Dr. Kexin  Liu
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Dr. Kexin Liu

Professor
The University of Tokyo, Japan


Highest Degree
Ph.D. in Pharmacy from The University of Tokyo, Japan

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Biography

Dr. Kexin Liu received his B.S. degree in Clinical Medicine and M.S. degree in Pharmacology from Dalian Medical University in China and Ph.D. degree in Pharmacy in The University of Tokyo (Laboratory of Yuichi Sugiyama, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences) in Japan. The focus of his research is on the Molecular Pharmacokinetics of Transport in Liver, Intestine, Kidney as well as Transporter-Mediated DDI and MDR. Dr. Kexin Liu is a coauthor of more than 180 publications in international journals such as Hepatology, Drug Metab Dispos, J Pharmacol Exp Ther, Am J Physiol, Pharm Res, Toxical Appl Pharm, Biochem Pharmacol and 50 book chapters as well as 30 review articles. He serves as a Vice President of CSSX from 2005 and a Dean in College of Pharmacy in Dalian Medical University from 2004-2015.

Area of Interest:

Medicine
100%
Molecular Pharmacokinetics
62%
Liver Transport
90%
Intestine Transport
75%
Kidney
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Zhang, X., X. Han, L. Yin, L. Xu and Y. Qi et al., 2015. Potent effects of dioscin against liver fibrosis. Scient. Rep., Vol. 5. 10.1038/srep09713.
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  2. Yu, H., L. Zheng, L. Xu, L. Yin and Y. Lin et al., 2015. Potent effects of the total saponins from Dioscorea nipponica makino against streptozotocin-induced type 2 diabetes mellitus in rats. Phytother. Res., 29: 228-240.
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  3. Xu, Q., C. Wang, Q. Liu, Q. Meng and H. Sun et al., 2015. Decreased liver distribution of entecavir is related to down-regulation of Oat2/Oct1 and up-regulation of Mrp1/2/3/5 in rat liver fibrosis. Eur. J. Pharmaceut. Sci., 71: 73-79.
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  4. Wu, S., H. Xu, J. Peng, C. Wang and Y. Jin et al., 2015. Potent anti-inflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1, ICAM-1 and EL expression via the NF-κB pathway. Biochimie, 110: 62-72.
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  5. Tian, X., X. Huo, P. Dong, B. Wu and X. Wang et al., 2015. Sulfation of melatonin: Enzymatic characterization, differences of organs, species and genders and bioactivity variation. Biochem. Pharmacol., 94: 282-296.
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  6. Tian, X., S. Liang, C. Wang, B. Wu and G. Ge et al., 2015. Regioselective glucuronidation of andrographolide and its major derivatives: Metabolite identification, isozyme contribution and species differences. AAPS J., 17: 156-166.
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  7. Tao, X., X. Sun, L. Yin, X. Han and L. Xu et al., 2015. Dioscin ameliorates cerebral ischemia/reperfusion injury through the downregulation of TLR4 signaling via HMGB-1 inhibition. Free Radical Biol. Med., 84: 103-115.
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  8. Song, A., H. Yu, C. Wang, X. Zhu, K. Liu and X. Ma, 2015. Novel dual small-molecule HIV inhibitors: Scaffolds and discovery strategies. Curr. Pharmaceut. Des., 21: 950-962.
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  9. Meng, Q., X.L. Chen, C.Y. Wang, Q. Liu and H.J. Sun et al., 2015. Alisol B 23-acetate protects against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes involved in bile acid homeostasis. Toxicol. Applied Pharmacol., 283: 178-186.
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  10. Meng, Q., X. Chen, C. Wang, Q. Liu and H. Sun et al., 2015. Protective effects of alisol B 23-acetate from an edible botanical Rhizoma alismatis against carbon tetrachloride-induced hepatotoxicity in mice. Food Funct., 6: 1241-1250.
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  11. Liu, M., L. Xu, L. Yin, Y. Qi and Y. Xu et al., 2015. Potent effects of dioscin against obesity in mice. Scient. Rep., Vol. 5. 10.1038/srep07973.
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  12. Lin, M., X. Zhai, G. Wang, X. Tian and D. Gao et al., 2015. Salvianolic acid B protects against acetaminophen hepatotoxicity by inducing Nrf2 and phase II detoxification gene expression via activation of the PI3K and PKC signaling pathways. J. Pharmacol. Sci., 127: 203-210.
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  13. Jin, Y., K. Liu, J. Peng, C. Wang, L. Kang, N. Chang and H. Sun, 2015. Rhizoma dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPARγ factor and the NADPH oxidase/ROS-NF-κB signal pathway. Toxicol. Lett., 232: 149-158.
