Dr. J. Francis Borgio
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Dr. J. Francis Borgio

Chairman and Associate Professor of Molecular Genetics
Imam Abdulrahman Bin Faisal University

Highest Degree
Certificate Course in Molecular Hematology from University of Zurich, Switzerland

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Biography

Dr. J. Francis Borgio is a Chairman of the Department of Epidemic Diseases Research, Associate Professor of Molecular Genetics and former Team Representative of the Department of Genetic Research at the Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Saudi Arabia. Dr Borgio is an Academic Editor: PLOS ONE. He served as Deputy Chairman in the International Indian School Dammam, one of the biggest schools. He received his Ph.D. Degree in Microbiology from CPRC, St. Xavier’s College, MS University, Tamil Nadu, India. Borgio has completed the Red Blood Cells Observerships, Red Blood Cell Research Group, University of ZÊrich, ZÊrich, Switzerland. Borgio has 12 Years of Experience in the field of Molecular Biology. Borgio currently engaged research in early prenatal diagnosis of genetic disorders, networks of genetic modifiers in HbF elevation and genomics of epidemic disease vectors. He is an author of a book, and 50 research papers in high impact journals. He reviewed over 200 research articles in modern biology for high impact journals. He has completed 14 projects with the budget of INR: 3,47,17,500.00. He serves as Principle Investigator or Co-I for 10+ small and 3 major ongoing funded projects. He received Indian Academy of Sciences Summer Research Fellowship for Lecturer at NBRI, and JNCASR. He has participated in more than 25 conferences, either as an invited speaker or as a participant. He has been a Ph.D supervisor and an external Ph.D examiner for various Universities. He is a recipient of various Fellowships, Grants and Awards like Outstanding Scientist, The best student’s trainer, Lifetime Achievement, Best Paper Award, University Rank, Best Student award, etc.,

Area of Interest:

Biomedical Sciences
100%
Microbiology
62%
Molecular Biology
90%
Genomics
75%
Molecular Medicine
55%

Research Publications in Numbers

Books
3
Chapters
3
Articles
69
Abstracts
0

Selected Publications

  1. Borgio, J.F., H.S. Alsuwat, W.M. Al Otaibi, A.M. Ibrahim and N. Almandil et al., 2020. State-of-the-art tools unveil potent drug targets amongst clinically approved drugs to inhibit helicase in SARS-CoV-2. Arch. Med. Sci., 16: 508-518.
    CrossRef  |  Direct Link  |  
  2. Azeez S., Z.G. Alhashim, W.M. Al-Otaibi, H.S. Alsuwat, A.M. Ibrahim, N.B. Almandil and J.F. Borgio, 2020. State-of-the-art tools to identify druggable protein ligand of sars-cov-2. Archives of Medical Science 16: 497-507.
    CrossRef  |  Direct Link  |  
  3. Asoom, L.I.A., M.M.A. Makhaita, N. Rafique, D.T.A. Afandi and W.M.A. Otaibi et al., 2020.

    Effects of u20133.7u03b1 deletion and sickle-cell trait on ventilatory and hemodynamic responses to maximum exercise in young Saudi females.

