Dr. Krishna Kumar Veeravalli
My Social Links

Dr. Krishna Kumar Veeravalli

Associate Professor
University of Illinois Chicago, USA


Highest Degree
Ph.D. in Pharmacology from Andhra University, India

Share this Profile

Area of Interest:

Neuroscience
100%
Stroke
62%
Spinal Cord Injury
90%
Stem Cells
75%
Pharmacology Toxicology
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
58
Abstracts
22

Selected Publications

  1. Challa, S.R., K.R. Nalamolu, C.A. Fornal, B.C. Wang and R.C. Martin et al., 2022. Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration. Front. Neurosci., 10.3389/fnins.2022.1012812.
    CrossRef  |  Direct Link  |  
  2. Challa, S.R., K.R. Nalamolu, C.A. Fornal, A. Mohandass, J.P. Mussman et al., 2022. The interplay between MMP-12 and t-PA in the brain after ischemic stroke. Neurochem. Int. Vol. 161. 10.1016/j.neuint.2022.105436.
    CrossRef  |  Direct Link  |  
  3. Arruri, V., A.K. Chokkalla, S. Jeong, B. Chelluboina, S.L. Mehta, K.K. Veeravalli and R. Vemuganti, 2022. MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice. Neurochem. Int., Vol. 161. 10.1016/j.neuint.2022.105432.
    CrossRef  |  Direct Link  |  
  4. Nalamolu, K.R., S.R. Challa, C.A. Fornal, N.A. Grudzien and L.C. Jorgenson et al., 2021. Attenuation of the induction of TLRS 2 and 4 mitigates inflammation and promotes neurological recovery after focal cerebral ischemia. Transl. Stroke Res., 12: 923-936.
    CrossRef  |  Direct Link  |  
  5. Nalamolu, K.R., B. Chelluboina, C.A. Fornal, S.R. Challa and D.M. Pinson et al., 2021. Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke Vasc. Neurol., 6: 519-527.
    CrossRef  |  Direct Link  |  
  6. Nalamolu, K.R., I. Venkatesh, A. Mohandass. J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2019. Exosomes treatment mitigates ischemic brain damage but does not improve poststroke neurological outcome. Cell Physiol. Biochem., 52: 1280-1291.
    CrossRef  |  Direct Link  |  
  7. Nalamolu, K.R., I. Venkatesh, A. Mohandass, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, A. Kunamneni and K.K. Veeravalli, 2019. Exosomes secreted by the cocultures of normal and oxygen–glucose-deprived stem cells improve post-stroke outcome. Neuromol. Med., 21: 529-539.
    CrossRef  |  Direct Link  |  
  8. Nalamolu, K.R., N.J. Smith, B. Chelluboina, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, R. Vemuganti and K.K. Veeravalli, 2018. Prevention of the severity of post-ischemic inflammation and brain damage by simultaneous knockdown of toll-like receptors 2 and 4. Neuroscience, 373: 82-91.
    CrossRef  |  Direct Link  |  
  9. Nalamolu, K.R. B. Chelluboina, I.B. Magruder, D.N. Fru and A. Mohandass, et al., 2018. Post-stroke mRNA expression profile of MMPs: effect of genetic deletion of MMP-12. Stroke Vasc. Neurol., 3: 153-159.
    CrossRef  |  Direct Link  |  
  10. Chelluboina, B., K.R. Nalamolu, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, R. Vemuganti and K.K. Veeravalli, 2018. MMP-12, a promising therapeutic target for neurological diseases. Mol. Neurobiol., 55: 1405-1409.
    CrossRef  |  Direct Link  |  
  11. Nersesyan, Y., L. Demirkhanyan, D. Cabezas-Bratesco, V. Oakes and R. Kusuda, et al., 2017. Oxytocin modulates nociception as an agonist of pain-sensing TRPV1. Cell Rep., 21: 1681-1691.
