1. Li, Z., Z. Wang, G. Meng, H. Lu, Z. Huang and F. Chen, 2018. Identification of an ene reductase from yeast Kluyveromyces marxianus and application in the asymmetric synthesis of (R)-profen esters. Asian J. Org. Chem., 7: 763-769.
   CrossRef  |  Direct Link  |  
2. Jin, K., H. Yin, E. de Clercq, C. Pannecouque, G. Meng and F. Chen, 2018. Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1. Eur. J. Med. Chem., 145: 726-734.
   CrossRef  |  Direct Link  |  
3. Huang, G., M. Liu, F. Xiong, G. Meng and Y. Tao et al., 2018. Chiral syn-1, 3-diol derivatives via a one-pot diastereoselective carboxylation/bromocyclization of homoallylic alcohols. iScience, 9: 513-520.
   CrossRef  |  Direct Link  |  
4. Wu, Y., M.J. Liu, H.Q. Huang, G.X. Huang, F.J. Xiong and F.E. Chen, 2017. Asymmetric synthesis of atorvastatin calcium through intramolecular oxidative oxygen-nucleophilic bromocyclization. Eur. J. Org. Chem., 25: 3681-3688.
   CrossRef  |  Direct Link  |  
5. Wang, X., L. Xu, F. Xiong, Y. Wu and F. Chen, 2017. An improved synthesis of (20S)-camptothecin and its analogue via an asymmetric α-hydroxylation with a chiral organocatalyst. Tetrahedron: Asymmetry, 28: 843-848.
   CrossRef  |  Direct Link  |  
6. Peng, H. and F.E. Chen, 2017. Recent advances in asymmetric total synthesis of prostaglandins. Org. Biomol. Chem., 15: 6281-6301.
   CrossRef  |  Direct Link  |  
7. Xiong, F., H. Wang, L. Yan, S. Han, Y. Tao, Y. Wu and F. Chen, 2016. Stereocontrolled synthesis of rosuvastatin calcium via iodine chloride-induced intramolecular cyclization. Org. Biomol. Chem., 14: 1363-1369.
   CrossRef  |  Direct Link  |  
8. Wang, H., L. Yan, F. Xiong, Y. Wu and F. Chen, 2016. New chloramphenicol Schiff base ligands for the titanium-mediated asymmetric aldol reaction of α,β-unsaturated aldehydes with diketene: A short synthesis of atorvastatin calcium. RSC Adv., 6: 75470-75477.
   CrossRef  |  Direct Link  |  
9. Xiong, F., H. Wang, L. Yan, L. Xu, Y. Tao, Y. Wu and F. Chen, 2015. Diastereoselective synthesis of pitavastatin calcium via bismuth-catalyzed two-component hemiacetal/oxa-Michael addition reaction. Org. Biomol. Chem., 13: 9813-9819.
   CrossRef  |  Direct Link  |  
10. Wu, H.Q., J. Yao, Q.Q. He, W.X. Chen and F.E. Chen et al., 2015. Synthesis and biological evaluation of DAPY-DPEs hybrids as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Med. Chem., 23: 624-631.
    CrossRef  |  Direct Link  |  
11. Wang, H., L. Yan, Y. Wu, Y. Lu and F. Chen, 2015. Asymmetric synthesis of vitamin D₃ analogues: Organocatalytic desymmetrization approach toward the A-ring precursor of calcifediol. Org. Lett., 17: 5452-5455.
    CrossRef  |  Direct Link  |  
12. Wan, Z.Y., Y. Tao, Y.F. Wang, T.Q. Mao and H. Yin et al., 2015. Hybrid chemistry. Part 4: Discovery of etravirine-VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg. Med. Chem., 23: 4248-4255.
    CrossRef  |  Direct Link  |  
13. Wan, Z.Y., J. Yao, Y. Tao, T.Q. Mao and X.L. Wang et al., 2015. Discovery of piperidin-4-yl-aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur. J. Med. Chem., 97: 1-9.
    CrossRef  |  Direct Link  |  
14. Wan, Z.Y., J. Yao, T.Q. Mao, X.L. Wang and H.F. Wang et al., 2015. Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue. Eur. J. Med. Chem., 102: 215-222.
    CrossRef  |  Direct Link  |  
15. Chen, W., F. Xiong, Q. Liu, L. Xu, Y. Wu and F. Chen, 2015. Substrate stereocontrol in bromine-induced intermolecular cyclization: Asymmetric synthesis of pitavastatin calcium. Tetrahedron, 71: 4730-4737.
    CrossRef  |  Direct Link  |  
16. Meng, G., Y. Liu, A. Zheng, F. Chen and W. Chen et al., 2014. Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors. Eur. J. Med. Chem., 82: 600-611.
