Dr. Sajid Rashid
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Dr. Sajid Rashid

Professor
National Centre for Bioinformatics, Quaid-i-Azam University, Pakistan

Highest Degree
PostDoc. in Molecular Biology from International Institute of Molecular and Cell Biology, Warsaw, Poland

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Biography

Dr. Sajid Rashid completed his Ph.D degree in Function Genomics in 2006. During Ph.D study, he worked on the generation and characterization of knock-out and transgenic mice for two dynein genes: Dnali1 and Tcte3 (Rashid et al., 2006, Rashid et al., 2010). Moreover, he completed three-year postdoctoral fellowship in the Partner Group of the Max Planck’s Institute of Molecular Cell Biology and Genetics in Dresden (the MPI-CBG/IIMCB Partner Group), Germany and IIMCB (International Institute of Molecular and Cellular Biology), Warsaw, Poland. During Post-doc studies, he performed a detailed analysis of endocytic proteins (APPL1 and APPL2) and described their novel roles in the canonical WNT pathway (Rashid et al., 2009). He joined National Center for Bioinformatics, QAU in August, 2009 as Assistant Professor where he is involved in teaching and research activities. To date, he produced 30 M.Phil students and 2 PhDs. He produced 30 publications in high impact factor journals belonging to prestigious fields. Dr. Sajid’s findings contributed in the elucidation of more potent and novel inhibitors for the treatment and cure of diseases including head and neck cancer (Sehgal et al., 2014), colorectal cancer (Iftikhar et al., 2013), diabetes and neurological disorders (Ain et al., 2014, Hassan et al., 2014). Moreover, his studies suggested several protein complex models through modeling 3-dimensional structures (Ain et al., 2013, Rashid et al., 2013). One recent study of Dr. Sajid Rashid (Kousar et al., 2013) highlighted a new molecular mechanism for the pathogenesis of Pseudomonas aeruginosa PAO, which gained much encouragement by the scientific community worldwide. In short, Dr. Sajid Rashid has immense potential to peruse out-of-the box ideas having the potential to profoundly improve the human health through molecular and Bioinformatics studies. On his research contributions, he has been awarded gold medal by Pakistan Academy of Medical Sciences in 2015.

Area of Interest:

Molecular Sciences
100%
Bioinformatics
62%
Functional Genomics
90%
Structural Computational Biology
75%
Proteomics
55%

