Dr. Deepak Kumar Semwal

Dr. Deepak Kumar Semwal

Assistant Professor
Uttarakhand Ayurved University, India


Highest Degree
Ph.D. in Phytochemistry from HNB Garhwal Central University, India

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Biography

Dr. Semwal is currently working as Assistant Professor in the Department of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, India. Prior to join this position, Dr. Semwal served as Postdoctoral Research Fellow in the Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, South Africa. His research was funded by Tshwane University of Technology and National Research Foundation, South Africa. He received his B.Sc. degree in 2003 with Zoology, Botany and Chemistry as major subjects. In 2005, he received his M.Sc. in Organic Chemistry and in 2009, he obtained his Ph.D. in Phytochemistry from HNB Garhwal University, Srinagar, India. During the PhD, he worked on the chemistry of selected plants of Central Himalaya having antidiabetic and antitubercular properties.
In 2005, he appointed as Lecturer (fixed tenure) in the Department of Chemistry, HNB Garhwal University, India. During 2010, he was worked as R&D scientist for an India based pharmaceutical industry and his key roles were method developments and technology transfer for various herbal products. In 2010, he received prestigious Dr DS Kothari Postdoctoral Fellowship from University Grants Commission, New Delhi, India. He did his postdoctoral work in the Department of Chemistry, Panjab University, Chandigarh, and his research was based on the investigation of antidiabetic principles from selected plant species from Indian origin.
He published his quality research in various journals of international repute and also presented his work in many national and international conferences. He received many prestigious awards including young scientist for his research and academic performance. His current research interests are phytochemistry, phytomedicine, drug discovery and development, drug delivery, Natural dyes and semi-synthesis.

Area of Interest:

Chemistry
100%
Pharmaceutical Chemistry
62%
Organic Chemistry
90%
Drug Delivery Systems
75%
Medicinal Plants
55%

Selected Publications

  1. Semwal, R.B., D.K. Semwal, S. Combrinck, J. Trill, S. Gibbons and A. Viljoen, 2019. Acacetin-a simple flavone exhibiting diverse pharmacological activities. Phytochem. Lett., 32: 56-65.
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  2. Semwal, D.K., A. Chauhan, A. Kumar, S. Aswal, R.B. Semwal and A. Kumar, 2019. Status of Indian medicinal plants in the International union for conservation of nature and the future of ayurvedic drugs: Shouldn't think about ayurvedic fundamentals?. J. Integr. Med., 17: 238-243.
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  3. Kumar, A., S. Aswal, R.B. Semwal, A. Chauhan, S.K. Joshi and D.K. Semwal, 2019. Role of plant-derived alkaloids against diabetes and diabetes-related complications: A mechanism-based approach. Phytochem. Rev., 10.1007/s11101-019-09648-6.
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  4. Kumar, A., S. Aswal, R.B. Semwal, A. Chauhan and D.K. Semwal, 2019. Insights on the pharmacological, phytochemical and ethnobotanical aspects of Artemisia roxburghiana: A rather less explored but therapeutically important species of lower Himalayas. Phytochem. Rev., 18: 199-214.
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  5. Kumar, A., S. Aswal, A. Chauhan, R.B. Semwal, A. Kumar and D.K. Semwal, 2019. Ethnomedicinal investigation of medicinal plants of chakrata region (Uttarakhand) used in the traditional medicine for diabetes by jaunsari tribe. Nat. Prod. Bioprospect., 9: 175-200.
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  6. Chandra, S., S. Saklani, R.B. Semwal and D.K. Semwal, 2019. Estimation of nutritional and mineral contents of eleusine coracana and echinochloa frumentacea-two edible wild crops of India. Curr. Nutr. Food Sci., 15: 363-366.
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  7. Aswal, S., A. Kumar, R.B. Semwal, A. Chauhan, A. Kumar, J. Lehmann and D.K. Semwal, 2019. Drimia indica: A plant used in traditional medicine and its potential for clinical uses. Medicina, Vol. 55. 10.3390/medicina55060255.
