Prof. Md Moklesur Rahman Sarker

Prof. Md Moklesur Rahman Sarker

Professor and Head of Academic & Research
State University of Bangladesh


Highest Degree
PostDoc Fellow in Pharmaceutical Sciences, Pharmacology from Universiti Malaya, Malaysia

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Biography

Prof. Dr. Md. Moklesur Rahman Sarker is currently working as a Professor and Head of Academic & Research Affairs in the Department of Pharmacy, State University of Bangladesh. He is also serving as the Chief Scientist of Health Med Science Research Limited (a research based company in Bangladesh). Prior to this, he served as the Director of Institutional Quality Assurance Cell of State University (a program of Higher Education Quality Enhancement Project of the University Grants Commission of Bangladesh). He is the Chairman of Institutional Animal Ethics Committee and Executive Member of Human Ethics Committee of the State University of Bangladesh.

Prof. Moklesur obtained PhD in Pharmaceutical Sciences from Okayama University (Japan) and Bachelor and Master of Pharmacy degrees from Jahangirnagar University. He has more than 20 years’ colourful working experiences in different academic and research institutions in Bangladesh, Malaysia and Japan. Before joining to State University of Bangladesh, he worked as Visiting Research Fellow and Principal Investigator of two High Impact Research Projects in the University of Malaya. He also worked as Head of Pharmacology Department, Coordinator for Post-Graduate Program, Chairman of Animal Ethics Committee, and Head of Animal Experimental Unit of Lincoln University College Malaysia; Head of Pharmacy Department in Daffodil International University (Bangladesh) and also worked in national and multinational Pharmaceutical companies in Bangladesh. He is a Registered “A” grade Pharmacist in Bangladesh and GCP certified Clinical Researcher endorsed by the DG Health of Malaysia.

Prof. Moklesur so far has supervised 1 Post-Doctoral, 3 PhD, 90 postgraduate and 62 undergraduate students’ research projects. He has already completed 80 Research Projects in Pharmaceutical and Health Sciences and published 82 scientific articles in peer reviewed international journals including high impact factor journals published by Elsevier, Wiley-Blackwell, Frontiers, Taylor & Francis, Informa Healthcare, Springer, BioMed Central, and Wolters Kluwer - Medknow Publications. He is serving as the Editor-in-Chief of Journal of Pharmacology and Toxicology, and Editorial Board Member and Reviewer of 20 other Peer Reviewed International journals. He has achieved 911 citations, H-index 17, I 10-index: 33, and Researchgate (RG) score: 28.40.

His research interests include diabetes & antidiabetic medicaments, immunomodulating agents, cancer & anticancer agents, lipid lowering/antiobesity agents, Prophetic medicines, phytomedicines/herbal medicines, functional foods & nutraceuticals, antibiotic resistance, rational use of drugs, substandard/adulterated/counterfeit drugs, impact of food adulteration on public health. His research team is currently focusing on the discovery and development of alternative medicines (herbal/phytomedicines, nutraceuticals, functional foods) for the treatment/management of diabetes, cancer, immunity, obesity/hyperlipidemia, fatty liver and aphrodisiac problems with minimum or without side-effects.

Prof. Moklesur attended a number of international conferences, workshops and scientific seminars as invited speaker and oral presenter, and bagged few awards as the best speaker. In the year 2015, he delivered his scientific presentation on his discovery of antidiabetic medications in Harvard University, USA, which was highly appreciated by the high level scientists from Harvard Medical School, National Institute of Health (USA), and scientist and academicians from different universities of USA and other countries. He obtained several research grants such as Project Director, Antidiabetic special Research Grant, Ministry of Science and Technology (Bangladesh) 2019; Project Director of research grant for the development of Immunobooster against COVID-19 infections, Ministry of Science and Technology (Bangladesh) 2020; Project Leader, BKP Research Grant, University of Malaya in 2014; Project leader of High Impact Research Grant, University of Malaya Allocated Research Project; Principal Investigator, MABL Chair for Prophetic Medicine, Taiba University (Saudi Arabia); and Several Contract Research Projects from Innoscience Research Sdn. Bhd (Malaysia).


Prof. Moklesur is currently mentoring a number of research projects of PhD, Post-Graduate and Undergraduate students and also involved with 20 different research projects in different academic and research institutions in Malaysia, USA, Australia, Japan, Saudi Arabia, and Bangladesh. He has obtained three PATENTs for the discovery and development of medications for diabetes, hyperlipidemia and immune-disorders. He is a member of several professional bodies, such as Academic Society of Functional Foods and Bioactive Compounds - USA, Malaysian Pharmaceutical Society, Pharmaceutical Society of Japan, Bangladesh Pharmaceutical Society, American Society of Microbiology, and Bangladesh Pharmacy Graduates’ Association. As an acknowledgement of his outstanding contribution for research and innovation, his biography has been published in the Marquis “Who’s Who in the World 2016” (33rd Edition, VIP Number: 37008993)”.