Research Publications in Numbers

Books
0
Chapters
1
Articles
65
Abstracts
0

Selected Publications

  1. Gul, M., A. Navid and S. Rashid, 2023. Structural basis of constitutive c-Src kinase activity due to R175L and W118A mutations. J. Biomol. Struct. Dyn., 41: 634-645.
    CrossRef  |  Direct Link  |  
  2. Zia, A. and S. Rashid, 2021. Systematic transition modeling analysis in the MEF2B-DNA binding interface due to Y69H and K4E variants. J. Mol. Graphics Modell., Vol. 108. 10.1016/j.jmgm.2021.108009.
    CrossRef  |  Direct Link  |  
  3. Zulfiqar, Z., F.A. Shah, S. Shafique, A. Alattar and T. Ali et al., 2020. Repurposing FDA approved drugs as JNK3 inhibitor for prevention of neuroinflammation induced by MCAO in rats. J. Inflammation Res., 13: 1185-1205.
    CrossRef  |  Direct Link  |  
  4. Zia, A., M. Imran and S. Rashid, 2020. In silico exploration of conformational dynamics and novel inhibitors for targeting MEF2-associated transcriptional activity. J. Chem. Inf. Model., 60: 1892-1909.
    CrossRef  |  Direct Link  |  
  5. Sameera, F.A. Shah and S. Rashid, 2020. Conformational ensembles of non-peptide ω-conotoxin mimetics and Ca+2 ion binding to human voltage-gated N-type calcium channel Cav2.2. Comput. Struct. Biotechnol. J., 18: 2357-2372.
    CrossRef  |  Direct Link  |  
  6. Najumuddin, M. Fakhar and S. Rashid, 2020. Evidence for NAD+-dependent histone dynamics and tunneling associated conformational transitions in circadian deacetylase SIRT1. J. Mol. Graphics Modell., Vol. 99. 10.1016/j.jmgm.2020.107646.
    CrossRef  |  Direct Link  |  
  7. Mehfooz, H., A. Saeed, M. Faisal, F.A. Larik and U. Muqadar et al., 2020. Facile one-pot synthesis, butyrylcholinesterase and α-glucosidase inhibitory activities, structure-activity relationship, molecular docking and DNA-drug binding analysis of Meldrum’s acid derivatives. Res. Chem. Intermed., 46: 2437-2456.
    CrossRef  |  Direct Link  |  
  8. Malik, S.S., A. Zia, S. Rashid, S. Mubarik and N. Masood et al., 2020. XPC as breast cancer susceptibility gene: Evidence from genetic profiling, statistical inferences and protein structural analysis. Breast Cancer, 27: 1168-1176.
    CrossRef  |  Direct Link  |  
  9. Malik, S.S., A. Zia, S. Mubarik, N. Masood, S. Rashid, A. Sherrard and M.T. Khadim, 2020. Correlation of MLH1 polymorphisms, survival statistics, in silico assessment and gene downregulation with clinical outcomes among breast cancer cases. Mol. Biol. Rep., 47: 683-692.
    CrossRef  |  Direct Link  |  
  10. Younis, S., S. Taj and S. Rashid, 2019. Structural studies of Staphylococcus aureus Sortase inhibiton via Conus venom peptides. Arch. Biochem. Biophy., 671: 87-102.
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  11. Shafique, S. and S. Rashid, 2019. Structural basis of βTrCP1-associated GLI3 processing. Scient. Rep., 9: 1-13.
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  12. Shafique, S. and S. Rashid, 2019. Structural basis for renal cancer by the dynamics of pVHL-dependent JADE1 stabilization and β-catenin regulation. Prog. Biophy. Mol. Biol., 145: 65-77.
    CrossRef  |  
  13. Gul, M., M. Fakhar and S.R. Najumuddin, 2019. Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors. PloS one, Vol. 14. 10.1371/journal.pone.0225132.
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  14. Bibi, N., S. Rashid, J. Nicholson, M. Malloy, R. O'Neill, D. Blake and T. Hupp, 2019. An integrative “Omics” approach, for identification of bona fides PLK1 Associated biomarker in esophageal adenocarcinoma. Curr. Cancer Drug Targets, 19: 742-755.
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  15. Bibi, N., H. Niaz, T. Hupp, M.A. Kamal and S. Rashid, 2019. Screening and Identification of PLK1-polo box binding peptides by high-throughput sequencing of phage-selected libraries. Protein Pept. Lett., 26: 620-633.
    CrossRef  |  
  16. Shafique, S., W. Ali, S. Kanwal and S. Rashid, 2018. Structural basis for cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics. Int. J. Biol. Macromolecules, 106: 532-543.
    CrossRef  |  Direct Link  |  
  17. Fakhar, M., M. Gul and S. Rashid, 2018. Interactive structural analysis of βTrCP1 and PER2 phosphoswitch binding through dynamics simulation assay. Arch. Biochem. Biophy., 651: 34-42.
    CrossRef  |  
  18. Fakhar, M., M. Gul and S. Rashid, 2018. Antagonistic role of klotho-derived peptides dynamics in the pancreatic cancer treatment through obstructing WNT-1 and frizzled binding. Biophy. Chem., 240: 107-117.
    CrossRef  |  Direct Link  |  
  19. Batool, A., M.A. Kamal, S. Rizvi and S. Rashid, 2018. Topical discoveries on multi-target approach to manage alzheimer's disease. Curr. Drug Metab., 19: 704-713.
    CrossRef  |  Direct Link  |  