    J. Blood Med., 11: 371-378.
    CrossRef  |  Direct Link  |  
  4. Alsubaie, L.M., H.S. Alsuwat, N.B. Almandil, A. AlSulaiman, S. AbdulAzeez and J.F. Borgio, 2020. Risk y-haplotypes and pathogenic variants of arab-ancestry boys with autism by an exome-wide association study. Mol. Biol. Rep., 47: 7623-7632.
    CrossRef  |  Direct Link  |  
  5. Albakri, A.H., M.B.S. Al-Shuhaib, S.L. Alwan, S. AbdulAzeez and J.F. Borgio, 2020. Deleterious missense variants in the aflatoxin biosynthesis genes explain the low toxicity of Aspergillus flavus from infected rice. Microb. Pathog., 10.1016/j.micpath.2020.104605.
    CrossRef  |  Direct Link  |  
  6. Alabdalall A.H., N.A. ALanazi, S.A. Aldakeel, S. AbdulAzeez and J.F. Borgio, 2020. Molecular, physiological, and biochemical characterization of extracellular lipase production by aspergillus niger using submerged fermentation. PeerJ 10.7717/peerj.9425 http://dx.doi.org/10.7717/peerj.9425.
    CrossRef  |  
  7. AlGhamdi, N.A., H.S. Alsuwat, J.F. Borgio and S. AbdulAzeez, 2020. Emerging of composition variations of SARS-CoV-2 spike protein and human ace2 contribute to the level of infection: in silico approaches. J. Biomol. Struct. Dyn., 10.1080/07391102.2020.1841032.
    CrossRef  |  Direct Link  |  
  8. Rehman, S., B.R. Jermy, S. Akhtar, J.F. Borgio and S.A. Azeez et al., 2019. Isolation and characterization of a novel thermophile; Bacillus haynesii, applied for the green synthesis of ZnO nanoparticles. Artif. Cells Nanomed. Biotechnol., 47: 2072-2082.
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  9. Jermy, B.R., M. Alomari, V. Ravinayagam, S.A. Almofty, S. Akhtar, J.F. Borgio and S. AbdulAzeez, 2019. SPIONs/3D SiSBA-16 based multifunctional nanoformulation for target specific cisplatin release in colon and cervical cancer cell lines. Sci. Rep., Vol. 9, 10.1038/s41598-019-51051-w.
    CrossRef  |  Direct Link  |  
  10. Cyrus, C., S. Chathoth, C. Vatte, N. Alrubaish and O. Almuhanna et al., 2019. Novel haplotype indicator for end-stage renal disease progression among saudi patients. Int. J. Nephrol., 2019: 1-6.
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  11. Azeez, S.A., N.H. Al Qahtani, N.B. Almandil, A.M. Al-Amodi, S.A. Aldakeel, N.Z. Ghanem, D.N. Alkuroud, A. Al Turki, Q.A. Al Qattan, A. Alghamdi, N.F. Alhur, H.A. Al Taifi, H.E. Aljofi, B.R. Jermy, V. Raman, A. Giambona, A. Maggio and J.F. Borgio, 2019. Genetic disorder prenatal diagnosis and pregnancy termination practices among high consanguinity population, Saudi Arabia. Sci. Rep., 10.1038/s41598-019-53655-8.
    CrossRef  |  Direct Link  |  
  12. Alomari, M., B.R. Jermy, V. Ravinayagam, S. Akhtar and S.A. Almofty et al., 2019. Cisplatin-functionalized three-dimensional magnetic SBA-16 for treating breast cancer cells (MCF-7). Artif. Cells Nanomed. Biotechnol., 47: 3079-3086.
    CrossRef  |  Direct Link  |  
  13. Almandil, N., D. Alkuroud, S.A. Azeez, A.A. Sulaiman, A. Elaissari and J. Borgio, 2019. Environmental and genetic factors in autism spectrum disorders: Special emphasis on data from Arabian studies. Int. J. Environ. Res. Public Health, Vol. 16, No. 4, 10.3390/ijerph16040658.
    CrossRef  |  Direct Link  |  
  14. Aldakeel, S.A., N.Z. Ghanem, A.M. Al-Amodi, A.K. Osman and L.I. Al Asoom et al., 2019. Identification of seven novel variants in the β-globin gene in transfusion-dependent and normal patients. Arch. Med. Sci., 16: 453-459.
    CrossRef  |  Direct Link  |  
  15. Abdulazeez S., S. Sultana, N.B. Almandil, D. Almohazey, B.J. Bency and J.F. Borgio, 2019. The rs61742690 (s783n) single nucleotide polymorphism is a suitable target for disrupting bcl11a-mediated foetal-to-adult globin switching. PLOS ONE 10.1371/journal.pone.0212492 http://dx.doi.org/10.1371/journal.pone.0212492.
    CrossRef  |  