Area of Interest:

Pharmacology
100%

Selected Publications

  1. Chen, Y., D. Liu, D. Wang, S. Lai and R. Zhong et al., 2019. Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice. Food Chem. Toxicol., 126: 295-302.
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  2. Shajib, M., R.B. Rashid, L.C. Ming, S. Islam and M.M.R. Sarker et al., 2018. Polymethoxyflavones from Nicotiana plumbaginifolia (Solanaceae) exert antinociceptive and neuropharmacological effects in mice. Front. Pharmacol., Vol. 9. 10.3389/fphar.2018.00085.
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  3. Nesa, M.L., S.M.S. Karim, K. Api, M.M.R. Sarker and M.M. Islam et al., 2018. Screening of Baccaurea ramiflora (Lour.) extracts for cytotoxic, analgesic, anti-inflammatory, neuropharmacological and antidiarrheal activities. BMC Complement. Altern. Med., Vol. 18. 10.1186/s12906-018-2100-5.
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  4. Eva, J.J., Y.W. Kassab, C.F. Neoh, L.C. Ming and Y.Y. Wong et al., 2018. Self-care and self-management among adolescent T2DM patients: A review. Front. Endocrinol., Vol. 9. 10.3389/fendo.2018.00489.
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  5. Chen, Y., Y. Liu, M.M.R. Sarker, X. Yan and C. Yang, Zhao et al., 2018. Structural characterization and antidiabetic potential of a novel heteropolysaccharide from Grifola frondosa via IRS1/PI3K-JNK signaling pathways. Carbohydr. Polym., 198: 452-461.
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  6. Ahmed, A., K.S. Lee, A. Bukhsh, Y.M. Al-Worafi, M.M.R. Sarker, L.C. Ming and T.M. Khan, 2018. Outbreak of vaccine-preventable diseases in Muslim majority countries. J. Infect. Public Health, 11: 153-155.
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  7. Ullah, K., M.M.R. Sarker, M.S. Khan, M.S. Mustapha and M.K. Ullah, 2017. Anti-diabetic activity of compound “2-[(trimethylsilyl) oxy]-methyl ester (cas) methyl-o-trim-ethyl-silylsalicylate” isolated from Pericampylus glaucus (Lam) Merr in STZ-induced diabetic rats. J. Basic Clin. Pharm., 8: 68-73.
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  8. Sheikh, B.Y., M.M.R. Sarker, M.N.A. Kamarudin and G. Mohan, 2017. Antiproliferative and apoptosis inducing effects of citral via p53 and ROS-induced mitochondrial-mediated apoptosis in human colorectal HCT116 and HT29 cell lines. Biomed. Pharmacother., 96: 834-846.
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  9. Sheikh, B.Y., M.M.R. Sarker, M.N.A. Kamarudin and A. Ismail, 2017. Prophetic medicine as potential functional food elements in the intervention of cancer: A review. Biomed. Pharmacother., 95: 614-648.
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  10. Sharma, D., R.P. Patel, S.T.R. Zaidi, M. Sarker, M. Rahman, Q.Y. Lean and L.C. Ming, 2017. Interplay of the quality of ciprofloxacin and antibiotic resistance in developing countries. Front. Pharmacol., Vol. 8. 10.3389/fphar.2017.00546.
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  11. Salem, H.A. and M.M.R. Sarker, 2017. Evaluation of A novel formulation from functional foods for hypoglycemic and weight loss activities in high-fat Balb/C mice. Int. J. Sci. Res., 6: 1020-1027.
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  12. Rouhi, S.Z.T., M.M.R. Sarker, A. Rahmat, S.A. Alkahtani and F. Othman, 2017. The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Dawley rats. BMC Complement. Altern. Med., Vol. 17. 10.1186/s12906-017-1667-6.
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  13. Krayemi, A.A.A. and M.M.R. Sarker, 2017. Evaluation of the anti-diabetic activity of a novel formulation of functional foods in streptozotocin-induced Balb/c diabetic mice model. Int. J. Sci. Res., 6: 2088-2096.
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  14. Kifayatullah, M., M.S. Mustapha, M.M.R. Sarker, S.K. Das and P. Sengupta, 2017. Effect of ethanolic extract of Pericampylus glaucus (Lam) Merr on biochemical parameters in high fats diets Sprague-Dawley rats. Pak. J. Pharmaceut. Res., 3: 1-8.
