Dr. Pei-Yi Chu
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Dr. Pei-Yi Chu

Associate Professor
Department of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan

Highest Degree
Ph.D. in Veterinary Anatomical Pathology from National Taiwan University, Taiwan

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Biography

Dr. Pei-Yi Chu is currently serving as Associate Head, Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University and also working as the Deputy Superintendent of Show Chwan Memorial Hospital for Medical Education and Medical Reearch.

Area of Interest:

Medical Sciences
100%
Personalized Medicine
62%
Computational Biology
90%
Biomedicine
75%
Molecular Sciences
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
117
Abstracts
0

Selected Publications

  1. Kan, J.Y., S.L. Shih, S.F. Yang, P.Y. Chu and F.M. Chen et al., 2024. Exosomal microRNA-92b Is a diagnostic biomarker in breast cancer and targets survival-related MTSS1L to promote tumorigenesis. Int. J. Mol. Sci., Vol. 25. 10.3390/ijms25021295.
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  2. Chu, P.Y., D.A. Chou, P.M. Chen and E.P.I. Chiang, 2023. Translocation of methionine adenosyl transferase MAT2A and its prognostic relevance for liver hepatocellular carcinoma. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24109103.
    CrossRef  |  Direct Link  |  
  3. Chen, P.M., C.N. Wong, C.N. Wong and P.Y. Chu, 2023. Actin-like protein 6A expression correlates with cancer stem cell-like features and poor prognosis in ovarian cancer. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24032016.
    CrossRef  |  Direct Link  |  
  4. Chen, C.C., P.Y. Chu and H.Y. Lin, 2023. Supervised learning and multi-omics integration reveals clinical significance of inner membrane mitochondrial protein (IMMT) in prognostic prediction, tumor immune microenvironment and precision medicine for kidney renal clear cell carcinoma. Int. J. Mol. Sci., Vol. 24. 10.3390/ijms24108807.
    CrossRef  |  Direct Link  |  
  5. Wu, H.J. and P.Y. Chu, 2022. Current and developing liquid biopsy techniques for breast cancer. Cancers, Vol. 14. 10.3390/cancers14092052.
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  6. Lin, Y.K., H.J. Wu, N. van Hieu, P.Y. Chu and T.V.T. Do et al., 2022. A new biorecognition-element-free IDμE sensor for the identification and quantification of E. coli. Biosensors, Vol. 12. 10.3390/bios12080561.
    CrossRef  |  Direct Link  |  
  7. Hung, Y.H., S.H. Hsu, Y.C. Hou, P.Y. Chu and Y.Y. Su et al., 2022. Semaphorin 6C suppresses proliferation of pancreatic cancer cells via inhibition of the AKT/GSK3/β-Catenin/Cyclin D1 pathway. Int. J. Mol. Sci., Vol. 23. 10.3390/ijms23052608.
    CrossRef  |  Direct Link  |  
  8. Hu, M.H., P.Y. Chu, S.M. Huang, B.S. Shih, C.L. Ko, J.J. Hu and W.C. Chen, 2022. Injectability, processability, drug loading, and antibacterial activity of gentamicin-impregnated mesoporous bioactive glass composite calcium phosphate bone cement in vitro. Biomimetics, Vol. 7. 10.3390/biomimetics7030121.
    CrossRef  |  Direct Link  |  
  9. Chen, C.C., P.Y. Chu and H.Y. Lin, 2022. Multi-omics analysis reveals clinical value and possible mechanisms of ATAD1 down-regulation in human prostate adenocarcinoma. Life, Vol. 12. 10.3390/life12111742.
    CrossRef  |  Direct Link  |  
