Dr. Ravi Kumar Gutti
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Dr. Ravi Kumar Gutti

Assistant Professor
Department of Biochemistry, School of Life Sciences, F49 University of Hyderabad, (PO) Gachibowli, Hyderabad, India


Highest Degree
Ph.D. in Molecular Biology and Biotechnology from Indian Agricultural Research Institute, New Delhi, India

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Biography

Dr. Ravi Kumar Gutti is currently working as Assistant Professor at University of Hyderabad, India. He earned his Ph.D. in Molecular Biology and Biotechnology from Indian Agricultural Research Institute, New Delhi, India. His main area of interest focuses on Biomedical Sciences, and Molecular Sciences. His area of expertise includes Hematopoiesis, Non-Coding RNA, Gene Regulation, Stem Cell, miRNA, Differentiation, Apoptosis, and Proliferation. He has 21 publications in journals contributed as author/co-author.

Area of Interest:

Biomedical Sciences
100%
Apoptosis
62%
Stem Cell
90%
MiRNA
75%
Proliferation
55%

Research Publications in Numbers

Books
2
Chapters
0
Articles
57
Abstracts
57

Selected Publications

  1. Sangeeth, A., M. Malleswarapu, A. Mishra and R.K. Gutti, 2022. Long non-coding RNA therapeutics: Recent advances and challenges. Curr. Drug Targets, 23: 1457-1464.
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  2. Amanullah, A., A. Upadhyay, R. Dhiman, S. Singh and A. Kumar et al., 2022. Development and challenges of diclofenac-based novel therapeutics: Targeting cancer and complex diseases. Cancers, Vol. 14. 10.3390/cancers14184385.
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  3. Sharma, D.S., S. Raghuwanshi, N. Kovuru, S. Dahariya, D.K. Gautam, I. Paddibhatla and R.K. Gutti, 2021. Virodhamine, an endocannabinoid, induces megakaryocyte differentiation by regulating MAPK activity and function of mitochondria. J. Cell. Physiol., 236: 1445-1453.
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  4. Gautam, D.K., A.V. Chimata, R.K. Gutti and I. Paddibhatla, 2021. Comparative hematopoiesis and signal transduction in model organisms. J. Cell. Physiol., 236: 5592-5619.
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  5. Dahariya, S., S. Raghuwanshi, A. Sangeeth, M. Malleswarapu, R. Kandi and R.K. Gutti, 2021. Megakaryoblastic leukemia: A study on novel role of clinically significant long non-coding RNA signatures in megakaryocyte development during treatment with phorbol ester. Cancer Immunol. Immunother., 70: 3477-3488.
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  6. Raghuwanshi, S., S. Dahariya, D.S. Sharma, N. Kovuru, I. Sahu and R.K. Gutti, 2020. RUNX1 and TGF-β signaling cross talk regulates Ca2+ ion channels expression and activity during megakaryocyte development. FEBS J., 287: 5411-5438.
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  7. Raghuwanshi, S., S. Dahariya, S.S. Musvi, U. Gutti and R. Kandi et al., 2019. MicroRNA function in megakaryocytes. Platelets, 30: 809-816.
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  8. Raghuwanshi, S., D.S. Sharma, R. Kandi, N. Kovuru and S. Dahariya et al., 2019. Pituitary adenylate cyclase-activating polypeptide (PACAP): Differential effects on neonatal vs adult megakaryocytopoiesis. Thrombosis Res., 175: 59-60.
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  9. Kovuru, N., S. Raghuwanshi and R.K. Gutti, 2019. Exosome mediated differentiation of megakaryocytes: a study on TLR mediated effects. J. Thrombosis Thrombolysis, 48: 171-173.
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  10. Sahu, I., R. Hebalkar, S. Kar, T.S. SreeVidya, U. Gutti and R.K. Gutti, 2018. Systems biology approach to study the role of miRNA in promoter targeting during megakaryopoiesis. Exp. Cell Res., 366: 192-198.
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  11. Karnati, H.K., S.R. Pasupuleti, R. Kandi, R.B. Undi and I. Sahu et al., 2015. TLR-4 signalling pathway: MyD88 independent pathway up-regulation in chicken breeds upon LPS treatment. Vet. Res. Commun., 39: 73-78.
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  12. Kandi, R., U. Gutti, R. Undi, I. Sahu and R.K. Gutti, 2015. Understanding thrombocytopenia: Physiological role of microRNA in survival of neonatal megakaryocytes. J. Thrombosis Thrombolysis. 10.1007/s11239-015-1238-y.
