Dr. Vijay Kumar
My Social Links

Dr. Vijay Kumar

Research Scientist
International Center for Genetic Engineering and Biotechnology, India

Highest Degree
PostDoc Fellow in Molecular Biology from Louis Pasteur University, France

Share this Profile

Biography

Dr. Vijay Kumar is currently working as J.C. Bose Fellow at International Center for Genetic Engineering and Biotechnology, India. He received his Ph.D. degree in Medical Science from All India Institute of Medical Sciences, New Delhi, India. His employment history includes worked as Junior Research Fellow, Ph.D. fellow and Lady Tata Senior Research Scholar, and Junior Research Officer at All India Institute of Medical Sciences, New Delhi, Indo-French Exchange Scholar at University of Louis Pasteur, Institut de Chimie Biologique, Strasbourg, France, and Research Scientist, Senior Research Scientist, and Staff Scientist at International Centre for Genetic Engineering & Biotechnology (I.C.G.E.B.), New Delhi. His area of specialization includes Molecular Biology of Oncogenic Viruses and Cancer, Steroid Hormone Receptors and Cancer, Gene Assembly, Cloning and Expression, and Epigenetic Regulation of DNA Replication and Transcription. Dr. Vijay Kumar received honor includes Gold Medal for securing first rank in M. Sc., Magadh University, Bodh-Gaya, Kul Prize for Best Science graduate, Bhagalpur University, Bhagalpur, Gold Medal Zoological Society of India, Fellow of National Academy of Sciences, India, National Academy of Agricultural Sciences, India, and fellow of National Academy of Medical Sciences, India. He has experience of successfully guided 22 PhD, 6 research associate, 6 research fellows, and 3 summer fellow. He is also serving as reviewer for several international journals. He organized 5 practical courses. He also delivered 80 invited lectures. He is member of various scientific committees. He has published more than 75 research articles in peer reviewed journal, 24 papers in serials, symposia proceedings and book chapters, 3 books and 3 patents contributed as author/co-author.

Area of Interest:

Molecular Sciences
100%
Molecular Biology
62%
Oncogenic Viruses
90%
Steroid Hormone Receptors
75%
Cloning
55%