  16. AbdulAzeez, S., N.B. Almandil, Z.A. Naserullah, S. Al-Jarrash, A.M. Al-Suliman, H.I. ElFakharay and J.F. Borgio, 2019. Co-inheritance of alpha globin gene deletion lowering serum iron level in female beta thalassemia patients. Mol. Biol. Rep., 47: 603-606.
    CrossRef  |  Direct Link  |  
  17. Borgio, J.F., S. Abdulazeez, N.B. Almandil, Z.A. Naserullah and S. Al Jarrash et al., 2018. The α3.7 deletion in α globin genes increases the concentration of fetal hemoglobin and hemoglobin A2 in a Saudi Arabian population. Mol. Med. Rep., 17: 1879-1884.
    CrossRef  |  Direct Link  |  
  18. Borgio, J.F., S. AbdulAzeez, A.M. Al-Muslami, Z.A. Naserullah and S. Al-Jarrash et al., 2018. KLF1 gene and borderline hemoglobin A2 in Saudi population. Arch. Med. Sci., 1: 230-236.
    CrossRef  |  Direct Link  |  
  19. Alaithan, M., S. AbdulAzeez and J.F. Borgio, 2018. A comprehensive review of the prevalence of beta globin gene variations and the co-inheritance of related gene variants in Saudi Arabians with beta-thalassemia. Saudi Med. J., 39: 329-335.
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  20. Al-Shuhaib, M.B.S., F.R. Al-Kafajy, M.A. Badi, S.A. Azeez, K. Marimuthu, H.A.I. Al-Juhaishi and J.F. Borgio, 2018. Highly deleterious variations in COX1, CYTB, SCG5, FK2, PRL and PGF genes are the potential adaptation of the immigrated African ostrich population. Comp. Biol. Med., 100: 17-26.
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  21. Al-Shuhaib, M.B.S., A.H. Albakri, S.H. Alwan, N.B. Almandil, S. AbdulAzeez and J.F. Borgio, 2018. Optimal pcr primers for rapid and accurate detection of Aspergillus flavus isolates. Microbial Pathog., 116: 351-355.
    CrossRef  |  Direct Link  |  
  22. Al-Amodi, A.M., N.Z. Ghanem, S.A. Aldakeel, L. Ibrahim Al Asoom and N.R. Ahmed et al., 2018. Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT). Curr. Med. Res. Opin., 34: 945-951.
    CrossRef  |  Direct Link  |  
  23. Cyrus, C., C. Vatte, J.F. Borgio, A. Al-Rubaish and S. Chathoth et al., 2017. Existence of HbF enhancer haplotypes at HBS1L-MYB intergenic region in transfusion-dependent saudiu03b2-thalassemia patients. BioMed Res. Int., 2017: 1-7.
    CrossRef  |  Direct Link  |  
  24. Borgio, J.F., 2017. Impact of annotation error in u03b1-globin genes on molecular diagnosis. PLoS ONE, 10.1371/journal.pone.0185270.
    CrossRef  |  Direct Link  |  
  25. Al-Shammari, M.S., R. Al-Ali, N. Al-Balawi, M.S. Al-Enazi and A.A. Al-Muraikhi et al., 2017. Type 2 diabetes associated variants of KCNQ1 strongly confer the risk of cardiovascular disease among the Saudi Arabian population. Genet. Mol. Biol., 40: 586-590.
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  26. Shay, J.W., N. Homma, R. Zhou, M.I. Naseer and A.G. Chaudhary et al., 2016. Abstracts from the 3rd international genomic medicine conference (3rd IGMC 2015). BMC Genomics, 10.1186/s12864-016-2858-0.
    CrossRef  |  Direct Link  |  
  27. Borgio, J.F., S. AbdulAzeez, Z.A. Naserullah, S. Al-Jarrash and R.A. Al-Ali et al., 2016. Mutations in the β-globin gene from a Saudi population: An update. Int. J. Lab. Hematol., Vol. 38. 10.1111/ijlh.12463.
    CrossRef  |  PubMed  |  Direct Link  |  
  28. Borgio, J.F., M.S. Al-Madan and S. AbdulAzeez, 2016. Mutation near the binding interfaces at α-hemoglobin stabilizing protein is highly pathogenic. Am. J. Transl. Res., 8: 4224-4232.
  29. Alyousef, Y.M., J.F. Borgio, S. AbdulAzeez, N. Al-Masoud, A.A. Al-Ali, E. Al-Shwaimi and A.K. Al-Ali, 2016. Association of MBL2 gene polymorphism with dental caries in Saudi children. Caries Res., 51: 12-16.
    CrossRef  |  PubMed  |  Direct Link  |  
  30. AbdulAzeez, S., A.N. Al-Nafie, K. Al-Faraidy, R.A. Al-Ali and M. Al-Mansory et al., 2016. Association of SNP rs2487928 on chromosome 10p11. 2 with the risk of coronary artery disease based myocardial infarction in a Saudi population. Int. J. Clin. Exp. Pathol., 9: 5628-5634.