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  14. Jiang, L., S.C. Liang, C. Wang, G.B. Ge and X.K. Huo et al., 2015. Identifying and applying a highly selective probe to simultaneously determine the O-glucuronidation activity of human UGT1A3 and UGT1A4. Scient. Rep., Vol. 5. 10.1038/srep09627.
    CrossRef  |  Direct Link  |  
  15. Fu, C., D. Xu, C.Y. Wang, Y. Jin and Q. Liu et al., 2015. Alpha-lipoic acid promotes osteoblastic formation in H2O2-treated MC3T3-E1 cells and prevents bone loss in ovariectomized rats. J. Cell. Physiol., 230: 2184-2201.
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  16. Chen, X., Q. Meng, C. Wang, Q. Liu and H. Sun et al., 2015. Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice. Pharmaceut. Res., 32: 538-548.
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  17. Chen, T., C. Wang, Q. Liu, Q. Meng and H. Sun et al., 2015. Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway. Cancer Biol. Therapy, 16: 106-114.
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  18. Zhu, Y., Q. Meng, C. Wang, Q. Liu and X. Huo et al., 2014. Methotrexate-bestatin interaction: Involvement of P-glycoprotein and organic anion transporters in rats. Int. J. Pharmaceut., 465: 368-377.
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  19. Zhang, C., J. Peng, S. Wu, Y. Jin and F. Xia et al., 2014. Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines. J. Biomed. Sci., Vol. 21. 10.1186/1423-0127-21-30.
    CrossRef  |  PubMed  |  Direct Link  |  
  20. Yu, H., L. Zheng, L. Yin, L. Xu and Y. Qi et al., 2014. Protective effects of the total saponins from Dioscorea nipponica Makino against carbon tetrachloride-induced liver injury in mice through suppression of apoptosis and inflammation. Int. Immunopharmacol., 19: 233-244.
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  21. Yan, H., Y. Jihong, Z. Feng, X. Xiaomei and Z. Xiaohan et al., 2014. Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury. Crit. Care Med., 42: e373-e381.
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  22. Xu, Q., C. Wang, Q. Meng, Q. Liu and P. Sun et al., 2014. The oligopeptide transporter 2-mediated reabsorption of entecavir in rat kidney. Eur. J. Pharmaceut. Sci., 52: 41-47.
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  23. Xu, L., Y. Wei, D. Dong, L. Yin and Y. Qi et al., 2014. iTRAQ-based proteomics for studying the effects of dioscin against nonalcoholic fatty liver disease in rats. RSC Adv., 4: 30704-30711.
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  24. Xu, L., C.Y. Wang, L. Lv, K.X. Liu, H.J. Sun and G.Z. Han, 2014. Pharmacokinetics of phosphocreatine and its active metabolite creatine in the mouse plasma and myocardium. Pharmacol. Rep., 66: 908-914.
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  25. Xia, F., C. Wang, Y. Jin, Q. Liu, Q. Meng, K. Liu and H. Sun, 2014. Luteolin protects HUVECs from TNF-α-induced oxidative stress and inflammation via its effects on the Nox4/ROS-NF-κB and MAPK pathways. J. Atheroscler. Thromb., 21: 768-783.
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  26. Wang, L., C. Wang, Q. Liu, Q. Meng and X. Huo et al., 2014. PEPT1- and OAT1/3-mediated drug-drug interactions between bestatin and cefixime in vivo and in vitro in rats and in vitro in human. Eur. J. Pharmaceut. Sci., 63: 77-86.
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  27. Wang, L., C. Wang, J. Peng, Q. Liu and Q. Meng et al., 2014. Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo. Toxicol. Applied Pharmacol., 277: 146-154.
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  28. Wang, G., Z. Chen, F. Zhang, H. Jing and W. Xu et al., 2014. Blockade of PKCβ protects against remote organ injury induced by intestinal ischemia and reperfusion via a p66shc-mediated mitochondrial apoptotic pathway. Apoptosis, 19: 1342-1353.
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  29. Wang, C., C. Wang, Q. Liu, Q. Meng and J. Cang et al., 2014. Aspirin and probenecid inhibit organic anion transporter 3-mediated renal uptake of cilostazol and probenecid induces metabolism of cilostazol in the rat. Drug Metab. Dispos., 42: 996-1007.
    CrossRef  |  Direct Link  |  
  30. Sun, P., C. Wang, Q. Liu, Q. Meng and A. Zhang et al., 2014. OATP and MRP2-mediated hepatic uptake and biliary excretion of eprosartan in rat and human. Pharmacol. Rep., 66: 311-319.
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  31. Meng, Q., X. Chen, C. Wang, Q. Liu and H. Sun et al., 2014. Alisol B 23-acetate promotes liver regeneration in mice after partial hepatectomy via activating farnesoid X receptor. Biochem. Pharmacol., 92: 289-298.