  10. Yang, Y.L., Y.H. Chang, C.J. Li, Y.H. Huang, M.C. Tsai, P.Y. Chu and H.Y. Lin, 2021. New insights into the role of miR-29a in hepatocellular carcinoma: Implications in mechanisms and theragnostics. J. Pers. Med., Vol. 11. 10.3390/jpm11030219.
    CrossRef  |  Direct Link  |  
  11. Yang, Y.L., M.C. Tsai, Y.H. Chang, C.C. Wang, P.Y. Chu, H.Y. Lin and Y.H. Huang, 2021. MIR29A impedes metastatic behaviors in hepatocellular carcinoma via targeting LOX, LOXL2, and VEGFA. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms22116001.
    CrossRef  |  Direct Link  |  
  12. Wu, H.J. and P.Y. Chu, 2021. Recent discoveries of macromolecule- and cell-based biomarkers and therapeutic implications in breast cancer. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms22020636.
    CrossRef  |  Direct Link  |  
  13. Lin, H.Y., H.W. Ho, Y.H. Chang, C.J. Wei and P.Y. Chu, 2021. The evolving role of ferroptosis in breast cancer: Translational implications present and future. Cancers, Vol. 13. 10.3390/cancers13184576.
    CrossRef  |  Direct Link  |  
  14. Li, C.J., Y.D.T. Tzeng, Y.H. Chiu, H.Y. Lin, M.F. Hou and P.Y. Chu, 2021. Pathogenesis and potential therapeutic targets for triple-negative breast cancer. Cancers, Vol. 13. 10.3390/cancers13122978.
    CrossRef  |  Direct Link  |  
  15. Li, C.J., L.T. Lin, P.Y. Chu, A.J. Chiang and H.W. Tsai et al., 2021. Identification of novel biomarkers and candidate drug in ovarian cancer. J. Pers. Med., Vol. 11. 10.3390/jpm11040316.
    CrossRef  |  Direct Link  |  
  16. Ko, C.J., S.L. Gao, T.K. Lin, P.Y. Chu and H.Y. Lin, 2021. Ferroptosis as a major factor and therapeutic target for neuroinflammation in Parkinson*s disease. Biomedicines, Vol. 9. 10.3390/biomedicines9111679.
    CrossRef  |  Direct Link  |  
  17. Huang, W.C., H.C. Chi, S.L. Tung, P.M. Chen, Y.C. Shih, Y.C. Huang and P.Y. Chu, 2021. Identification of the novel tumor suppressor role of FOCAD/miR-491-5p to inhibit cancer stemness, drug resistance and metastasis via regulating RABIF/MMP signaling in triple negative breast cancer. Cells, Vol. 10. 10.3390/cells10102524.
    CrossRef  |  Direct Link  |  
  18. Chu, P.Y., Y.D.T. Tzeng, Y.H. Chiu, H.Y. Lin, C.H. Kuo, M.F. Hou and C.J. Li, 2021. Multi-omics reveals the immunological role and prognostic potential of mitochondrial Ubiquitin Ligase MARCH5 in human breast cancer. Biomedicines, Vol. 9. 10.3390/biomedicines9101329.
    CrossRef  |  Direct Link  |  
  19. Chu, P.Y., H.J. Wu, S.M.Wang, Po-Ming Chen, Feng-Yao Tang, En-Pei Isabel Chiang 2021. MAT2A localization and its independently prognostic relevance in breast cancer patients. Int. J. Mol. Sci., Vol. 22. 10.3390/ijms22105382.
    CrossRef  |  Direct Link  |  
  20. Chu, P.Y. and S.H. Chan, 2021. Cure the incurable? Recent breakthroughs in immune checkpoint blockade for hepatocellular carcinoma. Cancers, Vol. 13. 10.3390/cancers13215295.
    CrossRef  |  Direct Link  |  
  21. Wang, Y.C., J.L. Huang, K.W. Lee, H.H. Lu and Y.J. Lin et al., 2020. Downregulation of the DNA repair gene DDB2 by arecoline is through p53’s DNA-binding domain and is correlated with poor outcome of head and neck cancer patients with betel quid consumption. Cancers, Vol. 12. 10.3390/cancers12082053.
    CrossRef  |  Direct Link  |  
  22. Lin, H.Y., C.J. Li, Y.L. Yang, Y.H. Huang, Y.T. Hsiau and P.Y. Chu, 2020. Roles of lysyl oxidase family members in the tumor microenvironment and progression of liver cancer. Int. J. Mol. Sci., Vol. 21. 10.3390/ijms21249751.