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  13. Sahu, I., S. Mishra, R. Undi, R. Kandi, U. Gutti and R.K. Gutti, 2014. Sequence and structural difference favors a distinct preference of Wnt3a binding with co-receptor LRP6. J. Biomol. Struct. Dynam. 10.1080/07391102.2014.991352.
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  14. Karnati, H.K., R.S. Yalagala, R. Undi, S.R. Pasupuleti and R.K. Gutti, 2014. Therapeutic potential of siRNA and DNAzymes in cancer. Tumor Biol., 35: 9505-9521.
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  15. Kandi, R., U. Gutti, R.G.V. Saladi and R.K. Gutti, 2014. MiR-125b and miR-99a encoded on chromosome 21 co-regulate vincristine resistance in childhood acute megakaryoblastic leukemia. Hematol. Oncol. Stem Cell Therapy, 8: 95-97.
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  16. Kandi, R., R. Undi and R.K. Gutti, 2014. MiR-125b regulates cell proliferation and survival in neonatal megakaryocytes. Ann. Hematol., 93: 1065-1066.
  17. Ferrer‐Marin, F., R. Gutti, Z.J. Liu and M. Sola‐Visner, 2014. MiR‐9 contributes to the developmental differences in CXCR‐4 expression in human megakaryocytes. J. Thrombosis Haemost., 12: 282-285.
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  18. Undi, R.B., R. Kandi and R.K. Gutti, 2013. MicroRNAs as haematopoiesis regulators. Adv. Hematol. 10.1155/2013/695754.
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  19. Gutti, R.K., B. Chintapalli and D.S.V. Chitra, 2013. How biotechnology will change healthcare? Int. Res. J. Biotechnol., 4: 68-75.
  20. Undi, R., R. Kandi, P.R. Thummala and R.K. Gutti, 2012. Cord blood banking: Current developments and future regenerative transplant medicine. Int. J. Gen. Med. Pharm., 1: 36-52.
  21. Tsai-Morris, C.H., H. Sato, R. Gutti and M.L. Dufau, 2012. Role of gonadotropin regulated testicular RNA helicase (GRTH/Ddx25) on polysomal associated mRNAs in mouse testis. PloS One, Vol. 7. 10.1371/journal.pone.0032470.
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  22. Liu, Z.J., J. Italiano, F. Ferrer-Marin, R. Gutti and M. Bailey et al., 2011. Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood, 117: 4106-4117.
  23. Dufau, M.L., H. Sato, R. Gutti and C.H. Tsai-Morris, 2011. Gonadotropin-regulated testicular helicase (GRTH/DDX25): A master post-transcriptional regulator of spermatogenesis. Adv. Exp. Med. Biol., 707: 23-29.
    CrossRef  |  PubMed  |  Direct Link  |  
  24. Tsai‐Morris, C.H., Y. Sheng, R.K. Gutti, P.Z. Tang and M.L. Dufau, 2010. Gonadotropin‐regulated testicular RNA Helicase (GRTH/DDX25): A multifunctional protein essential for spermatogenesis. J. Androl., 31: 45-52.
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  25. Tsai‐Morris, C.H., Y. Sheng, R. Gutti, J. Li, J. Pickel and M.L. Dufau, 2010. Gonadotropin‐regulated testicular RNA helicase (GRTH/DDX25) gene: Cell‐specific expression and transcriptional regulation by androgen in transgenic mouse testis. J. Cell. Biochem., 109: 1142-1147.
    CrossRef  |  
  26. Sallmon, H., R. Gutti, Z.J. Liu and M.C. Sola-Visner, 2010. STATE of ART-Increasing platelets without transfusion-Is it time to introduce novel thrombopoietic agents into neonatal care? J. Perinatol., 30: 765-769.
  27. Ferrer-Marin, F., Z.J. Liu, R. Gutti and M. Sola-Visner, 2010. Neonatal thrombocytopenia and megakaryocytopoiesis. Seminars Hematol., 47: 281-288.
    PubMed  |  
  28. Gutti, R.K., C.H. Tsai-Morris and M.L. Dufau, 2008. Gonadotropin-regulated testicular helicase (DDX25), an essential regulator of spermatogenesis, prevents testicular germ cell apoptosis. J. Biol. Chem., 283: 17055-17064.
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  29. Tsai-Morris, C.H., E. Koh, Y. Sheng, Y. Maeda, R. Gutti, M. Namiki and M.L. Dufau, 2007. Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: A missense mutation associated with loss of GRTH phosphorylation. Mol. Hum. Reprod., 13: 887-892.
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  30. Sheng, Y., C.H. Tsai-Morris, R. Gutti, Y. Maeda and M.L. Dufau, 2006. Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis. J. Biol. Chem., 281: 35048-35056.
    CrossRef  |  Direct Link  |  
  31. Gutti, R.K. and R. Kumar, 2002. Bridging traditional medicines with modern biotechnology. Chem. Biochem. Mol. Biol., 15: 1-13.