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  8. Semwal, R.B., D.K. Semwal, S. Aswal and A. Kumar, 2018. Spectral studies andpharmacological relevance of berberine isolated from Berberis aristataroots. Curr. Med. Drug Res., 2: 1-8.
  9. Semwal, R., R.B. Semwal, D.K. Semwal, 2018. Mucoadhesive assessment-An encyclopedic review. Curr. Med. Drug Res., 2: 1-18.
  10. Semwal, D.K., R.S. Dahiya, N. Joshi, R.B. Semwal, S. Aswal, A. Kumar and A. Kumar, 2018. Preclinical and clinical studies to evaluate the effect of Carica papaya leaf extract on platelets. Curr. Traditional Med., 4: 297-304.
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  11. Ravindra, S., U. Kumud, S.B. Ruchi and S.K. Deepak, 2018. Acceptability of nose-to-brain drug targeting in context to its advances and challenges. Drug Delivery Lett., 8: 20-28.
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  12. Bhatt, U.P., S.C. Sati, R.P. Bahuguna, R.B. Semwal and D.K. Semwal, 2018. Two antidiabetic constituents from Roylea cinerea (D. Don) Baill. Nat. Prod. Res., 32: 1281-1286.
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  13. Vinothini, K., M.S. Devi, V. Shalini, S. Sekar, R.B. Semwal, P. Arjun and D.K. Semwal, 2017. In vitro micropropagation, total phenolic content and comparative antioxidant activity of different extracts of Sesbania grandiflora (L.) pers. Curr. Sci., 113: 1142-1147.
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  14. Vinothini, K., M. Sri Devi, V. Shalini, S. Sekar, R.B. Semwal, P. Arjun and D.K. Semwal, 2017. In vitro micropropagation, total phenolic content and comparative antioxidant activity of different extracts of Sesbania grandiflora (L.) Pers. Curr. Sci., (In Press). .
  15. Chauhan, A., R. Ojha, D.K. Semwal, S.P. Mishra and R.B. Semwal, 2017. Combined treatment with CCI779 and SB203580 induces cellular senescence in renal cell carcinoma cell line via p53 pathway. Anti-Cancer Agents Med. Chem., Vol. 17. 10.2174/1871520617666170213111002.
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  16. Chauhan, A., R. Ojha, D.K. Semwal, S.P. Mishra and R.B. Semwal, 2017. Combined treatment with CCI779 and SB203580 induces cellular senescence in renal cell carcinoma cell line via p53 pathway. Anti-Cancer Agents Med. Chem., 17: 1545-1554.
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  17. Chauhan, A., D.K. Semwal, S.P. Mishra and R.B. Semwal, 2017. Yoga practice improves the body mass index and blood pressure: A randomized controlled trial. Int. J. Yoga, 10: 103-106.
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  18. Chauhan, A., D.K. Semwal, S.P. Mishra and R.B. Semwal, 2017. Ayurvedic concept of Shatkriyakala: A traditional knowledge of cancer pathogenesis and therapy. J. Integr. Med., 15: 88-94.
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  19. Chauhan, A., D.K. Semwal, R.B. Semwal and S. Singh, 2017. Ayurvedic approaches used in prevention and treatment of type 2 diabetes mellitus. J. Convent. Knowl. Holist. Health, 1: 1-15.
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  20. Bhatt, U., S.C. Sati, R.P. Bahuguna, R.B. Semwal and D.K. Semwal, 2017. Two antidiabetic constituents from Roylea cinerea (D. Don) Baill. Nat. Prod. Res., (In Press). .
  21. Arjun, P., D.K. Semwal, R.B. Semwal, M. Malaisamy, C. Sivaraj and S. Vijayakumar, 2017. Total phenolic content, volatile constituents and antioxidative effect of Coriandrum sativum, Murraya koenigii and Mentha arvensis. Nat. Prod. J., 7: 65-74.
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  22. Yadav, C., S. Chaubey, R. Kurele and D.K. Semwal, 2017. Sanjeevani booti-a majestic and elusive all curing divine herbin epic Ramayana. J. Conventional Knowl. Holistic Health, 1: 1-4.