    CrossRef  |  Direct Link  |  
  23. Li, C.J., H.Y. Lin, C.J. Ko, J.C. Lai and P.Y. Chu, 2020. A novel biomarker driving poor-prognosis liver cancer: Overexpression of the mitochondrial calcium gatekeepers. Biomedicines, Vol. 8. 10.3390/biomedicines8110451.
    CrossRef  |  Direct Link  |  
  24. Chu, P.Y., S.M. Wang, P.M. Chen, F.Y. Tang and E.P.I. Chiang, 2020. Expression of MTDH and IL-10 Is an independent predictor of worse prognosis in ER-negative or PR-negative breast cancer patients. J. Clin. Med., Vol. 9. 10.3390/jcm9103153.
    CrossRef  |  Direct Link  |  
  25. Yen, P.L., D.R. Chen, K.T. Yeh and P.Y. Chu, 2011. Development of a stiffness measurement accessory for ultrasound in breast cancer diagnosis. Med. Eng. Phys., (In Press). 10.1016/j.medengphy.2011.05.001.
    CrossRef  |  PubMed  |  Direct Link  |  
  26. Teng, I.W., P.C. Hou, K.D. Lee, P.Y. Chu and K.T. Yeh et al., 2011. Targeted methylation of two tumor suppressor genes is sufficient to transform mesenchymal stem cells into cancer stem/initiating cells. Cancer Res., 71: 4653-4663.
    CrossRef  |  PubMed  |  Direct Link  |  
  27. Su, T.C., K.H. Shen, H.K. Wang, P.Y. Chu and M.L. Chen, 2011. Lipomatous apocrine adenoma with syringocystadenoma papilliferum arising from the external auditory canal. Head Neck Oncol., 3: 36-36.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Soon, M.S., L.S. Hsu, C.J. Chen, P.Y. Chu and J.H. Liou et al., 2011. Expression of Kruppel-like factor 5 in gastric cancer and its clinical correlation in Taiwan. Virchows Arch., 459: 161-166.
    CrossRef  |  PubMed  |  Direct Link  |  
  29. Hsu, C.C., Y.W. Leu, M.J. Tseng, K.D. Lee and T.Y. Kuo et al., 2011. Functional characterization of Trip10 in cancer cell growth and survival. J. Biomed. Sci., 18: 12-12.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Chu, P.Y., C.H. Hsu, H.C. Tai, C.M. Yeh, S.H. Lin, M.F. Hou and K.T. Yeh, 2011. High nuclear protein kinase CΘ expression may correlate with disease recurrence and poor survival in oral squamous cell carcinoma. Hum. Pathol., (In Press). 10.1016/j.humpath.2011.05.001.
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  31. Chow, L.H., P.C. Lin, J.S. Chang, P.Y. Chu and P.K. Lee et al., 2011. Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method. Environ. Mol. Mutagen., (In Press). 10.1002/em.20673.
    CrossRef  |  Direct Link  |  
  32. Charoenfuprasert, S., Y.Y. Yang, Y.C. Lee, K.C. Chao and P.Y. Chu et al., 2011. Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. Oncogene, 30: 3570-3584.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Chang, N.W., M.H. Tsai, C. Lin, H.T. Hsu and P.Y. Chu et al., 2011. Fenofibrate exhibits a high potential to suppress the formation of squamous cell carcinoma in an oral-specific 4-nitroquinoline 1-oxide/arecoline mouse model. Biochim. Biophys. Acta, 1812: 558-564.
    PubMed  |  Direct Link  |  
  34. Yeh, Y.C., C.H. Lin, Y.M. Shih, J.H. Tsai, P.Y. Chu, J.L. Liu and K.T. Yeh, 2010. Intrapulmonary solitary fibrous tumor. Thoracic Med., 25: 56-61.
  35. Liu, J.L., P.Y. Chu, K.T. Yeh and R.H. Huang, 2010. Borderline clear cell adenofibroma with extensive hemorrhagic necrosis. Hematol. Oncol. Stem Cell Ther., 3: 158-160.
    PubMed  |  Direct Link  |  