  15. Kifayatullah, M., M.S. Mustapha, M.M.R. Sarker, Kaleemullah, M. Amin and F. Ali, 2017. Possible role of a compound identified from Pericampylus glaucus plant in controlling blood glucose in experimental animals. Egypt. Pharmaceut. J., 16: 37-42.
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  16. Kifayatullah, M., M.S. Mustapha, M.M.R. Sarker and M. Amin, 2017. Effect of compounds identified in the active fraction of Pericampylus glaucus on blood glucose and lipid profiles in streptozotocin-induced diabetic rats. Egypt. Pharmaceut. J., 16: 8-15.
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  17. Kifayatullah, M., M.M.R. Sarker and M.S. Mustapha, 2017. Phytochemical investigation of ethanolic extract of Pericampylus glaucus leaves from Malaysia by GC-MS analytical technique. Int. J. PharmTech Res., 9: 410-416.
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  18. Kamarudin, M.N.A., M.M.R. Sarker, H.A. Kadir and L.C. Ming, 2017. Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Clinacanthus nutans (Burm. f.) Lindau: A comprehensive review. J. Ethnopharmacol., 206: 245-266.
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  19. Jesuraj, S.A.V., M.M.R. Sarker, L.C. Ming, S.M.J. Praya, M. Ravikumar and W.T. Wui, 2017. Enhancement of the production of L-glutaminase, an anticancer enzyme, from Aeromonas veronii by adaptive and induced mutation techniques. PLoS ONE, Vol. 12. 10.1371/journal.pone.0181745.
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  20. Hossain, G., S.M. Uddin, A. Islam, A. Saw, P.E. Lestrel, H. Banna and M.R. Sarker, 2017. Factors associated with HIV testing behaviors among female sex workers in Rajshahi City, Bangladesh. J. Life Sci., 9: 104-110.
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  21. Elaswed, E.E.E. and M.R. Sarker, 2017. Evaluation of antidiabetic potential of a novel formulation from prophetic medicine in streptozotocin-induced diabetic Balb/C mice. Int. J. Sci. Res., 6: 857-865.
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  22. Das, S.K., P. Sengupta, M.S. Mustapha and M.M.R. Sarker, 2017. An experimental evaluation of adaptogenic potential of standardized Epipremnum aureum leaf extract. J. Pharm. BioAllied Sci., 9: 88-93.
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  23. Shah, M.A., M.M.R. Sarker and M. Gousuddin, 2016. Toxicity study of Brassica oleracea var. italica extracts in Sprague Dawley (SD) rats. Int. J. Pharmacogn. Phytochem. Res., 8: 735-741.
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  24. Shah, M.A., M.M.R. Sarker and M. Gousuddin, 2016. Antidiabetic potential of Brassica oleracea var. italica in type 2 diabetic Sprague Dawley (SD) rats. Int. J. Pharmacogn. Phytochem. Res., 8: 462-469.
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  25. Sarker, M.M.R., M.S. Rashid, A.A. Raju, M. Rana and M.F.B. Karim et al., 2016. Evaluation of the pharmaceutical quality of different brands of ranitidine tablets manufactured in Bangladesh: A pharmaceutical and public health prospective. J. Applied Pharmaceut. Sci., 6: 55-61.
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  26. Sarker, M.M.R., L.C. Ming, M.Z.I. Sarker and M.S.K. Choudhuri, 2016. Immunopotentiality of Ayurvedic polyherbal formulations “Saribadi” and “Anantamul Salsa” with augmentation of IgM production and lymphocytes proliferation: A preliminary study. Asian Pac. J. Trop. Biomed., 6: 568-573.
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  27. Saleh, M.S., S. Shaharuddin, M.M.R. Sarker and L.C. Ming, 2016. Safety and efficacy of Labisia pumila containing products. Arch. Pharm. Pract., 7: 53-56.
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  28. Rahim, N.H.A., L.C. Ming, Y.M.A. Al-Worafi and M.M.R. Sarker, 2016. A regulatory review for products containing glutathione. Arch. Pharm. Pract., 7: 57-60.
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  29. Sikder, M.M., M.R. Hasan, S.S. Lopa, N. Abedin and M.J. Uddin et al., 2015. Toxicological studies of an ayurvedic medicine “Karpur Ras” used in diarrhoea. Int. J. Pharm., 5: 472-477.
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  30. Sarker, M.M.R., M.A.T.R. Zihad, M. Islam, M. Nahar and M.M. Islam et al., 2015. Antihyperglycemic, insulin-sensitivity and anti-hyperlipidemic potential of Ganoderma lucidum, a dietary mushroom, on alloxan- and glucocorticoid-induced diabetic Long-Evans rats. Funct. Foods Health Dis., 5: 450-466.
