Dr. Jian Guan
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Dr. Jian Guan

Research Scientist
Central Florida Hospitalist Partners, Inc, China

Highest Degree
Ph.D. in Medicine from China Medical University, China

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Area of Interest:

Biomedical Sciences
100%
Hematology
62%
Cardiology
90%
Oncology
75%
Physiology
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Ur-Rahman, A., J. Guan, S. Khalid, A. Munaf and M. Sharbatji et al., 2018. Both full glasgow-blatchford score and modified Glasgow-Blatchford score predict the need for intervention and mortality in patients with acute lower gastrointestinal bleeding. Dig. Dis. Sci., 63: 3020-3025.
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  2. Shuja, A., J. Guan, C. Harris, A. Alkhasawneh, M. Malespin and S.W. De Melo Jr., 2018. Intestinal schistosomiasis: A rare cause of abdominal pain and weight loss. Cureus, Vol. 10, No. 1. 10.7759/cureus.2086.
    CrossRef  |  Direct Link  |  
  3. Shuja, A., A.U. Rahman, W. Skef, C. Smotherman, J. Guan, M. Malespin and S.W. de Melo Jr., 2018. A longitudinal analysis of the epidemiology and economic impact of inpatient admissions for chronic pancreatitis in the United States. Ann. Gastroenterol., 31: 499-505.
    PubMed  |  
  4. Guan, J., A. Munaf, A.V. Simmonds and I. Inayat, 2018. When the benign pneumatosis intestinalis becomes no longer benign: A rare case of bowel perforation in a patient with systemic sclerosis. Case Rep. Gastrointest. Med., Vol. 2018. 10.1155/2018/5124145.
    CrossRef  |  Direct Link  |  
  5. Guan, J., K.S. Lim, T. Mekhail and C.C. Chang, 2017. Programmed death ligand-1 (PD-L1) expression in the programmed death receptor-1 (PD-1)/PD-L1 blockade: a key player against various cancers. Arch. Pathol. Lab. Med., 141: 851-861.
    CrossRef  |  Direct Link  |  
  6. Guan, J., J. Khambhati, L.W. Jones, A. Morgans, M. Allaf, D.F. Penson and J. Moslehi, 2015. ABCDE steps for heart and vascular wellness following a prostate cancer diagnosis. Circulation, 132: e218-e220.
    CrossRef  |  PubMed  |  Direct Link  |  
  7. Sosnovik, D.E., C. Mekkaoui, S. Huang, H.H. Chen and G. Dai et al., 2014. Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor MRI tractography of the heart in vivo. Circulation, 129: 1731-1741.
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  8. Guan, J., S. Mishra, Y. Qiu, J. Shi and K. Trudeau et al., 2014. Lysosomal dysfunction and impaired autophagy underlie the pathogenesis of amyloidogenic light chain-mediated cardiotoxicity. EMBO Mol. Med., 6: 1493-1507.
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  9. Tsukamoto, K., D.R. Mani, J. Shi, S. Zhang and D.E. Haagensen et al., 2013. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc. Natl. Acad. Sci. USA., 110: 17023-17028.
    CrossRef  |  Direct Link  |  
  10. Shi, J., B. Jiang, Y. Qiu, J. Guan and M. Jain et al., 2013. PGC1α plays a critical role in TWEAK-induced cardiac dysfunction. PLoS ONE, Vol. 8. 10.1371/journal.pone.0054054.
    CrossRef  |  Direct Link  |  
  11. Mishra, S., J. Guan, E. Plovie, D.C. Seldin and L.H. Connors et al., 2013. Human amyloidogenic light chain proteins result in cardiac dysfunction, cell death and early mortality in zebrafish. Am. J. Physiol.-Heart Circ. Physiol., 305: H95-H103.
    CrossRef  |  Direct Link  |  