  36. Huang, R.H., T.C. Su, M.H. Lee, P.Y. Chu and M.L. Chen, 2010. Myofibroblastoma of male breast: Report of a case. Formosan J. Surg., 43: 104-107.
  37. Chu, P.Y., T.I. Hung, C.C. Lee and S.H. Hsiao, 2010. Gastric outlet obstruction caused by a giant gastric adenoma: Report of a case. Formosan J. Surg., 43: 141-144.
  38. Chu, P.Y., C.M. Yeh, N.C. Hsu, Y.S. Chang, J.G. Chang and K.T. Yeh, 2010. Epigenetic alteration of the SOCS1 gene in hepatocellular carcinoma. Swiss Med. Weekly, 140: w13065-w13065.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Teng, T.H., P.Y. Chu, C.P. Wei, Y.F. Liang and C.C. Lee, 2009. Secretory meningioma: Report of a case. Formosan J. Surg., 42: 276-280.
  40. Liao, A.T., P.Y. Chu, L.S. Yeh, C.T. Lin and C.H. Liu, 2009. A 12-year retrospective study of canine testicular tumors. J. Vet. Med. Sci., 71: 919-923.
    PubMed  |  Direct Link  |  
  41. Chu, P.Y., T.C. Su, K.T. Yeh, Y.W. Lu and S.H. Hsiao, 2009. The technologies of RNA interference and its applications in cancer treatment. Taiwan Med. J., 52: 21-24.
  42. Yen, P.L., D.R. Chen, K.T. Yeh and P.Y. Chu, 2008. Lateral exploration strategy for differentiating the stiffness ratio of an inclusion in soft tissue. Med. Eng. Phys., 30: 1013-1019.
    CrossRef  |  PubMed  |  Direct Link  |  
  43. Weng, C.T., P.Y. Chu, M.T. Liu and M.K. Chen, 2008. Small cell carcinoma of the head and neck: A single institution's experience and review of the literature. J. Otolaryngol. Head Neck Surg., 37: 788-793.
    PubMed  |  Direct Link  |  
  44. Huang, R.H., P.Y. Chu, K.T. Yeh and J.C. Hsu, 2008. Endometrial adenosarcoma. Taiwan J. Obstet. Gynecol., 47: 343-345.
    PubMed  |  
  45. Chu, P.Y., T.I. Hwang, T.H. Teng and C.C. Lee, 2007. A retroperitoneal bronchogenic cyst successfully treated by laparoscopic surgery. Ann. Saudi Med., 27: 199-200.
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  46. Chu, P.Y., T.H. Teng and C.C. Lee, 2007. Primary superficial basal cell carcinoma of the nipple. Ann. Saudi Med., 27: 296-297.
    CrossRef  |  PubMed  |  Direct Link  |  
  47. Huang, L.C., C.P. Li, C.C. Chen, C.C. Lee and P.Y. Chu, 2006. Small cell carcinoma of the uterine cervix: A case report with emphasis on cytopathological findings. Tzu Chi Med. J., 18: 456-461.
    Direct Link  |  
  48. Chu, P.Y., T.H. Teng, Z.J. Chen, Y.S. Hsieh and C.C. Lee, 2006. Bronchial washing cytology of primary tracheal adenoid cystic carcinoma: A case report. Tzu Chi Med. J., 18: 397-399.
    Direct Link  |  
  49. Chu, P.Y., T.H. Teng, T.N. Lu and C.C. Lee, 2006. Infantile myofibromatosis of multiple bones with spontaneous regression: A report of one case. Tzu Chi Med. J., 18: 319-322.
    Direct Link  |  
  50. Chu, P.Y., T.H. Teng, T.F. Cheng and C.C. Lee, 2006. Adenomyoepithelioma of the breast: A case report. Tzu Chi Med. J., 18: 65-67.
  51. Chu, P.Y., T.H. Teng, C.C. Lee and Y.Y. Chou, 2006. Adenocarcinomas arising from primary retroperitoneal teratoma in an adult female patient. Int. J. Urol., 13: 1352-1354.
    CrossRef  |  Direct Link  |  
  52. Chu, P.Y., C.P. Wei, Y.F. Tsai, T.H. Teng and C.C. Lee, 2006. Chondrosarcoma of the skull base: Report of two cases. Tzu Chi Med. J., 18: 229-231.
    Direct Link  |  
  53. Chen, C.C., L.C. Huang, C.P. Li, P.Y. Chu and C.C. Lee, 2006. Fine needle aspiration cytology of invasive cribriform carcinoma of the breast: A case report. J. Biomed. Lab. Sci., 18: 29-33.