Dr. Sanghapal D. Sawant
My Social Links

Dr. Sanghapal D. Sawant

Senior Principal Scientist
CSIR-Indian Institute of Integrative Medicine, India

Highest Degree
Ph.D. in Organic Synthesis and Medicinal Chemistry from CSIR-Indian Institute of Integrative Medicines, Jammu, India

Share this Profile

Biography

Sanghapal D. Sawant is currently working as a Senior Principal Scientist at CSIR-IIIM, Jammu and he is designated as Professor of AcSIR, Dr. Sawant obtained his Ph.D. jointly from the CSIR-Indian Institute of Integrative Medicine, Jammu, and SRTM University, Nanded. He has a wide experience of about 17 years and expertise in synthetic organic chemistry and medicinal chemistry.

Area of Interest:

Chemistry
100%
Medicinal Chemistry
62%
Organic Chemistry
90%
Drug Discovery
75%
Asymmetric Synthesis
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
29
Abstracts
0

Selected Publications

  1. Verma, P.K. and S.D. Sawant, 2022. Unravelling reaction selectivities via bio-inspired porphyrinoid tetradentate frameworks. Coord. Chem. Rev., Vol. 450. 10.1016/j.ccr.2021.214239.
    CrossRef  |  Direct Link  |  
  2. Sharma, A., H. Kour, J. Kour, Kamal and S.D. Sawant, 2022. Visible-light-promoted iron-catalyzed C-H functionalization of 1,4-naphthoquinones via oxidative coupling with sulfoximines. Chem. Commun., 58: 11312-11315.
    CrossRef  |  Direct Link  |  
  3. Mahajan, S. and S.D. Sawant, 2022. Iodine/TBHP-mediated one-pot multicomponent protocol for tandem C-N and C-S bond formation to access sulfenylimidazo[1,5-a]pyridines via C-H functionalization. J. Org. Chem., 87: 11387-11398.
    CrossRef  |  Direct Link  |  
  4. Kour, J., P. Khajuria, P.K. Verma, N. Kapoor, A. Kumar and S.D. Sawant, 2022. Selective synthesis of bis-heterocycles via mono- and di-selenylation of pyrazoles and other heteroarenes. ACS Omega, 7: 13000-13009.
    CrossRef  |  Direct Link  |  
  5. Kour, J., P. Khajuria, A. Sharma and S.D. Sawant, 2022. TBAX/oxone-mediated halogenation of pyrazoles and other heterocycles: An entry to important cross-coupling reactions. Chem. Asian J., 10.1002/asia.202200778.
    CrossRef  |  Direct Link  |  
  6. Khan, S.U., A.S. Pathania, A. Wani, K. Fatima and M.J. Mintoo, 2022. Activation of lysosomal mediated cell death in the course of autophagy by mTORC1 inhibitor. Sci. Rep., Vol. 12. 10.1038/s41598-022-07955-1.
    CrossRef  |  Direct Link  |  
  7. Behera, C., J. Kour, N. Banjare, P.K. Verma, G. Chashoo, S.D. Sawant and P.N. Gupta, 2022. Mechanistic investigation of synergistic interaction of tocopherol succinate with a quinoline-based inhibitor of mammalian target of rapamycin. J. Pharm. Pharmacol., 74: 605-617.
    CrossRef  |  Direct Link  |  
  8. Bag, D. and S.D. Sawant, 2022. Gold(I)-catalyzed cycloisomerization–indole addition cascade: Synthesis of 3(2H)-furanone-incorporated unsymmetrical 3,3′- bis(indolyl)methanes. Org. Lett., 24: 4930-4934.
    CrossRef  |  Direct Link  |  
  9. Kour, J., V. Venkateswarlu, P.K. Verma, Y. Hussain and G. Dubey et al., 2020. Oxone-DMSO triggered methylene insertion and C(sp2)-C(sp3)-H-C(sp2) bond formation to access functional bis-heterocycles. J. Org. Chem., 85: 4951-4962.
    CrossRef  |  Direct Link  |  