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  23. Semwal, D.K., R.B. Semwal, A. Chauhan and S.P. Mishra, 2016. Treatment of type 2 diabetes with ayurveda: A case report. Pharmacologia, 7: 239-242.
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  24. Semwal, D.K., A. Chauhan, S.P. Mishra and R.B. Semwal, 2016. Recent development in yoga: A scientific perspective. J. AYUSH: Ayurveda Yoga Unani Siddha Homeopathy, 5: 14-20.
  25. Semwal, D.K. and R.B. Semwal, 2016. Discovery of natural SGLT2-inhibitors for type 2 diabetes-possible way to reduce side effects. J. Nat. Remedies, 15: 86-87.
  26. Semwal, D., R. Semwal, S. Combrinck and A.M. Viljoen, 2016. A dietary molecule with diverse biological activities. Nutrients, .
  27. Chauhan, A., R. Ojha, D.K. Semwal, S.P. Mishra and R.B. Semwal, 2016. Speckle-type POZ protein acts as a predictive biomarker for mTOR target therapy in renal cell carcinoma. Curr. Sci., 111: 2014-2019.
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  28. Chauhan, A., D.K. Semwal, S.P. Mishra, S. Goyal, R. Marathe and R.B. Semwal, 2016. Combination of mTOR and MAPK inhibitors-a potential way to treat renal cell carcinoma. Med. Sci., Vol. 4. 10.3390/medsci4040016.
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  29. Semwal, R.B., D.K. Semwal, S.P. Mishra and R. Semwal, 2015. Chemical composition and antibacterial potential of essential oils from Artemisia capillaris, Artemisia nilagirica, Citrus limon, Cymbopogon flexuosus, Hedychium spicatum and Ocimum tenuiflorum. Nat. Prod. J., 5: 199-205.
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  30. Semwal, R.B., D.K. Semwal, S. Combrinck and A.M. Viljoen, 2015. Gingerols and shogaols: Important nutraceutical principles from ginger. Phytochemistry, 117: 554-568.
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  31. Semwal, R.B., D.K. Semwal, S. Combrinck and A. Viljoen, 2015. Butein: From ancient traditional remedy to modern nutraceutical. Phytochem. Lett., 11: 188-201.
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  32. Semwal, R.B., D.K. Semwal, I. Vermaak and A. Viljoen, 2015. A comprehensive scientific overview of Garcinia cambogia. Fitoterapia, 102: 134-148.
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  33. Semwal, R., R.B. Semwal and D.K. Semwal, 2015. Drug Delivery Systems: Selection Criteria and Use. In: Encyclopedia of Biomedical Polymers and Polymeric Biomaterial, Mishram, M. (Ed.). Taylor and Francis Group, New York, pp: 2938-2949.
  34. Semwal, D.K., S.P. Mishra, A. Chauhan and R.B. Semwal, 2015. Adverse health effects of tobacco and role of ayurveda in their reduction. J. Med. Sci., 15: 139-146.
  35. Semwal, D.K. and R.B. Semwal, 2015. Efficacy and safety of Stephania glabra: An Alkaloid-rich traditional medicinal plant. Nat. Prod. Res., 29: 396-410.
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  36. Mishra, S.P., D.K. Semwal and A. Chauhan, 2015. Scenario of ayurveda education in India: Some recommendations for development. Univ. News-Assoc. Indian Univ., 53: 3-8.
  37. Chauhan, A., D.K. Semwal, S.P. Mishra and R.B. Semwal, 2015. Ayurvedic research and methodology: Present status and future strategies. Ayu, 36: 364-369.
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  38. Chandel, S., U. Bagai, R.B. Semwal and D.K. Semwal, 2015. Antiplasmodial activity of aqueous extract of Berberis aristata roots against Plasmodium berghei-infected BALB/c mice. Pharm. Biol., 53: 1735-1740.
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  39. Arjun, P., D.K. Semwal, R.B. Semwal, S.P. Mishra, A.B. Vijayan and M. Krishnamoorthy, 2015. Quality retention and shelf-life improvement of fresh-cut apple, papaya, carrot and cucumber by chitosan-soy based edible coating. Curr. Nutr. Food Sci., 11: 282-291.
