Dr. Shadab Md.
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Dr. Shadab Md.

Associate Professor
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Saudi Arabia

Highest Degree
Ph.D. in Pharmaceutics from Hamdard University, New Delhi, India

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Area of Interest:

Biomedical Sciences
100%
Pharmaceutics
62%
Drug Delivery System
90%
Drug Bioavailability
75%
Nanotechnology
55%

Research Publications in Numbers

Books
2
Chapters
0
Articles
82
Abstracts
0

Selected Publications

  1. Yap, K., S. Gan, M. Candasamy, M. Shadab, A.A. Majeed and S. Bhattamisra, 2019. Effect of catalpol on liver glucose homeostasis in high fat diet/low dose streptozotocin-induced type 2 diabetes mellitus. Br. J. Pharmacol., 176: 3051-3052.
  2. Tzeyung, A.S., M. Shadab, S.K. Bhattamisra, T. Madheswaran, N.A. Alhakamy, H.M. Aldawsari and A.K. Radhakrishnan, 2019. Fabrication, optimization and evaluation of rotigotine-loaded chitosan nanoparticles for nose-to-brain delivery. Pharmaceutics, Vol. 11, No. 1. 10.3390/pharmaceutics11010026.
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  3. Shadab, M., N.A. Alhakamy, H.M. Aldawsari and H.Z. Asfour, 2019. Neuroprotective and antioxidant effect of naringenin-loaded nanoparticles for nose-to-brain delivery. Brain Sci., Vol. 9, No. 10. 10.3390/brainsci9100275.
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  4. Shadab, M., J.K.A.P.K. Singh, M. Waqas, M. Pandey and H. Choudhury et al., 2019. Nanoencapsulation of betamethasone valerate using high pressure homogenization-solvent evaporation technique: Optimization of formulation and process parameters for efficient dermal targeting. Drug Dev. Ind. Pharm., 45: 323-332.
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  5. Shadab, M., 2019. Introduction: An Overview of the Anatomy and Physiology of the Lung. In: Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer, Kesharwani, P. (Ed.)., 1st Edn., Elsevier Inc., USA., ISBN: 9780128157206..
  6. Pandey, M., H. Choudhury, T.A. Gunasegaran, S.S. Nathan and M. Shadab et al., 2019. Hyaluronic acid-modified betamethasone encapsulated polymeric nanoparticles: Fabrication, characterisation, in vitro release kinetics and dermal targeting. Drug Deliv. Transl. Res., 9: 520-533.
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  7. Nassir, A.M., I.A. Ibrahim, M. Shadab, M. Waris, M.R. Ain, I. Ahmad and N. Shahzad, 2019. Surface functionalized folate targeted oleuropein nano-liposomes for prostate tumor targeting: In vitro and in vivo activity. Life Sci., 220: 136-146.
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  8. Choudhury, H., N.F.B. Zakaria, P.A.B. Tilang, A.S. Tzeyung and M. Pandey et al., 2019. Formulation development and evaluation of rotigotine mucoadhesive nanoemulsion for intranasal delivery. J. Drug Delivery Sci. Technol., Vol. 54. 10.1016/j.jddst.2019.101301.
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  9. Choudhury, H., M. Pandey, T.H. Yin, T. Kaur and G.W. Jia et al., 2019. Rising horizon in circumventing multidrug resistance in chemotherapy with nanotechnology. Mater. Sci. Eng.: C, 101: 596-613.
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  10. Choudhury, H., M. Pandey, B. Gorain, B. Chatterjee and T. Madheswaran et al., 2019. Nanoemulsions as Effective Carriers for the Treatment of Lung Cancer. In: Nanotechnology-Based Targeted Drug Delivery Systems for Lung Cancer, Kesharwani, P. (Ed.)., 1st Edn., Elsevier Inc., USA., ISBN: 9780128157206..
  11. Aldawsari, H., B. Gorain, N. Alhakamy and M. Shadab, 2019. Role of therapeutic agents on repolarisation of tumour-associated macrophage to halt lung cancer progression. J. Drug Target., (In Press). 10.1080/1061186X.2019.1648478.
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  12. Shadab, M., S.Y. Gan, Y.H. Haw, H.C. Liang, W. Sinrun and H. Choudhury, 2018. In vitro neuroprotective effects of naringenin nanoemulsion against β-amyloid toxicity through the regulation of amyloidogenesis and tau phosphorylation. Int. J. Biol. Macromol., 118: 1211-1219.
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  13. Shadab, M., B.C.M. Kit, S. Jagdish, D.J.P. David, M. Pandey and L.A. Chatterjee, 2018. Development and in vitro evaluation of a zerumbone loaded nanosuspension drug delivery system. Crystals, Vol. 8, No. 7. 10.3390/cryst8070286.