  10. Balgotra, S., P.K. Verma, R.A. Vishwakarma and S.D. Sawant, 2020. Catalytic advances in direct functionalizations using arylated hydrazines as the building blocks. Catal. Rev., 62: 406-479.
    CrossRef  |  Direct Link  |  
  11. Bag, D., S. Mahajan and S.D. Sawant, 2020. Transition-metal-catalyzed carbohalogenative 1,2-difunctionalization of c-c multiple bonds. Adv. Synth. Catal., 362: 3948-3970.
    CrossRef  |  Direct Link  |  
  12. Bag, D., P.K. Verma and S.D. Sawant, 2020. Chiral transient directing group strategies in asymmetric synthesis. Chem. Asian J., 15: 3225-3238.
    CrossRef  |  Direct Link  |  
  13. Bag, D., H. Kour and S.D. Sawant, 2020. Photo-induced 1,2-carbohalofunctionalization of C–C multiple bonds via ATRA pathway. Org. Biomol. Chem., 18: 8278-8293.
    CrossRef  |  Direct Link  |  
  14. Verma, P.K., R.A. Vishwakarma and S.D. Sawant, 2019. Reaction medium as the installing reservoir for key functionalities in the molecules. Asian J. Org. Chem., 8: 777-801.
    CrossRef  |  Direct Link  |  
  15. Hudwekar, A.D., P.K. Verma, J. Kour, S. Balgotra and S.D. Sawant, 2019. Transition metal-free oxidative coupling of primary amines in polyethylene glycol at room temperature: Synthesis of imines, azobenzenes, benzothiazoles, and disulfides. Eur. J. Org. Chem., 2019: 1242-1250.
    CrossRef  |  Direct Link  |  
  16. Dar, M.I., S. Jan, G.L. Reddy, R. Wani and M. Syed et al., 2019. Differentiation of human neuroblastoma cell line IMR-32 by sildenafil and its newly discovered analogue IS00384. Cell. Signalling, Vol. 65. 10.1016/j.cellsig.2019.109425.
    CrossRef  |  Direct Link  |  
  17. Venkateswarlu, V., J. Kour, K.A.A. Kumar, P.K. Verma and G.L. Reddy et al., 2018. Direct N-heterocyclization of hydrazines to access styrylated pyrazoles: Synthesis of 1,3,5-trisubstituted pyrazoles and dihydropyrazoles. RSC Adv., 8: 26523-26527.
    CrossRef  |  Direct Link  |  
  18. Srinivas, M., A.S. Pathania, P. Mahajan, P.K. Verma and S.S. Chobe et al., 2018. Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity. Bioorg. Med. Chem. Lett., 28: 1005-1010.
    CrossRef  |  Direct Link  |  
  19. Balgotra, S., P.K. Verma, J. Kour, S. Gupta, R.A. Vishwakarma and S.D. Sawant, 2018. A novel approach to access aryl iodides and disulfides via dehydrazination of arylhydrazines and arylsulfonylhydrazides. ChemistrySelect, 3: 2800-2804.
    CrossRef  |  Direct Link  |  
  20. Saneja, A., D. Nayak, M. Srinivas, A. Kumar and V. Khare et al., 2017. Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells. Eur. J. Pharmaceut. Sci., 97: 79-91.
    CrossRef  |  Direct Link  |  
  21. Hudwekar, A.D., G.L. Reddy, P.K. Verma, S. Gupta, R.A. Vishwakarma and S.D. Sawant, 2017. Transition metal-free single step approach for arylated pyrazolopyrimidinones and quinazolinones using benzylamines/benzylalcohols/benzaldehydes. ChemistrySelect, 2: 4963-4968.
    CrossRef  |  Direct Link  |  
  22. Venkateswarlu, V., S. Balgotra, K.A. Kumar, R.A. Vishwakarma and S.D. Sawant, 2015. Metal-free chemoselective ortho-C (sp2)-F bond hydroxylation and N-trifluoroacylation of fluoroarylamines for domino synthesis of 2-(N-Trifluoroacyl) aminophenols. Synlett, 26: 1258-1262.