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  40. Semwal, R.B., D.K. Semwal, S. Combrinck, C. Cartwright-Jones and A. Viljoen, 2014. Lawsonia inermis: Ethnobotanical, phytochemical and pharmacological aspects. J. Ethnopharmacol., 155: 80-103.
  41. Semwal, R.B., D.K. Semwal, P.P. Badoni and P. Kapoor, 2014. Dyeing performance of aqueous extract and flavanone glycosides from the flowers of Butea monosperma (Lam.) kuntze. Records Nat. Prod., 8: 66-70.
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  42. Semwal, R., R.B. Semwal and D.K. Semwal, 2014. A gastroretentive drug delivery system of lisinopril imbibed on Isabgol-husk. Curr. Drug Delivery, 11: 371-379.
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  43. Semwal, D.K., R.B. Semwal, I. Vermaak and A. Viljoen, 2014. From arrow poison to herbal Medicine- the ethnobotanical, phytochemical and pharmacological significance of Cissampelos (Menispermaceae). J. Ethnopharmacol., 155: 1011-1028.
  44. Semwal, D.K., R.B. Semwal, A. Ahmad, G.P. Kamatou and A.M. Viljoen, 2014. Inhibitory effects of extracts and isolates from Kigelia Africana fruits against pathogenic bacteria and yeasts. Int. J. Biol. Vet. Agric. Food Eng., 8: 1196-1201.
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  45. Semwal, D.K., R.B. Semwal and G. Singh, 2014. Benzoquinone derivative and sarsasapogenin glycoside from Asparagus curillus. Chem. Nat. Compounds, 50: 865-867.
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  46. Sharma, A., S.C. Sati, M.D. Sati, O.P. Sati, S.K. Kothiyal, D.K. Semwal and A. Mehta, 2013. A novel triterpenoid saponin and antimicrobial activity of ethanolic extract from Sapindus mukorossi gaertn. J. Chem., 10.1155/2013/218510.
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  47. Semwal, R., R.B. Semwal and D.K. Semwal, 2013. Drug Delivery Systems: Utility and Selection Criteria. In: In: Encyclopedia of Biomedical Polymers and Polymeric Biomaterial, Mishra, M. (Ed.). Taylor and Francis Group, New York.
  48. Semwal, D.K., R.B. Semwal and G. Singh, 2013. Androstane-type steroidal glycoside from the roots of Asparagus curillus Buch.-Ham. ex Roxb. Helvetica Chimica Acta, 96: 520-524.
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  49. Semwal, D.K. and R.B. Semwal, 2013. Ethnobotany, Pharmacology and Phytochemistry of the Genus Phoebe (Lauraceae). Mini-Rev. Org. Chem., 10: 12-26.
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  50. Semwal, R.B., D.K. Semwal and P. Kapoor, 2012. Dyeing properties of Berberis aristata DC with natural and synthetic mordants. Trends Applied Sci. Res., 7: 392-399.
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  51. Semwal, R.B. and D.K. Semwal, 2012. Naturally Occurring Alkaloids and Iridoids: Chemistry and Biological Importance. Lambert Academic Publishing, Germany.
  52. Semwal, R.B. and D.K. Semwal, 2012. Analgesic and Anti-Inflammatory Activities of Extracts and Fatty Acids from Celtis australis L. Nat. Prod. J., 2: 323-327.
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  53. Semwal, D.K., R.B. Semwal and R. Semwal, 2012. Antibacterial activity of 8-(4'-methoxybenzyl)-xylopinine from stephania glabra tubers. Pharmacologia, 3: 539-541.
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  54. Sateesh Madhav, N.V., R. Semwal, D.K. Semwal and R.B. Semwal, 2012. Recent trends in oral transmucosal drug delivery systems: An emphasis on the soft palatal route. Expert Opin. Drug Deliv., 9: 629-647.
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  55. Kothiyal, S.K., S.C. Sati, M.S.M. Rawat, M.D. Sati and D.K. Semwal et al., 2012. Chemical Constituents and Biological Significance of the Genus Ilex (Aquifoliaceae). Nat. Prod. J., 2: 212-224.