Research Publications in Numbers

Books
0
Chapters
0
Articles
0
Abstracts
0

Selected Publications

  1. Nosrati, N., N.R. Kapoor and V. Kumar, 2015. DNA damage stress induces the expression of ribosomal protein S27a gene in a p53-dependent manner. Gene, 559: 44-51.
    CrossRef  |  Direct Link  |  
  2. Sidhu, K., S. Kumar, V.S. Reddy and V. Kumar, 2014. Mass spectrometric determination of disulfide bonds in the biologically active recombinant HBx protein of hepatitis B virus. Biochemistry, 53: 4685-4695.
    CrossRef  |  Direct Link  |  
  3. Saxena, N., A. Pandey, A.J. Ahuja and V. Kumar, 2014. Integration of in-silico approaches for designing B cell epitopes for disease diagnosis. Int. J. Curr. Res., 6: 7746-7753.
    Direct Link  |  
  4. Saxena, N. and V. Kumar, 2014. The HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37. PloS ONE, Vol. 9. 10.1371/journal.pone.0111256.
    CrossRef  |  Direct Link  |  
  5. Pandey, V. and V. Kumar, 2014. Breast cancer care-It's time to rethink and redesign. J. Clin. Exp. Pathol., Vol. 4. 10.4172/2161-0681.1000e118.
    CrossRef  |  Direct Link  |  
  6. Nosrati, N., N.R. Kapoor and V. Kumar, 2014. Combinatorial action of transcription factors orchestrates cell cycle-dependent expression of the ribosomal protein genes and ribosome biogenesis. FEBS J., 281: 2339-2352.
    CrossRef  |  Direct Link  |  
  7. Kumar, V., 2014. Animal Cells as Host for Recombinant DNA. In: The Gene and Its Engineering, Das, H.K. (Ed.). Wiley India Pvt. Ltd., New Delhi, India, pp: 388-409.
  8. Kumar, V. and D. Sahal, 2014. Genetic Engineering. In: Ullmann's Encyclopedia of Industrial Chemistry, Elvers, B. (Ed.). Wiley-VCH Verlag GmbH and Co., Germany, pp: 1-79.
  9. Kapoor, N.R. and V. Kumar, 2014. Emerging role of exosomal secretory pathway in human tumour virus pathogenesis. Int. J. Biochem. Res. Rev., 4: 653-665.
  10. Choedon, T., D. Dolma, G. Mathan and V. Kumar, 2014. Molecular insights into the anti-cancer properties of traditional Tibetan medicine Yukyung Karne. BMC Complement. Altern. Med., Vol. 14. 10.1186/1472-6882-14-380.
    CrossRef  |  Direct Link  |  
  11. Ahuja, R., A. Jamal, N. Nosrati, V. Pandey and P. Rajput et al., 2014. Human oncogenic viruses and cancer. Curr. Sci., 107: 768-785.
    Direct Link  |  
  12. Swarnalatha, M., A.K. Singh and V. Kumar, 2013. Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment. J. Cell Sci., 126: 4636-4646.
    CrossRef  |  Direct Link  |  
  13. Shukla, S.K. and V. Kumar, 2013. Bioactive Foods and Supplements for Protection against Liver Diseases. In: Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease, Watson, R.R. and V.R. Preedy (Eds.). Academic Press, San Diego, USA., pp: 557-567.
  14. Saxena, N. and V. Kumar, 2013. Oncogenic viruses: DUBbing their way to cancer. Virol. Discov. 10.7243/2052-6202-1-5.
    CrossRef  |  Direct Link  |  
  15. Kapoor, N.R., R. Ahuja, S.K. Shukla and V. Kumar, 2013. The HBx protein of Hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression. FEBS Lett., 587: 1287-1292.
    CrossRef  |  Direct Link  |  
  16. Swarnalatha, M., A.K. Singh and V. Kumar, 2012. The epigenetic control of E-box and Myc-dependent chromatin modifications regulate the licensing of lamin B2 origin during cell cycle. Nucl. Acids Res., 40: 9021-9035.
    CrossRef  |  Direct Link  |  
  17. Shukla, S.K. and V. Kumar, 2012. Hepatitis B virus X protein and c‐Myc cooperate in the upregulation of ribosome biogenesis and in cellular transformation. FEBS J., 279: 3859-3871.
    CrossRef  |  Direct Link  |  
  18. Sehrawat, A. and V. Kumar, 2012. Butein imparts free radical scavenging, anti-oxidative and pro-apoptotic properties in the flower extracts of Butea monosperma. Biocell, 36: 63-71.
    Direct Link  |  
  19. Pandey, V. and V. Kumar, 2012. HBx protein of hepatitis B virus promotes reinitiation of DNA replication by regulating expression and intracellular stability of replication licensing factor CDC6. J. Biol. Chem., 287: 20545-20554.
    Direct Link  |  
  20. Kumar, V.L., B. Guruprasad and V. Kumar, 2012. Herbal Medicines Affecting Angiogenesis. In: Recent Progress in Medicinal Plants, Volume 32: Ethnomedicine and Therapeutic Validation, Govil, J.N. and G. Kaushik (Eds.). Studium Press, USA., pp: 127-150.