    CrossRef  |  Direct Link  |  
17. Chen, X., F. Xiong, W. Chen, Q. He and F. Chen, 2014. Asymmetric synthesis of the HMG-CoA reductase inhibitor atorvastatin calcium: An organocatalytic anhydride desymmetrization and cyanide-free side chain elongation approach. J. Org. Chem., 79: 2723-2728.
    CrossRef  |  Direct Link  |  
18. Chen, X., F. Xiong, C. Zheng, J. Li and F. Chen, 2014. Synthetic studies on statins. Part 3: A facile synthesis of rosuvastatin calcium through catalytic enantioselective allylation strategy. Tetrahedron, 70: 5794-5799.
    CrossRef  |  Direct Link  |  
19. Chen, X. and F. Chen, 2014. An efficient synthesis of Katsube nitrile: A key building block for Eburnamine-Vincamine alkaloids. Synthesis, 46: 1506-1510.
    CrossRef  |  Direct Link  |  
20. Yang, H.J., F.J. Xiong, X.F. Chen and F.E. Chen, 2013. Highly enantioselective thiolysis of prochiral cyclic anhydrides catalyzed by amino alcohol bifunctional organocatalysts and its application to the synthesis of pregabalin. Eur. J. Org. Chem., 21: 4495-4498.
    CrossRef  |  Direct Link  |  
21. Wu, H.Q., Z.H. Yan, W.X. Chen, Q.Q. He and F.E. Chen et al., 2013. Towards new C6-rigid S-DABO HIV-1 reverse transcriptase inhibitors: Synthesis, biological investigation and molecular modeling studies. Bioorg. Med. Chem., 21: 6477-6483.
    CrossRef  |  Direct Link  |  
22. Liu, Q., F.J. Xiong, Q.Q. He and F.E. Chen, 2013. Development of an efficient process for the decomposition of the borate complexes formed during the large-scale synthesis of (S)-1,2,4-butanetriol. Org. Process Res. Dev., 17: 1540-1542.
    CrossRef  |  Direct Link  |  
23. Yang, H.J., L. Dai, S.Q. Yang and F.E. Chen, 2012. Direct bifunctional squaramide-catalyzed asymmetric N-nitroso aldol reaction of tertiary β-carbonyl esters. Synlett, 23: 948-950.
    CrossRef  |  Direct Link  |  
24. Dai, L., H. Yang, J. Niu and F. Chen, 2012. Enantioselective protonation in the sulfa-Michael addition using chiral squaramides as hydrogen-bonding organocatalysts. Synlett, 2: 314-316.
    CrossRef  |  Direct Link  |  
25. Zhao, L., X.D. Ma and F.E. Chen, 2011. Development of two scalable syntheses of 4-amino-5-aminomethyl-2-methylpyrimidine: Key intermediate for vitamin B₁. Org. Process Res. Dev., 16: 57-60.
    CrossRef  |  Direct Link  |  
26. Zhao, L., F.J. Xiong, W.X. Chen and F.E. Chen, 2011. A novel and enantioselective total synthesis of (20S)-camptothecin via a sharpless asymmetric dihydroxylation strategy. Synthesis, 24: 4045-4049.
    CrossRef  |  Direct Link  |  
27. Li, F., Z.H. Wang, L. Zhao and F.E. Chen, 2011. A facile and efficient asymmetric synthesis of florfenicol. Synlett, 19: 2883-2885.
    CrossRef  |  Direct Link  |  
28. Chen, F.E., 2011. Drug Discovery and Synthesis Methods. People's Health Press, Beijing, China.
29. Xiong, F., X.X. Chen, Z.Q. Liu and F.E. Chen, 2010. A novel synthetic strategy for the stereospecific total synthesis of (±)-biotin. Tetrahedron Lett., 51: 3670-3672.
    CrossRef  |  Direct Link  |  
30. Xiong, F., X.X. Chen and F.E. Chen, 2010. An improved asymmetric total synthesis of (+)-biotin via the enantioselective desymmetrization of a meso-cyclic anhydride mediated by cinchona alkaloid-based sulfonamide. Tetrahedron: Asymmetry, 21: 665-669.
    CrossRef  |  Direct Link  |  
31. Huang, J.P., X.X. Chen, S.X. Gu, L. Zhao, W.X. Chen and F.E. Chen, 2010. An efficient method for removal of residual palladium from organic solution of faropenem sodium in the Pd(II)-catalyzed cleavage of allyl faropenem. Org. Process Res. Dev., 14: 939-941.
    CrossRef  |  Direct Link  |  
32. Dai, L., S.X. Wang and F.E. Chen, 2010. A bifunctional Cinchona alkaloid-squaramide catalyst for the highly enantioselective conjugate addition of thiols to trans-chalcones. Adv. Synth. Catal., 352: 2137-2141.
    CrossRef  |  Direct Link  |  
33. Wang, Y.P., F.E. Chen, E. de Clercq, J. Balzarini and C. Pannecouque, 2009. Synthesis and in vitro anti-HIV evaluation of a new series of 6-arylmethyl-substituted S-DABOs as potential non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur. J. Med. Chem., 44: 1016-1023.