  20. Ali, W., S. Shafique and S. Rashid, 2018. Structural characterization of β-catenin and RX-5902 binding to phospho-p68 RNA helicase by molecular dynamics simulation. Prog. Biophy. Mol. Biol., 140: 79-89.
    CrossRef  |  Direct Link  |  
  21. Younis, S. and S. Rashid, 2017. Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study. PLoS ONE, Vol. 12. 10.1371/journal.pone.0189154.
    CrossRef  |  Direct Link  |  
  22. Shafique, S. and S. Rashid, 2017. Antiviral drug acyclovir exhibits antitumor activity via targeting βTrCP1: Molecular docking and dynamics simulation study. J. Mol. Graphics Modell., 72: 96-105.
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  23. Raza, S.I., A.K. Navid, Z. Noor, K. Shah and N.R. Dar et al., 2017. GLY67ARG substitution in RSPO4 disrupts the WNT signaling pathway due to an abnormal binding pattern with LGRs leading to anonychia. RSC Adv., 7: 17357-17366.
    Direct Link  |  
  24. Fakhar, M. and S. Rashid, 2017. Targeted inhibition of klotho binding to fibroblast growth factor 23 prevents hypophosphetemia. J. Mol. Graphics Modell., 75: 9-19.
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  25. Channar, P.A., A. Saeed, F.A. Larik, S. Rashid and Q. Iqbal et al., 2017. Design and synthesis of 2,6-di(substituted phenyl)thiazolo[3,2-b]-1,2,4-triazoles as α-glucosidase and α-amylase inhibitors, co-relative Pharmacokinetics and 3D QSAR and risk analysis. Biomed. Pharmacother., 94: 499-513.
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  26. Batool, A., S. Yasmeen and S. Rashid, 2017. T8M mutation in connexin-26 impairs the connexon topology and shifts its interaction paradigm with lipid bilayer leading to non-syndromic hearing loss. J. Mol. Liq., 227: 168-177.
    CrossRef  |  Direct Link  |  
  27. Shafique, S., S. Younis, H. Niaz and S. Rashid, 2016. Elucidation, functional clustering and structural characterization of βTrCP1 substrates through a molecular dynamics study. Mol. BioSyst., 12: 2233-2246.
    Direct Link  |  
  28. Shafique, S., N. Bibi and S. Rashid, 2015. In silico identification of putative bifunctional Plk1 inhibitors by integrative virtual screening and structural dynamics approach. J. Theor. Biol., 388: 72-84.
    CrossRef  |  Direct Link  |  
  29. Rashid, S., N. Bibi, Z. Parveen and S. Shafique, 2015. Inhibition of Janus kinases by Tyrosine phosphorylation inhibitor, Tyrphostin AG-490. J. Biomol. Struct. Dynam., 33: 2368-2379.
    CrossRef  |  Direct Link  |  
  30. Noor, Z., N. Afzal and S. Rashid, 2015. Exploration of novel inhibitors for class I histone deacetylase isoforms by QSAR modeling and molecular dynamics simulation assays. PLoS ONE, Vol. 10. 10.1371/journal.pone.0139588.
    CrossRef  |  Direct Link  |  
  31. Ul Ain, Q., N.H. Greig, M.S. Nawaz, S. Rashid and M.A. Kamal, 2014. Exploring N1-p-fluorobenzyl-cymserine as an inhibitor of 5-lipoxygenase as a candidate for type 2 diabetes and neurodegenerative disorder treatment. CNS Neurol. Disord. Drug Targets, 13: 197-202.
    Direct Link  |  
  32. Sohail, I. and S. Rashid, 2014. Molecular dynamics and regulation of butyrylcholinesterase cholinergic activity by RNA binding proteins. CNS Neurol. Disord. Drug Targets, 8: 1366-1377.
    PubMed  |  Direct Link  |  
  33. Sehgal, S.A., R.A. Tahir, S. Shafique, M. Hassan and S. Rashid, 2014. Molecular modeling and docking analysis of CYP1A1 associated with head and neck cancer to explore its binding regions. J. Theoret. Comput. Sci., Vol. 1. .
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  34. Sehgal, S.A., M. Hassan and S. Rashid, 2014. Pharmacoinformatics elucidation of potential drug targets against migraine to target ion channel protein KCNK18. Drug Design Dev. Therapy, 8: 571-581.
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  35. Raza, S.I., D. Muhammad, A. Jan, R.H. Ali, M. Hassan, W. Ahmad and S. Rashid, 2014. In silico analysis of missense mutations in LPAR6 reveals abnormal phospholipid signaling pathway leading to hypotrichosis. PLoS ONE, Vol. 8. 10.1371/journal.pone.0104756.
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  36. Parveen, Z., Z. Bibi, N. Bibi, J. Neesen and S. Rashid, 2014. Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1. Comput. Biol. Chem., 53: 214-225.
    CrossRef  |  Direct Link  |  
  37. Parveen, Z., Z. Bibi, N. Bibi, J. Neesen and S. Rashid, 2014. Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1. Comput. Biol., Chem., 53: 214-225.
    CrossRef  |  Direct Link  |  
  38. Nawaz, M.S., Z. Parveen, L. Wang, S. Rashid, F. Qaiser and M.A. Kamal, 2014. Computational study of human tyrosine hydroxylase mutants to uphold [4-(Propan-2-yl) Phenyl]Carbamic acid as a potential Inhibitor. CNS Neurol. Disord. Drug Targets, 13: 1169-1174.
    PubMed  |  
