Dr. Afaf  H. Alnadaf
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Dr. Afaf H. Alnadaf

Associate Professor
Department of Pharmaceutical Chemistry, Mutah University, Karak City, Karak, Jordan

Highest Degree
Ph.D. in Medicinal Chemistry and Drug Discovery from The University of Jordan, Amman, Jordan

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Dr. Afaf H. Alnadaf holds a position of Associate Professor at Mutah University, Jordan. She obtained her Ph.D. in Organic Chemistry from same University. Her main area of interest related to Computer-Aided Molecular Design Techniques, Organic/Green Chemistry and Drug Analysis. Her area of expertise includes Computer-Aided Molecular Design, 3D-QSAR, Drug Analysis, Polymer Chemistry, Anti-Alzheimers Leads, Multi-Targets, Synthetic Modifications, Traditional QSAR Models, and Green Approaches in Synthetic Chemistry, Microwave Synthesis, Anti-Hypertensive Leads, and Cyclodextrin Complexes. She is author/co-author of 6 journal papers.

Area of Interest:

Organic Chemistry
Green Chemistry
Drug Analysis
Synthetic Modifications

Research Publications in Numbers


Selected Publications

  1. Al-Nadaf, A.H., S.A. Salah and M.O. Taha, 2018. Discovery of new Gyrase β inhibitors via structure based modeling. Comput. Biol. Chem., 74: 263-272.
  2. Al-Nadaf, A.H., N.J. Seder and W. Abu Rayyan, 2018. Wound healing; antimicrobial and anti-oxidant activity for Jordanian Juglans regia L. unripe fruits. J. Innovations Pharm. Biol. Sci., 5: 26-34.
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  3. Al-Nadaf, A.H., H.M. Bastoni and D.F. Hamdan, 2018. Microwave-assisted efficient extraction of phenolics from Juglans regia L.: Pellicle; kernel unripe fruits and leaves in different solvents. Int. J. Green Pharm., 12: 182-190.
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  4. Thiab, S.H., I.I. Hamdan, D. El-Sabawi and A.H. Al-Nadaf, 2016. Effect of loratadine on the dissolution and bioavailability of gliclazide from its hydroxypropyl-β-cyclodextrin complex. J. Inclusion Phenomena Macrocyclic Chem., 85: 203-216.
    CrossRef  |  Direct Link  |  
  5. Al-Nadaf, A.H., M.O. Taha and H.K. Aldal'in, 2015. Haloperidol inhibits Memapsin 2: Innovation by docking simulation and in vitro assay. Pak. J. Pharm. Sci3, 28: 139-146.
  6. Al-Nadaf, A.H. and M.O. Taha, 2015. Identification of small molecule memapsin inhibitors via computation-based virtual screening. Adv. Pharmacol. Pharm., 3: 53-63.
  7. Taha, M.O., M.A. Al-Sha'er, M.A. Khanfar and A.H. Al-Nadaf, 2014. Discovery of nanomolar phosphoinositide 3-kinase gamma (PI3Kγ) inhibitors using ligand-based modeling and virtual screening followed by in vitro analysis. Eur. J. Med. Chem., 84: 454-465.
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  8. Al-Shawabkeh, J.D., A.H. Al-Nadaf, L.A. Dahabiyeh and M.O. Taha, 2014. Design, synthesis and structure-activity relationship of new HSL inhibitors guided by pharmacophore models. Med. Chem. Res., 23: 127-145.
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  9. Al-Nadaf, A. and M.O. Taha, 2013. Ligand-based pharmacophore exploration and QSAR analysis of transition state analogues followed by in silico screening guide the discovery of new sub-micromolar β-secreatase inhibitors. Med. Chem. Res., 22: 1979-1997.
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  10. Aldal'in, H.K.H., A.H. Al-Nadaf and A.W.R. Hamad, 2012. Study the effect of photoperiod duration on dynamic carbohydrates composition and enzymes activity in soybean leaves. Pak. J. Nutr., 11: 1166-1176.
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  11. Al-Nadaf, A.H. and M.O. Taha, 2011. Discovery of new renin inhibitory leads via sequential pharmacophore modeling, QSAR analysis, in silico screening and in vitro evaluation. J. Mol. Graphics Modell., 29: 843-864.
    CrossRef  |  PubMed  |  Direct Link  |  
  12. Mohammad, M.K., I.M. Almasri, K. Tawaha, A. Issa and A. Al-Nadaf et al., 2010. Antioxidant, antihyperuricemic and xanthine oxidase inhibitory activities of Hyoscyamus reticulatus. Pharm. Biol., 48: 1376-1383.
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  13. Al-Nadaf, A., G.A. Sheikha and M.O. Taha, 2010. Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent β-secretase inhibitory leads. Bioorg. Med. Chem., 18: 3088-3115.
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