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  14. Nassir, A.M., N. Shahzad, I.A. Ibrahim, I. Ahmad, M. Shadab and M.R. Ain, 2018. Resveratrol-loaded PLGA nanoparticles mediated programmed cell death in prostate cancer cells. Saudi Pharm. J., 26: 876-885.
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  15. Haque, S., M. Shadab, M. Whittaker and L.M. Kaminskas, 2018. The applications of 3d printing in pulmonary drug delivery and treatment of respiratory disorders. Curr. Pharm. Des., 24: 5072-5080.
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  16. Shahzad, N., W. Khan, M.D. Shadab, A. Ali and S.S. Saluja et al., 2017. Phytosterols as a natural anticancer agent: Current status and future perspective. Biomed. Pharmacother., 88: 786-794.
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  17. Shadab, M., S.K. Bhattmisra, F. Zeeshan, N. Shahzad and M. Ali et al., 2017. Nano-carrier enabled drug delivery systems for nose to brain targeting for the treatment of neurodegenerative disorders. J. Drug Delivery Sci. Technol., 43: 295-310.
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  18. Shadab, M., S. Haque, T. Madheswaran, F. Zeeshan, V.S. Meka, A.K. Radhakrishnan and P. Kesharwani, 2017. Lipid based nanocarriers system for topical delivery of photosensitizers. Drug Discov. Today, 22: 1274-1283.
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  19. Shadab, M., S. Haque, R. Sheshala, L.W. Meng, V.S. Meka and J. Ali, 2017. Recent advances in non-invasive delivery of macromolecules using nanoparticulate carriers system. Curr. Pharm. Design, 23: 440-453.
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  20. Gaba, B., S. Kumar, M. Shadab, S. Baboota, J.K. Narang and J. Ali, 2017. Natural Neuroprotectives for the Management of Parkinson’s Disease. In: Natural Products: Clinical Aspects and Mode of Action, Brahmachari, G. (Ed.)., 1st Edn., Wiley, New York .
  21. Qidwai, A., S. Khan, M. Shadab, M. Fazil, S. Baboota, J.K. Narang and J. Ali, 2016. Nanostructured lipid carrier in photodynamic therapy for the treatment of basal-cell carcinoma. Drug Delivery, 23: 1476-1485.
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  22. Qian, Y.S., S. Ramamurthy, M. Candasamy, M. Shadab, H.R. Kumar and V.S. Meka, 2016. Production, characterization and evaluation of kaempferol nanosuspension for improving oral bioavailability. Curr. Pharm. Biotechnol., 17: 549-555.
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  23. Mittal, D., M. Shadab, Q. Hasan, M. Fazil, A. Ali, S. Baboota and J. Ali, 2016. Brain targeted nanoparticulate drug delivery system of rasagiline via intranasal route. Drug Delivery, 23: 130-139.
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  24. Shadab, M., G. Mustafa, S. Baboota and J. Ali, 2015. Nanoneurotherapeutics approach intended for direct nose to brain delivery. Drug Dev. Ind. Pharm., 41: 1922-1934.
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  25. Jafarieh, O., M. Shadab, M. Ali, S. Baboota and J.K. Sahni et al., 2015. Design, characterization and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting. Drug Dev. Ind. Pharm., 41: 1674-1681.
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  26. Shadab, M., S. Haque, M. Fazil, M. Kumar, S. Baboota, J.K. Sahni and J. Ali, 2014. Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: Biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method. Expert Opin. Drug Delivery, 11: 827-842.
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  27. Mittal, D., A. Ali, S. Md, S. Baboota, J.K. Sahni and J. Ali, 2014. Insights into direct nose to brain delivery: Current status and future perspective. Drug Delivery, 21: 75-86.
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  28. Iqbal, M.A., M. Shadab, G. Mustafa, M. Kumar, S. Baboota, J.K. Sahni and J. Ali, 2014. Formulation, optimization and evaluation of nanostructured lipid carrier system of acyclovir for topical delivery. J. Bionanosci., 8: 235-247.
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  29. Haque, S., M. Shadab, J.K. Sahni, J. Ali and S. Baboota, 2014. Development and evaluation of brain targeted intranasal alginate nanoparticles for treatment of depression. J. Psychiatric Res., 48: 1-12.
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  30. Bhavna, M. Shadab, M. Ali, S. Baboota, J.K. Sahni, A. Bhatnagar and J. Ali, 2014. Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting. Drug Dev. Ind. Pharm., 40: 278-287.