  31. AbdulAzeez, S., A.N. Al-Nafie, A. Al-Shehri, J.F. Borgio and E.V. Baranova et al., 2016. Intronic polymorphisms in the CDKN2B-AS1 gene are strongly associated with the risk of myocardial infarction and coronary artery disease in the Saudi population. Int. J. Mol. Sci., Vol. 17. 10.3390/ijms17030395.
    CrossRef  |  PubMed  |  Direct Link  |  
  32. AbdulAzeez, S. and J.F. Borgio, 2016. In-silico computing of the most deleterious nsSNPs in HBA1 gene. PLoS ONE, Vol. 11. 10.1371/journal.pone.0147702.
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  33. Borgio, J.F., 2015. Molecular nature of alpha-globin genes in the Saudi population. Saudi Med. J., 36: 1271-1276.
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  34. Al-Nafie, A.N., J.F. Borgio, S. AbdulAzeez, A.M. Al-Suliman and F.S. Qaw et al., 2015. Co-inheritance of novel ATRX gene mutation and globin (α & β) gene mutations in transfusion dependent beta-thalassemia patients. Blood Cells Mol. Dis., 55: 27-29.
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  35. Sahayaraj, K., J.F. Borgio and L. Lucini, 2014. Route of infection and hematological effect of Metarhizium anisopliae (Metsch.) sorokin on Dysdercus cingulatus (Fab.) adult. J. Basic Microbiol., 54: 6-17.
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  36. Borgio, J.F., S. AbdulAzeez, A.N. Al-Nafie, Z.A. Naserullah and S. Al-Jarrash et al., 2014. A novel HBA2 gene conversion in cis or trans: α12 allele in a Saudi population. Blood Cells Mol. Dis., 53: 199-203.
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  37. Akhtar, M.S., F. Qaw, J.F. Borgio, W. Albuali and A. Suliman et al., 2013. Spectrum of α-thalassemia mutations in transfusion-dependent β-thalassemia patients from the eastern province of Saudi Arabia. Hemoglobin, 37: 65-73.
    CrossRef  |  PubMed  |  Direct Link  |  
  38. Sahayaraj, K., J.A.F. Borgio and S.M. Kumar, 2012. First Record of Aspergillus flavus as a Fungal Pathogen of the Predator Rhynocoris marginatus (Hemiptera: Reduviidae). EntomoBrasilis, 5: 80-81.
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  39. Sahayaraj, K. and J.F. Borgio, 2012. Screening of some mycoinsecticides for the managing hairy caterpillar, Pericallia ricini fab. (Lepidoptera: Arctiidae) in castor. J. Entomol., 9: 89-97.
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  40. Upadhyay, S.K., K. Chandrashekar, N. Thakur, P.C. Verma and J.F. Borgio et al., 2011. RNA Interference for the Control of Whiteflies (Bemisia tabaci) by Oral Route. J. Biosci., 36: 153-161.
    CrossRef  |  PubMed  |  Direct Link  |  
  41. Francis Borgio, J., B.J. Bency, P.K. Thorat and A.D. Lonkar, 2011. Gynandropsis pentaphylla DC extracts on the production of microbial proteins. Am. J. Drug Discovery Dev., 1: 129-136.
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  42. Borgio, J.F., K. Sahayaraj and I.A. Susurluk, 2011. Microbial Insecticides: Principles and Applications. Nova Publisher, New York, ISBN: 978-1-61209-223-2, Pages: 492.
  43. Borgio, J.F., 2011. Production and quality control of entomopathogenic fungal pathogens-a review. Res. Rev.: J. Microbiol. Virol., 1: 5-18.
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  44. Borgio, J.F., 2011. Immobilization of microbial (wild and mutant strains) amylase on coconut fiber and alginate matrix for enhanced activity. Am. J. Biochem. Mol. Biol., 1: 255-264.
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  45. Borgio, J.F. and K. Sahayaraj, 2011. Mass Production of Entomopathogenic Fungi. In: Microbial insecticides: Principles and application, Borgio, J.F., K. Sahayaraj and I.A. Susurluk (Eds.). Nova Science Publishers, New York, USA., pp: 47-70.
  46. Sahayaraj, K. and J.F. Borgio, 2010. Virulence of entomopathogenic fungus Metarhizium Anisopliae (Metsch.) sorokin on seven insect pests. Indian J. Agric. Res., 44: 195-200.