  21. Khattar, E., A. Mukherji and V. Kumar, 2012. Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation. FEBS J., 279: 1220-1230.
    CrossRef  |  Direct Link  |  
  22. Kapoor, N.R. and V. Kumar, 2012. Hepatitis B virus: A molecular perspective. Proc. Natl. Acad. Sci. India Sect. B: Biol. Sci., 82: 31-41.
    CrossRef  |  Direct Link  |  
  23. Fatima, G., G. Mathan and V. Kumar, 2012. The HBx protein of hepatitis B virus regulates the expression, intracellular distribution and functions of ribosomal protein S27a. J. Gen. Virol., 93: 706-715.
    Direct Link  |  
  24. Choedon, T. and V. Kumar, 2012. Medicinal Plants used in the Practice of Tibetan Medicine. In: Recent Progress in Medicinal Plants, Volume 34: Phytoconstituents and Physiological Processes, Govil, J.N., G. Kaushik and N. Rai (Eds.). Chapter 18, Studium Press, USA., ISBN-13: 9781933699240, pp: 387-405.
  25. Singh, A.K., M. Swarnalatha and V. Kumar, 2011. c-ETS1 facilitates G1/S-phase transition by up-regulating cyclin E and CDK2 genes and cooperates with hepatitis B virus X protein for their deregulation. J. Biol. Chem., 286: 21961-21970.
    Direct Link  |  
  26. Mathan, G., G. Fatima, A.K. Saxena, B.K. Chandan and B.S. Jaggi et al., 2011. Chemoprevention with aqueous extract of Butea monosperma flowers results in normalization of nuclear morphometry and inhibition of a proliferation marker in liver tumors. Phytother. Res., 25: 324-328.
    CrossRef  |  Direct Link  |  
  27. Choedon, T., D. Dolma and V. Kumar, 2011. Pro-apoptotic and anticancer properties of Thapring-A Tibetan herbal formulation. J. Ethnopharmacol., 137: 320-326.
    CrossRef  |  Direct Link  |  
  28. Sehrawat A. and V. Kumar, 2010. Herbs and Bioactive Foods in Prevention and Treatment of Hepatocellular Carcinoma. In: Bioactive Foods and Extracts: Cancer Treatment and Prevention, Watson, R.R. and V.R. Preedy (Eds.). CRC Press, USA., pp: 555-582.
  29. Kumar, V.L. and V. Kumar, 2010. Anticancer Properties of Plant-Derived Food, Phytochemicals and Plant-Expressed Recombinant Pharmaceuticals. In: Comprehensive Bioactive Natural Products, Volume 1: Potential and Challenges, Gupta, V.K. (Ed.). Studium Press, USA., ISBN-13: 978-1933699516, pp: 307-321.
  30. Kumar, V., S. Das and S. Jameel, 2010. The biology and pathogenesis of hepatitis viruses. Curr. Sci., 98: 312-325.
    Direct Link  |  
  31. Khattar, E. and V. Kumar, 2010. Mitogenic regulation of p27Kip1 gene is mediated by AP-1 transcription factors. J. Biol. Chem., 285: 4554-4561.
    Direct Link  |  
  32. Janbandhu, V.C., A.K. Singh, A. Mukherji and V. Kumar, 2010. p65 negatively regulates transcription of the cyclin E gene. J. Biol. Chem., 285: 17453-17464.
    Direct Link  |  
  33. Choedon, T., S.K. Shukla and V. Kumar, 2010. Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. J. Ethnopharmacol., 129: 208-213.
    CrossRef  |  Direct Link  |  
  34. Bui-Nguyen, T.M., S.B. Pakala, R.D. Sirigiri, W. Xia and M.C. Hung et al., 2010. NF-κB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx. Oncogene, 29: 1179-1189.
    CrossRef  |  Direct Link  |  
  35. Mukherji, A., V.C. Janbandhu and V. Kumar, 2009. HBx protein modulates PI3K/Akt pathway to overcome genotoxic stress-induced destabilization of cyclin D1 and arrest of cell cycle. Indian J. Biochem. Biophys., 46: 37-44.
  36. Mukherji, A., V.C. Janbandhu and V. Kumar, 2008. GSK-3β-dependent destabilization of cyclin D1 mediates replicational stress-induced arrest of cell cycle. FEBS Lett., 582: 1111-1116.
    CrossRef  |  Direct Link  |  
  37. Mukherji, A. and V. Kumar, 2008. Regulation of Cell Cycle by the Hepatitis B Virus X Protein. In: The Pleiotropic Functions of the Viral Protein HBx and the Development of Liver Cancer, Kobarg, J. (Ed.). Research Signpost, Trivandrum, India, pp: 165-177.
  38. Kumar, V.L., A. Srivastava and V. Kumar, 2008. Observations on the expression of bcg-1 gene in breast tumor and adjacent tissue. Indian J. Cancer, 45: 77-77.
    CrossRef  |  PubMed  |  Direct Link  |  
  39. Kumar, V., 2008. Animal Models of Hepatitis B-Related Hepatocellular Carcinoma in Cancer Research. In: The Pleiotropic Functions of the Viral Protein HBx and the Development of Liver Cancer, Kobarg, J. (Ed.). Research Signpost, Trivandrum, India, pp: 179-194.