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  56. Badoni, R. and D.K. Semwal, 2012. Dyeing performance of symplocos paniculata and celtis australis. Asian Dyer, 9: 51-58.
  57. Sudhir, K.K., S.C. Satish, D.S. Manisha, R. Bipin and S. Amita et al., 2011. The Alkaloids: Genus Daphniphyllam (Daphniphyllaceae). Int. Res. J. Pharm., 2: 13-21.
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  58. Semwal, R.B., D.K. Semwal, R. Badoni, R. Singh and M.S. Rawat, 2011. Chemical constituents from the stem bark of Symplocos paniculata Thunb. with antimicrobial, analgesic and anti-inflammatory activities. J. Ethnopharmacol., 135: 78-87.
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  59. Semwal, D.K., R.B. Semwal, R. Semwal, V. Jacob and G. Singh, 2011. Analgesic and antipyretic activities of gindarudine, a morphine alkaloid from Stephania glabra. Curr. Bioact. Compounds, 7: 214-217.
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  60. Semwal, D.K. and R.B. Semwal, 2011. Triterpenoids: An Important Bioactive Class of Natural Products. Lambert Academic Publishing, Germany, Pages: 68.
  61. Rawat, U., V. Joshi, D.K. Semwal, A. Bamola, S. Semwal, R. Badoni and O.P. Sati, 2011. Triterpenoidal saponin and phenolic glycosides of Rhododendron barbatum flowers. Med. Plants, 3: 73-76.
  62. Badoni, R., D.K. Semwal, P.P. Badoni, S. Kumar and U. Rawat, 2011. A novel bacteriohopanoid from Celtis australis L. bark. Chinese Chem. Lett., 22: 81-84.
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  63. Badoni, R., D. Kumar-Semwal, U. Rawat and M. Singh-Maniyari-Rawat, 2011. Chemical constituents from fruits and stem bark of Celtis australis L. Helvetica Chim. Acta, 94: 464-473.
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  64. Semwal, R., D.K. Semwal, R. Badoni, S. Gupta and A.K. Madan, 2010. Targeted drug nanoparticles: An emphasis on self-assembled polymeric system. J. Med. Sci., 10: 130-137.
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  65. Semwal, R., D.K. Semwal, A.K. Madan, P. Paul, F. Mujaffer and R. Badoni, 2010. Dendrimers: A novel approach for drug targeting. J. Pharmacy Res., 3: 2238-2247.
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  66. Semwal, R., D.K. Semwal and R. Badoni, 2010. Chewing gum: A novel approach for drug delivery. J. Applied Res., 10: 115-123.
  67. Semwal, D.K., U. Rawat, R. Semwal, R. Singh and G.J.P. Singh, 2010. Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers. J. Asian Nat. Prod. Res., 12: 99-105.
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  68. Semwal, D.K., U. Rawat, R. Badoni, R. Semwal and R. Singh, 2010. Anti-hyperglycemic effect of Stephania glabra tubers in alloxan induced diabetic mice. J. Med., 11: 17-19.
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  69. Semwal, D.K., R. Badoni, R. Semwal, S.K. Kothiyal, G.J.P. Singh and U. Rawat, 2010. The Genus Stephania (Menispermaceae): Chemical and pharmacological perspectives. J. Ethnopharmacol., 132: 369-383.
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  70. Kothiyal, S.K., D.K. Semwal, R. Badoni and U. Rawat, 2010. GC-MS analysis of fatty acids and antimicrobial activity of Ilex dipyrena wallich leaves. Asian J. Trad. Med., 5: 153-157.
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  71. Badoni, R., D.K. Semwal, U. Rawat and G.J.P. Singh, 2010. Celtisanin, a novel sulphonated phenolic from Celtis australis L. fruits. Nat. Prod. Res., 24: 1282-1286.
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  72. Badoni, R., D.K. Semwal, S.K. Kothiyal and U. Rawat, 2010. Chemical constituents and biological applications of the genus Symplocos. J. Asian Nat. Prod. Res., 12: 1069-1080.