  12. Guan, J., S. Mishra, J. Shi, E. Plovie and Y. Qiu et al., 2013. Stanniocalcin1 is a key mediator of amyloidogenic light chain induced cardiotoxicity. Basic Res. Cardiol., Vol. 108, No. 5. 10.1007/s00395-013-0378-5.
    CrossRef  |  Direct Link  |  
  13. Ward, J.E., R. Ren, G. Toraldo, P. SooHoo and J. Guan et al., 2011. Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood, 118: 6610-6617.
    CrossRef  |  PubMed  |  Direct Link  |  
  14. Oikonomopoulos, A., K.I. Sereti, F. Conyers, M. Bauer and A. Liao et al., 2011. Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. Circ. Res., 109: 1363-1374.
    CrossRef  |  PubMed  |  Direct Link  |  
  15. Guan, J., S. Mishra, R.H. Falk and R. Liao, 2011. Current perspectives on cardiac amyloidosis. Am. J. Physiol.-Heart Circ. Physiol., 302: H544-H552.
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  16. Shi, J., J. Guan, B. Jiang, D.A. Brenner and F. del Monte et al., 2010. Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38α MAPK pathway. Proc. Natl. Acad. Sci. USA., 107: 4188-4193.
    CrossRef  |  Direct Link  |  
  17. Mokashi, S.A., J. Guan, D. Wang, V. Tchantchaleishvili and M. Brigham et al., 2010. Preventing cardiac remodeling: The combination of cell-based therapy and cardiac support therapy preserves left ventricular function in rodent model of myocardial ischemia. J. Thoracic Cardiovasc. Surg., 140: 1374-1380.
    CrossRef  |  Direct Link  |  
  18. Jain, M., A. Jakubowski, L. Cui, J. Shi and L. Su et al., 2009. A novel role for tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the development of cardiac dysfunction and failure. Circulation, 119: 2058-2068.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Cao, B., X.P. Chen, P. Zhu, L. Ding, J. Guan and Z.L. Shi, 2008. Inhibitory effect of interferon-α-2b on expression of cyclooxygenase-2 and vascular endothelial growth factor in human hepatocellular carcinoma inoculated in nude mice. World J. Gastroenterol., 14: 6802-6807.
    Direct Link  |  
  20. Guan, J., X.P. Chen, Q. Wang, B.X. Zhang, W.G. Zhang and Z.W. Zhang, 2007. [Up-regulated expression of Twist gene in human hepatocellular carcinoma cell line]. Chin. J. Abdominal Surg., 20: 115-117, (In Chinese).
    Direct Link  |  
  21. Luo, S., X. Chen, H. Zhu, B. Zhang and J. Guan, 2006. Role of hypoxia-inducible factor-1α in formation of multidrug resistance induced by microenvironment in hepatocellular carcinoma. Chin.-Ger. J. Clin. Oncol., 5: 178-183.
    CrossRef  |  Direct Link  |  
  22. Chen, X.P., Q. Wang, J. Guan, Z.Y. Huang, W.G. Zhang and B.X. Zhang, 2006. Reversing multidrug resistance by RNA interference through the suppression of MDR1 gene in human hepatoma cells. World J. Gastroenterol., 12: 3332-3337.
    Direct Link  |  
  23. Zhu, H., X.P. Chen, S.F. Luo, J. Guan, W.G. Zhang and B.X. Zhang, 2005. Involvement of hypoxia-inducible factor-1-alpha in multidrug resistance induced by hypoxia in HepG2 cells. J. Exp. Clin. Cancer Res., 24: 565-574.
    PubMed  |  
  24. Ding, L., X.P. Chen, Z.W. Zhang, J. Guan and W.G. Zhang et al., 2005. Synergistic effect of bromocriptine and tumor necrosis factor-α on reversing hepatocellular carcinoma multidrug resistance in nude mouse MDR1 model of liver neoplasm. World J. Gastroenterol., 11: 5621-5626.
    Direct Link  |  
  25. Guan, J., X.P. Chen, H. Zhu, S.F. Luo, B. Cao and L. Ding, 2004. Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line. World J. Gastroenterol., 10: 3522-3527.
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