  40. Mukherji, A., V.C. Janbandhu and V. Kumar, 2007. HBx-dependent cell cycle deregulation involves interaction with cyclin E/A-cdk2 complex and destabilization of p27Kip1. Biochem, J., 401: 247-256.
    Direct Link  |  
  41. Kumar, V.L., S. Kumar, A. Srivastava and V. Kumar, 2006. Observations on the presence of E domain variants of estrogen receptor-α in the breast tumors. J. Surg. Oncol., 94: 332-337.
    CrossRef  |  Direct Link  |  
  42. Kalra, N. and V. Kumar, 2006. The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c-Myc. FEBS Lett., 580: 431-436.
    CrossRef  |  Direct Link  |  
  43. Hung, L. and V. Kumar, 2006. Antisense regulation of expression and transactivation functions of the tumorigenic HBx and c-Myc genes. Biochem. Biophys. Res. Commun., 344: 293-299.
    CrossRef  |  Direct Link  |  
  44. Choedon, T., G. Mathan, S. Arya, V.L. Kumar and V. Kumar, 2006. Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma. World J. Gastroenterol., 12: 2517-2522.
    CrossRef  |  Direct Link  |  
  45. Kumar, V.L., A. Srivastava, R. Singhal and V. Kumar, 2005. Immunoreactive estrogen receptor in breast tumor and adjacent tissue: Association with clinicopathological characteristics in Indian population. J. Surg. Oncol., 89: 251-255.
    CrossRef  |  Direct Link  |  
  46. Reddi, H.V. and V. Kumar, 2004. Self-association of the hepatitis B virus X protein in the yeast two-hybrid system. Biochem. Biophys. Res. Commun., 317: 1017-1022.
    CrossRef  |  Direct Link  |  
  47. Misra, K.P., A. Mukherji and V. Kumar, 2004. The conserved amino-terminal region (amino acids 1-20) of the hepatitis B virus X protein shows a transrepression function. Virus Res., 105: 157-165.
    CrossRef  |  Direct Link  |  
  48. Kumar, V. and D.P. Sarkar, 2004. Hepatitis B Virus X Protein (HBx): Structure-Function Relationships and Role in Viral Pathogenesis. In: Handbook of Experimental Pharmacology, Triezenberg, S.J., J. Kaufman and M. Gossen (Eds.). Springer-Verlag, Germany, pp: 377-407.
  49. Kalra, N. and V. Kumar, 2004. c-Fos is a mediator of the c-myc-induced apoptotic signaling in serum-deprived hepatoma cells via the p38 mitogen-activated protein kinase pathway. J. Biol. Chem., 279: 25313-25319.
    Direct Link  |  
  50. Hung, L. and V. Kumar, 2004. Specific inhibition of gene expression and transactivation functions of hepatitis B virus X protein and c-myc by small interfering RNAs. FEBS Lett., 560: 210-214.
    CrossRef  |  Direct Link  |  
  51. Singh, M. and V. Kumar, 2003. Transgenic mouse models of hepatitis B virus‐associated hepatocellular carcinoma. Rev. Med. Virol., 13: 243-253.
    CrossRef  |  Direct Link  |  
  52. Reddi, H., R. Kumar, S.K. Jain and V. Kumar, 2003. A carboxy-terminal region of the hepatitis B virus X protein promotes DNA interaction of CREB and mimics the native protein for transactivation function. Virus Genes, 26: 227-238.
    CrossRef  |  Direct Link  |  
  53. Lakhtakia, R., V. Kumar, H. Reddi, M. Mathur, S. Dattagupta and S.K. Panda, 2003. Hepatocellular carcinoma in a hepatitis B x transgenic mouse model: A sequential pathological evaluation. J. Gastroenterol. Hepatol., 18: 80-91.
    CrossRef  |  Direct Link  |  
  54. Reddi, H., A. Bhattacharya and V. Kumar, 2002. The calcium‐binding protein of Entamoeba histolytica as a fusion partner for expression of peptides in Escherichia coli. Biotechnol. Applied Biochem., 36: 213-218.
    CrossRef  |  Direct Link  |  
  55. Kumar, V.L., P.K. Majumder and V. Kumar, 2002. In vivo modulation of androgen receptor by androgens. Asian J Androl., 4: 229-231.
    Direct Link  |  
  56. Nijhara, R., S.S. Jana, S.K. Goswami, V. Kumar and D.P. Sarkar, 2001. An internal segment (residues 58-119) of the hepatitis B virus X protein is sufficient to activate MAP kinase pathways in mouse liver. FEBS Lett., 504: 59-64.
    CrossRef  |  Direct Link  |  
  57. Nijhara, R., S.S. Jana, S.K. Goswami, A. Rana, S.S. Majumdar, V. Kumar and D.P. Sarkar, 2001. Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo. J. Virol., 75: 10348-10358.
    Direct Link  |  
  58. Kumar, V., 2001. Transgenic and Knockout Mouse Models in New Drug Discovery. In: Pharmacology and Therapeutics in the New Millennium, Gupta, S.K. (Ed.). Narosa Publishing House, New Delhi, India, pp: 177-184.

© All rights reserved | Design By: LiveDNA Member since October, 2015
Record last modified Jul 25, 2022, 10:14 am