Dr. Weiguo  Zou

Dr. Weiguo Zou

Post-doctoral Fellow
Harvard School of Public Health, USA

Highest Degree
Ph.D. in Biochemistry and Molecular Biology from Institute of Biochemistry and Cell Biology, China

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Area of Interest:

Molecular Sciences
Gene Therapy
Molecular Biology

Selected Publications

  1. Shim, J.H., M.B. Greenblatt, M. Xie, M.D. Schneider and W. Zou et al., 2009. TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J., 28: 2028-2041.
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  2. Zou, W., J.H. Kim, A. Handidu, X. Li and K.I. Kim et al., 2007. Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 Usp18 deficient macrophages. Biochem. Biophys. Res. Commun., 356: 193-199.
    PubMed  |  

  3. Zou, W., J. Wang and D.E. Zhang, 2007. Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. Biochem. Biophys. Res. Commun., 354: 321-327.
    PubMed  |  Direct Link  |  

  4. Okumura, F., W. Zou and D.E. Zhang, 2007. ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP. Genes Dev., 21: 255-260.
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  5. Zou, W. and D.E. Zhang, 2006. The interferon-inducible ubiquitin-protein isopeptide ligase (E3) EFP also functions as an ISG15 E3 ligase. J. Biol. Chem., 281: 3989-3994.
    CrossRef  |  PubMed  |  

  6. Wang, B., W. Zou, W. Liu and X. Liu, 2006. The lower cytotoxicity of cinnamomin (a type II RIP) is due to its B-chain. Arch. Biochem. Biophys., 451: 91-96.
    PubMed  |  Direct Link  |  

  7. Malakhova, O.A., K.I. Kim, J.K. Luo, W. Zou and K.G. Kumar et al., 2006. UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J., 25: 2358-2367.
    PubMed  |  Direct Link  |  

  8. Kim, K.I., M. Yan, O. Malakhova, J.K. Luo and M.F. Shen et al., 2006. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Mol. Cell. Biol., 26: 472-479.
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  9. Zhang, Z.L., W.G. Zou, J.H. Wang, J.F. Gu and Y.K. Dang et al., 2005. Suppression of tumor growth by oncolytic adenovirus-mediated delivery of an antiangiogenic gene, Soluble Flt-1. Mol. Ther., 11: 553-562.
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  10. Liu, X., S. Qiu, W. Zou, Z. Pei and J. Gu et al., 2005. Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. Mol. Ther., 11: 531-541.
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  11. Giannakopoulos, N.V., J. Luo, V. Papov, W. Zou and D.J. Lenschow et al., 2005. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Biochem. Biophys. Res. Commun., 336: 496-506.
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  12. Zou, W., C. Luo, Z. Zhang, J. Liu and J. Gu et al., 2004. A novel oncolytic adenovirus targeting to telomerase activity in tumor cells with potent. Oncogene, 23: 457-464.
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  13. Pei, Z., L. Chu, W. Zou, Z. Zhang and S. Qiu et al., 2004. An oncolytic adenoviral vector of Smac increases antitumor activity of TRAIL against HCC in human cells and in mice. Hepatology, 39: 1371-1381.
    PubMed  |  Direct Link  |  

  14. Zhang, Z.L., W.G. Zou, C.X. Luo, B. Li and J.H. Wang et al., 2003. An armed oncolytic adenovirus system, ZD55-gene, demonstrating potent antitumoral efficacy. Cell Res., 13: 481-489.
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  15. Zou, W., J. Zeng, M. Zhuo, W. Xu, L. Sun, J. Wang and X. Liu, 2002. Involvement of caspase-3 and p38 mitogen-activated protein kinase in cobalt chloride-induced apoptosis in PC12 cells. J. Neurosci. Res., 67: 837-843.
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  16. Zou, W., D. Wang, M. Lang, D. Jin and D. Xu et al., 2002. Human interleukin 10 gene therapy decreases the severity and mortality of lethal pancreatitis in rats. J. Surg. Res., 103: 121-126.
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  17. Liu, J., W. Zou, M. Lang, J. Luo and L. Sun et al., 2002. Cancer-specific killing by the CD suicide gene using the human telomerase reverse transcriptase promoter. Int. J. Oncol., 21: 661-666.
    PubMed  |  Direct Link  |  

  18. Zou, W., M. Yan, W. Xu, H. Huo, L. Sun, Z. Zheng and X. Liu, 2001. Cobalt chloride induces PC12 cells apoptosis through reactive oxygen species and accompanied by AP-1 activation. J. Neurosci. Res., 64: 646-653.
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