    CrossRef  |  Direct Link  |  
  12. Chelluboina, B., K.R. Nalamolu, G.G. Mendez, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2017. Mesenchymal stem cell treatment prevents post-stroke dysregulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Cell Physiol. Biochem., 44: 1360-1369.
    CrossRef  |  Direct Link  |  
  13. Veeravalli, K.K., 2016. Stem cell treatment after ischemic stroke alters the expression of DNA damage signaling molecules. J. Stem Cell Res. Ther., 1: 281-288.
    CrossRef  |  Direct Link  |  
  14. Chelluboina, B., J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, R. Vemuganti and K.K. Veeravalli, 2015. Matrix metalloproteinase-12 induces blood–brain barrier damage after focal cerebral ischemia. Stroke, 46: 3523-3531.
    CrossRef  |  Direct Link  |  
  15. Chelluboina, B., D.H. Dinh and K.K.Veeravalli, 2015. Transdifferentiation of differentiated stem cells contributes to remyelination. Stem. Cell Res. Ther., Vol. 6. 10.1186/s13287-015-0186-y.
    CrossRef  |  Direct Link  |  
  16. Chelluboina, B., A. Warhekar, M. Dillard, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2015. Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage. Sci. Rep., Vol. 5. 10.1038/srep09504.
    CrossRef  |  Direct Link  |  
  17. Dasari, V.R., K.K. Veeravalli and D.H. Dinh, 2014. Mesenchymal stem cells in the treatment of spinal cord injuries: A review. World J. Stem Cells, 6: 120-133.
    Direct Link  |  
  18. Chelluboina, B., J.D. Klopfenstein, M. Gujrati, J.S. Rao and K.K. Veeravalli, 2014. Temporal regulation of apoptotic and anti-apoptotic molecules after middle cerebral artery occlusion followed by reperfusion. Mol. Neurobiol., 49: 50-65.
    CrossRef  |  PubMed  |  Direct Link  |  
  19. Chelluboina, B., J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2014. Stem cell treatment after cerebral ischemia regulates the gene expression of apoptotic molecules. Neurochem. Res., 39: 1511-1521.
    Direct Link  |  
  20. Zhuang, T., B. Chelluboina, S. Ponnala, K.K. Velpula and A.A. Rehman et al., 2013. Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration. BMC Cancer, Vol. 13. 10.1186/1471-2407-13-590.
    CrossRef  |  Direct Link  |  
  21. Velpula, K.K., A.A. Rehman, B. Chelluboina, V.R. Dasari, C.S. Gondi, J.S. Rao and K.K. Veeravalli, 2012. Glioma stem cell invasion through regulation of the interconnected ERK, integrin α6 and N-cadherin signaling pathway. Cell. Signal., 24: 2076-2084.
    Direct Link  |  
  22. Veeravalli, K.K., V.R. Dasari and J.S. Rao, 2012. Regulation of proteases after spinal cord injury. J. Neurotrauma, 29: 2251-2262.
    Direct Link  |  
  23. Veeravalli, K.K., S. Ponnala, C. Chetty, A.J. Tsung, M. Gujrati and J.S. Rao, 2012. Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway. Cell. Signal., 24: 272-281.
    Direct Link  |  
  24. Veeravalli, K.K. and J.S. Rao, 2012. MMP-9 and uPAR regulated glioma cell migration. Cell Adhesion Migration, 6: 509-512.
    Direct Link  |  
  25. Veeravalli, K.K., V.R. Dasari, D. Fassett, D.H. Dinh and J.S. Rao, 2011. Human umbilical cord blood derived mesenchymal stem cells upregulate myelin basic protein in shiverer mice. Stem Cells Dev., 20: 881-891.
    Direct Link  |  
  26. Ponnala, S., K.K. Veeravalli, C. Chetty, D.H. Dinh and J.S. Rao, 2011. Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice. Plos One, Vol. 6. .
