U.S.A., 105: 17626-17631.
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Wang, X. and N.C. Seeman, 2007. Assembly and characterization of 8-arm and 12-arm DNA branched junctions. J. Am. Chem. Soc., 129: 8169-8176.
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Lin, C., X. Wang, Y. Liu, N.C. Seeman and H. Yan, 2007. Rolling circle enzymatic replication of a complex multi-crossover DNA nanostructure. J. Am. Chem. Soc., 129: 14475-14481.
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Constantinou, P.E., T. Wang, J. Kopatsch, L.B. Israel and X. Zhang et al., 2006. Double cohesion in structural DNA nanotechnology. Org. Biomol. Chem., 4: 3414-3419.
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