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  31. Rajamanickam, G., S. Selvaraj, J. Selvaraj, T. Rajendran and M.M.R. Sarker, 2015. In vitro anthelmintic and antimicrobial activity of novel series of quinoxaline-2,3-dione-6-sulphonyl benzimidazole(s). J. Chem. Pharmaceut. Sci., 8: 656-660.
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  32. Nahar, K., M.R. Hasan, S.K. Chowdhury, P. Chakma and G. Begum et al., 2015. Preclinical blood chemistry safety profile studies of “Basanta Kusumakar Ras” after chronic administration to male Sprague-Dawley rats. Int. J. Pharm., 5: 146-152.
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  33. Kifayatullah, M., M.S. Mustafa, P. Sengupta, M.M.R. Sarker, A. Das and S.K. Das, 2015. Evaluation of the acute and sub-acute toxicity of the ethanolic extract of Pericampylus glaucus (Lam.) Merr. in BALB/c mice. J. Acute Dis., 4: 309-315.
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  34. Kazemipoor, M., G.A. Cordell, M.M.R. Sarker, C.W.J.B.W.M. Radzi, M. Hajifaraji and P.E. Kiat, 2015. Alternative treatments for weight loss: Safety/risks and effectiveness of anti-obesity medicinal plants. Int. J. Food Proper., 18: 1942-1963.
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  35. Karim, M.F.B., H. Imam, M.M.R. Sarker, N. Uddin, N. Hasan, N. Paul and T. Haque, 2015. Free radical scavenging, antidiarrheal and anthelmintic activity of Pistia stratiotes L. extracts and its phytochemical analysis. Pak. J. Pharmaceut. Sci., 28: 915-920.
    PubMed  |  
  36. Jesuraj, A.V., M. Ravikumar, M.M.R. Sarker and M. Praya, 2015. Apoptotic induction on HT29 cells by immobilized L-glutaminase. Pharmanest, 6: 2960-2963.
  37. Hasan, M.A., M.R. Hasan, M.J. Uddin, G. Begum and N. Abdullah et al., 2015. Preclinical blood chemistry safety profile studies of “Rohitakarista” on the kidney function after chronic administration to male Sprague-Dawley rats. Int. J. Pharm., 5: 367-373.
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  38. Easmin, M.S., M.Z.I. Sarker, S. Ferdosh, S.H. Shamsudin and K.B. Yunus et al., 2015. Bioactive compounds and advanced processing technology: Phaleria macrocarpa (sheff.) Boerl, a review. J. Chem. Technol. Biotechnol., 90: 981-991.
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  39. Das, S.K., P. Sengupta, S. Mustapha, A. Das, M.M.R. Sarker and M. Kifayatullah, 2015. Toxicological investigation of ethanolic extract of Epipremnum aureum in rodents. J. Applied Pharmaceut. Sci., 5: 57-61.
    Direct Link  |  
  40. Sarker, M.R., H. Imam, M.S. Bhuiyan and K.M.S. Choudhuri, 2014. In vitro assessment of Prasarani Sandhan, a traditional polyherbal ayurvedic medicine, for immunostimulating activity in splenic cells of BALB/c mice. Int. J. Pharm. Pharmaceut. Sci., 6: 531-534.
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  41. Sarker, M.M.R., K.N. Islam, H.Z. Huri, M. Rahman and H. Imam et al., 2014. Studies of the impact of occupational exposure of pharmaceutical workers on the development of antimicrobial drug resistance. J. Occup. Health, 56: 260-270.
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  42. Sarker, M.M.R., 2014. Therapeutic efficacy and safety of traditional Ayurvedic medicines: Demands for extensive research and publications. J. Homeopathy Ayurvedic Med., Vol. 3. 10.4172/2167-1206.1000e113.
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  43. Sarker, M.M.R., 2014. Selection of proper antidiabetic drugs for diabetic patients with cardiovascular diseases: Why so important? Pharmaceut. Sci., 20: 38-39.
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  44. Sarker, M.M.R., 2014. Adulteration of herbal medicines and dietary supplements with undeclared synthetic drugs: Dangerous for human health. Int. J. Pharm. Pharmaceut. Sci., 6: 1-2.
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  45. Sarker, M.M.R. and M. Zhong, 2014. Keyhole limpet hemocyanin augmented the killing activity, cytokine production and proliferation of NK cells and inhibited the proliferation of Meth A sarcoma cells in vitro. Indian J. Pharmacol., 46: 40-45.
