Dr. Sreekanth Thota
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Dr. Sreekanth Thota

Postdoctoral Researcher
Oswaldo Cruz Foundation Fiocruz, Brazil

Highest Degree
Ph.D. in Pharmaceutical Chemistry from Jawaharlal Nehru Technological University, India

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Area of Interest:

Chemistry
100%
Medicinal Chemistry
62%
Synthetic Chemistry
90%
Pharmacy
75%
Anticancer Research
55%

Research Publications in Numbers

Books
3
Chapters
2
Articles
38
Abstracts
1

Selected Publications

  1. Rodrigues, D.A., P. de Sena M. Pinheiro, F.S. Sagrillo, M.C.R. Freitas and M.A. Alves et al., 2020. Structure-property relationship studies of 3-acyl-substituted furans: The serendipitous identification and characterization of a new non-classical hydrogen bond donor moiety. New J. Chem., 44: 10994-11005.
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  2. Rodrigues, D.A., F.S. Guerra, F.S. Sagrillo, P.S.M. Pinheiro and M.A. Alves et al., 2020. Design, synthesis, and pharmacological evaluation of first-in-class multitarget N-acylhydrazone derivatives as selective HDAC6/8 and PI3Kα inhibitors. ChemMedChem, 15: 539-551.
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  3. Thota, S., D.A. Rodrigues, P. de Sena Murteira Pinheiro, L.M. Lima, C.A.M. Fraga and E.J. Barreiro, 2018. N-Acylhydrazones as drugs. Bioorg. Med. Chem. Lett., 28: 2797-2806.
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  4. Thota, S., D.A. Rodrigues, D.C. Crans and E.J. Barreiro, 2018. Ru(II) Compounds: Next-generation anticancer metallotherapeutics? J. Med. Chem., 61: 5805-5821.
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  5. Thota, S. and D.C. Crans, 2018. Metal Nanoparticles: Synthesis and Applications in Pharmaceutical Sciences. Wiley-VCH Verlag GmbH & Co. KGaA, Germany, ISBN: 978-3-527-33979-2.
  6. Thota, S. and D.C. Crans, 2018. Introduction. In: Synthesis and Applications in Pharmaceutical Sciences, Thota, S. and D.C. Crans (Eds.)., Wiley-VCH Verlag GmbH & Co. KGaA, Germany, pp: 1-14.
  7. Thota, S. and C.M. Morel, 2018. Drug discovery for paediatric chagas disease. Mini-Rev. Med. Chem., 18: 776-780.
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  8. Rodrigues, D.A., P.D.S.M. Pinheiro, T.T.D.S.C. Ferreira, S. Thota and C.A.M. Fraga, 2018. Structural basis for the agonist action at free fatty acid receptor 1 (FFA1R or GPR40). Chem. Biol. Drug Design, 91: 668-680.
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  9. Kadasi, S., T.E.M.M. Costa, N. Arukala, M. Toshakani and C. Duggineti et al., 2018. Drug design, synthesis and in vitro evaluation of substituted benzofurans as Hsp90 inhibitors. Med. Chem., 14: 44-52.
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  10. Thota, S., S. Vallala, R. Yerra, D.A. Rodrigues, N.M. Raghavendra and E.J. Barreiro, 2016. Synthesis, Characterization, DNA binding, DNA cleavage, protein binding and cytotoxic Activities of novel Ru(II) complexes. Int. J. Biol. Macromol., 82: 663-670.
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  11. Thota, S., S. Vallala, R. Yerra, D.A. Rodrigues and E.J. Barreiro, 2016. Design, synthesis, structural characterization and in vitro cytotoxic activity of mononuclear Ru(II) complexes. Med. Chem. Res., 25: 2127-2132.
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  12. Thota, S., 2016. Overview of Chemical Drug Design. In: Chemical Drug Design, Gupta, G.K. and V. Kumar (Eds.)., De Gruyter, Berlin, Boston, pp: 1-14.
  13. Thota, S. and R. Yerra, 2016. Drug discovery and development of antimalarial agents: Recent advances. Curr. Protein Pept. Sci., 17: 275-279.
