Dr. Krishna Kumar Veeravalli
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Dr. Krishna Kumar Veeravalli

Associate Professor
University of Illinois Chicago, USA

Highest Degree
Ph.D. in Pharmacology from Andhra University, India

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Area of Interest:

Neuroscience
100%
Stroke
62%
Spinal Cord Injury
90%
Stem Cells
75%
Pharmacology Toxicology
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
58
Abstracts
22

Selected Publications

  1. Challa, S.R., K.R. Nalamolu, C.A. Fornal, B.C. Wang and R.C. Martin et al., 2022. Therapeutic efficacy of matrix metalloproteinase-12 suppression on neurological recovery after ischemic stroke: Optimal treatment timing and duration. Front. Neurosci., 10.3389/fnins.2022.1012812.
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  2. Challa, S.R., K.R. Nalamolu, C.A. Fornal, A. Mohandass, J.P. Mussman et al., 2022. The interplay between MMP-12 and t-PA in the brain after ischemic stroke. Neurochem. Int. Vol. 161. 10.1016/j.neuint.2022.105436.
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  3. Arruri, V., A.K. Chokkalla, S. Jeong, B. Chelluboina, S.L. Mehta, K.K. Veeravalli and R. Vemuganti, 2022. MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice. Neurochem. Int., Vol. 161. 10.1016/j.neuint.2022.105432.
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  4. Nalamolu, K.R., S.R. Challa, C.A. Fornal, N.A. Grudzien and L.C. Jorgenson et al., 2021. Attenuation of the induction of TLRS 2 and 4 mitigates inflammation and promotes neurological recovery after focal cerebral ischemia. Transl. Stroke Res., 12: 923-936.
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  5. Nalamolu, K.R., B. Chelluboina, C.A. Fornal, S.R. Challa and D.M. Pinson et al., 2021. Stem cell treatment improves post stroke neurological outcomes: a comparative study in male and female rats. Stroke Vasc. Neurol., 6: 519-527.
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  6. Nalamolu, K.R., I. Venkatesh, A. Mohandass. J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2019. Exosomes treatment mitigates ischemic brain damage but does not improve poststroke neurological outcome. Cell Physiol. Biochem., 52: 1280-1291.
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  7. Nalamolu, K.R., I. Venkatesh, A. Mohandass, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, A. Kunamneni and K.K. Veeravalli, 2019. Exosomes secreted by the cocultures of normal and oxygen–glucose-deprived stem cells improve post-stroke outcome. Neuromol. Med., 21: 529-539.
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  8. Nalamolu, K.R., N.J. Smith, B. Chelluboina, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, R. Vemuganti and K.K. Veeravalli, 2018. Prevention of the severity of post-ischemic inflammation and brain damage by simultaneous knockdown of toll-like receptors 2 and 4. Neuroscience, 373: 82-91.
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  9. Nalamolu, K.R. B. Chelluboina, I.B. Magruder, D.N. Fru and A. Mohandass, et al., 2018. Post-stroke mRNA expression profile of MMPs: effect of genetic deletion of MMP-12. Stroke Vasc. Neurol., 3: 153-159.
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  10. Chelluboina, B., K.R. Nalamolu, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, R. Vemuganti and K.K. Veeravalli, 2018. MMP-12, a promising therapeutic target for neurological diseases. Mol. Neurobiol., 55: 1405-1409.
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  11. Nersesyan, Y., L. Demirkhanyan, D. Cabezas-Bratesco, V. Oakes and R. Kusuda, et al., 2017. Oxytocin modulates nociception as an agonist of pain-sensing TRPV1. Cell Rep., 21: 1681-1691.
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  12. Chelluboina, B., K.R. Nalamolu, G.G. Mendez, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2017. Mesenchymal stem cell treatment prevents post-stroke dysregulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Cell Physiol. Biochem., 44: 1360-1369.
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  13. Veeravalli, K.K., 2016. Stem cell treatment after ischemic stroke alters the expression of DNA damage signaling molecules. J. Stem Cell Res. Ther., 1: 281-288.