    Direct Link  |  
  27. Ponnala, S., C. Chetty, K.K. Veeravalli, D.H. Dinh, J.D. Klopfenstein and J.S. Rao, 2011. Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells. Int. J. Oncol., 40: 509-518.
    Direct Link  |  
  28. Ponnala, S., C. Chetty, K.K. Veeravalli, D.H. Dinh, J.D. Klopfenstein and J.S. Rao, 2011. MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells. Cell. Signal., 23: 2065-2075.
    Direct Link  |  
  29. Kotipatruni, R.R., V.R. Dasari, K.K. Veeravalli, D.H. Dinh, D. Fassett, and J.S. Rao, 2011. P53- and Bax-mediated apoptosis in injured rat spinal cord. Neurochem. Res., 36: 2063-2074.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. Veeravalli, K.K., C. Chetty, S. Ponnala, C.S. Gondi and S.S. Lakka et al., 2010. MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice. PLoS One, Vol. 5. 10.1371/journal.pone.0011583.
    CrossRef  |  PubMed  |  Direct Link  |  
  31. Gondi, C.S., K.K. Veeravalli, B. Gorantla, D.H. Dinh and D. Fassett et al., 2010. Human umbilical cord blood stem cells show PDGF-D dependent glioma cell tropism in vitro and in vivo. Neuro-Oncology, 12: 453-465.
    Direct Link  |  
  32. Chetty, C., S.S. Lakka, P. Bhoopathi, K.K. Veeravalli and D. Fassett et al., 2010. Urokinase Plasminogen Activator Receptor and/or Matrix Metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in Glioblastoma xenograft cells. Mol. Cancer Ther., 9: 2605-2617.
    CrossRef  |  PubMed  |  Direct Link  |  
  33. Veeravalli, K.K., V.R. Dasari, A.J. Tsung, D.H. Dinh, M. Gujrati, D. Fassett and J.S. Rao, 2009. Stem cells downregulate the elevated levels of tissue plasminogen activator in rats after spinal cord injury. Neurochem. Res., 34: 1183-1194.
    CrossRef  |  Direct Link  |  
  34. Veeravalli, K.K., V.R. Dasari, A.J. Tsung, D.H. Dinh, M. Gujrati, D. Fassett and J.S. Rao, 2009. Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury. Neurobiol. Dis., 36: 200-212.
    CrossRef  |  PubMed  |  
  35. Dasari, V.R., K.K. Veeravalli, A.J. Tsung, C.S. Gondi, M. Gujrati, D.H. Dinh and J.S. Rao, 2009. Neuronal apoptosis is inhibited by cord blood stem cells after spinal cord injury. J. Neurotrauma, 26: 2057-2069.
    Direct Link  |  
  36. Dasari, V.R., K.K. Veeravalli, K.L. Saving, M. Gujrati and D. Fassett et al., 2008. Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway. Neurobiol. Dis., 32: 486-498.
    CrossRef  |  
  37. Rao, P.R., K.K. Veeravalli, R.K. Viswanath and G.V. Subbaraju, 2005. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol. Pharmaceut. Bull., 28: 2319-2322.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Krishna, K.M., G.S. Gopal, C.R. Chalam, K. Madan, K.K. Veeravalli, G.J. Prakash and A. Annapurna, 2005. The influence of sulindac on diabetic cardiomyopathy: A non-invasive evaluation by Doppler echocardiography in streptozotocin-induced diabetic rats. Vascul Pharmacol., 43: 91-100.
    PubMed  |  
  39. Krishna, K.M., A. Annapurna, G.S. Gopal, C.R. Chalam, K. Madan, K.K. Veeravalli and G.J. Prakash, 2005. Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats. Can. J. Physiol. Pharmacol., 83: 343-355.
    PubMed  |  
  40. Annapurna, A., K.M. Krishna, K.K. Veeravalli and G.J. Prakash, 2005. Mechanisms, pathology and therapeutic interventions of restenosis. Indian J. Pharm. Sci., 67: 11-18.