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  14. Rodrigues, D.A., S. Thota and C.A.M. Fraga, 2016. Beyond the selective inhibition of histone deacetylase 6. Mini Rev. Med. Chem., 16: 1175-1184.
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  15. Anchuri, S.S., K. Gangarapu, S. Thota, S.S. Karki and E. de Clercq et al., 2016. Synthesis and biological evaluation of novel mononuclear Ru(II) compounds as potential antiviral and cytotoxic agents. Biointerface Res. Applied Chem., 6: 1491-1496.
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  16. Thota, S., S. Vallala, S. Vudutha and R. Yerra, 2015. Ru(II) complexes as cytotoxic agents: Synthesis and structural characterization. World J. Pharm. Res., 4: 775-782.
  17. Thota, S., S. Vallala, R. Yerra and E.J. Barreiro, 2015. Design, Synthesis, Characterization, Cytotoxic and structure activity relationships of novel Ru(II) complexes. Chin. Chem. Lett., 26: 712-726.
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  18. Thota, S., K. Nadipelly, A. Shenkesi and R. Yerra, 2015. Design, synthesis, characterization, antioxidant and in vitro cytotoxic activities of novel coumarin thiazole derivatives. Med. Chem. Res., 24: 1162-1169.
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  19. Thota, S. and C.M. Morel, 2015. Recent advances in synthetic chemistry of diabetic research. Mini Rev. Med. Chem., 15: 1159-1163.
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  20. Anchuri, S. and S. Thota, 2015. Mononuclear Ruthenium (II) compounds as novel cytotoxic agents. Int. J. Pharm. Biol. Sci., 5: 138-144.
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  21. Thota, S., R. Yerra, S.S. Karki and S.S. Karki, 2014. Ruthenium Compounds as Antineoplastic Agents. Lambert Academic Publishing, Germany, ISBN: 9783845404042, Pages: 100.
  22. Sreekanth, T., N. Kavitha, A. Shyamsunder, Y. Rajeshwar, K.S. Somalingappa, J. Balzarini and E. de Clercq, 2014. Synthesis, characterization, in vitro cytotoxic and antioxidant activities of novel coumarin thiazolyl derivatives. Int. J. Pharm. Educ. Res., 1: 29-35.
  23. Rajeshwar, Y., T. Sreekanth, K. Narasimha and A. Shyamsunder, 2014. Free radical scavenging and antifungal activity of Asparagus racemosus root extract-An in vitro study. Int. J. Pharm. Educ. Res., 1: 57-60.
  24. Rajeshwar, Y., T. Sreekanth, A. Shyamsunder and B.T. Divya, 2014. Investigation of phytoconstituents, TLC profile and antimicrobial activity of methanol extract of Asparagus racemosus willd. roots. Int. J. Pharmacogn. Phytochem. Res., 6: 128-132.
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  25. Karki, S.S., T.K. Ravikumar, A. Khatiyar, S. Thota and S. Kumar et al., 2014. Synthesis, cytostatic and antiviral activity of some ruthenium (II) complexes. Turk. J. Pharm. Sci., 11: 163-174.
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  26. Gangarapu, K., S. Manda, A. Jallapally, S. Thota and S.S. Karki et al., 2014. Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents. Med. Chem. Res., 23: 1046-1056.
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  27. Thota, S., S. Vallala, M. Imran, S. Mekala and S.S. Anchuri et al., 2013. Synthesis, spectroscopic characterization, in vitro cytotoxic and structure activity relationships of some mononuclear Ru(II) complexes. J. Coordination Chem., 66: 1031-1045.
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  28. Anchuri, S.S., S. Thota, R.N. Bongoni, R. Yerra, R.N. Reddy and S. Dhulipala, 2013. Antimicrobial and antimalarial activity of novel synthetic mononuclear ruthenium(II) compounds. J. Chinese Chem. Soc., 60: 153-159.