    CrossRef  |  Direct Link  |  
34. Wang, S.X. and F.E. Chen, 2009. A novel cost-effective thiourea bifunctional organocatalyst for highly enantioselective alcoholysis of meso-cyclic anhydrides: Enhanced enantioselectivity by configuration inversion. Adv. Synth. Catal., 351: 547-552.
    CrossRef  |  Direct Link  |  
35. Yu, X., S. Wang and F. Chen, 2008. Solid-phase synthesis of solanesol. J. Combinatorial Chem., 10: 605-610.
    CrossRef  |  Direct Link  |  
36. Huang, J., F. Xiong and F.E. Chen, 2008. Total synthesis of (+)-biotin via a quinine-mediated asymmetric alcoholysis of meso-cyclic anhydride strategy. Tetrahedron: Asymmetry, 19: 1436-1443.
    CrossRef  |  Direct Link  |  
37. Dai, H.F., W.X. Chen, L. Zhao, F. Xiong, H. Sheng and F.E. Chen, 2008. Synthetic Studies on (+)-biotin, part 11: Application of Cinchona alkaloid-mediated asymmetric alcoholysis of meso-cyclic anhydride in the total synthesis of (+)-biotin. Adv. Synth. Catal., 350: 1635-1641.
    CrossRef  |  Direct Link  |  
38. Chen, F.E., B. Xie, P. Zhang, J.F. Zhao, H. Wang and L. Zhao, 2007. An efficient and green oxidation of vicinal diols to aldehydes using polymer-supported (diacetoxyiodo) benzene as the oxidant. Synlett, 4: 619-622.
    CrossRef  |  Direct Link  |  
39. Chen, F.E., X.X. Chen, H.F. Dai, Y.Y. Kuang, B. Xie and J.F. Zhao, 2005. Synthetic studies on d-biotin, part 8:^[1] An efficient chemoenzymatic approach to the asymmetric total synthesis of d-biotin via a polymer-supported PLE-mediated desymmetrization of meso-symmetic dicarboxylic esters. Adv. Synth. Catal., 347: 549-554.
    CrossRef  |  Direct Link  |  
40. Chen, F.E. and J. Huang, 2005. Reserpine: A challenge for total synthesis of natural products. Chem. Rev., 105: 4671-4706.
    CrossRef  |  Direct Link  |  
41. Chen, F.E., Y.Y. Kuang, H.F. Dai, L. Lu and M. Huo, 2003. A selective and mild oxidation of primary amines to nitriles with trichloroisocyanuric acid. Synthesis, 17: 2629-2631.
    CrossRef  |  Direct Link  |  
42. Chen, F.E., J.L. Yuan, H.F. Dai, Y.Y. Kuang and Y. Chu, 2003. Synthetic studies on d-biotin, part 6: An expeditious and enantiocontrolled approach to the total synthesis of d-biotin via a polymer-supported chiral oxazaborolidine-catalyzed reduction of meso-cyclic imide strategy. Synthesis, 14: 2155-2160.
    CrossRef  |  Direct Link  |  
43. Chen, F.E., H.F. Dai, Y.Y. Kuang and H.Q. Jia, 2003. Synthetic studies on d-biotin. Part 7: A practical asymmetric total synthesis of d-biotin via enantioselective reduction of meso-cyclic imide catalyzed by oxazborolidine. Tetrahedron: Asymmetry, 14: 3667-3672.
    CrossRef  |  Direct Link  |  
44. Chen, F.E., Y.Y. Li, M. Xu and H.Q. Jia, 2002. Tetrabutylammonium peroxydisulfate in organic synthesis; XIII.^[1] A simple and highly efficient one-pot synthesis of nitriles by nickel-catalyzed oxidation of primary alcohols with tetrabutylammonium peroxydisulfate. Synthesis, 13: 1804-1806.
    CrossRef  |  Direct Link  |  
45. Chen, F.E., Z.Z. Peng, H. Fu, G. Meng, Y. Cheng and Y.X. Lu, 2000. A novel and efficient method for the oxidative removal of O-benzyl protective groups of carbohydrates by tetrabutylammonium peroxydisulfate. Synlett, 5: 627-628.
    CrossRef  |  Direct Link  |  
46. Chen, F.E., Y.D. Huang, H. Fu, Y. Cheng, D.M. Zhang, Y.Y. Li and Z.Z. Peng, 2000. An efficient and enantioselective synthesis of d-biotin. Synthesis, 14: 2004-2008.
    CrossRef  |  Direct Link  |  
47. Chen, F.E., 1998. Organic Drug Synthesis Method. Chinese Medical Science and Technology Press, Beijing, China.
48. Chen, F.E., 1995. Science-based Drug Design. Huazhong University Press, Wuhan, China.