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  31. Bhavna, M. Shadab, M. Ali, R. Ali, A. Bhatnagar, S. Baboota and J. Ali, 2014. Donepezil nanosuspension intended for nose to brain targeting: In vitro and in vivo safety evaluation. Int. J. Biol. Macromolecules, 67: 418-425.
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  32. Bhavna, M. Shadab, M. Ali, A. Bhatnagar, S. Baboota, J.K. Sahni and J. Ali, 2014. Design, development, optimization and characterization of donepezil loaded chitosan nanoparticles for brain targeting to treat Alzheimer's disease. Sci. Adv. Mater., 6: 720-735.
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  33. Shadab, M., R.A. Khan, G. Mustafa, K. Chuttani, S. Baboota, J.K. Sahni and J. Ali, 2013. Bromocriptine loaded chitosan nanoparticles intended for direct nose to brain delivery: Pharmacodynamic, pharmacokinetic and scintigraphy study in mice model. Eur. J. Pharm. Sci., 48: 393-405.
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  34. Mustafa, G., A. Ahuja, J. Ali, M. Shadab and N. Kumar et al., 2013. Nose to brain targeting potential of a chitosan coated nano-formulation: Pharmacodynamic and pharmacoscintigraphic evaluation. Sci. Adv. Mater., 5: 1236-1249.
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  35. Shadabul Haque, M. Shadab, M.I. Alam, J.K. Sahni, J. Ali and S. Baboota, 2012. Nanostructure-based drug delivery systems for brain targeting. Drug Dev. Ind. Pharm., 38: 387-411.
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  36. Shadab, M.D., M. Kumar, S. Baboota, J.K. Sahni and J. Ali, 2012. Preparation, characterization and evaluation of bromocriptine loaded chitosan nanoparticles for intranasal delivery. Sci. Adv. Mater., 4: 949-960.
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  37. Shadab, M., G.K. Singh, A. Ahuja, R.K. Khar, S. Baboota, J.K. Sahni and J. Ali, 2012. Mucoadhesive microspheres as a controlled drug delivery system for gastroretention. Syst. Rev. Pharm., 3: 4-14.
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  38. Iqbal, M.A., M. Shadab, J.K. Sahni, S. Baboota, S. Dang and J. Ali, 2012. Nanostructured lipid carriers system: Recent advances in drug delivery. J. Drug Target., 20: 813-830.
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  39. Haque, S., M. Shadab, M. Fazil, M. Kumar, J.K. Sahni, J. Ali and S. Baboota, 2012. Venlafaxine loaded chitosan NPs for brain targeting: Pharmacokinetic and pharmacodynamic evaluation. Carbohydrate Polymers, 89: 72-79.
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  40. Fazil, M., M. Shadab, S. Haque, M. Kumar, S. Baboota, J.K. Sahni and J. Ali, 2012. Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting. Eur. J. Pharm. Sci., 47: 6-15.
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  41. Fazil, M., M. Shadab, S. Baboota, J.K. Sahni and J. Ali, 2012. Nanotherapeutics for Alzheimer’s disease (AD): Past, present and future. J. Drug Target., 20: 97-113.
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  42. Ali, J., M. Shadab, S. Baboota and J.K. Sahni, 2012. Polymeric Nanoparticles, Magnetic Nanoparticles and Quantum Dots-Current and Future Perspectives. In: Patenting Nanomedicine, Souto, E.B. (Ed.)., Springer, Berlin, Heidelberg, ISBN: 978-3-642-29265-1, pp: 99-149.
  43. Shadabul Haque, M. Shadab, M.I. Alam, J.K. Sahni, J. Ali and S. Baboota, 2011. Nanomedicines for brain targeting: A patent review. Recent Patents Nanomed., 1: 149-161.
  44. Shadab, S., Shadabul Haque, J.K. Sahni, S. Baboota and J. Ali, 2011. New non-oral drug delivery systems for Parkinson's disease treatment. Expert Opin. Drug Deliv., 8: 359-374.
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  45. Shadab, M., A. Ahuja, R.K. Khar, S. Baboota, K. Chuttani, A.K. Mishra and J. Ali, 2011. Gastroretentive drug delivery system of acyclovir-loaded alginate mucoadhesive microspheres: Formulation and evaluation. Drug Deliv., 18: 255-264.
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  46. Shadab, M., A. Ahuja, R.K. Khar, S. Baboota, J. Ali, K. Chuttani and A.K. Mishra, 2011. Acyclovir-loaded chitosan microspheres for gastroretention: Development and evaluation. J. Dispersion Sci. Technol., 32: 1318-1324.
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  47. Iqbal, B., A. Ali, J. Ali, S. Baboota and S. Gupta et al., 2011. Recent advances and patents in solid dispersion technology. Recent Patents Drug Deliv. Formulation, 5: 244-264.
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