  23. Venkateswarlu, V., K.A. Kumar, S. Gupta, D. Singh, R.A. Vishwakarma and S.D. Sawant, 2015. DMSO/I2 mediated C-C bond cleavage of α-ketoaldehydes followed by C-O bond formation: A metal-free approach for one-pot esterification. Org. Biomol. Chem., 13: 7973-7978.
    Direct Link  |  
  24. Venkateswarlu, V., A.S. Pathania, K.A. Kumar, P. Mahajan and A. Nargotra et al., 2015. 4-(N-Phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl) quinolines as inhibitors of mammalian target of rapamycin. Bioorg. Med. Chem., 23: 4237-4247.
    Direct Link  |  
  25. Sawant, S.D., G.L. Reddy, M.I. Dar, M. Srinivas and G. Gupta et al., 2015. Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5. Bioorg. Med. Chem., 23: 2121-2128.
    CrossRef  |  Direct Link  |  
  26. Raghupathy, R., A.A. Anilkumar, A. Polley, P.P. Singh and M. Yadav et al., 2015. Transbilayer lipid interactions mediate nanoclustering of lipid-anchored proteins. Cell, 161: 581-594.
    Direct Link  |  
  27. Munagala, G., K.R. Yempalla, S. Singh, S. Sharma and N.P. Kalia et al., 2015. Synthesis of new generation triazolyl-and isoxazolyl-containing 6-nitro-2, 3-dihydroimidazooxazoles as anti-TB agents: In vitro, structure-activity relationship, pharmacokinetics and in vivo evaluation. Org. Biomol. Chemistry, 13: 3610-3624.
    Direct Link  |  
  28. Kumar, S., S.K. Guru, V. Venkateswarlu, F.A. Malik, R. Vishwakarma, D.S. Sawant and S. Bhushan, 2015. A novel quinoline based second-generation mTOR inhibitor that induces apoptosis and disrupts PI3K-Akt-mTOR signaling in human Leukemia HL-60 cells. Anti-Cancer Agents Med. Chem., 15: 1297-1304.
    Direct Link  |  
  29. Kumar, K.A., V. Venkateswarlu, R.A. Vishwakarma and S.D. Sawant, 2015. A metal-free approach to carboxylic acids by oxidation of Alkyl, Aryl, or Heteroaryl Alkyl ketones or arylalkynes. Synthesis, 47: 3161-3168.
  30. Gul, T., H.M. Balkhi, G.L. Reddy, S.D. Sawant, A. Hamid and E. Haq, 2015. Effect of combination of Suberoylanilide hydroxamic acid and O2', O3', O5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine on various obesity related markers in 3T3-L1 pre-adipocytic cell line. Int. J. Biol. Pharmaceut. Res., 6: 831-838.
    Direct Link  |  
  31. Balgotra, S., V. Venkateswarlu, R.A. Vishwakarma and S.D. Sawant, 2015. Direct C-N bond cleavage of N-vinyl or N-allyl arylamines: A metal-free strategy for N-devinylation and N-deallylation. Tetrahedron Lett., 56: 4289-4292.
    CrossRef  |  Direct Link  |  
  32. 6. Srinivas, M., A.D. Hudwekar, V. Venkateswarlu, G.L. Reddy, K.A. Kumar, R.A. Vishwakarma and S.D. Sawant, 2015. A metal-free approach for transamidation of amides with amines in aqueous media. Tetrahedron Lett., 56: 4775-4779.
    CrossRef  |  Direct Link  |  
  33. Yadav, M., R. Raghupathy, V. Saikam, S. Dara and P.P. Singh et al., 2014. Synthesis of non-hydrolysable mimics of glycosylphosphatidylinositol (GPI) anchors. Org. Biomol. Chem., 12: 1163-1179.
    Direct Link  |  
  34. Venkateswarlu, V., K.A. Kumar, S. Balgotra, G.L. Reddy, M. Srinivas, R.A. Vishwakarma and S.D. Sawant, 2014. C-H Oxygenation and N‐trifluoroacylation of arylamines under metal‐free conditions: A convenient approach to 2‐aminophenols and N‐trifluoroacyl‐ortho‐aminophenols. Chem.: A Eur. J., 20: 664-6645.