  39. Iftikhar, H. and S. Rashid, 2014. Molecular docking studies of flavonoids for their inhibition pattern against β-catenin and pharmacophore model generation from experimentally known flavonoids to fabricate more potent inhibitors for wnt signaling pathway. Pharmacognosy Mag., 10: 264-271.
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  40. Hassan, M., S.A. Sehgal and S. Rashid, 2014. Regulatory cascade of neuronal loss and glucose metabolism. CNS Neurol. Disord. Drug Targets, 13: 1232-1245.
    PubMed  |  Direct Link  |  
  41. Aziz, A., Irfanullah, S. Khan, F.K. Zimri, N. Muhammad, S. Rashid and W. Ahmad, 2014. Novel homozygous mutations in the WNT10B gene underlying autosomal recessive split hand/foot malformation in three consanguineous families. Gene, 534: 265-271.
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  42. Al‐Masoudi, N.A., D.S. Ali, B. Saeed, R.W. Hartmann, M. Engel, S. Rashid and A. Saeed, 2014. New CYP17 hydroxylase inhibitors: Synthesis, biological evaluation, QSAR and molecular docking study of new pregnenolone analogs. Chem. Life Sci., 347: 896-907.
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  43. Ul Ain, Q., U. Seemab , S. Rashid, M.S. Nawaz and M.A. Kamal, 2013. Prediction of structure of human WNT-CRD (FZD) complex for computational drug repurposing. PLoS ONE, Vol. 8. 10.1371/journal.pone.0054630.
    CrossRef  |  Direct Link  |  
  44. Seemab, U., Q.U. Ain, M.S. Nawaz, Z. Saeed and S. Rashid, 2013. TrFAST: A tool to predict signaling pathway-specific transcription factor binding sites. Genomics, Proteomics Bioinf., 10: 354-359.
    CrossRef  |  Direct Link  |  
  45. Rashid, S., Z. Parveen, S. Ferdous and N. Bibi, 2013. Mutually exclusive binding of APPLPH to BAR domain and Reptin regulates β-catenin dependent transcriptional events. Comput. Biol. Chem., 47: 48-55.
    CrossRef  |  Direct Link  |  
  46. Khebichat, N., K. Nekkaz, S. Ghalem, S. Rashid and M.A. Kamal, 2013. Conformational search on the tripeptides structure by molecular dynamics: Study of L,L-Gly-Phe-Phe, L,L-Phe-Gly-Phe and L,L-Phe-Phe-Gly. Drug Design., Vol. 2. .
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  47. Kausar, S., M. Asif, N. Bibi and S. Rashid, 2013. Comparative molecular docking analysis of cytoplasmic dynein light chain DYNLL1 with pilin to explore the molecular mechanism of pathogenesis caused by Pseudomonas aeruginosa PAO. PLoS ONE, Vol. 8. 10.1371/journal.pone.0076730.
    CrossRef  |  Direct Link  |  
  48. Bibi, N., Z. Parveen and S. Rashid, 2013. Identification of potential Plk1 targets in a cell-cycle specific proteome through structural dynamics of kinase and polo box-mediated interactions. PLoS ONE, Vol. 8. 10.1371/journal.pone.0070843.
    CrossRef  |  Direct Link  |  
  49. Batool, S., S. Ferdous, M.A. Kamal, H. Iftikhar and S. Rashid, 2013. In silico screening for identification of novel aurora kinase inhibitors by molecular docking, dynamics simulations and ligand-based hypothesis approaches. Enzyme Eng., Vol. 2. .
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  50. Nawaz, M.S. and S. Rashid, 2012. MotViz: A tool for sequence motif prediction in parallel to structural visualization and analyses. Genom. Proteom. Bioinform., 10: 35-43.
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  51. Torun, A., S. Rashid, E. Szymanska, I. Pilecka and M. Miaczynska, 2011. Regulation of the canonical Wnt pathway by endocytic proteins. FEBS J., 278: 482-482.
  52. Saqib, M.A.N., B.M. Awan, M. Sarfraz, M.N. Khan, S. Rashid and M. Ansar, 2011. Genetic analysis of four Pakistani families with achromatopsia and a novel S4 motif mutation of CNGA3. Japan. J. Ophthalmol., 55: 676-680.
    CrossRef  |  Direct Link  |  
  53. Ain, Q., U. Seemab, S. Nawaz and S. Rashid, 2011. Integrative analyses of conserved WNT clusters and their co-operative behavior in human breast cancer. Bioinformation, 7: 339-346.
  54. Rashid, S., P. Grzmil, J.D. Drenckhahn, A. Meinhardt, I. Adham, W. Engel and J. Neesen, 2010. Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia. Reproduction, 139: 99-111.
    CrossRef  |  Direct Link  |  
  55. Rashid, S., I. Pilecka, A. Torun, M. Olchowik, B. Bielinska and M. Miaczynska, 2009. Endosomal adaptor proteins APPL1 and APPL2 are novel activators of β-catenin/TCF-mediated transcription. J. Biol. Chem., 284: 18115-18128.
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  56. Rashid, S., R. Breckle, M. Hupe, S. Geisler, N. Doerwald and J. Neesen, 2006. The murine Dnali1 gene encodes a flagellar protein that interacts with the cytoplasmic dynein heavy chain 1. Mol. Reprod. Dev., 73: 784-794.
    CrossRef  |  Direct Link  |  
  57. Rashid, S., 2006. Bioinformatics resource development in pakistan: A review. Proc. Pak. Acad. Sci., 43: 295-307.
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