    CrossRef  |  Direct Link  |  
  32. Meng, Q. and K. Liu, 2014. Pharmacokinetic interactions between herbal medicines and prescribed drugs: Focus on drug metabolic enzymes and transporters. Curr. Drug Metab., 15: 791-807.
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  33. Mai, Z.P., C. Wang, Y. Wang, H.L. Zhang and B.J. Zhang et al., 2014. Bioactive metabolites of Schisanlactone E transformed by Cunninghamella blakesleana AS 3.970. Fitoterapia, 99: 352-361.
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  34. Liu, Q., C. Wang, Q. Meng, X. Huo and H. Sun et al., 2014. MDR1 and OAT1/OAT3 mediate the drug-drug interaction between puerarin and methotrexate. Pharmaceut. Res., 31: 1120-1132.
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  35. Li, W., C. Wang, J. Peng, J. Liang and Y. Jin et al., 2014. Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-Κ B and PI3K/Akt pathways. Curr. Pharmaceut. Biotechnol., 15: 1173-1182.
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  36. Li, L., D. Xiang, S. Shigdar, W. Yang and Q. Li et al., 2014. Epithelial cell adhesion molecule aptamer functionalized PLGA-lecithin-curcumin-PEG nanoparticles for targeted drug delivery to human colorectal adenocarcinoma cells. Int. J. Nanomed., 9: 1083-1096.
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  37. Huo, X., Q. Liu, C. Wang, Q. Meng and H. Sun et al., 2014. Inhibitory effect of valsartan on the intestinal absorption and renal excretion of bestatin in rats. J. Pharmaceut. Sci., 103: 719-729.
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  38. Guo, X., Q. Meng, Q. Liu, C. Wang and X. Huo et al., 2014. Simultaneous determination of three dipeptides (JBP485, Gly-Sar and JBP923) in the cell lysates by liquid chromatography-tandem mass spectrometry: Application to identify the function of the PEPT1 transfected cell. Biomed. Chromatogr., 28: 1839-1845.
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  39. Gao, M., H. Xu, C. Zhang, K. Liu and X. Bao et al., 2014. Preparation and characterization of curcumin thermosensitive hydrogels for intratumoral injection treatment. Drug Dev. Ind. Pharm., 40: 1557-1564.
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  40. Dong, D., L. Xu, X. Han, Y. Qi and Y. Xu et al., 2014. Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis. Molecules, 19: 7189-7206.
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  41. Chen, H., L. Xu, L. Yin, Y. Xu and X. Han et al., 2014. iTRAQ-based proteomic analysis of dioscin on human HCT-116 colon cancer cells. Proteomics, 14: 51-73.
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  42. Zhang, A., C. Wang, Q. Liu, Q. Meng and J. Peng et al., 2013. Involvement of organic anion-transporting polypeptides in the hepatic uptake of dioscin in rats and humans. Drug Metab. Dispos., 41: 994-1003.
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  43. Ye, J., Q. Liu, C. Wang, Q. Meng and H. Sun et al., 2013. Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3. Pharmacol. Rep., 65: 505-512.
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  44. Xu, Q., C. Wang, Q. Meng, Q. Liu and H. Sun et al., 2013. OAT1 and OAT3: Targets of drug-drug interaction between entecavir and JBP485. Eur. J. Pharmaceut. Sci., 48: 650-657.
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  45. Wang, L., Q. Meng, C. Wang, Q. Liu and J. Peng et al., 2013. Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-κB signaling inhibition. J. Nat. Prod., 76: 909-914.
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  46. Miao, Q., Q. Liu, C. Wang, Q. Meng and X. Guo et al., 2013. Inhibitory effect of 1α,25-dihydroxyvitamin D3 on excretion of JBP485 via organic anion transporters in rats. Eur. J. Pharm. Sci., 48: 351-359.
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  47. Liu, Z. and K. Liu, 2013. The transporters of intestinal tract and techniques applied to evaluate interactions between drugs and transporters. Asian J. Pharmaceut. Sci., 8: 151-158.
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  48. Huo, X., Q. Liu, C. Wang, Q. Meng and H. Sun et al., 2013. Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin. Eur. J. Pharmaceut. Sci., 50: 420-428.
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  49. Guo, X., Q. Meng, Q. Liu, C. Wang and H. Sun et al., 2013. JBP485 improves gentamicin-induced acute renal failure by regulating the expression and function of Oat1 and Oat3 in rats. Toxicol. Applied Pharmacol., 271: 285-295.
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