    Direct Link  |  
  47. Borgio, J.F., 2010. RNAi mediated gene knockdown in sucking and chewing insect pests. J. Biopesticides, 3: 386-393.
    Direct Link  |  
  48. Borgio, J.F., 2010. Is the Failure of Expression of Recombinant Protein due to qiRNA? Chron. Young Sci., 1: 1-1.
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  49. Bency, B.J., P. Marin, S. Muthukumar and J.F. Borgio, 2010. Microbial quality of packaged drinking water and soft drinks sold in Kanyakumari district of Tamil Nadu. Indian J. Environ. Protect., 30: 948-952.
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  50. Sahayaraj, K., J.F. Borgio and G. Raju, 2009. Antifungal activity of three fern extracts on causative agents of groundnut early leaf spot and rust diseases. J. Plant Prot., 49: 141-144.
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  51. Sahayaraj, K. and J.F. Borgio, 2009. Distribution of Metarhizium anisopliae (Metsch) Sorokin (Deuteromycotina: Hyphomycetes) in Tamil Nadu, India: its biocontrol potential on Dysdercus cingulatus (Fab) (Hemiptera: Pyrrhocoridae). Arch. Phytopathol. Plant Protect., 42: 424-435.
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  52. Kalidass, C., M. Glory, F. Borgio and V.S. Manickam, 2009. Antibacterial Activity of Leptadenia reticulata (Retz.) Wight. and Arn. (Asclepidaceae). Ancient Sci. Life, 28: 10-12.
    PubMed  |  Direct Link  |  
  53. Borgio, J.F., B.J. Bency, S. Ramesh and M. Amuthan, 2009. Exopolysaccharide Production by Bacillus subtilis NCIM 2063, Pseudomonas aeruginosa NCIM 2862 and Streptococcus mutans MTCC 1943 Using Batch Culture in Different Media. Afr. J. Biotechnol., 9: 5454-5457.
    Direct Link  |  
  54. Borgio, J.F., 2009. RNA interference (RNAi) technology: A promising tool for medicinal plant research. J. Med. Plants Res., 3: 1176-1183.
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  55. Sahayaraj, K. and J.F. Borgio, 2008. Tri-tropic interaction of cotton, red cotton bug and green muscardine fungi under in-vitro conditions. BioPesticides, 1: 41-46.
  56. Borgio, J.F., K.T. Pravin and D.L. Archana, 2008. Toxicity of Gynandropsis pentaphylla DC extracts against microbials and its phytochemical profile. Ethnobotanical Leaflets, 12: 320-336.
    Direct Link  |  
  57. Borgio, J.F., K.T. Pravin and D.L. Archana, 2008. Antimycotic and antibacterial activities of Gynandropsis pentaphylla DC extracts and its phytochemical studies. Internet J. Microbiol., 5: 1-11.
  58. Borgio, J.F., B.J. Bency and S. Neha, 2008. Compatibility of Metarhizium anisopliae (Metsch.) Sorok. with Ocimum sanctum Linn. (Tulsi) (Lamiaceae) extracts. Ethnobotanical Leaflets, 12: 698-704.
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  59. Sahayaraj, K., R.J. Alakiaraj and J.F. Borgio, 2006. Ovicidal and oviposotional effect of Pedalium murex Linn (Pedaliaceae) root on Dysdercus cingulatus (Fab.) (Hemiptera: Pyrrhocoridae). Entomon, 31: 57-60.
  60. Sahayaraj, K., K.R. Raja and J.F. Borgio, 2006. Fungicidal activity of three plant extracts on cowpea wilt pathogen, Fusarium oxysporum f. sp. ciceris. J. Plant Protect. Res., 46: 335-338.
  61. Sahayaraj, K., J.F. Borgio, S. Muthu-Kumar and G. Prem-Anandh, 2006. Antibacterial activity of Rhynocoris marginatus (Fab.) and Catamirus brevipennis (Servile) (Hemiptera: Reduviidae) venoms against human pathogens. Venomous Anim. Toxins Includ. Trop. Dis., 12: 487-496.
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  62. Sahayaraj, K., G. Raju, and J.F. Borgio, 2006. Space, Prey Feed Modulation, Reduviid Predator and its Prey Density on the Reproductive Potential of acanthaspis pedestris stal. In: Perspective in Animal Ecology and Reproduction, Guptha, V.K. and A.K. Verma, (Eds.). Vol. 3 Daya Publishing House, New Delhi, pp 289-309.

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