Biography

I received my Ph.D. from Department of Zoology (Biochemistry and Molecular biology Lab), BHU, Varanasi in 2004 where I explored the mechanisms of differential gene regulation by Androgen Receptor promoter during aging in the mouse brain cortex under Prof. M.K. Thakur. Having gained experience in Molecular Neurobiology, I joined as a postdoc under Prof. V. Ravindranath at NBRC, Manesar where I studied the role of Estrogens as neuroprotectors for Parkinson’s and Alzheimer’s disease.

Thereafter, I joined as a postdoc under Prof. Pierre Chambon/Prof. Daniel Metzger at IGBMC, Strasbourg, France to work on the role of nuclear receptors in Prostate Cancer and to develop and validate mouse models that mimic the kinetics of human prostate cancer progression. Subsequently, I moved to A*STAR IMCB, as a research fellow to investigate the role of Cdks in Meiosis and epigenetic modifiers in Head and Neck and Gastric cancer and had profiled patient tumors for pre-clinical testing of chemotherapeutic agents using PDX. Thereafter I joined as an Associate Professor at YRC in 2018 to continue working on Epigenetics and Cancer Biology.

Area of Interest:

Biochemistry and Molecular Biology

100%

Research Publications in Numbers

Books
0

Chapters
1

Articles
14

Abstracts
0

Selected Publications

Krishnan, S., S. Kanthaje, D.R. Punchappady, M. Mujeeburahiman and C.K. Ratnacaram, 2022. Circulating metabolite biomarkers: A game changer in the human prostate cancer diagnosis. J. Cancer Res. Clin. Oncol., 10.1007/s00432-022-04113-y.
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Johnson, R.P., C.K. Ratnacaram, L. Kumar and J. Jose, 2022. Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer. Drug Resistance Updates, 10.1016/j.drup.2022.100865.
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Kanthaje, S., N. Baikunje, I. Kandal and C.K. Ratnacaram, 2021. Repertoires of MicroRNA-30 family as gate-keepers in lung cancer. Front. Biosci. (Schol Ed), 13: 141-156.
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Palmer, N., S.Z.A. Talib, C.K. Ratnacaram, D. Low and X. Bisteau et al., 2019. CDK2 regulates the NRF1/Ehmt1 axis during meiotic prophase I. J. Cell Biol., 218: 2896-2918.
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Chauhan, S., M.K. Diril, J.H.S. Lee, X. Bisteau and V. Manoharan et al., 2016. CDK2 catalytic activity is essential for meiotic cell division in vivo. Biochem. J., 473: 2783-2798.
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Dewaele, M., T. Tabaglio, K. Willekens, M. Bezzi and S.X. Teo et al., 2015. Antisense oligonucleotideu2013mediated MDM4 exon 6 skipping impairs tumor growth. J. Clin. Invest., 126: 68-84.
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Diril, M.K., C.K. Ratnacaram, V.C. Padmakumar, T. Du and M. Wasser et al., 2012. Cyclin-dependent kinase 1 (CDK1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration. Proc. Nat. Acad. Sci., 109: 3826-3831.
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Gopinathan, L., C.K. Ratnacaram and P. Kaldis, 2011. Established and novel cdk/cyclin complexes regulating the cell cycle and development. In: Cell Cycle in Development. Results and Problems in Cell Differentiation, Kubiak, J., Springer Berlin Heidelberg Germany, ISBN-978-3-642-19064-3, pp: 365-389.
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Saeed, U., S. Karunakaran, D.P. Meka, R.C. Koumar and S. Ramakrishnan et al., 2009. Redox activated MAP kinase death signaling cascade initiated by ASK1 is not activated in female mice following MPTP: novel mechanism of neuroprotection. Neurotoxic. Res., 16: 116-126.
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Ratnacaram, C.K., M. Teletin, M. Jiang, X. Meng, P. Chambon and D. Metzger, 2008. Temporally controlled ablation of pten in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma. Proc. Nat. Acad. Sci., 105: 2521-2526.
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Thakur, M.K. and R.C. Kumar, 2007. 17u03b2-estradiol modulates age-dependent binding of 40 kDa nuclear protein to androgen receptor promoter in mouse cerebral cortex. Biogerontology, 8: 575-582.
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Karunakaran, S., U. Saeed, S. Ramakrishnan, R.C. Koumar and V. Ravindranath, 2007. Constitutive expression and functional characterization of mitochondrial glutaredoxin (Grx2) in mouse and human brain. Brain Res., 1185: 8-17.
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Kumar, R.C. and M.K. Thakur, 2004. Sex steroids reduce DNAsei accessibility of androgen receptor promoter in adult male mice brain. Mol. Brain Res., 131: 1-7.
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Kumar, R.C. and M.K. Thakur, 2004. Androgen receptor mRNA is inversely regulated by testosterone and estradiol in adult mouse brain. Neurobiol. Aging, 25: 925-933.
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Mani, S.T., R.C. Kumar and M.K. Thakur, 2001. Age- and sex-related expression of norbin in the brain cortex of mice. Neurosci. Lett., 308: 57-59.
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