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  29. Anchuri, S.S., S. Dhulipala, S. Thota, R. Yerra, J. Balzarini and E. Clercq, 2013. Antinociceptive and antitumor activity of novel synthetic mononuclear Ruthenium (II) compounds. J. Res. Med. Sci., 18: 215-221.
  30. Thota, S., S.S. Karki and Y. Rajeshwar, 2012. Ruthenium Complexes as Anticancer Agents. LAP Lambert Academic Publishing, Germany, ISBN: 978-3-65912485-3.
  31. Thota, S., S.S. Karki and R. Yerra, 2012. Ruthenium Complexes as Anticancer Agents. Lambert Academic Publishing, Germany, ISBN: 9783659124853, Pages: 164.
  32. Thota, S., M. Imran, M. Udugula, S.S. Karki and N. Kanjarla et al., 2012. Synthesis, spectroscopic characterization, antineoplastic, in vitro-cytotoxic and antibacterial activities of mononuclear ruthenium (II) complexes. J. Coordination Chem., 65: 823-839.
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  33. Thota, S., M. Imran, M. Udugula, R. Yerra, S.S. Karki, J. Balzarini and E. de Clercq, 2012. Synthesis, spectroscopic characterization and in vitro antitumor activities of some novel mononuclear Ru(II) complexes. Chinese Chem. Lett., 23: 466-469.
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  34. Sreekanth, T. and S.S. Karki, 2012. Synthesis, antimicrobial screening and beta lactamase inhibitory activity of 3-(3-chloro-4-fluorophenylimino) indolin-2-one and 5-chloro indolin-2-one derivatives. Turk. J. Pharm. Sci., 9: 353-358.
  35. Gangarapu, K., S. Manda, S. Thota, R. Yerra and S. Karki et al., 2012. Microwave assisted synthesis, characterization of some new isatin and thiophene derivatives as cytotoxic and chemopreventive agents. Lett. Drug Design Discov., 9: 934-941.
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  36. Anchuri, S.S., S. Thota, R. Yerra and S. Dhulipala, 2012. In vitro antioxidant activity of some novel synthetic mononuclear ruthenium (II) compounds. Lett. Drug Design Discov., 9: 421-425.
  37. Anchuri, S.S., S. Dhulipala, S. Thota, R. Yerra and K.P. Devarakonda, 2012. Novel mononuclear ruthenium(II) compounds in cancer therapy. Asian Pac. J. Cancer Prev., 13: 3293-3298.
  38. Karki, S.S., S. Thota, A. Katiyar, K.N. Jayaveera, E. de Clercq and J. Balzarini, 2011. Synthesis, characterization and cytotoxic activity of some Ru(II) complexes. Turk. J. Pharm. Sci., 8: 207-218.
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  39. Thota, S., S.S. Karki, K.N. Jayaveera, J. Balzarini and E. De Clercq, 2010. Synthesis, characterization antitumor and cytotoxic activities of mononuclear Ru(II) complexes. J. Coordination Chem., 63: 4332-4346.
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  40. Thota, S., S.S. Karki, K.N. Jayaveera, J. Balzarini and E. De Clercq, 2010. Synthesis, antineoplastic and cytotoxic activities of some mononuclear Ru(II) complexes. J. Enzyme Inhib. Med. Chem., 25: 513-519.
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  41. Sreekanth, T., S.S. Karki, K.N. Jayaveera, J. Balzarini and C. Ede, 2010. Synthesis and cytotoxic activities of some mononuclear Ru(II) complexes. Res. J. Pharm. Biol. Chem. Sci., 1: 704-713.
  42. Sreekanth, T., S.S. Karki and B. Baburao, 2009. Synthesis, characterization and antibacterial activity of some novel mononuclear Ru(II) complexes. Int. J. Pharm. Pharm. Sci., 1: 62-70.
  43. Rao, B.B., T. Sreekanth, G. Kiran, P. Rajaabhilash, A. Shyamsunder, P. Ravi and Y. Rajeshwar, 2009. Preliminary studies on antiinflammatory and analgesic activities of baliospermum montanum. Pharmacology, 1: 366-372.
  44. Karki, S.S., S. Thota, S.Y. Darj, J. Balzarini and E. De Clercq, 2007. Synthesis, anticancer and cytotoxic activities of some mononuclear Ru(II)compounds. Bioorganic Med. Chem., 15: 6632-6641.
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