  35. Sawant, S.D., A.D. Hudwekar, K.A.A Kumar, V. Venkateswarlu, P.P. Singh and R.A. Vishwakarma, 2014. Ligand- and base-free synthesis of phenols by rapid oxidation of arylboronic acids using iron(III) oxide. Tetrahedron Lett., 55: 811-814.
  36. Reddy, G.L., S.K. Guru, M. Srinivas, A.S. Pathania and P. Mahajan et al., 2014. Synthesis of 5-substituted-1H-pyrazolo [4, 3-d] pyrimidin-7 (6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors. Eur. J. Med. Chem., 80: 201-208.
    CrossRef  |  Direct Link  |  
  37. Sawant, S.D., M. Srinivas, K.A. Kumar, G.L. Reddy and P.P. Singh et al., 2013. Ligand-free C-N bond formation in aqueous medium using a reusable Cu-Mn bimetallic catalyst. Tetrahedron Lett., 54: 5351-5354.
    Direct Link  |  
  38. Khazir, J., P.P. Singh, D.M. Reddy, I. Hyder and S. Shafi et al., 2013. Synthesis and anticancer activity of novel spiro-isoxazoline and spiro-isoxazolidine derivatives of α-santonin. Eur. J. Med. Chem., 63: 279-289.
    Direct Link  |  
  39. Bharate, S.B., S.D. Sawant, P.P. Singh and R.A. Vishwakarma, 2013. Kinase inhibitors from marine origin. Chem. Rev., 113: 6761-6815.
  40. Singh, P.P., T. Thatikonda, K.A. Kumar, S.D. Sawant and B. Singh et al., 2012. Cu-Mn spinel oxide catalyzed regioselective halogenation of phenols and N-Heteroarenes. J. Org. Chem., 77: 5823-5828.
    Direct Link  |  
  41. Singh, P.P., S. Gudup, H. Aruri, U. Singh and S. Ambala et al., 2012. New method for C-H arylation/alkylation at α-position of cyclic aliphatic ethers by iron-oxide mediated reaction. Org. Biomol. Chem., 10: 1587-1597.
    Direct Link  |  
  42. Sawant, S.D., M. Srinivas, G.L. Reddy, V.V. Rao, P.P. Singh and R.A. Vishwakarma, 2012. One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives. Tetrahedron Lett., 53: 6195-6198.
    Direct Link  |  
  43. Singh, P.P., S. Gudup, S. Ambala, U. Singh and S. Dadhwal et al., 2011. Iron oxide mediated direct C-H arylation/alkylation at α-position of cyclic aliphatic ethers. Chem. Commun., 47: 5852-5854.
  44. Saikam, V., R. Raghupathy, M. Yadav, V. Gannedi and P.P. Singh et al., 2011. Synthesis of new fluorescently labeled glycosylphosphatidylinositol (GPI) anchors. Tetrahedron Lett., 52: 4277-4279.
    Direct Link  |  
  45. Reddy, D.M., N.A. Qazi, S.D. Sawant, A.H. Bandey and J. Srinivas et al., 2011. Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents. Eur. J. Med. Chem., 46: 3210-3217.
    Direct Link  |  
  46. Sawant, S.D., P.P. Singh, N.A. Qazi and H.S. Kumar, 2007. Addition of allylindium bromide to nitrile oxides in aqueous media: Convenient synthesis of 5-methylisoxazolines. Chem. Lett., 36: 296-297.
    Direct Link  |  
  47. Singh, P.P., P.B. Reddy, S.D. Sawant, S. Koul, S.C. Taneja and H.S. Kumar, 2006. Domino synthesis of indenols and alkyl-indene ethers under modified Vilsmeier conditions. Tetrahedron Lett., 47: 7241-7243.
    CrossRef  |  Direct Link  |  
  48. Reddy, P.B., P.P. Singh, S.D. Sawant, S. Koul, S.C. Taneja and H.M.S. Kumar, 2006. Microwave promoted novel synthesis of indenols catalyzed by SiO2 in dry media. Arkivoc, 13: 142-146.
    Direct Link  |  
  49. Kumar, H.M.S., P. Chakravarthy, S.D. Sawant, P.P. Singh, M. Shesha Rao and J.S. Yadav, 2005. Catalytic transfer hydrogenation reactions of PEG-bound succinyl esters. Tetrahedron Lett., 46: 3591-3593.
    CrossRef  |  Direct Link  |