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  14. Chelluboina, B., J.D. Klopfenstein, D.M. Pinson, D.Z. Wang, R. Vemuganti and K.K. Veeravalli, 2015. Matrix metalloproteinase-12 induces blood–brain barrier damage after focal cerebral ischemia. Stroke, 46: 3523-3531.
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  15. Chelluboina, B., D.H. Dinh and K.K.Veeravalli, 2015. Transdifferentiation of differentiated stem cells contributes to remyelination. Stem. Cell Res. Ther., Vol. 6. 10.1186/s13287-015-0186-y.
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  16. Chelluboina, B., A. Warhekar, M. Dillard, J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2015. Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage. Sci. Rep., Vol. 5. 10.1038/srep09504.
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  17. Dasari, V.R., K.K. Veeravalli and D.H. Dinh, 2014. Mesenchymal stem cells in the treatment of spinal cord injuries: A review. World J. Stem Cells, 6: 120-133.
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  18. Chelluboina, B., J.D. Klopfenstein, M. Gujrati, J.S. Rao and K.K. Veeravalli, 2014. Temporal regulation of apoptotic and anti-apoptotic molecules after middle cerebral artery occlusion followed by reperfusion. Mol. Neurobiol., 49: 50-65.
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  19. Chelluboina, B., J.D. Klopfenstein, D.M. Pinson, D.Z. Wang and K.K. Veeravalli, 2014. Stem cell treatment after cerebral ischemia regulates the gene expression of apoptotic molecules. Neurochem. Res., 39: 1511-1521.
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  20. Zhuang, T., B. Chelluboina, S. Ponnala, K.K. Velpula and A.A. Rehman et al., 2013. Involvement of nitric oxide synthase in matrix metalloproteinase-9- and/or urokinase plasminogen activator receptor-mediated glioma cell migration. BMC Cancer, Vol. 13. 10.1186/1471-2407-13-590.
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  21. Velpula, K.K., A.A. Rehman, B. Chelluboina, V.R. Dasari, C.S. Gondi, J.S. Rao and K.K. Veeravalli, 2012. Glioma stem cell invasion through regulation of the interconnected ERK, integrin α6 and N-cadherin signaling pathway. Cell. Signal., 24: 2076-2084.
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  22. Veeravalli, K.K., V.R. Dasari and J.S. Rao, 2012. Regulation of proteases after spinal cord injury. J. Neurotrauma, 29: 2251-2262.
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  23. Veeravalli, K.K., S. Ponnala, C. Chetty, A.J. Tsung, M. Gujrati and J.S. Rao, 2012. Integrin α9β1-mediated cell migration in glioblastoma via SSAT and Kir4.2 potassium channel pathway. Cell. Signal., 24: 272-281.
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  24. Veeravalli, K.K. and J.S. Rao, 2012. MMP-9 and uPAR regulated glioma cell migration. Cell Adhesion Migration, 6: 509-512.
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  25. Veeravalli, K.K., V.R. Dasari, D. Fassett, D.H. Dinh and J.S. Rao, 2011. Human umbilical cord blood derived mesenchymal stem cells upregulate myelin basic protein in shiverer mice. Stem Cells Dev., 20: 881-891.
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  26. Ponnala, S., K.K. Veeravalli, C. Chetty, D.H. Dinh and J.S. Rao, 2011. Regulation of DNA repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice. Plos One, Vol. 6. .
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  27. Ponnala, S., C. Chetty, K.K. Veeravalli, D.H. Dinh, J.D. Klopfenstein and J.S. Rao, 2011. Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells. Int. J. Oncol., 40: 509-518.
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  28. Ponnala, S., C. Chetty, K.K. Veeravalli, D.H. Dinh, J.D. Klopfenstein and J.S. Rao, 2011. MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells. Cell. Signal., 23: 2065-2075.