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  46. Karim, M.F.B., H. Imam, N. Uddin, N. Paul, T. Haque, M.M.R. Sarker and M.S. Rana, 2014. Phytochemical and pharmacological investigations of Pistia stratiotes L. Int. J. Innov. Pharmaceut. Sci. Res., 2: 640-652.
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  47. Imam, H., A. Chowdhury, N.U. Mahbub, A. Hossain, M.F.B. Karim, M.B. Uddin and M.M.R. Sarker, 2014. Oxidizability assay of unfractionated plasma of patients' with different plasma profile: A methodological study. J. Diabetes Metab. Disord., Vol. 13. 10.1186/2251-6581-13-54.
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  48. Sarker, M.M.R. and E. Gohda, 2013. Promotion of anti-keyhole limpet hemocyanin IgM and IgG antibody productions in vitro by red bell pepper extract. J. Funct. Foods, 5: 1918-1926.
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  49. Imam, H., N.U. Mahbub, M.F. Khan, H.K. Hana and M.M.R. Sarker, 2013. Alpha amylase enzyme inhibitory and anti-inflammatory effect of Lawsonia inermis. Pak. J. Biol. Sci., 16: 1796-1800.
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  50. Sarker, M.M.R., S. Nahar, M. Shahriar, S. Seraj and M.S.K. Choudhuri, 2012. Preliminary study of the immunostimulating activity of an ayurvedic preparation, Kanakasava, on the splenic cells of BALB/c mice in vitro. Pharmaceut. Biol., 50: 1467-1472.
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  51. Sarker, M.M.R., M.S.K. Choudhuri and M. Zhong, 2012. Effect of Chandanasav, an ayurvedic formulation, on mice whole splenocytes for the production of polyclonal IgM and proliferation of cells: A preliminary study. Int. J. Pharmaceut. Sci. Res., 3: 1294-1299.
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  52. Sarker, M.M.R., I. Nimmi and M.H. Kawsar, 2012. Preliminary screening of six popular fruits of Bangladesh for in vitro IgM production and proliferation of splenocytes. Bangladesh Pharmaceut. J., 15: 31-37.
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  53. Sarker, M.M.R., 2012. Induction of humoral immunity through the enhancement of IgM production in murine splenic cells by ethanolic extract of seed of Piper nigrum L. J. Scient. Res., 4: 751-756.
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  54. Harun-or-Rashid, M., M.A. Gafur, M.M.R. Sarker and N. Karim, 2012. A spinasteryl glycoside from Ipomoea turpethum L. herb (stem) growing in Bangladesh. J. Bangladesh Acad. Sci., 36: 13-17.
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  55. Sarker, M.M.R., M.E.H. Mazumder and M.H. Rashid, 2011. In vitro enhancement of polyclonal IgM production by ethanolic extract of Nigella sativa L. seeds in whole spleen cells of female BALB/c mice. Bangladesh Pharmaceut. J., 14: 73-77.
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  56. Goto, T., M.M.R. Sarker, M. Zhong, S. Tanaka and E. Gohda, 2010. Enhancement of immunoglobulin M production in B cells by the extract of red bell pepper. J. Health Sci., 56: 304-309.
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  57. Yasmin, H., M.A. Kaisar, M.M.R. Sarker, M.S. Rahman and M.A. Rashid, 2009. Preliminary anti-bacterial activity of some indigenous plants of Bangladesh. Dhaka Univ. J. Pharm. Sci., 8: 61-65.
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  58. Sarker, M.M.R. and A. Ghani, 2008. Cultural and health management practices of the Garo community of Bangladesh: A case study of the Garos of greater Mymensingh district. Stamford J. Pharmaceut. Sci., 1: 29-37.
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  59. Sarker, M.M.R., M.H. Kawsar and A. Ghani, 2007. Health management practices and influence of socio-cultural habits on the health management systems of an ethnic group of people in Bangladesh. Univ. Sci. Technol. Annu., 13: 19-36.
  60. Sarker, M.M.R., M.A. Hossain, M. Rafiquzzaman and M.M. Hoque, 2006. Chemical (HPLC) analysis and bioassay studies on the quality of some brands of Ciprofloxacin tablets marketed in Bangladesh. Univ. Sci. Technol. Annu., 12: 24-37.