  41. Veeravalli, K.K., A. Annapurna and K.M. Krishna, 2004. Myocardial infarction: A review. Antiseptic, 101: 182-187.
  42. Veeravalli, K.K. and A. Akula, 2004. Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction. Pharmacol. Res., 49: 23-29.
    PubMed  |  
  43. Pragada, R.R., K.K. Veeravalli, K.P.R. Chowdary and K.V. Routhu, 2004. Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats. J. Ethnopharmacol., 93: 105-108.
    PubMed  |  
  44. Annapurna, A., V.R. Krishna, K.M. Krishna and K.K. Veeravalli, 2004. Prasad KB. Studies on the nootropic activity of ramipril and losartan on scopolamine-induced amnesia in rats. Indian J. Pharm. Sci., 66: 31-35.
  45. Annapurna, A, K.M. Krishna, K.K. Veeravalli, G.J. Prakash and V. Satyanarayana, 2004. Microdialysis: An overview. Indian J. Pharm. Sci., 66: 382-391.
  46. Veeravalli, K.K., A. Akula, K.V. Routhu and M.K. Kota, 2003. Infarct size limiting effect of apstatin alone and in combination with enalapril, lisinopril and ramipril in rats with experimental myocardial infarction. Pharmacol. Res., 48: 557-563.
    PubMed  |  
  47. Veeravalli, K.K., A. Akula and M.K. Kota, 2003. Nitric oxide and prostaglandin mediated cardioprotection by bradykinin in myocardial ischemia and reperfusion injury. Polish J. Pharmacol., 55: 1021-1029.
    PubMed  |  
  48. Akula, A., K.K. Veeravalli, K.V. Routhum and M.K. Kota, 2003. Studies on the involvement of bradykinin using enalapril and 2-mercaptoethanol in ischemia-reperfusion induced myocardial infarction in albino rats. Pharmazie, 58: 906-909.
    PubMed  |  
  49. Annapurna, A., K.K. Veeravalli, P.M.M. Rao, K.S. Rao and J. Rajasekhar, 2002. Multiple sclerosis: The disease and its treatment. Indian J. Pharmacol., 34: 3-15.
  50. Annapurna, A., K.K. Veeravalli and G. Sreenivas, 2002. Possible role of nitric oxide in the cardioprotective actions of enalapril and lisinopril in rats. Indian J. Pharm. Sci., 64: 151-154.
  51. Annapurna, A. and K.K. Veeravalli, 2002. Influence of nimesulide and aspirin on the cardioprotective effect offered by the combined treatment of ramipril and 2-mercaptoethanol in rats. Indian J. Pharmacol., 34: 48-51.
  52. Akula, A., K.K. Veeravalli, S. Potharaju and M.K. Kota, 2002. Studies on the signal cascade mechanism mediating the cardioprotective actions of bradykinin. Pharmazie, 57: 332-336.
    PubMed  |  
  53. Annapurna, A., M.R. Babu, Y.S.C.K. Reddy and K.K. Veeravalli, 2001. Cardioprotective effects of acutely administered ramipril and losartan on myocardial infarct size in cholesterol-fed and salt-fed rats. Indian J. Pharmacol., 33: 437-441.
  54. Annapurna, A., K.V. Kumar, K.K. Veeravalli, G. Rambabu and S. Nammi, 2001. Ceramide: A novel second messenger. Proc. Indian Nat. Sci. Acad., 67: 97-106.
  55. Annapurna, A., K.K. Veeravalli, J. Rajasekhar and A.U. Srinivas, 2001. Ebrotidine: A novel H2-receptor antagonist. Indian Drugs, 38: 114-121.
  56. Annapurna, A. and K.K. Veeravalli, 2001. Effect of inhibition of angiotensin converting enzyme by ramipril and aminopeptidase P by 2-mercaptoethanol in rats with experimental myocardial infarction. Indian J. Pharmacol., 33: 72-76.
  57. Annapurna, A. and K.K. Veeravalli, 2001. Diabetic nephropathy. Indian J. Pharm. Sci., 63: 273-278.