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  29. Kotipatruni, R.R., V.R. Dasari, K.K. Veeravalli, D.H. Dinh, D. Fassett, and J.S. Rao, 2011. P53- and Bax-mediated apoptosis in injured rat spinal cord. Neurochem. Res., 36: 2063-2074.
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  30. Veeravalli, K.K., C. Chetty, S. Ponnala, C.S. Gondi and S.S. Lakka et al., 2010. MMP-9, uPAR and cathepsin B silencing downregulate integrins in human glioma xenograft cells in vitro and in vivo in nude mice. PLoS One, Vol. 5. 10.1371/journal.pone.0011583.
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  31. Gondi, C.S., K.K. Veeravalli, B. Gorantla, D.H. Dinh and D. Fassett et al., 2010. Human umbilical cord blood stem cells show PDGF-D dependent glioma cell tropism in vitro and in vivo. Neuro-Oncology, 12: 453-465.
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  32. Chetty, C., S.S. Lakka, P. Bhoopathi, K.K. Veeravalli and D. Fassett et al., 2010. Urokinase Plasminogen Activator Receptor and/or Matrix Metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in Glioblastoma xenograft cells. Mol. Cancer Ther., 9: 2605-2617.
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  33. Veeravalli, K.K., V.R. Dasari, A.J. Tsung, D.H. Dinh, M. Gujrati, D. Fassett and J.S. Rao, 2009. Stem cells downregulate the elevated levels of tissue plasminogen activator in rats after spinal cord injury. Neurochem. Res., 34: 1183-1194.
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  34. Veeravalli, K.K., V.R. Dasari, A.J. Tsung, D.H. Dinh, M. Gujrati, D. Fassett and J.S. Rao, 2009. Human umbilical cord blood stem cells upregulate matrix metalloproteinase-2 in rats after spinal cord injury. Neurobiol. Dis., 36: 200-212.
    CrossRef  |  PubMed  |  
  35. Dasari, V.R., K.K. Veeravalli, A.J. Tsung, C.S. Gondi, M. Gujrati, D.H. Dinh and J.S. Rao, 2009. Neuronal apoptosis is inhibited by cord blood stem cells after spinal cord injury. J. Neurotrauma, 26: 2057-2069.
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  36. Dasari, V.R., K.K. Veeravalli, K.L. Saving, M. Gujrati and D. Fassett et al., 2008. Neuroprotection by cord blood stem cells against glutamate-induced apoptosis is mediated by Akt pathway. Neurobiol. Dis., 32: 486-498.
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  37. Rao, P.R., K.K. Veeravalli, R.K. Viswanath and G.V. Subbaraju, 2005. Cardioprotective activity of alcoholic extract of Tinospora cordifolia in ischemia-reperfusion induced myocardial infarction in rats. Biol. Pharmaceut. Bull., 28: 2319-2322.
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  38. Krishna, K.M., G.S. Gopal, C.R. Chalam, K. Madan, K.K. Veeravalli, G.J. Prakash and A. Annapurna, 2005. The influence of sulindac on diabetic cardiomyopathy: A non-invasive evaluation by Doppler echocardiography in streptozotocin-induced diabetic rats. Vascul Pharmacol., 43: 91-100.
    PubMed  |  
  39. Krishna, K.M., A. Annapurna, G.S. Gopal, C.R. Chalam, K. Madan, K.K. Veeravalli and G.J. Prakash, 2005. Partial reversal by rutin and quercetin of impaired cardiac function in streptozotocin-induced diabetic rats. Can. J. Physiol. Pharmacol., 83: 343-355.
    PubMed  |  
  40. Annapurna, A., K.M. Krishna, K.K. Veeravalli and G.J. Prakash, 2005. Mechanisms, pathology and therapeutic interventions of restenosis. Indian J. Pharm. Sci., 67: 11-18.
  41. Veeravalli, K.K., A. Annapurna and K.M. Krishna, 2004. Myocardial infarction: A review. Antiseptic, 101: 182-187.
  42. Veeravalli, K.K. and A. Akula, 2004. Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction. Pharmacol. Res., 49: 23-29.