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  73. Badoni, R., D.K. Semwal and U. Rawat, 2010. Fatty acid composition and antimicrobial activity of Celtis australis L. fruits. J. Sci. Res., 2: 397-402.
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  74. Badoni, R., D.K. Semwal and U. Rawat, 2010. Composition variation in essential oils of Artemisia nilagirica and Artemisia capillaries, growing in India. J. Applied Natural Sci., 2: 30-33.
  75. Semwal, D.K., U. Rawat, R. Semwal, R. Singh and B. Saini et al., 2009. Chemical constituents from the leaves of Boehmeria rugulosa with antidiabetic and antimicrobial activities. J. Asian Natl. Prod. Res., 11: 1045-1055.
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  76. Semwal, D.K., U. Rawat, R. Semwal, K. Singh and R. Singh et al., 2009. Hypoglycemic effect of Phoebe lanceolata on alloxan induced diabetic mice. Pharmacologyonline, 1: 1021-1026.
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  77. Semwal, D.K., U. Rawat, A. Bomola and R. Samwal, 2009. Antimicrobial activity of Phoebe lanceolata and Stephania glabra; preliminary screening studies. J. Sci. Res., 1: 662-666.
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  78. Semwal, D.K. and U. Rawat, 2009. Gindarudine, a novel morphine alkaloid from Stephania glabra. Chinese Chem. Lett., 20: 823-826.
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  79. Semwal, D.K. and U. Rawat, 2009. Antimicrobial hasubanalactam alkaloid from Stephania glabra. Planta Med., 75: 378-380.
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  80. Rawat, U., S. Semwal, D.K. Semwal, R. Badoni and A. Bamola, 2009. A new flavonoid glycoside from Salix denticulata aerial parts. Molbank, M622: 1-5.
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  81. Kothiyal, S.K., D.K. Semwal, R. Badoni and U. Rawat, 2009. Seasonal variation in the essential oil composition from Morina longifolia Wallich. Int. J. Essential Oil Therapeutics, 4: 171-174.
  82. Bamola, A., D.K. Semwal, S. Semwal and U. Rawat, 2009. Flavonoid glycosides from Myrica esculenta leaves. J. Indian Chem. Soc., 86: 535-536.
  83. Badoni, R., D.K. Semwal, S.C. Sati and U. Rawat, 2009. Optimization of dyeing procedure on wool yarn with Pistacia integerrima dye using synthetic and natural mordants. Colourage, 56: 67-70.
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  84. Badoni, R., D.K. Semwal and U. Rawat, 2009. Altitudinal variation in the volatile constituents of Artemisia nilagirica. Int. J. Essential Oil Ther., 3: 66-68.
  85. Semwal, D.K., U. Rawat and G.J.P. Singh, 2008. Further aporphine alkaloids from Phoebe lanceolata. Molbank, M581: 1-5.
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  86. Bamola, A., S. Semwal, D. Semwal and U. Rawat, 2008. Application and Optimization of Natural Mordants in Modern Dyeing. In: Phytochemicals: A Therapeutant for Critical Disease Management, Khanna, D.R., A.K. Chopra, G. Prasad, D.S. Malik and R. Bhutiani (Eds.). Daya Publishing House, India, pp: 357-361.
  87. Semwal, D.K., A. Bamola and U. Rawat, 2007. Chemical constituents from some antidiabetic plants. J. Phytochem. Ayurvedic Heights, 2: 40-48.
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  88. Semwal, D.K. and U. Rawat, 2007. Physico-chemical examination of drinking water sample in and near Srinagar city (Uttarakhand). Acta Ciencia Indica, 33: 231-232.
  89. Semwal, D.K. and U. Rawat, 2007. Nordelporphine alkaloid from bark of Phoebe lanceolata. Oriental J. Chem., 23: 771-772.
  90. Kandwal, D., A. Bamola, S. Semwal, D.K. Semwal and U. Rawat, 2007. Phytochemicals from Rhamnus triqueter. Acta Ciencia Indica, 33: 389-390.
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