    PubMed  |  
  43. Pragada, R.R., K.K. Veeravalli, K.P.R. Chowdary and K.V. Routhu, 2004. Cardioprotective activity of Hydrocotyle asiatica L. in ischemia-reperfusion induced myocardial infarction in rats. J. Ethnopharmacol., 93: 105-108.
    PubMed  |  
  44. Annapurna, A., V.R. Krishna, K.M. Krishna and K.K. Veeravalli, 2004. Prasad KB. Studies on the nootropic activity of ramipril and losartan on scopolamine-induced amnesia in rats. Indian J. Pharm. Sci., 66: 31-35.
  45. Annapurna, A, K.M. Krishna, K.K. Veeravalli, G.J. Prakash and V. Satyanarayana, 2004. Microdialysis: An overview. Indian J. Pharm. Sci., 66: 382-391.
  46. Veeravalli, K.K., A. Akula, K.V. Routhu and M.K. Kota, 2003. Infarct size limiting effect of apstatin alone and in combination with enalapril, lisinopril and ramipril in rats with experimental myocardial infarction. Pharmacol. Res., 48: 557-563.
    PubMed  |  
  47. Veeravalli, K.K., A. Akula and M.K. Kota, 2003. Nitric oxide and prostaglandin mediated cardioprotection by bradykinin in myocardial ischemia and reperfusion injury. Polish J. Pharmacol., 55: 1021-1029.
    PubMed  |  
  48. Akula, A., K.K. Veeravalli, K.V. Routhum and M.K. Kota, 2003. Studies on the involvement of bradykinin using enalapril and 2-mercaptoethanol in ischemia-reperfusion induced myocardial infarction in albino rats. Pharmazie, 58: 906-909.
    PubMed  |  
  49. Annapurna, A., K.K. Veeravalli, P.M.M. Rao, K.S. Rao and J. Rajasekhar, 2002. Multiple sclerosis: The disease and its treatment. Indian J. Pharmacol., 34: 3-15.
  50. Annapurna, A., K.K. Veeravalli and G. Sreenivas, 2002. Possible role of nitric oxide in the cardioprotective actions of enalapril and lisinopril in rats. Indian J. Pharm. Sci., 64: 151-154.
  51. Annapurna, A. and K.K. Veeravalli, 2002. Influence of nimesulide and aspirin on the cardioprotective effect offered by the combined treatment of ramipril and 2-mercaptoethanol in rats. Indian J. Pharmacol., 34: 48-51.
  52. Akula, A., K.K. Veeravalli, S. Potharaju and M.K. Kota, 2002. Studies on the signal cascade mechanism mediating the cardioprotective actions of bradykinin. Pharmazie, 57: 332-336.
    PubMed  |  
  53. Annapurna, A., M.R. Babu, Y.S.C.K. Reddy and K.K. Veeravalli, 2001. Cardioprotective effects of acutely administered ramipril and losartan on myocardial infarct size in cholesterol-fed and salt-fed rats. Indian J. Pharmacol., 33: 437-441.
  54. Annapurna, A., K.V. Kumar, K.K. Veeravalli, G. Rambabu and S. Nammi, 2001. Ceramide: A novel second messenger. Proc. Indian Nat. Sci. Acad., 67: 97-106.
  55. Annapurna, A., K.K. Veeravalli, J. Rajasekhar and A.U. Srinivas, 2001. Ebrotidine: A novel H2-receptor antagonist. Indian Drugs, 38: 114-121.
  56. Annapurna, A. and K.K. Veeravalli, 2001. Effect of inhibition of angiotensin converting enzyme by ramipril and aminopeptidase P by 2-mercaptoethanol in rats with experimental myocardial infarction. Indian J. Pharmacol., 33: 72-76.
  57. Annapurna, A. and K.K. Veeravalli, 2001. Diabetic nephropathy. Indian J. Pharm. Sci., 63: 273-278.